Cited by 353Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ

Shema, Reut, Sacktor, Todd Charlton, Dudai, Yadin·2007·Science

Abstract

Little is known about the neuronal mechanisms that subserve long-term memory persistence in the brain. The components of the remodeled synaptic machinery, and how they sustain the new synaptic or cellwide configuration over time, are yet to be elucidated. In the rat cortex, long-term associative memories vanished rapidly after local application of an inhibitor of the protein kinase C isoform, protein kinase M zeta (PKMζ). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form.

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Crossref · 10.1126/science.1144334

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  • Positive feedback loops that maintain key kinases and other molecules in persistently active states at strengthened synapses may also contribute to long-term memory storage.

    “Positive feedback loops that maintain key kinases and other molecules in persistently active states at strengthened synapses may also contribute to such long-term memory storage75–79.”

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Authors
Shema, R., Sacktor, T. C., & Dudai, Y.
Affiliations
SUNY Downstate Health Sciences University (US)
Corresponding author
Dudai, Yadin
Venue
Science
Published
2007-08-17
Volume
317
Issue
5840
Pages
951-953
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2099036181
Cited by
353
References
32
Citations by year
2026: 6 · 2025: 1 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 24 · 2016: 18 · 2015: 26 · 2014: 20 · 2013: 36 · 2012: 30
FWCI
14.49
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH 57068, R01MH53576, R01MH053576)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
long-term memory, memory persistence, PKMzeta, protein kinase C, memory erasure, neocortex, synaptic plasticity, memory consolidation
MeSH terms
Animals, Conditioning, Psychological, Enzyme Inhibitors, Hippocampus, Male, Memory, Oligopeptides, Protein Kinase C, Taste, Time Factors, Rats, Wistar, Neocortex, Rats

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