The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
Open accessAbstract
The slow (<1 Hz) rhythm, the most important electroencephalogram (EEG) signature of non–rapid eye movement (NREM) sleep, is generally viewed as originating exclusively from neocortical networks. Here we argue that the full manifestation of this fundamental sleep oscillation in a corticothalamic module requires the dynamic interaction of three cardinal oscillators: one predominantly synaptically based cortical oscillator and two intrinsic, conditional thalamic oscillators. The functional implications of this hypothesis are discussed in relation to other EEG features of NREM sleep, with respect to coordinating activities in local and distant neuronal assemblies and in the context of facilitating cellular and network plasticity during slow-wave sleep.
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“Apart from thalamic afferents and cortical astrocytes, somatostatin positive interneurons inhibiting pyramidal dendrites appear to be specifically implicated in the induction of downstates.161,172,173”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [173]
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“In vivo calcium imaging in naturally sleeping mice revealed that spindles, which nest into a SO upstate are characterized by a unique constellation of activity in cortical microcircuits, where inhibition (by somatostatin positive cells) is released from the dendrites of pyramidal cells that themselves display strongly increased calcium activity, whereas an effective somatic inhibition of the pyram”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [173]
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“The slow oscillation is generated in cortical networks and can occur in isolated cortical slices (239, 1028, 1198).”
From About Sleep's Role in Memory (2013) · cites this paper as [239]
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“Nevertheless, the slow oscillation of the intact brain likely reflects an interaction between cortical and thalamic networks (239, 1196).”
From About Sleep's Role in Memory (2013) · cites this paper as [239]
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Cites
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Cited by
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Regional Slow Waves and Spindles in Human Sleep
Nir, Y., Staba, R. J., Andrillon, T., Vyazovskiy, V. V., Cirelli, C., Fried, I., & Tononi, G. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.043 · Cited by 924
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Metadata
- Authors
- Crunelli, V., & Hughes, S. W.
- Affiliations
- Cardiff University (GB)
- Eli Lilly (United Kingdom) (GB)
- Corresponding author
- Crunelli, Vincenzo
- Venue
- Nature Neuroscience
- Published
- 2009-12-06
- Volume
- 13
- Issue
- 1
- Pages
- 9-17
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2980822
- OpenAlex
- W2078049175
- Semantic Scholar
- 3ab0af75d4a753ac35afe4eed6a3db4f6dfe8853
- Cited by
- 435
- References
- 98
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 14 · 2023: 15 · 2022: 24 · 2021: 22 · 2020: 23 · 2019: 27 · 2018: 30 · 2017: 28 · 2016: 26 · 2015: 40 · 2014: 39 · 2013: 44 · 2012: 32
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (078403, 078311, 78403, 78311, 071436, 71436)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- slow-wave sleep, NREM sleep, EEG oscillations, cell assemblies, network plasticity
- MeSH terms
- Action Potentials, Anesthetics, Animals, Biological Clocks, Brain Mapping, Cats, Cerebral Cortex, Delta Rhythm, Humans, Models, Biological, Nerve Net, Neurons, Sleep Stages, Thalamus, In Vitro Techniques
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