pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence
Open accessAbstract
Mycobacterium tuberculosis is a major, globally spread, aerosol-transmitted human pathogen, thought to have evolved by clonal expansion from a Mycobacterium canettii-like progenitor. In contrast, extant M. canettii strains are rare, genetically diverse, and geographically restricted mycobacteria of only marginal epidemiological importance. Here, we show that the contrasting evolutionary success of these two groups is linked to loss of lipooligosaccharide biosynthesis and subsequent morphotype changes. Spontaneous smooth-to-rough M. canettii variants were found to be mutated in the polyketide-synthase-encoding pks5 locus and deficient in lipooligosaccharide synthesis, a phenotype restored by complementation. Importantly, these rough variants showed an altered host-pathogen interaction and increased virulence in cellular- and animal-infection models. In one variant, lipooligosaccharide deficiency occurred via homologous recombination between two pks5 genes and removal of the intervening acyltransferase-encoding gene. The resulting single pks5 configuration is similar to that fixed in M. tuberculosis, which is known to lack lipooligosaccharides. Our results suggest that pks5-recombination-mediated bacterial surface remodelling increased virulence, driving evolution from putative generalist mycobacteria towards professional pathogens of mammalian hosts.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
M. canettii strains represent a group of rare tubercle bacilli thought to resemble the ancestor of M. tuberculosis and have been isolated mainly from tuberculosis patients in the Horn of Africa.
“representing a group of rare tubercle bacilli that are thought to resemble the ancestor of M. tuberculosis and have been isolated mainly from tuberculosis patients in the region of the Horn of Africa (East Africa) (56,57).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Application of Phylogenetic Networks in Evolutionary Studies
Huson, D. H., & Bryant, D. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msj030 · Cited by 8,751 · see citing works
Using Tablet for visual exploration of second-generation sequencing data
Milne, I., Stephen, G., Bayer, M., Cock, P., Pritchard, L., Cardle, L., Shaw, P. D., & Marshall, D. (2012) · Briefings in Bioinformatics · doi:10.1093/bib/bbs012 · Cited by 949 · see citing works
Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis
Gutierrez, M. C., Brisse, S., Brosch, R., Fabre, M., Omaïs, B., Marmiesse, M., Supply, P., & Vincent, V. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010005 · Cited by 646 · see citing works
Self-citationStinear, T. P., Seemann, T., Harrison, P. F., Jenkin, G. A., Davies, J. K., Johnson, P. D. R., Abdellah, Z., Arrowsmith, C., Chillingworth, T., Churcher, C., et al. (2008) · Genome Research · doi:10.1101/gr.075069.107 · Cited by 570 · see citing works
Self-citationEmergence of Communication Networks
Monge, P. R., & Contractor, N. (2001) · Sage eBooks · doi:10.4135/9781412986243.n12 · Cited by 487 · see citing works
Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids
Cambier, C. J., Takaki, K. K., Larson, R. P., Hernandez, R. E., Tobin, D. M., Urdahl, K. B., Cosma, C. L., & Ramakrishnan, L. (2014) · Nature · doi:10.1038/nature12799 · Cited by 480 · see citing works
Portevin, D., d’Auria, C. D. S., Houssin, C., Grimaldi, C., Chami, M., Daffé, M., & Guilhot, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305439101 · Cited by 394 · see citing works
Self-citationHoward, S. T., Rhoades, E. R., Recht, J., Pang, X., Alsup, A. A., Kolter, R., Lyons, C. R., & Byrd, T. F. (2006) · Microbiology · doi:10.1099/mic.0.28625-0 · Cited by 360 · see citing works
van Soolingen, D., Hoogenboezem, T., de Haas, P. E. W., Hermans, P. W. M., Koedam, M. A., Teppema, K., Brennan, P. J., Besra, G. S., Portaels, F., Top, J., et al. (1997) · International Journal of Systematic Bacteriology · doi:10.1099/00207713-47-4-1236 · Cited by 357 · see citing works
SHRiMP2: Sensitive yet Practical Short Read Mapping
David, M., Dzamba, M., Lister, D., Ilie, L., & Brudno, M. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr046 · Cited by 348 · see citing works
Supply, P., Marceau, M., Mangenot, S., Roche, D., Rouanet, C., Khanna, V., Majlessi, L., Criscuolo, A., Tap, J., Pawlik, A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2517 · Cited by 305 · see citing works
Self-citationOrtalo-Magné, A., Lemassu, A., Lanéelle, M., Bardou, F., Silve, G., Gounon, P., Marchal, G., & Daffé, M. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.2.456-461.1996 · Cited by 269 · see citing works
Self-citationConstant, P., Pérez‐Herrán, E., Malaga, W., Lanéelle, M., Saurel, O., Daffé, M., & Guilhot, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206538200 · Cited by 249 · see citing works
Self-citationBrosch, R., Gordon, S. V., Billault, A., Garnier, T., Eiglmeier, K., Soravito, C., Barrell, B. G., & Cole, S. T. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.2221-2229.1998 · Cited by 228 · see citing works
Self-citationDormans, J. A. M. A., Burger, M., Aguilar, D., Hernández‐Pando, R., Kremer, K., Roholl, P. J. M., Arend, S. M., & van Soolingen, D. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02551.x · Cited by 213 · see citing works
Hypervirulence of a Rough Variant of the Mycobacterium abscessus Type Strain
Catherinot, É., Clarissou, J., Etienne, G., Neulat-Ripoll, F., Emile, J., Daffé, M., Perronne, C., Soudais, C., Gaillard, J.-L., & Rottman, M. (2006) · Infection and Immunity · doi:10.1128/iai.00835-06 · Cited by 207 · see citing works
Self-citationPawlik, A., Garnier, G., Orgeur, M., Tong, P., Lohan, A. J., Chevalier, F. L., Sapriel, G., Roux, A., Conlon, K. M., Honoré, N., et al. (2013) · Molecular Microbiology · doi:10.1111/mmi.12387 · Cited by 194 · see citing works
Self-citationDelogu, G., Pusceddu, C., Bua, A., Fadda, G., Brennan, M. J., & Zanetti, S. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04007.x · Cited by 193 · see citing works
Mycobacterium tuberculosis pks12 Produces a Novel Polyketide Presented by CD1c to T Cells
Matsunaga, I., Bhatt, A., Young, D. C., Cheng, T., Eyles, S. J., Besra, G. S., Briken, V., Porcelli, S. A., Costello, C. E., Jacobs, W. R., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041429 · Cited by 175 · see citing works
Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis
Mortaz, E., Adcock, I. M., Tabarsi, P., Masjedi, M. R., Mansouri, D., Velayati, A. A., Casanova, J., & Barnes, P. J. (2014) · Journal of Clinical Immunology · doi:10.1007/s10875-014-0103-7 · Cited by 174 · see citing works
The cell envelope glycoconjugates ofMycobacterium tuberculosis
Angala, S. K., Belardinelli, J. M., Huc‐Claustre, E., Wheat, W. H., & Jackson, M. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.925420 · Cited by 161 · see citing works
Rhoades, E. R., Archambault, A. S., Greendyke, R., Hsu, F., Streeter, C., & Byrd, T. F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802181 · Cited by 153 · see citing works
An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity
Danilchanka, O., Sun, J., Pavlenok, M., Maueröder, C., Speer, A., Siroy, A., Marrero, J., Trujillo, C., Mayhew, D. L., Doornbos, K. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400136111 · Cited by 131 · see citing works
Insights from genomic comparisons of genetically monomorphic bacterial pathogens
Achtman, M. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0303 · Cited by 129 · see citing works
Majlessi, L., Brodin, P. M., Brosch, R., Rojas, M.-J., Khun, H., Huerre, M., Cole, S. T., & Leclerc, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3570 · Cited by 128 · see citing works
Self-citationNovel type-specific lipooligosaccharides from Mycobacterium tuberculosis
Daffé, M., McNeil, M., & Brennan, P. J. (1991) · Biochemistry · doi:10.1021/bi00216a011 · Cited by 111 · see citing works
Self-citationChemical basis of rough and smooth variation in mycobacteria
Belisle, J. T., & Brennan, P. J. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.6.3465-3470.1989 · Cited by 110 · see citing works
Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum
Ren, H., Dover, L. G., Islam, S. T., Alexander, D. C., Chen, J. M., Besra, G. S., & Liu, J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05603.x · Cited by 106 · see citing works
Koeck, J.-L., Fabre, M., Simon, F., Daffé, M., Garnotel, É., Matan, A., Gérôme, P., Jj, B., Buisson, Y., & Pourcel, C. (2010) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2010.03347.x · Cited by 99 · see citing works
Self-citationBiosynthesis of mycobacterial lipids by polyketide synthases and beyond
Quadri, L. E. N. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.896859 · Cited by 94 · see citing works
Onwueme, K. C., Ferreras, J. A., Buglino, J. A., Lima, C. D., & Quadri, L. E. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306928101 · Cited by 94 · see citing works
Pham, T. T. T., Jacobs‐Sera, D., Pedulla, M. L., Hendrix, R. W., & Hatfull, G. F. (2007) · Microbiology · doi:10.1099/mic.0.2007/008904-0 · Cited by 92 · see citing works
Roux, A., Ray, A. A., Pawlik, A., Medjahed, H., Etienne, G., Rottman, M., Catherinot, É., Coppée, J., Chaoui, K., Monsarrat, B., et al. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01565.x · Cited by 92 · see citing works
Self-citationInsights on the Emergence of Mycobacterium tuberculosis from the Analysis of Mycobacterium kansasii
Wang, J., McIntosh, F. A., Radomski, N., Dewar, K., Siméone, R., Enninga, J., Brosch, R., Rocha, E. P. C., Veyrier, F. J., & Behr, M. A. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv035 · Cited by 89 · see citing works
Self-citationBoritsch, E. C., Supply, P., Honoré, N., Seeman, T., Stinear, T. P., & Brosch, R. (2014) · Molecular Microbiology · doi:10.1111/mmi.12720 · Cited by 88 · see citing works
Self-citationBarrow, W. W., & Brennan, P. J. (1982) · Journal of Bacteriology · doi:10.1128/jb.150.1.381-384.1982 · Cited by 86 · see citing works
Bange, F. C., Collins, F. M., & Jacobs, W. R. (1999) · Tubercle and Lung Disease · doi:10.1054/tuld.1998.0201 · Cited by 80 · see citing works
Delahay, R. M., Knutton, S., Shaw, R. K., Hartland, E. L., Pallen, M. J., & Frankel, G. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35969 · Cited by 77 · see citing works
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis
Rousseau, C., Sirakova, T. D., Dubey, V. S., Bordat, Y., Kolattukudy, P. E., Gicquel, B., & Jackson, M. (2003) · Microbiology · doi:10.1099/mic.0.26278-0 · Cited by 73 · see citing works
Burguière, A., Hitchen, P. G., Dover, L. G., Kremer, L., Ridell, M., Alexander, D. C., Liu, J., Morris, H. R., Minnikin, D. E., Dell, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507500200 · Cited by 73 · see citing works
Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti
Blouin, Y., Cazajous, G., Dehan, C., Soler, C., Vong, R., Hassan, M. O., Hauck, Y., Boulais, C., Andriamanantena, D., Martinaud, C., et al. (2014) · Emerging infectious diseases · doi:10.3201/eid2001.130652 · Cited by 73 · see citing works
Etienne, G., Malaga, W., Laval, F., Lemassu, A., Guilhot, C., & Daffé, M. (2009) · Journal of Bacteriology · doi:10.1128/jb.01235-08 · Cited by 68 · see citing works
Self-citationVitamin B 12 Metabolism in Mycobacterium Tuberculosis
Gopinath, K., Moosa, A., Mizrahi, V., & Warner, D. F. (2013) · Future Microbiology · doi:10.2217/fmb.13.113 · Cited by 67 · see citing works
Panas, M. W., Jain, P., Yang, H., Mitra, S., Biswas, D., Wattam, A. R., Letvin, N. L., & Jacobs, W. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414207111 · Cited by 62 · see citing works
Bottai, D., Frigui, W., Clark, S., Rayner, E., Zelmer, A., Andreu, N., de Jonge, M. I., Bancroft, G. J., Williams, A., Brodin, P., et al. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.083 · Cited by 60 · see citing works
Self-citationKansal, R. G., Gomez‐Flores, R., & Mehta, R. T. (1998) · Microbial Pathogenesis · doi:10.1006/mpat.1998.0227 · Cited by 58 · see citing works
Bhatt, K., Gurcha, S. S., Bhatt, A., Besra, G. S., & Jacobs, W. R. (2007) · Microbiology · doi:10.1099/mic.0.2006/003103-0 · Cited by 53 · see citing works
Mycobacterial Pathogenomics and Evolution
Bottai, D., Stinear, T. P., Supply, P., & Brosch, R. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.mgm2-0025-2013 · Cited by 50 · see citing works
Self-citationEckstein, T. M., Inamine, J. M., Lambert, M. L., & Belisle, J. T. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.21.6177-6182.2000 · Cited by 49 · see citing works
van der Woude, A. D., Sarkar, D., Bhatt, A., Sparrius, M., Raadsen, S. A., Boon, L., Geurtsen, J., van der Sar, A. M., Luirink, J., Houben, E. N. G., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336461 · Cited by 47 · see citing works
Xer Site-Specific Recombination, an Efficient Tool To Introduce Unmarked Deletions into Mycobacteria
Cascioferro, A., Boldrin, F., Serafini, A., Provvedi, R., Palù, G., & Manganelli, R. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00382-10 · Cited by 46 · see citing works
Self-citationLemassu, A., Lévy‐Frébault, V., Lanéelle, M., & Daffé, M. (1992) · Journal of General Microbiology · doi:10.1099/00221287-138-7-1535 · Cited by 40 · see citing works
Self-citationIncreased Phagocytosis of Mycobacterium marinum Mutants Defective in Lipooligosaccharide Production
Alibaud, L., Pawełczyk, J., Gannoun-Zaki, L., Singh, V. K., Rombouts, Y., Drancourt, M., Dziadek, J., Guérardel, Y., & Kremer, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.525550 · Cited by 40 · see citing works
Fatty Acyl Chains of Mycobacterium marinum Lipooligosaccharides
Rombouts, Y., Alibaud, L., Carrère‐Kremer, S., Maes, E., Tokarski, C., Elass, E., Kremer, L., & Guérardel, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.273920 · Cited by 39 · see citing works
Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis
Young, D. B., Comas, I., & de Carvalho, L. P. S. (2015) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2015.00006 · Cited by 37 · see citing works
Robinson, R., Orme, I. M., & Cooper, A. M. (2015) · Immunological Reviews · doi:10.1111/imr.12259 · Cited by 36 · see citing works
Mycobacterium Tuberculosis Evolutionary Pathogenesis and its Putative Impact on Drug Development
Chevalier, F. L., Cascioferro, A., Majlessi, L., Herrmann, J., & Brosch, R. (2014) · Future Microbiology · doi:10.2217/fmb.14.70 · Cited by 36 · see citing works
Self-citationNataraj, V., Pang, P., Haslam, S. M., Veerapen, N., Minnikin, D. E., Dell, A., Besra, G. S., & Bhatt, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122804 · Cited by 13 · see citing works
Accurate Whole-Genome Sequencing-Based Epidemiological Surveillance of Mycobacterium Tuberculosis
Pouseele, H., & Supply, P. (2015) · Methods in microbiology · doi:10.1016/bs.mim.2015.04.001 · Cited by 8 · see citing works
Self-citationGenomes 2000 International Conference on Microbial and Model Genomes
Wixon, J. (2000) · Yeast · doi:10.1002/1097-0061(20000630)17:2 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ecology and evolution of Mycobacterium tuberculosis
Gagneux, S. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2018.8 · Cited by 599 · see citing works
ESX secretion systems: mycobacterial evolution to counter host immunity
Gröschel, M. I., Sayes, F., Simeone, R., Majlessi, L., & Brosch, R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.131 · Cited by 382 · see citing works
Self-citationNgabonziza, J. C. S., Loiseau, C., Marceau, M., Jouet, A., Menardo, F., Tzfadia, O., Antoine, R., Niyigena, E. B., Mulders, W., Fissette, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16626-6 · Cited by 212 · see citing works
Self-citationThe Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis
Queval, C. J., Brosch, R., & Simeone, R. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02284 · Cited by 215 · see citing works
Self-citationThe architectures of iterative type I PKS and FAS
Herbst, D. A., Townsend, C. A., & Maier, T. (2018) · Natural Product Reports · doi:10.1039/c8np00039e · Cited by 191 · see citing works
Batt, S. M., Minnikin, D. E., & Besra, G. S. (2020) · Biochemical Journal · doi:10.1042/bcj20200194 · Cited by 160 · see citing works
Boritsch, E. C., Khanna, V., Pawlik, A., Honoré, N., Navas, V. H., Ma, L., Bouchier, C., Seemann, T., Supply, P., Stinear, T. P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604921113 · Cited by 111 · see citing works
Self-citationA new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus
Dupont, C., Viljoen, A. J., Dubar, F., Blaise, M., Bernut, A., Pawlik, A., Bouchier, C., Brosch, R., Guérardel, Y., Lelièvre, J., et al. (2016) · Molecular Microbiology · doi:10.1111/mmi.13406 · Cited by 119 · see citing works
Self-citationBottai, D., Frigui, W., Sayes, F., Luca, M. D., Spadoni, D., Pawlik, A., Zoppo, M., Orgeur, M., Khanna, V., Hardy, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14508-5 · Cited by 108 · see citing works
Self-citationEvolution of virulence in the Mycobacterium tuberculosis complex
Orgeur, M., & Brosch, R. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.11.021 · Cited by 107 · see citing works
Self-citationThe Enigmatic PE/PPE Multigene Family of Mycobacteria and Tuberculosis Vaccination
Brennan, M. J. (2017) · Infection and Immunity · doi:10.1128/iai.00969-16 · Cited by 107 · see citing works
Maphasa, R. E., Meyer, M., & Dube, A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.618414 · Cited by 100 · see citing works
Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex
Chiner‐Oms, Á., Sánchez-Busó, L., Corander, J., Gagneux, S., Harris, S. R., Young, D. B., Gónzález‐Candelas, F., & Comas, I. (2019) · Science Advances · doi:10.1126/sciadv.aaw3307 · Cited by 101 · see citing works
The role of hydrophobicity in tuberculosis evolution and pathogenicity
Jankute, M., Nataraj, V., Lee, O. Y.-C., Wu, H. H. T., Ridell, M., Garton, N. J., Barer, M. R., Minnikin, D. E., Bhatt, A., & Besra, G. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-01501-0 · Cited by 96 · see citing works
Evolution and emergence ofMycobacterium tuberculosis
Orgeur, M., Sous, C., Madacki, J., & Brosch, R. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae006 · Cited by 92 · see citing works
Self-citationMmpL transporter-mediated export of cell-wall associated lipids and siderophores in mycobacteria
Chalut, C. (2016) · Tuberculosis · doi:10.1016/j.tube.2016.06.004 · Cited by 85 · see citing works
Blending genomes: distributive conjugal transfer in mycobacteria, a sexier form of HGT
Gray, T. A., & Derbyshire, K. M. (2018) · Molecular Microbiology · doi:10.1111/mmi.13971 · Cited by 70 · see citing works
Gonzalo‐Asensio, J., Pérez, I., Aguiló, N., Uranga, S., Picó, A., Lampreave, C., Cebollada, A., Otal, I., Samper, S., & Martı́n, C. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007282 · Cited by 79 · see citing works
Halloum, I., Viljoen, A. J., Khanna, V., Craig, D., Bouchier, C., Brosch, R., Coxon, G. D., & Kremer, L. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02509-16 · Cited by 79 · see citing works
Self-citationThe Mycobacterial Cell Envelope: A Relict From the Past or the Result of Recent Evolution?
Vincent, A. T., Nyongesa, S., Morneau, I., Reed, M. B., Tocheva, E. I., & Veyrier, F. J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02341 · Cited by 75 · see citing works
The Evolution of Strain Typing in the Mycobacterium tuberculosis Complex
Merker, M., Kohl, T. A., Niemann, S., & Supply, P. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-64371-7_3 · Cited by 71 · see citing works
Self-citationTransporters Involved in the Biogenesis and Functionalization of the Mycobacterial Cell Envelope
Jackson, M., Stevens, C. M., Zhang, L., Zgurskaya, H. I., & Niederweis, M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00869 · Cited by 68 · see citing works
Mycobacteria Clumping Increase Their Capacity to Damage Macrophages
Brambilla, C., Llorens-Fons, M., Julián, E., Noguera-Ortega, E., Tomàs-Martínez, C., Pérez‐Trujillo, M., Byrd, T. F., Alcaide, F., & Luquin, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01562 · Cited by 65 · see citing works
Dubois, V., Viljoen, A. J., Laencina, L., Moigne, V. L., Bernut, A., Dubar, F., Blaise, M., Herrmann, J., Guérardel, Y., Kremer, L., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812984115 · Cited by 62 · see citing works
Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis
Chisholm, R. H., Trauer, J. M., Curnoe, D., & Tanaka, M. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603224113 · Cited by 56 · see citing works
ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins
Vaziri, F., & Brosch, R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.psib-0029-2019 · Cited by 50 · see citing works
Self-citationAtes, L. S., Sayes, F., Frigui, W., Ummels, R., Damen, M. P. M., Bottai, D., Behr, M. A., van Heijst, J. W. J., Bitter, W., Majlessi, L., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007139 · Cited by 44 · see citing works
Self-citationLuò, T., Xu, P., Zhang, Y., Porter, J. L., Ghanem, M., Liu, Q., Jiang, Y. Z., Li, J., Miao, Q., Hu, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22760-6 · Cited by 47 · see citing works
Self-citationLevillain, F., Poquet, Y., Mallet, L., Mazères, S., Marceau, M., Brosch, R., Bange, F., Supply, P., Magalon, A., & Neyrolles, O. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006752 · Cited by 44 · see citing works
Self-citationPeters, J. S., Ismail, N. A., Dippenaar, A., Ma, S., Sherman, D. R., Warren, R. M., & Kana, B. D. (2020) · Annual Review of Genetics · doi:10.1146/annurev-genet-022820-085940 · Cited by 43 · see citing works
Esx Systems and the Mycobacterial Cell Envelope: What's the Connection?
Bosserman, R. E., & Champion, P. A. (2017) · Journal of Bacteriology · doi:10.1128/jb.00131-17 · Cited by 42 · see citing works
Sapriel, G., & Brosch, R. (2019) · Genome Biology and Evolution · doi:10.1093/gbe/evz162 · Cited by 41 · see citing works
Self-citationNebenzahl-Guimaraes, H., Yimer, S. A., Holm‐Hansen, C., de Beer, J., Brosch, R., & van Soolingen, D. (2016) · Microbial Genomics · doi:10.1099/mgen.0.000063 · Cited by 39 · see citing works
Self-citationKanipe, C. R., & Palmer, M. V. (2020) · Tuberculosis · doi:10.1016/j.tube.2020.102006 · Cited by 38 · see citing works
Harvey, D. J. (2021) · Mass Spectrometry Reviews · doi:10.1002/mas.21651 · Cited by 33 · see citing works
The Biology and Epidemiology of Mycobacterium canettii
Supply, P., & Brosch, R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-64371-7_2 · Cited by 33 · see citing works
Self-citationEvolution of Mycobacterium tuberculosis : New Insights into Pathogenicity and Drug Resistance
Boritsch, E. C., & Brosch, R. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0020-2016 · Cited by 32 · see citing works
Self-citationImpact of Genetic Diversity on the Biology of Mycobacterium tuberculosis Complex Strains
Niemann, S., Merker, M., Kohl, T. A., & Supply, P. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0022-2016 · Cited by 31 · see citing works
Self-citationCoping and caring in different ways: understanding and meaningful involvement.
Sydnor-Greenberg, N., & Dokken, D. L. (2000) · PubMed · Cited by 30 · see citing works
Mycobacterium canettii Infection of Adipose Tissues
Bouzid, F., Brégeon, F., Poncin, I., Weber, P., Drancourt, M., & Canaan, S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00189 · Cited by 26 · see citing works
The Impact of Genome Region of Difference 4 (RD4) on Mycobacterial Virulence and BCG Efficacy
Ru, H.-W., Liu, X., Lin, C., Yang, J., Chen, F.-Z., Sun, R., Zhang, L., & Liu, J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00239 · Cited by 24 · see citing works
Madacki, J., Fiol, G. M., & Brosch, R. (2018) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2018.12.013 · Cited by 25 · see citing works
Self-citationYruela, I., Contreras‐Moreira, B., Magalhães, C., Osório, N. S., & Gonzalo‐Asensio, J. (2016) · Genome Biology and Evolution · doi:10.1093/gbe/evw279 · Cited by 23 · see citing works
Insight into the biology of Mycobacterium mucogenicum and Mycobacterium neoaurum clade members
Behra, P. R. K., Pettersson, B. M. F., Ramesh, M., Dasgupta, S., & Kirsebom, L. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-55464-5 · Cited by 23 · see citing works
Mycobacterial virulence: impact on immunogenicity and vaccine research
Kroesen, V. M., Madacki, J., Frigui, W., Sayes, F., & Brosch, R. (2019) · F1000Research · doi:10.12688/f1000research.20572.1 · Cited by 24 · see citing works
Self-citationReady Experimental Translocation of Mycobacterium canettii Yields Pulmonary Tuberculosis
Bouzid, F., Brégeon, F., Lépidi, H., Donoghue, H. D., Minnikin, D. E., & Drancourt, M. (2017) · Infection and Immunity · doi:10.1128/iai.00507-17 · Cited by 20 · see citing works
Multifaceted Role of Lipids in Mycobacterium Leprae
Kaur, G., & Kaur, J. (2017) · Future Microbiology · doi:10.2217/fmb-2016-0173 · Cited by 19 · see citing works
Yenew, B., Ghodousi, A., Diriba, G., Tesfaye, E., Cabibbe, A. M., Amare, M., Moga, S., Alemu, A., Dagne, B., Sinshaw, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42755-9 · Cited by 16 · see citing works
Self-citationPeng, Y., Zhu, X., Gao, L., Wang, J., Liu, H., Zhu, T., Zhu, Y., Tang, X., Hu, C., Chen, X., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.829410 · Cited by 16 · see citing works
Evolution of Tuberculosis Pathogenesis
Pepperell, C. S. (2022) · Annual Review of Microbiology · doi:10.1146/annurev-micro-121321-093031 · Cited by 16 · see citing works
Reis, A. C., & Cunha, M. V. (2021) · Scientific Reports · doi:10.1038/s41598-021-98226-y · Cited by 15 · see citing works
Lipids of Clinically Significant Mycobacteria
Minnikin, D. E., & Brennan, P. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-15147-8_7 · Cited by 16 · see citing works
Green, A. G., Vargas, R., Marin, M. G., Freschi, L., Xie, J., & Farhat, M. R. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad131 · Cited by 14 · see citing works
Malaga, W., Payros, D., Meunier, E., Frigui, W., Sayes, F., Pawlik, A., Orgeur, M., Berrone, C., Moreau, F., Mazères, S., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011437 · Cited by 14 · see citing works
Self-citationLarge genomics datasets shed light on the evolution of the Mycobacterium tuberculosis complex
Chiner‐Oms, Á., & Comas, I. (2019) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2019.02.028 · Cited by 14 · see citing works
Brown, T. S., Narechania, A., Walker, J. R., Planet, P. J., Bifani, P. J., Kolokotronis, S., Kreiswirth, B. N., & Mathema, B. (2016) · BMC Genomics · doi:10.1186/s12864-016-3298-6 · Cited by 13 · see citing works
Guan, Q., Garbati, M. A., Mfarrej, S., AlMutairi, T., Laval, T., Singh, A., Fagbo, S. F., Smyth, A., Browne, J. A., urRahman, M. A., et al. (2021) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqab070 · Cited by 14 · see citing works
Báez-Ramírez, E., Querales, L., Aranaga, C., López, G., Guerrero, E., Kremer, L., Carrère-Kremer, S., Viljoen, A., Daffé, M., Laval, F., et al. (2021) · The Cell Surface · doi:10.1016/j.tcsw.2021.100060 · Cited by 12 · see citing works
Self-citationAn Update on Mycobacterium Tuberculosis Lipoproteins
Bigi, M. M., Forrellad, M. A., y García, J. S., Blanco, F. C., Vázquez, C. L., & Bigi, F. (2023) · Future Microbiology · doi:10.2217/fmb-2023-0088 · Cited by 11 · see citing works
A glycosylated lipooctapeptide promotes uptake and growth of Mycobacterium abscessus in the host
Leclercq, L.-D., Moigne, V. L., Daher, W., Cortès, M., Viljoen, B., Tasrini, Y., Trivelli, X., Lavanant, H., Schmitz‐Afonso, I., Durand, N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58455-5 · Cited by 9 · see citing works
Hu, Y., Zheng, X., Forsman, L. D., Ning, Z., Chen, C., Gao, Y., Zhang, Z., Lu, W., Werngren, J., Bruchfeld, J., et al. (2021) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2021.04.001 · Cited by 9 · see citing works
Weng, Y., Shepherd, D., Liu, Y., Krishnan, N., Robertson, B. D., Platt, N., Larrouy-Maumus, G. J., & Platt, F. M. (2022) · Nature Communications · doi:10.1038/s41467-022-32553-0 · Cited by 9 · see citing works
Szulc-Kiełbik, I., Pawełczyk, J., Kiełbik, M., Kremer, L., Dziadek, J., & Klink, M. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0829-z · Cited by 9 · see citing works
Population heterogeneity in Mycobacterium smegmatis and Mycobacterium abscessus
Born, S. E. M., Reichlen, M. J., Bartek, I. L., Benoit, J. B., Frank, D. N., & Voskuil, M. I. (2023) · Microbiology · doi:10.1099/mic.0.001402 · Cited by 8 · see citing works
Davis, N., Chionh, Y. H., McBee, M. E., Hia, F., Ma, D., Liang, C., Sharaf, M. L., Cai, W. M., Jumpathong, W., Levine, S. S., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06562-2 · Cited by 7 · see citing works
Towards the reconstruction of a global TB history using a new pipeline “TB-Annotator"
Senelle, G., Sahal, M. R., La, K., Billard‐Pomares, T., Marin, J., Mougari, F., Bridier‐Nahmias, A., Carbonnelle, É., Cambau, E., Refrégier, G., et al. (2023) · Tuberculosis · doi:10.1016/j.tube.2023.102376 · Cited by 7 · see citing works
Evolution, Phylogenetics, and Phylogeography of Mycobacterium tuberculosis complex
Sola, C., Владиславович, М. И., Sahal, M. R., La, K., Senelle, G., Guyeux, C., Refrégier, G., & Cambau, E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28818-0.00025-2 · Cited by 6 · see citing works
Mata, E., Farrell, D., Ma, R., Uranga, S., Gómez, A. B., Monzón, M., Badiola, J. J., Anel, A., Gonzalo‐Asensio, J., Martı́n, C., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1009061 · Cited by 6 · see citing works
Gonzalo, X., Yrah, S., Broda, A., Laurenson, I. F., Claxton, P., Kostrzewa, M., Drobniewski, F. A., & Larrouy-Maumus, G. J. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.10.017 · Cited by 6 · see citing works
Lipids of Clinically Significant Mycobacteria
Minnikin, D. E., & Brennan, P. J. (2020) · Springer eBooks · doi:10.1007/978-3-319-72473-7_7-1 · Cited by 7 · see citing works
ESX/Type VII Secretion Systems-An Important Way Out for Mycobacterial Proteins
Vaziri, F., & Brosch, R. (2019) · ASM Press eBooks · doi:10.1128/9781683670285.ch28 · Cited by 8 · see citing works
Self-citationEvolution ofMycobacterium tuberculosis: New Insights into Pathogenicity and Drug Resistance
Boritsch, E. C., & Brosch, R. (2017) · ASM Press eBooks · doi:10.1128/9781555819569.ch22 · Cited by 5 · see citing works
Self-citationBacterial evolution: Emergence of virulence in TB
Brennan, P. J. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2015.31 · Cited by 5 · see citing works
Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus
Pidot, S. J., Klatt, S., Ates, L. S., Frigui, W., Sayes, F., Majlessi, L., Izumi, H., Monk, I. R., Porter, J. L., Bennett-Wood, V. R., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012440 · Cited by 4 · see citing works
Self-citationEspinoza, M. E., Swing, A. M., Elghraoui, A., Modlin, S. J., & Valafar, F. (2025) · mSystems · doi:10.1128/msystems.00499-24 · Cited by 4 · see citing works
Host-directed insights into mycobacterial infections: Toward targeted immunomodulation
Menon, A. M., Abhinand, K., Thomas, S. S., Salini, S., Edison, L. K., Mohanan, P. C. P., Arun, K. B., Babu, P., Kumar, G. B., Nair, B. G., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108233 · Cited by 3 · see citing works
Guan, Q., Garbati, M. A., Mfarrej, S., AlMutairi, T., Smyth, A., Singh, A., Fagbo, S. F., Browne, J. A., urRahman, M. A., Alruwaili, A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/728923 · Cited by 3 · see citing works
Functional analysis of the Mycobacterium bovis AF2122/97 PhoPR system
Urtasun-Elizari, J. M., Ma, R., Pickford, H., Farrell, D., González, G., Perets, V., Nakajima, C., Suzuki, Y., MacHugh, D. E., Bhatt, A., et al. (2024) · Tuberculosis · doi:10.1016/j.tube.2024.102544 · Cited by 2 · see citing works
Wang, C., Bei, C., Fan, Y., Liu, Q., Ding, Y., Takiff, H. E., & Gao, Q. (2025) · mLife · doi:10.1002/mlf2.70025 · Cited by 2 · see citing works
Adaptive Evolution of the Mycobacterium tuberculosis Complex to Different Hosts
Broset, E., & Gonzalo‐Asensio, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-799942-5.00023-8 · Cited by 2 · see citing works
Impact of Genetic Diversity on the Biology ofMycobacterium tuberculosisComplex Strains
Niemann, S., Merker, M., Kohl, T. A., & Supply, P. (2017) · ASM Press eBooks · doi:10.1128/9781555819569.ch21 · Cited by 1 · see citing works
Self-citationMmpL12 transports lipooligosaccharides and impacts virulence in Mycobacterium marinum
Bailo, R., Kumar, C. M. S., Singh, A., Lund, P. A., Bavro, V. N., & Bhatt, A. (2025) · Microbiology · doi:10.1099/mic.0.001618 · Cited by 1 · see citing works
Brosch, R. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2606859123 · Cited by 1 · see citing works
Self-citationNovel D-LAK peptides combinations against mycobacteria : bioefficacy and mechanistic studies
Man, D. K.-W. (2019) · doi:10.5353/th_991044122098103414 · Cited by 1 · see citing works
The discovery of genome-wide mutational dependence in naturally evolving populationsPreprint
Green, A. G., Vargas, R., Marin, M. G., Freschi, L., Xie, J., & Farhat, M. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.24.497504 · Cited by 1 · see citing works
Kipkorir, T. (2019) · Open University of Cape Town (University of Cape Town)
Weng, Y., Shepherd, D., Zhu, J., Liu, Y., Krishnan, N., Robertson, B. D., Platt, N., Larrouy-Maumus, G. J., & Platt, F. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.06.459187
Mycobacterium canettii Tuberculosis Lymphadenopathy in a 3-Year-old Child
Faury, H., Stanzelova, A., Ferroni, A., Belhous, K., Morand, P., Toubiana, J., Bille, E., Isnard, P., Simon, F., & Lécuyer, H. (2023) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003983
Dedon, P. C., Davis, N., Chionh, Y. H., McBee, M. E., Hia, F., Ma, D., Cui, L., Sharaf, M. L., Cai, W. M., Jumpathong, W., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3193999/v1
A marine sponge-associated mycobacterium closely related to Mycobacterium tuberculosisPreprint
Pidot, S. J., Klatt, S., Ates, L. S., Frigui, W., Sayes, F., Majlessi, L., Izumi, H., Monk, I. R., Porter, J. L., Bennett-Wood, V. R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.23.576949
Self-citationPopulation genomics of Mycobacterium kansasii
Luò, T. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99886-4.00008-9
Wang, C., Bei, C., Fan, Y., Liu, Q., Ding, Y., Takiff, H. E., & Gao, Q. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.30.596634
Host Adaptation in the Mycobacterium Genus: An Evolutionary and Genomic Perspective
Seral, J. C., Pardos, E. C., & Gonzalo‐Asensio, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28818-0.00003-3
Araujo, C. D. N., Silva, F., Zimpel, C. K., Pereira, T. S., Camargo, N., de Melo, F. M., de Araújo, M. V., & Guimarães, A. M. S. (2025) · Microbes and Infection · doi:10.1016/j.micinf.2025.105503
Loss of Mycobacterium marinum ESX-1 genes increase transcription of ESX-6 genesPreprint
Behra, P. R. K., Ramesh, M., Pettersson, B. M. F., & Kirsebom, L. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.18.712377
- Authors
- Boritsch, E. C., Frigui, W., Cascioferro, A., Malaga, W., Etienne, G., Laval, F., Pawlik, A., Le Chevalier, F., Orgeur, M., Ma, L., Bouchier, C., Stinear, T. P., Supply, P., Majlessi, L., Daffé, M., Guilhot, C., & Brosch, R.
- Affiliations
- Institut Pasteur (FR)
- Centre National de la Recherche Scientifique (FR)
- The University of Melbourne (AU)
- Corresponding author
- Guilhot, Christophe
- Brosch, Roland
- ORCID
- Venue
- Nature Microbiology
- Published
- 2016-01-27
- Volume
- 1
- Issue
- 2
- Pages
- 15019-15019
- ISSN
- 2058-5276 (ISSN-L)
- OpenAlex
- W2272836913
- Cited by
- 104
- References
- 60
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 5 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 18 · 2016: 12
- FWCI
- 15.69
- Type
- journal article
- Language
- en
- Open access
- green
- pasteur.hal.science
- Licence
- Locations
- Nature Microbiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- HAL (submittedVersion)
- LillOA (Université de Lille (University Of Lille)) (submittedVersion, other-oa)
- Funders
- European Commission (115337, 260872)
- Agence Nationale de la Recherche (ANR-10-INBS-0009, ANR-14-JAMR-0001)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- Mycobacterium tuberculosis, Mycobacterium canettii, polyketide synthase, lipooligosaccharide biosynthesis, homologous recombination, virulence, host-pathogen interaction, bacterial evolution, clonal expansion
- MeSH terms
- Animals, Disease Models, Animal, Genetic Complementation Test, Humans, Lipopolysaccharides, Mycobacterium, Mycobacterium Infections, Virulence, Gene Deletion, Evolution, Molecular, Polyketide Synthases, Mice, Biosynthetic Pathways, Host-Pathogen Interactions, Homologous Recombination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review