Cited by 435Sleep and Wakefulness ResearchNeural dynamics and brain functionNeuroscience of respiration and sleep

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The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators

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Crunelli, Vincenzo, Hughes, Stuart W·2010·Nature Neuroscience

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Abstract

The slow (<1 Hz) rhythm, the most important electroencephalogram (EEG) signature of non–rapid eye movement (NREM) sleep, is generally viewed as originating exclusively from neocortical networks. Here we argue that the full manifestation of this fundamental sleep oscillation in a corticothalamic module requires the dynamic interaction of three cardinal oscillators: one predominantly synaptically based cortical oscillator and two intrinsic, conditional thalamic oscillators. The functional implications of this hypothesis are discussed in relation to other EEG features of NREM sleep, with respect to coordinating activities in local and distant neuronal assemblies and in the context of facilitating cellular and network plasticity during slow-wave sleep.

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Steriade, M., Nunez, A., & Amzica, F. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03252.1993 · Cited by 1,903
Local sleep and learning
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854
Boosting slow oscillations during sleep potentiates memory
Marshall, L., Helgadóttir, H., Mölle, M., & Born, J. (2006) · Nature · doi:10.1038/nature05278 · Cited by 1,792
Coordinated memory replay in the visual cortex and hippocampus during sleep
Ji, D., & Wilson, M. A. (2007) · Nature Neuroscience · doi:10.1038/nn1825 · Cited by 1,669
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives, M. V., & McCormick, D. A. (2000) · Nature Neuroscience · doi:10.1038/79848 · Cited by 1,539
Natural waking and sleep states: a view from inside neocortical neurons
Steriade, M., Timofeev, I., & Grenier, F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.1969 · Cited by 1,296
Grouping of brain rhythms in corticothalamic systems
Steriade, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.029 · Cited by 1,296
Memory of sequential experience in the hippocampus during slow wave sleep
Lee, A. K., & Wilson, M. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01096-6 · Cited by 1,296
The sleep slow oscillation as a traveling wave
Massimini, M., Huber, R., Ferrarelli, F., Hill, S., & Tononi, G. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1318-04.2004 · Cited by 1,221
Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
McCormick, D. A. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90012-4 · Cited by 1,117
Turning on and off recurrent balanced cortical activity
Shu, Y., Hasenstaub, A., & McCormick, D. A. (2003) · Nature · doi:10.1038/nature01616 · Cited by 1,054
Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider, B., Duque, A., Hasenstaub, A. R., & McCormick, D. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5297-05.2006 · Cited by 962
Sleep spindles: an overview
Gennaro, L. D., & Ferrara, M. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0252 · Cited by 957
Replay and Time Compression of Recurring Spike Sequences in the Hippocampus
Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J., & Buzsáki, G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09497.1999 · Cited by 932
Communication between neocortex and hippocampus during sleep in rodents
Sirota, A., Csicsvari, J., Buhl, D., & Buzsáki, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437938100 · Cited by 930
Intracellular analysis of relations between the slow (< 1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram
Steriade, M., Nunez, A., & Amzica, F. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03266.1993 · Cited by 894
Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837
Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Peigneux, P., Laureys, S., Fuchs, S., Collette, F., Perrin, F., Reggers, J., Phillips, C., Degueldre, C., Del Fiore, G., Aerts, J., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.007 · Cited by 766
Functional organization of thalamocortical relays
Sherman, S. M., & Guillery, R. W. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.1367 · Cited by 762
The slow (< 1 Hz) oscillation in reticular thalamic and thalamocortical neurons: scenario of sleep rhythm generation in interacting thalamic and neocortical networks
Steriade, M., Contreras, D., Dossi, R. C., & Núñez, Á. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03284.1993 · Cited by 723
Origin of Slow Cortical Oscillations in Deafferented Cortical Slabs
Timofeev, I. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.12.1185 · Cited by 710
Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships
Contreras, D., & Steriade, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00604.1995 · Cited by 700
Bursting of Thalamic Neurons and States of Vigilance
Llinás, R. R., & Steriade, M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00166.2006 · Cited by 682
Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
Petersen, C. C. H., Hahn, T. T. G., Mehta, M. R., Grinvald, A., & Sakmann, B. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235811100 · Cited by 679
Attractor dynamics of network UP states in the neocortex
Cossart, R., Aronov, D., & Yuste, R. (2003) · Nature · doi:10.1038/nature01614 · Cited by 659
Grouping of spindle activity during slow oscillations in human non-rapid eye movement sleep
Mölle, M., Marshall, L., Gais, S., & Born, J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10941.2002 · Cited by 617
Sleep as a fundamental property of neuronal assemblies
Krueger, J. M., Rector, D. M., Roy, S., Van Dongen, H. P. A., Belenky, G., & Panksepp, J. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2521 · Cited by 596
The Slow (4 Hz) Oscillation in Reticular Thalamic and Thalamocortical Neurons: Scenario of Sleep Rhythm Generation in Interacting Thalamic and Neocortical Networks
Steriade, M., Contreras, D., & Nuiiez, A. (1993) · Cited by 584
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity
Huber, R., Ghilardi, M. F., Massimini, M., Ferrarelli, F., Riedner, B. A., Peterson, M. J., & Tononi, G. (2006) · Nature Neuroscience · doi:10.1038/nn1758 · Cited by 579
Low-frequency (<1Hz) oscillations in the human sleep electroencephalogram
Achermann, P., & Borbély, A. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00186-3 · Cited by 577
From waking to sleeping: neuronal and chemical substrates
Jones, B. E. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.09.009 · Cited by 577
Cellular bases of neocortical activation: modulation of neural oscillations by the nucleus basalis and endogenous acetylcholine
Metherate, R., Cox, C. L., & Ashe, J. H. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04701.1992 · Cited by 575
Spatiotemporal analysis of local field potentials and unit discharges in cat cerebral cortex during natural wake and sleep states
Destexhe, A., Contreras, D., & Steriade, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04595.1999 · Cited by 573
Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model
Compte, A., Sanchez-Vives, M. V., McCormick, D. A., & Wang, X. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00845.2002 · Cited by 536
Sequential structure of neocortical spontaneous activity in vivo
Luczak, A., Barthó, P., Marguet, S. L., Buzsáki, G., & Harris, K. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605643104 · Cited by 515
The impact of 'bursting' thalamic impulses at a neocortical synapse
Swadlow, H. A., & Gusev, A. G. (2001) · Nature Neuroscience · doi:10.1038/86054 · Cited by 500
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick, D. A., & von Krosigk, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2774 · Cited by 500
Integration and Segregation of Activity in Entorhinal-Hippocampal Subregions by Neocortical Slow Oscillations
Isomura, Y., Sirota, A., Özen, S., Montgomery, S., Mizuseki, K., Henze, D. A., & Buzsáki, G. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.023 · Cited by 500
Imaging input and output of neocortical networks in vivo
Kerr, J. N. D., Greenberg, D., & Helmchen, F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506029102 · Cited by 474
Model of Thalamocortical Slow-Wave Sleep Oscillations and Transitions to Activated States
Bazhenov, M., Timofeev, I., Steriade, M., & B, T. J. S. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08691.2002 · Cited by 461
Spontaneous neural activity during human slow wave sleep
Dang-Vu, T. T., Schabus, M., Desseilles, M., Albouy, G., Boly, M., Darsaud, A., Gais, S., Rauchs, G., Sterpenich, V., Vandewalle, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801819105 · Cited by 455
Do all animals sleep?
Siegel, J. M. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.001 · Cited by 434
Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance [published erratum appears in Cereb Cortex 1997 Dec;7(8):779]
Steriade, M. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.583 · Cited by 429
Modeling Sleep and Wakefulness in the Thalamocortical System
Hill, S., & Tononi, G. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00915.2004 · Cited by 417
Population imaging of ongoing neuronal activity in the visual cortex of awake rats
Greenberg, D. S., Houweling, A. R., & Kerr, J. N. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2140 · Cited by 412
Synchronization of fast (30-40 Hz) spontaneous oscillations in intrathalamic and thalamocortical networks
Steriade, M., Contreras, D., Amzica, F., & Timofeev, I. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02788.1996 · Cited by 404
The Human K-Complex Represents an Isolated Cortical Down-State
Cash, S. S., Halgren, E., Dehghani, N., Rossetti, A. O., Thesen, T., Wang, C., Devinsky, O., Kuzniecky, R., Doyle, W., Madsen, J. R., et al. (2009) · Science · doi:10.1126/science.1169626 · Cited by 394
Internal Dynamics Determine the Cortical Response to Thalamic Stimulation
MacLean, J. N., Watson, B. O., Aaron, G. B., & Yuste, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.035 · Cited by 373
Spontaneous Subthreshold Membrane Potential Fluctuations and Action Potential Variability of Rat Corticostriatal and Striatal Neurons In Vivo
Stern, E. A., Kincaid, A. E., & Wilson, C. J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.4.1697 · Cited by 362
The cortex as a central pattern generator
Yuste, R., MacLean, J. N., Smith, J., & Lansner, A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1686 · Cited by 355
Are corticothalamic ‘up’ states fragments of wakefulness?
Destexhe, A., Hughes, S. W., Rudolph, M., & Crunelli, V. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.04.006 · Cited by 355
Self-citation
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Timofeev, I., & Steriade, M. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.6.4152 · Cited by 353
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Lörincz, M. L., Kékesi, K. A., Juhász, G. D., Crunelli, V., & Hughes, S. W. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.012 · Cited by 348
Self-citation
The K-complex: Its slow (<1-Hz) rhythmicity and relation to delta waves
Amzica, F., & Steriade, M. (1997) · Neurology · doi:10.1212/wnl.49.4.952 · Cited by 334
Spindle oscillation in cats: the role of corticothalamic feedback in a thalamically generated rhythm.
Contreras, D., & Steriade, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021133 · Cited by 329
Precise Long-Range Synchronization of Activity and Silence in Neocortical Neurons during Slow-Wave Sleep
Volgushev, M., Chauvette, S., Mukovski, M., & Timofeev, I. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0279-06.2006 · Cited by 289
Synchronized Oscillations at α and θ Frequencies in the Lateral Geniculate Nucleus
Hughes, S. W., Lörincz, M. L., Cope, D. W., Blethyn, K. L., Kékesi, K. A., Parri, H. R., Juhász, G. D., & Crunelli, V. (2004) · Neuron · doi:10.1016/s0896-6273(04)00191-6 · Cited by 281
Self-citation
Inhibition Determines Membrane Potential Dynamics and Controls Action Potential Generation in Awake and Sleeping Cat Cortex
Rudolph, M., Pospischil, M., Timofeev, I., & Destexhe, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4652-06.2007 · Cited by 247
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Hughes, S. W., Cope, D. W., Blethyn, K. L., & Crunelli, V. (2002) · Neuron · doi:10.1016/s0896-6273(02)00623-2 · Cited by 243
Self-citation
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Wolansky, T., Clement, E., Peters, S. R., Palczak, M. A., & Dickson, C. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5594-05.2006 · Cited by 236
Learning increases human electroencephalographic coherence during subsequent slow sleep oscillations
Mölle, M., Marshall, L., Gais, S., & Born, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402820101 · Cited by 222
Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation
Amzica, F., & Steriade, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04658.1995 · Cited by 221
The ‘window’ component of the low threshold Ca2+ current produces input signal amplification and bistability in cat and rat thalamocortical neurones
Williams, S. R., Toth, T. I., Turner, J. P., Hughes, S. W., & Crunelli, V. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.689ba.x · Cited by 219
Self-citation
T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites
Cueni, L., Canepari, M., Luján, R., Emmenegger, Y., Watanabe, M., Bond, C. T., Franken, P., Adelman, J. P., & Lüthi, A. (2008) · Nature Neuroscience · doi:10.1038/nn.2124 · Cited by 215
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Mena‐Segovia, J., Sims, H. M., Magill, P. J., & Bolam, J. P. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.153874 · Cited by 214
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Amzica, F., & Steriade, M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00319-9 · Cited by 192
Characterization of sensory and corticothalamic excitatory inputs to rat thalamocortical neurones in vitro
Turner, J. P., & Salt, T. E. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.829bj.x · Cited by 192
Neuronal metabolism governs cortical network response state
Cunningham, M. O., Pervouchine, D. D., Racca, C., Kopell, N., Davies, C. H., Jones, R. S. G., Traub, R. D., & Whittington, M. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600604103 · Cited by 177
Selective GABAergic Control of Higher-Order Thalamic Relays
Bokor, H., Frère, S. G. A., Eyre, M. D., Slézia, A., Ulbert, I., Lüthi, A., & Acsády, L. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.048 · Cited by 169
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Crunelli, V., Toth, T. I., Cope, D. W., Blethyn, K. L., & Hughes, S. W. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.076273 · Cited by 167
Self-citation
The functional significance of K-complexes
Amzica, F., & Steriade, M. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0181 · Cited by 161
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Crunelli, V., Cope, D. W., & Hughes, S. W. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.04.022 · Cited by 151
Self-citation
Thalamocortical Up States: Differential Effects of Intrinsic and Extrinsic Cortical Inputs on Persistent Activity
Rigas, P., & Castro‐Alamancos, M. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0003-07.2007 · Cited by 147
Persistently active, pacemaker-like neurons in neocortex
Bon-Jégo, M. L. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.009.2007 · Cited by 145
Ultrastructural Localization Suggests that Retinal and Cortical Inputs Access Different Metabotropic Glutamate Receptors in the Lateral Geniculate Nucleus
Godwin, D. W., Horn, S. C. V., Erişir, A., Sesma, M. A., Romano, C., & Sherman, S. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08181.1996 · Cited by 137
Neuronal Basis of the Slow (<1 Hz) Oscillation in Neurons of the Nucleus Reticularis ThalamiIn Vitro
Blethyn, K. L., Hughes, S. W., Toth, T. I., Cope, D. W., & Crunelli, V. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3607-05.2006 · Cited by 135
Self-citation
EEG Slow (∼1 Hz) Waves Are Associated With Nonstationarity of Thalamo-Cortical Sensory Processing in the Sleeping Human
Massimini, M., Rosanova, M., & Mariotti, M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00373.2002 · Cited by 124
Control of Dendritic Outputs of Inhibitory Interneurons in the Lateral Geniculate Nucleus
Cox, C. L., & Sherman, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00069-6 · Cited by 119
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Hughes, S. W., Cope, D. W., Toth, T. I., Williams, S. R., & Crunelli, V. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0805s.x · Cited by 109
Self-citation
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Beierlein, M., Fall, C. P., Rinzel, J., & Yuste, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09885.2002 · Cited by 106
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Puig, M. V., Ushimaru, M., & Kawaguchi, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712219105 · Cited by 101
Cellular mechanisms of burst firing‐mediated long‐term depression in rat neocortical pyramidal cells
Czarnecki, A., Birtoli, B., & Ulrich, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123588 · Cited by 99
Synchronization of low-frequency rhythms in corticothalamic networks
Contreras, D., & Steriade, M. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00393-4 · Cited by 94
Properties and origin of spikelets in thalamocortical neurones in vitro
Hughes, S. W., Blethyn, K. L., Cope, D. W., & Crunelli, V. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00577-2 · Cited by 90
Self-citation
Impact of Cortical Network Activity on Short-term Synaptic Depression
Reig, R., Gallego, R., Nowak, L. G., & Sanchez-Vives, M. V. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj014 · Cited by 90
Role of Thalamic and Cortical Neurons in Augmenting Responses and Self-Sustained Activity: Dual Intracellular Recordings In Vivo
Steriade, M., Timofeev, I., Grenier, F., & Dürmüller, N. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06425.1998 · Cited by 89
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Simon, N. R., Manshanden, I., & da Silva, F. H. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01974-0 · Cited by 73
Cortico-hippocampal interaction during up-down states and memory consolidation
Mehta, M. R. (2006) · Nature Neuroscience · doi:10.1038/nn0107-13 · Cited by 70
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Hoffman, K. L., Battaglia, F. P., Harris, K., MacLean, J. N., Marshall, L., & Mehta, M. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3501-07.2007 · Cited by 66
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De Gennaro, L., Fratello, F., Marzano, C., Moroni, F., Curcio, G., Tempesta, D., Pellicciari, M. C., Pirulli, C., Ferrara, M., & Rossini, P. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002483 · Cited by 60
State-dependent fluctuations of low-frequency rhythms in corticothalamic networks
Contreras, D., & Steriade, M. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00392-2 · Cited by 54
Synaptic activation of the group I metabotropic glutamate receptor mGlu1 on the thalamocortical neurons of the rat dorsal Lateral Geniculate Nucleus in vitro
Turner, J. P., & Salt, T. E. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00280-3 · Cited by 52
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Zhu, L., Blethyn, K. L., Cope, D. W., Tsomaia, V., Crunelli, V., & Hughes, S. W. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.069 · Cited by 52
Self-citation
A role for low‐frequency, rhythmic synaptic potentials in the synchronization of cat thalamocortical cells.
Soltész, I., & Crunelli, V. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019377 · Cited by 50
Self-citation
Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons: in vivo patch‐clamp analysis
Doi, A., Mizuno, M., Katafuchi, T., Furue, H., Koga, K., & Yoshimura, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05885.x · Cited by 35
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Tononi, G., Massimini, M., & Riedner, B. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.014 · Cited by 32
Functional Synaptic Contacts by Intranuclear Axon Collaterals of Thalamic Relay Neurons
Cox, C. L., Reichova, I., & Sherman, S. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07642.2003 · Cited by 26
Analysis and biophysical interpretation of bistable behaviour in thalamocortical neurons
Toth, T. I., Hughes, S. W., & Crunelli, V. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00118-3 · Cited by 18
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Simon, N.R., Kemp, B., Manshanden, I. & Lopes da Silva, F.H. Whole-head measures of sleep from MEG signals and the ubiquitous “slow oscillation”. Sleep Res. Online 5, 105–113 (2003).
Jones, E.G. The Thalamus (Plenum Press, New York, 2008).

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Authors: Crunelli, V., & Hughes, S. W.
Affiliations: Cardiff University (GB)
Eli Lilly (United Kingdom) (GB)
Corresponding author: Crunelli, Vincenzo
ORCID: Crunelli, Vincenzo
Hughes, Stuart W
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2009-12-06
Volume: 13
Issue: 1
Pages: 9-17
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.2445
PMC: PMC2980822
OpenAlex: W2078049175
Semantic Scholar: 3ab0af75d4a753ac35afe4eed6a3db4f6dfe8853
Cited by: 435
References: 98
Citations by year: 2026: 7 · 2025: 12 · 2024: 14 · 2023: 15 · 2022: 24 · 2021: 22 · 2020: 23 · 2019: 27 · 2018: 30 · 2017: 28 · 2016: 26 · 2015: 40 · 2014: 39 · 2013: 44 · 2012: 32
FWCI: 2.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust (078403, 078311, 78403, 78311, 071436, 71436)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: slow-wave sleep, NREM sleep, EEG oscillations, cell assemblies, network plasticity
MeSH terms: Action Potentials, Anesthetics, Animals, Biological Clocks, Brain Mapping, Cats, Cerebral Cortex, Delta Rhythm, Humans, Models, Biological, Nerve Net, Neurons, Sleep Stages, Thalamus, In Vitro Techniques

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The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators

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