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Cited by 591

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Exploiting rRNA operon copy number to investigate bacterial reproductive strategies

Open access
Roller, Benjamin R. K., Stoddard, Steven F., Schmidt, Thomas M.·2016·Nature Microbiology
DOI 10.1038/nmicrobiol.2016.160
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Abstract

The potential for rapid reproduction is a hallmark of microbial life, but microbes in nature must also survive and compete when growth is constrained by resource availability. Successful reproduction requires different strategies when resources are scarce and when they are abundant1,2, but a systematic framework for predicting these reproductive strategies in bacteria has not been available. Here, we show that the number of ribosomal RNA operons (rrn) in bacterial genomes predicts two important components of reproduction—growth rate and growth efficiency—which are favoured under contrasting regimes of resource availability3,4. We find that the maximum reproductive rate of bacteria doubles with a doubling of rrn copy number, and the efficiency of carbon use is inversely related to maximal growth rate and rrn copy number. We also identify a feasible explanation for these patterns: the rate and yield of protein synthesis mirror the overall pattern in maximum growth rate and growth efficiency. Furthermore, comparative analysis of genomes from 1,167 bacterial species reveals that rrn copy number predicts traits associated with resource availability, including chemotaxis and genome streamlining. Genome-wide patterns of orthologous gene content covary with rrn copy number, suggesting convergent evolution in response to resource availability. Our findings imply that basic cellular processes adapt in contrasting ways to long-term differences in resource availability. They also establish a basis for predicting changes in bacterial community composition in response to resource perturbations using rrn copy number measurements5 or inferences6,7.

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Metadata

Authors
Roller, B. R. K., Stoddard, S. F., & Schmidt, T. M.
Venue
Nature Microbiology
Publisher
Springer Science and Business Media LLC
Published
2016-09-12
Volume
1
Issue
11
Pages
16160-16160
ISSN
2058-5276 (ISSN-L)
DOI
10.1038/nmicrobiol.2016.160
OpenAlex
W2520096949
Cited by
591
References
51
FWCI
23.73
Type
journal article
Language
en
Open access
green

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