The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking
Abstract
The maintenance of long-term memory in hippocampus, neocortex and amygdala requires the persistent action of the atypical protein kinase C isoform, protein kinase Mzeta (PKMzeta). We found that inactivating PKMzeta in the amygdala impaired fear memory in rats and that the extent of the impairment was positively correlated with a decrease in postsynaptic GluR2. Blocking the GluR2-dependent removal of postsynaptic AMPA receptors abolished the behavioral impairment caused by PKMzeta inhibition and the associated decrease in postsynaptic GluR2 expression, which correlated with performance. Similarly, blocking this pathway for removal of GluR2-containing receptors from postsynaptic sites in amygdala slices prevented the reversal of long-term potentiation caused by inactivating PKMzeta. Similar behavioral results were obtained in the hippocampus for unreinforced recognition memory of object location. Together, these findings indicate that PKMzeta maintains long-term memory by regulating the trafficking of GluR2-containing AMPA receptors, the postsynaptic expression of which directly predicts memory retention.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“these effects were regulated by glutamate subunit 2-dependent AMPA-R”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Migues et al., 2010
Citations
Cites
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993
Storage of spatial information by the maintenance mechanism of LTP
Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006) · Science · doi:10.1126/science.1128657 · Cited by 848
Self-citationPostsynaptic receptor trafficking underlying a form of associative learning
Rumpel, S., LeDoux, J., Zador, A., & Malinow, R. (2005) · Science · doi:10.1126/science.1103944 · Cited by 775
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 711
Self-citationNSF Binding to GluR2 Regulates Synaptic Transmission
Nishimune, A., Isaac, J. T. R., Molnár, E., Noël, J., Nash, S. R., Tagaya, M., Collingridge, G. L., Nakanishi, S., & Henley, J. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80517-6 · Cited by 545
Role of the Basolateral Amygdala in the Storage of Fear Memories across the Adult Lifetime of Rats
Gale, G. D., Anagnostaras, S., Godsil, B. P., Mitchell, S., Nozawa, T., Sage, J. R., Wiltgen, B. J., & Fanselow, M. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4100-03.2004 · Cited by 454
Protein kinase Mζ is necessary and sufficient for LTP maintenance
Ling, D. S. F., Benardo, L. S., Serrano, P. A., Blace, N., Kelly, M. T., Crary, J. F., & Sacktor, T. C. (2002) · Nature Neuroscience · doi:10.1038/nn829 · Cited by 419
Self-citationInteraction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors
Song, I., Kamboj, S. K., Xia, J., Dong, H., Liao, D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80548-6 · Cited by 399
Osten, P., Srivastava, S., Inman, G. J., Vilim, F. S., Khatri, L., Lee, L. M., States, B. A., Einheber, S., Milner, T. A., Hanson, P. I., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80518-8 · Cited by 358
Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ
Shema, R., Sacktor, T. C., & Dudai, Y. (2007) · Science · doi:10.1126/science.1144334 · Cited by 353
Self-citationAnterograde and retrograde amnesia in rats with dorsal hippocampal or dorsomedial thalamic lesions
Winocur, G. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90012-4 · Cited by 352
Extracellular interactions between GluR2 and N-cadherin in spine regulation
Saglietti, L., Dequidt, C., Kamieniarz, K., Rousset, M.-C., Valnegri, P., Thoumine, O., Beretta, F., Fagni, L., Choquet, D., Sala, C., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.012 · Cited by 341
Experience Strengthening Transmission by Driving AMPA Receptors into Synapses
Takahashi, T., Svoboda, K., & Malinow, R. (2003) · Science · doi:10.1126/science.1079886 · Cited by 306
Noël, J., Ralph, G. S., Pickard, L., Williams, J., Molnár, E., Uney, J. B., Collingridge, G. L., & Henley, J. M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80786-2 · Cited by 298
Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization
Brebner, K., Wong, T. P., Liu, L., Liu, Y., Campsall, P. A., Gray, S. L., Phelps, L., Phillips, A. G., & Wang, Y. T. (2005) · Science · doi:10.1126/science.1116894 · Cited by 296
Self-citationAhmadian, G., Ju, W., Liu, L., Wyszynski, M., Lee, S. H., Dunah, A. W., Taghibiglou, C., Wang, Y., Lu, J., Wong, T. P., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600126 · Cited by 296
Self-citationYao, Y., Kelly, M. T., Sajikumar, S., Serrano, P. A., Tian, D., Bergold, P. J., Frey, J. U., & Sacktor, T. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0223-08.2008 · Cited by 272
Self-citationHuang, Y.-Y., Martin, K. C., & Kandel, E. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06317.2000 · Cited by 269
Subunit Rules Governing the Sorting of Internalized AMPA Receptors in Hippocampal Neurons
Lee, S. H., Simonetta, A., & Sheng, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.015 · Cited by 268
PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories
Serrano, P. A., Friedman, E., Kenney, J., Taubenfeld, S. M., Zimmerman, J., Hanna, J., Alberini, C. M., Kelley, A. E., Maren, S., Rudy, J. W., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060318 · Cited by 267
Self-citationSpatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus
Xu, L., Anwyl, R., & Rowan, M. J. (1998) · Nature · doi:10.1038/29783 · Cited by 260
NSF ATPase and α-/β-SNAPs Disassemble the AMPA Receptor-PICK1 Complex
Hanley, J. G., Khatri, L., Hanson, P. I., & Ziff, E. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00638-4 · Cited by 197
Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases
Hayashi, T., & Huganir, R. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0799-04.2004 · Cited by 177
Synaptic AMPA Receptor Exchange Maintains Bidirectional Plasticity
McCormack, S. G., Stornetta, R. L., & Zhu, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.027 · Cited by 92
Hardt, O., Migues, P. V., Hastings, M., Wong, J., & Nader, K. (2010) · Hippocampus · doi:10.1002/hipo.20708 · Cited by 79
Self-citationYu, S. Y., Wu, D., Liu, L., Ge, Y., & Wang, Y. T. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05461.x · Cited by 75
Self-citationMigues, P. V., Lehmann, I., Fluechter, L., Cammarota, M., Gurd, J. W., Sim, A. T. R., Dickson, P. W., & Rostas, J. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03876.x · Cited by 47
Self-citationFeligioni, M., Holman, D., Haglerød, C., Davanger, S., & Henley, J. M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04087.x · Cited by 43
Flagged first, then by citations
Cited by
Sorted by citations
Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012
Long-term depression in the CNS
Collingridge, G. L., Peineau, S., Howland, J. G., & Wang, Y. T. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2867 · Cited by 926
Self-citationPharmacological brake-release of mRNA translation enhances cognitive memory
Sidrauski, C., Acosta‐Alvear, D., Khoutorsky, A., Vedantham, P., Hearn, B. R., Li, H., Gamache, K., Gallagher, C. M., Ang, K. K. H., Wilson, C. G. M., et al. (2013) · eLife · doi:10.7554/elife.00498 · Cited by 716
Self-citationThe synaptic plasticity and memory hypothesis: encoding, storage and persistence
Takeuchi, T., Duszkiewicz, A. J., & Morris, R. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0288 · Cited by 712
Mahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 643
Metadata
- Authors
- Migues, P. V., Hardt, O., Wu, D. C., Gamache, K., Sacktor, T. C., Wang, Y. T., & Nader, K.
- Affiliations
- McGill University (CA)
- University of British Columbia (CA)
- SUNY Downstate Health Sciences University (US)
- Corresponding author
- Migues, Paola Virginia
- Venue
- Nature Neuroscience
- Published
- 2010-04-11
- Volume
- 13
- Issue
- 5
- Pages
- 630-634
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1974491267
- Cited by
- 283
- References
- 31
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 16 · 2019: 15 · 2018: 22 · 2017: 14 · 2016: 23 · 2015: 17 · 2014: 16 · 2013: 33 · 2012: 26
- FWCI
- 20.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- National Institute of Mental Health (MH 57068, R01MH53576, R01MH053576)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- PKMzeta, GluR2, AMPA receptor trafficking, long-term memory, fear memory, amygdala, hippocampus, long-term potentiation, object recognition memory, memory maintenance
- MeSH terms
- Analysis of Variance, Animals, Avidin, Behavior, Animal, Cerebral Cortex, Conditioning, Psychological, Electroshock, Fear, Hippocampus, Male, Memory, Synaptic Transmission, Peptides, Protein Kinase C, Subcellular Fractions, Rats, Sprague-Dawley, Long-Term Potentiation, Receptors, AMPA, Patch-Clamp Techniques, Statistics, Nonparametric, Biotinylation, Rats, Long-Evans, Protein Transport, Recognition, Psychology, Freezing Reaction, Cataleptic, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
