A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression

Jurado, Sandra; Biou, Virginie; Malenka, Robert C

doi:10.1038/nn.2613

Cited by 101Neuroscience and Neuropharmacology ResearchSignaling Pathways in DiseaseMemory and Neural Mechanisms

A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression

Open access

Jurado, Sandra, Biou, Virginie, Malenka, Robert C·2010·Nature Neuroscience

DOI 10.1038/nn.2613PMC PMC2943866

Open this paper in CoChat — free account

Abstract

AKAP79/150 is a protein scaffold that is thought to position specific kinases (protein kinase A and C) and phosphatases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term depression solely because of its interaction with calcineurin.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nn.2613

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

AKAP5 is a signaling scaffold protein required for LTD.
“AKAP5 (also called AKAP79/AKAP150) is a signaling scaffold protein required for LTD (Sanderson et al., 2016, Jurado et al., 2010).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Jurado et al., 2010
The Abstract identifies AKAP79/150 as a protein scaffold and reports that it is required for NMDA receptor-dependent LTD. The unqualified claim is broader than the finding: the paper reports no detectable effect of AKAP knockdown on mGluR-dependent LTD. (LLM, conf=0.86)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083 · see citing works
Self-citation
Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression
Tavalin, S. J., Colledge, M., Hell, J. W., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03044.2002 · Cited by 222 · see citing works
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD.
Xu, W., Schlüter, O. M., Steiner, P., Czervionke, B. L., Sabatini, B., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.027 · Cited by 193 · see citing works
Self-citation
A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors
Bhattacharyya, S., Biou, V., Xu, W., Schlüter, O., & Malenka, R. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2249 · Cited by 185 · see citing works
Self-citation
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity
Hoshi, N., Langeberg, L. K., & Scott, J. D. (2005) · Nature Cell Biology · doi:10.1038/ncb1315 · Cited by 183 · see citing works
Regulation of neuronal PKA signaling through AKAP targeting dynamics
Dell’Acqua, M. L., Smith, K. E., Gorski, J. A., Horne, E. A., Gibson, E. S., & Gomez, L. L. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.01.010 · Cited by 173 · see citing works
Age‐dependent requirement of AKAP150‐anchored PKA and GluR2‐lacking AMPA receptors in LTP
Lü, Y., Allen, M., Halt, A. R., Weisenhaus, M., Dallapiazza, R. F., Hall, D. D., Usachev, Y. M., McKnight, G. S., & Hell, J. W. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601884 · Cited by 166 · see citing works
Loss of AKAP150 perturbs distinct neuronal processes in mice
Tunquist, B. J., Hoshi, N., Guire, E. S., Zhang, F., Müllendorff, K., Langeberg, L. K., Raber, J., & Scott, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805922105 · Cited by 154 · see citing works
Mapping the Protein Phosphatase-2B Anchoring Site on AKAP79
Dell’Acqua, M. L., Dodge‐Kafka, K. L., Tavalin, S. J., & Scott, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207833200 · Cited by 132 · see citing works
Subcellular Dynamics of Type II PKA in Neurons
Zhong, H., Sia, G.-M., Sato, T., Gray, N. W., Mao, T., Khuchua, Z. A., Huganir, R. L., & Svoboda, K. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.013 · Cited by 125 · see citing works
Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression
Snyder, E. M., Colledge, M., Crozier, R. A., Chen, W. S., Scott, J. D., & Bear, M. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409693200 · Cited by 119 · see citing works
AKAP79 Inhibits Calcineurin through a Site Distinct from the Immunophilin-binding Region
Kashishian, A., Howard, M. L., Loh, C., Gallatin, W. M., Hoekstra, M. F., & Lai, Y. Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27412 · Cited by 93 · see citing works
AKAP150‐anchored PKA activity is important for LTD during its induction phase
Lü, Y., Zhang, M., Lim, I. A., Hall, D. D., Allen, M., Medvedeva, Y. V., McKnight, G. S., Usachev, Y. M., & Hell, J. W. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.151662 · Cited by 72 · see citing works
Regulation of Postsynaptic Structure and Function by an A-Kinase Anchoring Protein-Membrane-Associated Guanylate Kinase Scaffolding Complex
Robertson, H. R., Gibson, E. S., Benke, T. A., & Dell’Acqua, M. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6093-08.2009 · Cited by 68 · see citing works
Orchestration of synaptic plasticity through AKAP signaling complexes
Bauman, A. L., Goehring, A. S., & Scott, J. D. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.09.016 · Cited by 61 · see citing works

Flagged first, then by citations

Research works printed but not linked: 15

[1]Bauman AL Goehring AS Scott JD Neuropharmacol 2004 46 299 310 14975685
[2]Dell’Acqua ML Eur. J. Cell Biol 2006 85 627 633 16504338
[3]Tunquist MJ Proc. Natl. Acad. Sci. USA 2008 105 12557 12562 18711127 PMC2527950
[4]Lu Y EMBO J 2007 26 4879 4890 17972919 PMC2099463
[5]Lu Y J. Physiol 2008 586 4155 4164 18617570 PMC2652176
[6]Xu W Neuron 2008 57 248 262 18215622 PMC3147180
[7]Bhattacharyya S Biou V Xu W Schulter O Malenka RC Nat. Neurosci 2009 12 172 181 19169250 PMC2694745
[8]Dell’Acqua ML Dodge KL Tavalin SJ Scott JD J. Biol. Chem 2002 277 48796 48802 12354762 PMC3923414
[9]Hoshi N Langeberg LK Scott JD Nat. Cell Biol 2005 7 1066 1073 16228013 PMC3923410
[10]Robertson HR Gibson ES Benke TA Dell’Acqua ML J. Neurosci 2009 29 7929 7943 19535604 PMC2716089
[11]Tavalin SJ J. Neurosci 2002 22 3044 3051 11943807 PMC6757527
[12]Snyder EM J. Biol. Chem 2005 280 16962 16968 15718245 PMC3923403
[13]Zhong H Neuron 2009 62 363 374 19447092 PMC2702487
[14]Mulkey RM Endo S Shenolikar S Malenka RC Nature 1994 369 486 488 7515479
[15]Kashishian A J. Biol. Chem 1998 273 27412 27419 9765270

Sorted by citations

AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968 · see citing works
The AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844 · see citing works
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert
Reiner, A., & Levitz, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.018 · Cited by 637 · see citing works
Interaction of calcineurin with substrates and targeting proteins
Li, H., Rao, A., & Hogan, P. G. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.09.011 · Cited by 372 · see citing works
The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
Chater, T. E., & Goda, Y. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00401 · Cited by 342 · see citing works
Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens
Schwartz, N., Temkin, P., Jurado, S., Lim, B. K., Heifets, B. D., Polepalli, J. S., & Malenka, R. C. (2014) · Science · doi:10.1126/science.1253994 · Cited by 278 · see citing works
Self-citation
NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca 2+ -Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin
Sanderson, J. L., Gorski, J. A., & Dell’Acqua, M. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.043 · Cited by 210 · see citing works
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance
Schreiweis, C., Bornschein, U., Burguière, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C. A., Puliyadi, R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414542111 · Cited by 190 · see citing works
The Alzheimer’s therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity
Crouch, P. J., Savva, M. S., Hung, L. W., Donnelly, P. S., Mot, A. I., Parker, S. J., Greenough, M. A., Volitakis, I., Adlard, P. A., Cherny, R. A., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07402.x · Cited by 183 · see citing works
Neural functions of calcineurin in synaptic plasticity and memory: Figure 1.Preprint
Baumgärtel, K., & Mansuy, I. M. (2012) · Learning & Memory · doi:10.1101/lm.027201.112 · Cited by 162 · see citing works
Routes, destinations and delays: recent advances in AMPA receptor trafficking
Henley, J. M., Barker, E. A., & Glebov, O. O. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.004 · Cited by 158 · see citing works
PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity
Diering, G. H., Gustina, A. S., & Huganir, R. L. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.024 · Cited by 153 · see citing works
The interplay between Hebbian and homeostatic synaptic plasticity
Vitureira, N., & Goda, Y. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201306030 · Cited by 152 · see citing works
AKAP signaling complexes: pointing towards the next generation of therapeutic targets?
Esseltine, J. L., & Scott, J. D. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.10.005 · Cited by 139 · see citing works
AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca<sup>2+</sup>-Permeable AMPA Receptors
Sanderson, J. L., Gorski, J. A., Gibson, E. S., Lam, P., Freund, R. K., Chick, W. S., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-12.2012 · Cited by 137 · see citing works
Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity
Woolfrey, K. M., & Dell’Acqua, M. L. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.657262 · Cited by 118 · see citing works
Phosphorylation-Dependent Regulation of Ca2+-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity
Purkey, A., & Dell’Acqua, M. L. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00008 · Cited by 113 · see citing works
Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease
Hudry, E., Wu, H.-Y., Arbel‐Ornath, M., Hashimoto, T., Matsouaka, R., Fan, Z., Spires‐Jones, T. L., Betensky, R. A., Bacskai, B. J., & Hyman, B. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6439-11.2012 · Cited by 110 · see citing works
Palmitoylation of A-Kinase Anchoring Protein 79/150 Regulates Dendritic Endosomal Targeting and Synaptic Plasticity Mechanisms
Keith, D. J., Sanderson, J. L., Gibson, E. S., Woolfrey, K. M., Robertson, H. R., Olszewski, K., Kang, R., El-Husseini, A., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0784-12.2012 · Cited by 108 · see citing works
Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders
Ting, J. T., Peça, J., & Feng, G. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150442 · Cited by 106 · see citing works
A‐kinase anchoring proteins as potential drug targets
Tröger, J., Moutty, M. C., Skroblin, P., & Klußmann, E. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01796.x · Cited by 106 · see citing works
ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex
Lalo, U., Palygin, O., Verkhratsky, A., Grant, S. G. N., & Pankratov, Y. V. (2016) · Scientific Reports · doi:10.1038/srep33609 · Cited by 106 · see citing works
Control of PKA stability and signalling by the RING ligase praja2
Lignitto, L., Carlucci, A., Sepe, M., Stefan, E., Cuomo, O., Nisticò, R., Scorziello, A., Savoia, C., Garbi, C., Annunziato, L., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2209 · Cited by 99 · see citing works
GluA1 Phosphorylation Contributes to Postsynaptic Amplification of Neuropathic Pain in the Insular Cortex
Qiu, S., Zhang, M., Liu, Y., Guo, Y., Zhao, H., Song, Q., Zhao, M., Huganir, R. L., Luo, J., Xu, H., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1431-14.2014 · Cited by 97 · see citing works
AMPA Receptor Trafficking in Natural and Pathological Aging
Jurado, S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00446 · Cited by 73 · see citing works
Self-citation
Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca 2+ -Permeable AMPA Receptors
Sanderson, J. L., Scott, J. D., & Dell’Acqua, M. L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2362-17.2018 · Cited by 75 · see citing works
Cross-talk and regulation between glutamate and GABAB receptors
Kantamneni, S. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00135 · Cited by 74 · see citing works
Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling
Patriarchi, T., Buonarati, O. R., & Hell, J. W. (2018) · The EMBO Journal · doi:10.15252/embj.201899771 · Cited by 65 · see citing works
The Palmitoyl Acyltransferase DHHC2 Regulates Recycling Endosome Exocytosis and Synaptic Potentiation through Palmitoylation of AKAP79/150
Woolfrey, K. M., Sanderson, J. L., & Dell’Acqua, M. L. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2243-14.2015 · Cited by 69 · see citing works
Adenylyl Cyclase Anchoring by a Kinase Anchor Protein AKAP5 (AKAP79/150) Is Important for Postsynaptic β-Adrenergic Signaling
Zhang, M., Patriarchi, T., Stein, I. S., Qian, H., Matt, L., Nguyen, M., Xiang, Y. K., & Hell, J. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.449462 · Cited by 66 · see citing works
Calmodulin Kinase IV –dependent CREB activation is required for neuroprotection via NMDA receptor‐ PSD 95 disruption
Bell, K. F. S., Bent, R. J., Meese‐Tamuri, S., Ali, A., Forder, J. P., & Aarts, M. M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12176 · Cited by 63 · see citing works
AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP
Purkey, A., Woolfrey, K. M., Crosby, K. C., Stich, D., Chick, W. S. H., Aoto, J. N., & Dell’Acqua, M. L. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.085 · Cited by 65 · see citing works
A-Kinase Anchoring Protein 150 and Protein Kinase A Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress
Zhou, H.-Y., He, J., Hu, Z., Xue, S.-G., Xu, J., Cui, Q., Gao, S., Zhou, B., Wu, P., Long, L., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.967 · Cited by 63 · see citing works
Histone Deacetylase Inhibition Rescues Maternal Deprivation-Induced GABAergic Metaplasticity through Restoration of AKAP Signaling
Authement, M. E., Jayaraj, K. N., Gouty, S., Rusnak, M., Symes, A. J., Cox, B. M., & Nugent, F. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.024 · Cited by 59 · see citing works
Molecular Constraints on Synaptic Tagging and Maintenance of Long-Term Potentiation: A Predictive Model
Smolen, P. D., Baxter, D. A., & Byrne, J. H. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002620 · Cited by 59 · see citing works
CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression
Woolfrey, K. M., O’Leary, H., Goodell, D. J., Robertson, H. R., Horne, E. A., Coultrap, S. J., Dell’Acqua, M. L., & Bayer, K. U. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.813808 · Cited by 56 · see citing works
Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk
Huentelman, M. J., Muppana, L., Corneveaux, J. J., Dinu, V., Pruzin, J. J., Reiman, R., Borish, C. N., De Both, M., Ahmed, A., Todorov, A., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0135076 · Cited by 52 · see citing works
Calcineurin in development and disease
Chen, L., Song, M., & Yao, C. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.03.002 · Cited by 53 · see citing works
The C‐terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease
Warnet, X. L., Bakke Krog, H., Sevillano‐Quispe, O. G., Poulsen, H., & Kjaergaard, M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14842 · Cited by 50 · see citing works
Neuroprotective Copper Bis(thiosemicarbazonato) Complexes Promote Neurite Elongation
Bica, L., Liddell, J. R., Donnelly, P. S., Duncan, C., Caragounis, A., Volitakis, I., Paterson, B. M., Cappai, R., Grubman, A., Camakaris, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090070 · Cited by 45 · see citing works
AKAP Signaling in Reinstated Cocaine Seeking Revealed by iTRAQ Proteomic Analysis
Reissner, K. J., Uys, J. D. K., Schwacke, J. H., Comte-Walters, S., Rutherford-Bethard, J. L., Dunn, T. E., Blumer, J., Schey, K. L., & Kalivas, P. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3452-10.2011 · Cited by 45 · see citing works
Roles of palmitoylation in structural long-term synaptic plasticity
Ji, B., & Skup, M. (2021) · Molecular Brain · doi:10.1186/s13041-020-00717-y · Cited by 43 · see citing works
AKAP12 Signaling Complex: Impacts of Compartmentalizing cAMP‐Dependent Signaling Pathways in the Heart and Various Signaling Systems
Qasim, H., & McConnell, B. K. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016615 · Cited by 42 · see citing works
A ‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases
Poppinga, W. J., Muñoz-LLancao, P., González-Billault, C. E., & Schmidt, M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12882 · Cited by 41 · see citing works
S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics
Han, J., Wu, P.-F., Wang, F., & Chen, J.-G. (2014) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2014.12.002 · Cited by 37 · see citing works
A-Kinase Anchoring Protein–Calcineurin Signaling in Long-Term Depression of GABAergic Synapses
Dacher, M., Gouty, S., Dash, S., Cox, B. M., & Nugent, F. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2037-12.2013 · Cited by 38 · see citing works
Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA
Shepard, R. D., Gouty, S., Kassis, H., Berenji, A., Zhu, W. Y., Cox, B. M., & Nugent, F. S. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.002 · Cited by 39 · see citing works
Morphine-induced synaptic plasticity in the VTA is reversed by HDAC inhibition
Authement, M. E., Langlois, L. D., Kassis, H., Gouty, S., Dacher, M., Shepard, R. D., Cox, B. M., & Nugent, F. S. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00238.2016 · Cited by 37 · see citing works
Dopamine-Dependent Long-Term Depression at Subthalamo-Nigral Synapses Is Lost in Experimental Parkinsonism
Dupuis, J. P., Feyder, M. T., Miguélez, C., García, L., Morin, S., Choquet, D., Hosy, E., Bézard, E., Fisone, G., Bioulac, B. H., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1681-13.2013 · Cited by 38 · see citing works
Protein Kinase C (PKC)ζ Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation
Bogard, A. S., & Tavalin, S. J. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.099457 · Cited by 37 · see citing works
Spatial organization of palmitoyl acyl transferases governs substrate localization and function
Philippe, J. M., & Jenkins, P. M. (2019) · Molecular Membrane Biology · doi:10.1080/09687688.2019.1710274 · Cited by 34 · see citing works
A frontier in the understanding of synaptic plasticity: Solving the structure of the postsynaptic density
Gold, M. G. (2012) · BioEssays · doi:10.1002/bies.201200009 · Cited by 33 · see citing works
Regulation of the phosphatase PP2B by protein–protein interactions
Nygren, P. J., & Scott, J. D. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160150 · Cited by 32 · see citing works
N-Methyl D-aspartate receptor subunit signaling in fear extinction
Radulović, J., Ren, L. Y., & Gao, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5022-5 · Cited by 32 · see citing works
The key genes, phosphoproteins, processes, and pathways affected by efavirenz‐activated CYP46A1 in the amyloid‐decreasing paradigm of efavirenz treatment
Petrov, A. M., Mast, N., Li, Y., & Pikuleva, I. A. (2019) · The FASEB Journal · doi:10.1096/fj.201900092r · Cited by 31 · see citing works
Histone deacetylase inhibition reduces ventral tegmental area dopamine neuronal hyperexcitability involving AKAP150 signaling following maternal deprivation in juvenile male rats
Shepard, R. D., Langlois, L. D., Authement, M. E., & Nugent, F. S. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24613 · Cited by 30 · see citing works
Calcineurin and Its Role in Synaptic Transmission
Tarasova, E. O., Gaydukov, A. E., & Balezina, O. P. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918060056 · Cited by 29 · see citing works
The synergistic interaction between the calcineurin B subunit and IFN-γ enhances macrophage antitumor activity
Su, Z., Yang, R., Zhang, W., Xu, L., Zhong, Y., Yin, Y., Cen, J., DeWitt, J. P., & Wei, Q. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.92 · Cited by 29 · see citing works
AMPA Receptor Function in Hypothalamic Synapses
Royo, M., Aznar-Escolano, B., Madrigal, M. P., & Jurado, S. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.833449 · Cited by 29 · see citing works
Self-citation
Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity
Nygren, P. J., Mehta, S., Schweppe, D. K., Langeberg, L. K., Whiting, J. L., Weisbrod, C. R., Bruce, J. E., Zhang, J., Veesler, D., & Scott, J. D. (2017) · eLife · doi:10.7554/elife.30872 · Cited by 26 · see citing works
AKAP79 enables calcineurin to directly suppress protein kinase A activity
Church, T. W., Tewatia, P., Hannan, S. B., Antunes, J., Eriksson, O., Smart, T. G., Kotaleski, J. H., & Gold, M. G. (2021) · eLife · doi:10.7554/elife.68164 · Cited by 29 · see citing works
The role of post-translational modifications in synaptic AMPA receptor activity
Corti, E., & Duarte, C. B. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220827 · Cited by 23 · see citing works
Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression
Bacaj, T., Ahmad, M., Jurado, S., Malenka, R. C., & Südhof, T. C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1581-14.2015 · Cited by 24 · see citing works
Self-citation
Amyloid-β-Induced Dendritic Spine Elimination Requires Ca 2+ -Permeable AMPA Receptors, AKAP-Calcineurin-NFAT Signaling, and the NFAT Target Gene Mdm2
Martinez, T. A., Larsen, M. E., Sullivan, E. J., Woolfrey, K. M., & Dell’Acqua, M. L. (2024) · eNeuro · doi:10.1523/eneuro.0175-23.2024 · Cited by 22 · see citing works
Signal Transducer and Activator of Transcription 3 (STAT3) Degradation by Proteasome Controls a Developmental Switch in Neurotrophin Dependence
Murase, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.470583 · Cited by 21 · see citing works
Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain
Hopp, S. C., Bihlmeyer, N. A., Corradi, J., Vanderburg, C. R., Cacace, A. M., Das, S., Clark, T. W., Betensky, R. A., Hyman, B. T., & Hudry, E. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14469 · Cited by 21 · see citing works
Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling
Prikhodko, O., Freund, R. K., Sullivan, E. M., Kennedy, M. J., & Dell’Acqua, M. L. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0675-24.2024 · Cited by 16 · see citing works
Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice
Wang, W.-T., Pan, G.-Q., Zhang, Z., Suo, Z., Yang, X. Z., & Hu, X. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.031 · Cited by 16 · see citing works
Regulation of fear extinction versus other affective behaviors by discrete cortical scaffolding complexes associated with NR2B and PKA signaling
Corcoran, K. A., Leaderbrand, K., Jovasevic, V., Guedea, A. L., Kassam, F., & Radulović, J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.150 · Cited by 15 · see citing works
Preferential generation of Ca2+-permeable AMPA receptors by AKAP79-anchored protein kinase C proceeds via GluA1 subunit phosphorylation at Ser-831
Summers, K. C., Bogard, A. S., & Tavalin, S. J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004340 · Cited by 15 · see citing works
Relationship Between Na+, K+-ATPase and NMDA Receptor at Central Synapses
Arnaiz, G. R. D. L., & Bersier, M. G. (2014) · Current Protein and Peptide Science · doi:10.2174/1389203715666140903145608 · Cited by 16 · see citing works
A single amino acid difference between the intracellular domains of amyloid precursor protein and amyloid-like precursor protein 2 enables induction of synaptic depression and block of long-term potentiation
Trillaud-Doppia, É., Paradis-Isler, N., & Boehm, J. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.016 · Cited by 14 · see citing works
AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula
Simmons, S. C., Flerlage, W. J., Langlois, L. D., Shepard, R. D., Bouslog, C., Thomas, E. H., Gouty, K. M., Sanderson, J. L., Gouty, S., Cox, B. M., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06041-8 · Cited by 10 · see citing works
Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD
Cheng, W., Siedlecki‐Wullich, D., Català-Solsona, J., Fábregas, C., Fadó, R., Casals, N., Solé, M., Unzeta, M., Saura, C. A., Rodrı́guez-Álvarez, J., et al. (2020) · eNeuro · doi:10.1523/eneuro.0218-19.2020 · Cited by 10 · see citing works
Glutamate treatment mimics LTP- and LTD-like biochemical activity in viable synaptosome preparation
Gharami, K., & Biswas, S. C. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104655 · Cited by 9 · see citing works
Protein Phosphatase 2B Dual Function Facilitates Synaptic Integrity and Motor Learning
Lin, Z., Wu, B., Paul, M. W., Li, K. W., Yao, Y., Smal, I., Onori, M. P., Hasanbegović, H., Bezstarosti, K., Demmers, J., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1741-20.2021 · Cited by 6 · see citing works
Long-term cyclosporine A treatment promotes anxiety-like behavior: Possible relation with glutamate signaling in rat hippocampus
Cararo-Lopes, M. M., de Souza, D. G., Ganzella, M., Hansel, G., Kazlauckas, V., Mello, P. S. D., Lima, L. D. S., Kawamoto, E. M., Portela, L. V., Souza, D. O., et al. (2022) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2022.100394 · Cited by 6 · see citing works
Metaplastic regulation of neocortical long-term depression in vivo is sensitive to distinct phases of conditioned taste aversion
Urrieta, E., & Escobar, M. L. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107449 · Cited by 6 · see citing works
Modulation of Neurotransmission by the GABAB Receptor
Kantamneni, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-46044-4_7 · Cited by 6 · see citing works
Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?
Chu, C.-C., Hu, Y.-H., Li, G.-Z., Chen, J., Zhang, N.-N., Gu, Y., Wu, S., Zhang, H., Xu, Y.-Y., Guo, H.-L., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106812 · Cited by 4 · see citing works
A molecular pathway analysis of the glutamatergic–monoaminergic interplay serves to investigate the number of depressive records during citalopram treatment
Drago, A., Cocchi, E., Crisafulli, C., & Serretti, A. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1267-2 · Cited by 3 · see citing works
The PSD
Banerjee, A., Borgmann‐Winter, K. E., Ray, R., & Hahn, C.-G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801829-3.00016-1 · Cited by 3 · see citing works
Preparation of Rat Organotypic Hippocampal Slice Cultures Using the Membrane-Interface Method
Church, T. W., & Gold, M. G. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0818-0_12 · Cited by 3 · see citing works
Lipids and phosphates at odds in synaptic depression
Omelchenko, A., & Firestein, B. L. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.h117.813808 · Cited by 2 · see citing works
Stress experiences and coping mechanisms of science and mathematics students on online learning amidst COVID-19 pandemic
Franco, Z. I., Go, J. A., & Iniego, J. (2023) · International Journal of Research Studies in Education · doi:10.5861/ijrse.2023.1004 · Cited by 2 · see citing works
Serine/Threonine Phosphatases in LTP: Two B or Not to Be the Protein Synthesis Blocker-Induced Impairment of Early Phase
Maltsev, A. V., Bal, N. V., & Balaban, P. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094857 · Cited by 2 · see citing works
Studies of Neuronal Gene Regulation Controlling the Molecular Mechanisms Underlying Neural Plasticity
Fukuchi, M. (2017) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.17-00107 · Cited by 1 · see citing works
FKBP5 deficiency selectively impairs NMDAR-dependent long-term depression via enhanced calcineurin activity: Implications for stress resilience
Zhang, S., Jeon, Y.-J., Han, J., Park, H.-Y., & Chung, C. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102801 · Cited by 1 · see citing works
On independency of functional and morphological synapse plasticity
Maximov, D. (2026) · Biosystems · doi:10.1016/j.biosystems.2026.105768 · Cited by 1 · see citing works
From synapse to strategy: a bibliometric map of ionotropic glutamate receptors in depression
Liu, Y., Zhong, R., Yao, F., Zhao, H., Wang, Y., Li, C., Zhang, J., & Kou, Z. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05353-2 · Cited by 1 · see citing works
Upregulation of RCAN1.4 in spinal dorsal horn is involved in inflammatory pain hypersensitivity
Bai, X., Gao, M., Li, Y., Chen, H., Ma, X., Bai, H.-H., Liu, Y., Hu, X., & Suo, Z. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136538 · Cited by 1 · see citing works
Targeting AKAP79/150 in Human Disorders: An Emerging Opportunity for Future Therapies?
Chen, F., Chu, C.-C., Wu, C., Chen, F., Xu, J., Zhou, L., Fang, W. R., Lu, X., & Hu, Y. H. (2023) · Progress in Neurobiology · doi:10.60124/j.pneuro.2023.10.06
AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenulaPreprint
Simmons, S. C., Flerlage, W. J., Langlois, L. D., Shepard, R. D., Bouslog, C., Thomas, E. H., Gouty, K. M., Sanderson, J. L., Gouty, S., Cox, B. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.06.570160 · Cited by 1 · see citing works
Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
Nair, R. (2011) · doi:10.53846/goediss-511
Role of EPAC in axon determination
Muñoz-LLancao, P. (2015)
Alterations of synaptic plasticity and network functions in APP and APLP-deficient mice
Herrmann, U. (2015) · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG)) · doi:10.24355/dbbs.084-201505271053-0
Janus Synapses as Modular Neurointerfaces
Cho, W.-S., Jung, M., & Chung, T. D. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c01266
AMPc et prise alimentaire sous le contrôle des récepteurs 5-HT4 de la sérotonine dans le noyau accumbens
Pratlong, M. (2014) · theses.fr (ABES) · doi:10.70675/02dafa47zd1cfz49e6z86a9zb57e2f9d693f
Pathophysiological consequences of a Fragile X missense mutation
Garcia, M. P. (2020) · theses.fr (ABES) · doi:10.70675/b8e86263z5926z4a83zbaf6z0f61bf2d15f9

A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression. Nat. Neurosci. 2010; 13:1053–1055. [PubMed: 20694001
Jurado, R., Biou, V., & Malenka, R. C. (2016)
Self-citation
cAMP-Dependent Protein Kinase Postsynaptic Localization Regulated by NMDA Receptor Activation through Translocation of an A-Kinase Anchoring Protein Scaffold Protein
Smith, K. E., Gibson, E. S., & Dell’Acqua, M. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3092-05.2006 · Cited by 141 · see citing works
Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin
Gomez, L. L., Alam, S., Smith, K. E., Horne, E., & Dell'Acqua, M. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07027.2002 · Cited by 170 · see citing works
Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression
Snyder, E. M., Colledge, M., Crozier, R. A., Chen, W. S., Scott, J. D., & Bear, M. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409693200 · Cited by 119 · see citing works
(AKAP79) Signaling Complex Shares Properties with Long-Term Depression
Tavalin, S. J., Colledge, M., Hell, J. W., Langeberg, L. K., Huganir, R. L., Scott, J. D., & Hughes, H. (2013)

Authors: Jurado, S., Biou, V., & Malenka, R. C.
Affiliations: Stanford Medicine (US)
Corresponding author: Malenka, Robert C
ORCID: Jurado, Sandra
Malenka, Robert C
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-08-08
Volume: 13
Issue: 9
Pages: 1053-1055
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.2613
PMC: PMC2943866
OpenAlex: W2050187823
Cited by: 101
References: 15
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 11 · 2017: 3 · 2016: 7 · 2015: 11 · 2014: 12 · 2013: 8 · 2012: 7
FWCI: 2.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: National Institute of Mental Health (R37MH063394, R01MH063394, P50MH086403, MH63394)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: AKAP79/150, calcineurin, NMDA receptor, long-term depression, synaptic plasticity, protein scaffolds, hippocampus, excitatory synapses, protein kinase A, protein kinase C
MeSH terms: Animals, Cells, Cultured, Synaptic Transmission, Neurons, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Pyramidal Cells, Receptors, AMPA, Receptors, Metabotropic Glutamate, Calcineurin, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Rats, A Kinase Anchor Proteins, CA1 Region, Hippocampal, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks