PKMζ maintains 1‐day‐ and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus
Abstract
Continuous activity of the atypical protein kinase C isoform M zeta (PKMzeta) is necessary for maintaining long-term memory acquired in aversively or appetitively motivated associative learning tasks, such as active avoidance, aversive taste conditioning, auditory and contextual fear conditioning, radial arm maze, and watermaze. Whether unreinforced, nonassociative memory will also require PKMzeta for long-term maintenance is not known. Using recognition memory for object location and object identity, we found that inactivating PKMzeta in dorsal hippocampus abolishes 1-day and 6-day-old long-term recognition memory for object location, while recognition memory for object identity was not affected by this treatment. Memory for object location persisted for no more than 35 days after training. These results suggest that the dorsal hippocampus mediates long-term memory for where, but not what things have been encountered, and that PKMzeta maintains this type of spatial knowledge as long as the memory exists.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inactivating the atypical protein kinase C isoform M zeta (PKMζ) in the dorsal hippocampus abolished memory for OPP but not NOP.
“Inactivating the atypical protein kinase C isoform M zeta (PKMζ) in the dorsal hippocampus abolished memory for OPP, but not NOP”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Hardt et al., 2010
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706 · see citing works
Self-citationSpatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985 · see citing works
Independent Codes for Spatial and Episodic Memory in Hippocampal Neuronal Ensembles
Leutgeb, S., Leutgeb, J. K., Barnes, C. A., Moser, E. I., McNaughton, B. L., & Moser, M. (2005) · Science · doi:10.1126/science.1114037 · Cited by 911 · see citing works
Moscovitch, M., Rosenbaum, R. S., Gilboa, A., Addis, D. R., Westmacott, R., Grady, C., McAndrews, M. P., Levine, B., Black, S., Winocur, G., et al. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00421.x · Cited by 893 · see citing works
Storage of spatial information by the maintenance mechanism of LTP
Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006) · Science · doi:10.1126/science.1128657 · Cited by 848 · see citing works
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714 · see citing works
The cognitive neuroscience of remote episodic, semantic and spatial memory
Moscovitch, M., Nadel, L., Winocur, G., Gilboa, A., & Rosenbaum, R. S. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.03.013 · Cited by 660 · see citing works
Schafe, G. E., & LeDoux, J. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0003.2000 · Cited by 611 · see citing works
2004 IEEE International Joint Conference on Neural Networks
(2004) · International Joint Conference on Neural Networks (IJCNN) · doi:10.1109/ijcnn.2004.1381025 · Cited by 574 · see citing works
Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval
Winters, B. D., Saksida, L. M., & Bussey, T. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.004 · Cited by 568 · see citing works
Sacktor, T. C., Osten, P., Valsamis, H. A., Jiang, X., Naik, M. U., & Sublette, M. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8342 · Cited by 450 · see citing works
Protein kinase Mζ is necessary and sufficient for LTP maintenance
Ling, D. S. F., Benardo, L. S., Serrano, P. A., Blace, N., Kelly, M. T., Crary, J. F., & Sacktor, T. C. (2002) · Nature Neuroscience · doi:10.1038/nn829 · Cited by 419 · see citing works
Save, É., Poucet, B., Foreman, N., & Buhot, M.-C. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.3.447 · Cited by 383 · see citing works
Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ
Shema, R., Sacktor, T. C., & Dudai, Y. (2007) · Science · doi:10.1126/science.1144334 · Cited by 353 · see citing works
Integrated Memory for Object, Place, and Context in Rats: A Possible Model of Episodic-Like Memory?
Eacott, M. J., & Norman, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2975-03.2004 · Cited by 344 · see citing works
Maurer, A. P., VanRhoads, S. R., Sutherland, G. R., Lipa, P., & McNaughton, B. L. (2005) · Hippocampus · doi:10.1002/hipo.20114 · Cited by 308 · see citing works
PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories
Serrano, P., Friedman, E., Kenney, J., Taubenfeld, S., Zimmerman, J. M., Hanna, J., Alberini, C., Kelley, A., Maren, S., Rudy, J., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060318 · Cited by 273 · see citing works
The role of hippocampal subregions in detecting spatial novelty
Lee, I., Hunsaker, M. R., & Kesner, R. P. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.1.145 · Cited by 270 · see citing works
Yao, Y., Kelly, M. T., Sajikumar, S., Serrano, P. A., Tian, D., Bergold, P. J., Frey, J. U., & Sacktor, T. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0223-08.2008 · Cited by 268 · see citing works
Persistent Phosphorylation by Protein Kinase Mζ Maintains Late-Phase Long-Term Potentiation
Serrano, P. A., Yao, Y., & Sacktor, T. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5132-04.2005 · Cited by 220 · see citing works
Retrograde and anterograde object recognition in rats with hippocampal lesions
Gaskin, S., Tremblay, A., & Mumby, D. G. (2003) · Hippocampus · doi:10.1002/hipo.10154 · Cited by 160 · see citing works
Contrasting Hippocampal and Perirhinalcortex Function using Immediate Early Gene Imaging
Aggleton, J. P., & Brown, M. W. (2005) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/02724990444000131 · Cited by 158 · see citing works
Elements of episodic-like memory in animal models
Crystal, J. D. (2009) · Behavioural Processes · doi:10.1016/j.beproc.2008.09.009 · Cited by 86 · see citing works
Storage or retrieval deficit: The yin and yang of amnesiaPreprint
Hardt, O. M., Wang, S., & Nader, K. (2009) · Learning & Memory · doi:10.1101/lm.1267409 · Cited by 80 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
How does PKMζ maintain long-term memory?
Sacktor, T. C. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2949 · Cited by 431 · see citing works
Decay happens: the role of active forgetting in memory
Hardt, O., Nader, K., & Nadel, L. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.01.001 · Cited by 416 · see citing works
Self-citationPKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking
Migues, P. V., Hardt, O., Wu, D. C., Gamache, K., Sacktor, T. C., Wang, Y. T., & Nader, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2531 · Cited by 283 · see citing works
Self-citationChao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Migues, P. V., Liu, L., Archbold, G. E. B., Einarsson, E. Ö., Wong, J., Bonasia, K., Ko, S. H., Wang, Y. T., & Hardt, O. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3333-15.2016 · Cited by 153 · see citing works
Self-citationNelson, A. J. D., Cooper, M. T., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2011) · Behavioral Neuroscience · doi:10.1037/a0023337 · Cited by 53 · see citing works
Ozawa, T., Yamada, K., & Ichitani, Y. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.04.022 · Cited by 48 · see citing works
Balderas, I., Moreno‐Castilla, P., & Bermudez‐Rattoni, F. (2013) · Hippocampus · doi:10.1002/hipo.22143 · Cited by 46 · see citing works
Migues, P. V., Hardt, O., Finnie, P., Wang, Y. W., & Nader, K. (2014) · Hippocampus · doi:10.1002/hipo.22295 · Cited by 33 · see citing works
Self-citationHales, J. B., Ocampo, A. C., Broadbent, N. J., & Clark, R. E. (2015) · Neural Plasticity · doi:10.1155/2015/847136 · Cited by 7 · see citing works
- Authors
- Hardt, O., Migues, P. V., Hastings, M., Wong, J., & Nader, K.
- Affiliations
- McGill University (CA)
- Corresponding author
- Hardt, Oliver
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2009-10-05
- Volume
- 20
- Issue
- 6
- Pages
- 691-695
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2110054375
- Cited by
- 79
- References
- 26
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 7 · 2013: 12 · 2012: 8
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- PKMzeta, protein kinase C, long-term memory, object location memory, recognition memory, dorsal hippocampus, memory maintenance, spatial memory, memory consolidation
- MeSH terms
- Protein Kinase C zeta, Animals, Conditioning, Classical, Enzyme Inhibitors, Hippocampus, Memory, Protein Kinase C, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review