AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
Abstract
An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2gamma regulates laminar fate in a region-specific manner. Deletion of AP2gamma (also known as Tcfap2c) during development resulted in a specific reduction of upper layer neurons in the occipital cortex, leading to impaired function and enhanced plasticity of the adult visual cortex. AP2gamma functions in apical progenitors, and its absence resulted in mis-specification of basal progenitors in the occipital cortex at the time at which upper layer neurons were generated. AP2gamma directly regulated the basal progenitor fate determinants Math3 (also known as Neurod4) and Tbr2, and its overexpression promoted the generation of layer II/III neurons in a time- and region-specific manner. Thus, AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex.
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More rostrally- than caudally-enriched genes were found in nearly every cortical layer, whereas two studies of prenatal mouse brain identified more or comparable caudally-enriched genes, indicating potential species differences related to areal patterning.
“Interestingly, we find more rostrally- than caudally-enriched genes in nearly every cortical layer (Fig. 5h), whereas two studies of gradient expression in prenatal mouse brain identified more49 or comparable51 caudally-enriched genes, indicating potential species differences related to areal patterning.”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [51]
Comparing these data to a microarray analysis of rostral versus caudal cortex in E14 mouse identified 20 additional genes with consistent rostrocaudal gradation between species.
“Comparing these data to a microarray analysis of rostral versus caudal cortex in E14 mouse51 identified 20 additional genes with consistent rostrocaudal gradation between species (Suppl. Table 9; Suppl. Methods).”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [51]
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- Authors
- Pinto, L., Drechsel, D., Schmid, M.-T., Ninkovic, J., Irmler, M., Brill, M. S., Restani, L., Gianfranceschi, L., Cerri, C., Weber, S. N., Tarabykin, V., Baer, K., Guillemot, F., Beckers, J., Zecevic, N., Dehay, C., Caleo, M., Schorle, H., & Götz, M.
- Affiliations
- Helmholtz Munich (DE)
- Neuroscience Institute (IT)
- University of Bonn (DE)
- Max Planck Society (DE)
- Swansea University (GB)
- National Institute for Medical Research (GB)
- Inserm (FR)
- Center for Integrated Protein Science Munich (DE)
- Corresponding author
- Götz, Magdalena
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2009-09-13
- Volume
- 12
- Issue
- 10
- Pages
- 1229-1237
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2047479713
- Cited by
- 100
- References
- 50
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 7 · 2014: 11 · 2013: 12 · 2012: 10
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-05-01)
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Site cant be reached (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- cortical lamination, primary visual cortex, occipital cortex, Tbr2, apical progenitors, regional specification, visual cortex plasticity, spatial resolution, transcription factors
- MeSH terms
- PAX6 Transcription Factor, Empty Spiracles Homeobox Proteins, Adult, Animals, Bromodeoxyuridine, Cell Count, Cell Differentiation, Cell Line, Transformed, Cerebral Cortex, Embryo, Mammalian, Evoked Potentials, Visual, Eye Proteins, Fetus, Humans, Macaca fascicularis, Mice, Inbred C57BL, Mice, Transgenic, Photic Stimulation, Repressor Proteins, RNA, Messenger, Transcription Factors, Transfection, Gene Deletion, Immediate-Early Proteins, Homeodomain Proteins, Gene Expression Regulation, Developmental, Ki-67 Antigen, T-Box Domain Proteins, Tumor Suppressor Proteins, Green Fluorescent Proteins, Transcription Factor AP-2, Mice, Paired Box Transcription Factors, Embryonic Stem Cells, Neurogenesis
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