Cited by 79Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

PKMζ maintains 1‐day‐ and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus

Hardt, Oliver, Migues, Paola V., Hastings, Margaret, Wong, Jacinda, Nader, Karim·2010·Hippocampus

Abstract

Continuous activity of the atypical protein kinase C isoform M zeta (PKMzeta) is necessary for maintaining long-term memory acquired in aversively or appetitively motivated associative learning tasks, such as active avoidance, aversive taste conditioning, auditory and contextual fear conditioning, radial arm maze, and watermaze. Whether unreinforced, nonassociative memory will also require PKMzeta for long-term maintenance is not known. Using recognition memory for object location and object identity, we found that inactivating PKMzeta in dorsal hippocampus abolishes 1-day and 6-day-old long-term recognition memory for object location, while recognition memory for object identity was not affected by this treatment. Memory for object location persisted for no more than 35 days after training. These results suggest that the dorsal hippocampus mediates long-term memory for where, but not what things have been encountered, and that PKMzeta maintains this type of spatial knowledge as long as the memory exists.

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Crossref · 10.1002/hipo.20708

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Authors
Hardt, O., Migues, P. V., Hastings, M., Wong, J., & Nader, K.
Affiliations
McGill University (CA)
Corresponding author
Hardt, Oliver
Venue
Hippocampus
Publisher
Wiley
Published
2009-10-05
Volume
20
Issue
6
Pages
691-695
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
OpenAlex
W2110054375
Cited by
79
References
26
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 7 · 2013: 12 · 2012: 8
FWCI
3.71
Type
journal article
Language
en
Open access
closed
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
PKMzeta, protein kinase C, long-term memory, object location memory, recognition memory, dorsal hippocampus, memory maintenance, spatial memory, memory consolidation
MeSH terms
Protein Kinase C zeta, Animals, Conditioning, Classical, Enzyme Inhibitors, Hippocampus, Memory, Protein Kinase C, Rats

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