Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

Cellular and Molecular Mechanisms of Pain

Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344 · see citing works

From motivation to action: Functional interface between the limbic system and the motor system

MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331 · see citing works

Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action

Balleine, B. W., & O'Doherty, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.131 · Cited by 1,775 · see citing works

The mysterious motivational functions of mesolimbic dopamine

Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418 · see citing works

Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy

Richardson, N. R., & Roberts, D. C. S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00153-0 · Cited by 1,357 · see citing works

Fatigue in neurological disorders

Chaudhuri, A., & Behan, P. O. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15794-2 · Cited by 1,297 · see citing works

Concurrent activation of striatal direct and indirect pathways during action initiation

Cui, G., Jun, S. B., Jin, X., Pham, M. D., Vogel, S. S., Lovinger, D. M., & Costa, R. M. (2013) · Nature · doi:10.1038/nature11846 · Cited by 1,260 · see citing works

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013) · Nature · doi:10.1038/nature12518 · Cited by 1,161 · see citing works

Corticostriatal functional connectivity predicts transition to chronic back pain

Baliki, M. N., Petre, B., Torbey, S., Herrmann, K. M., Huang, L., Schnitzer, T. J., Fields, H. L., & Apkarian, A. V. (2012) · Nature Neuroscience · doi:10.1038/nn.3153 · Cited by 1,050 · see citing works

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

von Hehn, C. A., Baron, R., & Woolf, C. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.008 · Cited by 804 · see citing works

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

Johansen, J. P., Fields, H. L., & Manning, B. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141218998 · Cited by 677 · see citing works

Chronic Pain and Psychopathology: Research Findings and Theoretical Considerations

Dersh, J., Polatin, P. B., & Gatchel, R. J. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200209000-00010 · Cited by 676 · see citing works

Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity

Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649 · see citing works

The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System

Land, B. B., Bruchas, M. R., Lemos, J. C., Xu, M., Melief, E. J., & Chavkin, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4458-07.2008 · Cited by 601 · see citing works

Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned

Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., Maclean, A. W., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2010.109 · Cited by 444 · see citing works

Interaction between glucocorticoid hormones, stress and psychostimulant drugs*

Marinelli, M., & Piazza, P. V. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02089.x · Cited by 426 · see citing works

Diversity in NMDA Receptor Composition

Sanz-Clemente, A., Nicoll, R. A., & Roche, K. W. (2012) · The Neuroscientist · doi:10.1177/1073858411435129 · Cited by 397 · see citing works

The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons

Lobo, M. K., & Nestler, E. J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00041 · Cited by 371 · see citing works

Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

Lim, B. K., Huang, K. W., Grueter, B. A., Rothwell, P. E., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11160 · Cited by 368 · see citing works

Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

Kasanetz, F., Deroche‐Gamonet, V., Berson, N., Balado, É., Lafourcade, M., Manzoni, O. J., & Piazza, P. V. (2010) · Science · doi:10.1126/science.1187801 · Cited by 364 · see citing works

Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens

Grueter, B. A., Brasnjo, G., & Malenka, R. C. (2010) · Nature Neuroscience · doi:10.1038/nn.2685 · Cited by 353 · see citing works

Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis

Shields, S. D., Eckert, W. A., & Basbaum, A. I. (2003) · Journal of Pain · doi:10.1067/s1526-5900(03)00781-8 · Cited by 322 · see citing works

Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive

Lemos, J. C., Wanat, M. J., Smith, J. S., Reyes, B. A. S., Hollon, N. G., Bockstaele, E. J. V., Chavkin, C., & Phillips, P. E. M. (2012) · Nature · doi:10.1038/nature11436 · Cited by 304 · see citing works

Variations in the Human Pain Stress Experience Mediated by Ventral and Dorsal Basal Ganglia Dopamine Activity

Scott, D., Heitzeg, M. M., Koeppe, R. A., Stohler, C. S., & Zubieta, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2577-06.2006 · Cited by 298 · see citing works

D2R striatopallidal neurons inhibit both locomotor and drug reward processes

Durieux, P. F., Bearzatto, B., Guiducci, S., Buch, T., Waisman, A., Zoli, M., Schiffmann, S. N., & de Kerchove d'Exaerde, A. (2009) · Nature Neuroscience · doi:10.1038/nn.2286 · Cited by 297 · see citing works

Comorbidities in Chronic Neuropathic Pain

Nicholson, B. D., & Verma, S. (2004) · Pain Medicine · doi:10.1111/j.1526-4637.2004.04019.x · Cited by 255 · see citing works

Inflammation-induced decrease in voluntary wheel running in mice: A nonreflexive test for evaluating inflammatory pain and analgesia

Cobos, E. J., Ghasemlou, N., Araldi, D., Segal, D., Duong, K., & Woolf, C. J. (2012) · Pain · doi:10.1016/j.pain.2012.01.016 · Cited by 240 · see citing works

The Flexible Approach Hypothesis: Unification of Effort and Cue-Responding Hypotheses for the Role of Nucleus Accumbens Dopamine in the Activation of Reward-Seeking Behavior

Nicola, S. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3958-10.2010 · Cited by 238 · see citing works

A Time-Dependent History of Mood Disorders in a Murine Model of Neuropathic Pain

Yalçın, İ., Bohren, Y., Waltisperger, E., Ciocca, D., Yin, J. C. P., Freund‐Mercier, M. J., & Barrot, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.017 · Cited by 233 · see citing works

Drd1a-tdTomato BAC Transgenic Mice for Simultaneous Visualization of Medium Spiny Neurons in the Direct and Indirect Pathways of the Basal Ganglia

Shuen, J. A., Chen, M., Gloss, B. R., & Calakos, N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5492-07.2008 · Cited by 231 · see citing works

Critical assessment of how to study addiction and its treatment: Human and non-human animal models

O’Brien, C. P., & Gardner, E. L. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.018 · Cited by 221 · see citing works

Biological mechanisms of chronic fatigue

Norheim, K. B., Jonsson, G., & Omdal, R. (2011) · Lara D. Veeken · doi:10.1093/rheumatology/keq454 · Cited by 216 · see citing works

Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity

Urban, R., Scherrer, G., Goulding, E. H., Tecott, L. H., & Basbaum, A. I. (2011) · Pain · doi:10.1016/j.pain.2010.12.003 · Cited by 189 · see citing works

Assessment and Treatment of Psychosocial Comorbidities in Patients With Neuropathic Pain

Turk, D. C., Audette, J. F., Levy, R. M., Mackey, S., & Stanos, S. P. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0648 · Cited by 159 · see citing works

Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus

Sergeyev, V., Broberger, C., & Hökfelt, T. G. M. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00088-2 · Cited by 153 · see citing works

Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors

Farrar, A. M., Segovia, K. N., Randall, P. A., Nunes, E. J., Collins, L. E., Stopper, C. M., Port, R. G., Hockemeyer, J., Müller, C. E., Correa, M., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.056 · Cited by 128 · see citing works

Reward‐aversion circuitry in analgesia and pain: Implications for psychiatric disorders

Borsook, D., Becerra, L. R., Carlezon, W. A., Shaw, M. E., Renshaw, P. F., Elman, I., & Levine, J. D. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.12.005 · Cited by 122 · see citing works

Cocaine-induced metaplasticity in the nucleus accumbens: Silent synapse and beyond

Lee, B. R., & Dong, Y. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.033 · Cited by 103 · see citing works

A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression

Jurado, S., Biou, V., & Malenka, R. C. (2010) · Nature Neuroscience · doi:10.1038/nn.2613 · Cited by 101 · see citing works

ON THE APPLIED USE OF PROGRESSIVE‐RATIO SCHEDULES OF REINFORCEMENT

Roane, H. S. (2008) · Journal of Applied Behavior Analysis · doi:10.1901/jaba.2008.41-155 · Cited by 99 · see citing works

Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice

Lü, X., & Bartfai, T. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0394-z · Cited by 70 · see citing works

A Clinical Genetic Method to Identify Mechanisms by Which Pain Causes Depression and Anxiety

Max, M. B., Wu, T., Atlas, S. J., Edwards, R. R., Haythornthwaite, J. A., Bollettino, A. F., Hipp, H. S., McKnight, C. D., Osman, I. A., Crawford, E. N., et al. (2006) · Molecular Pain · doi:10.1186/1744-8069-2-14 · Cited by 62 · see citing works

The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions

Santerre, J. L., Nunes, E. J., Kovner, R., Leser, C. E., Randall, P. A., Collins‐Praino, L. E., López‐Cruz, L., Correa, M., Baqi, Y., Müller, C. E., et al. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.06.009 · Cited by 49 · see citing works

Polymorphisms in the galanin gene are associated with symptom–severity in female patients suffering from panic disorder

Unschuld, P. G., Ising, M., Erhardt, A., Lucae, S., Kohli, M., Kloiber, S. M., Salyakina, D., Thoeringer, C. K., Kern, N., Lieb, R., et al. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.05.006 · Cited by 48 · see citing works

Dopamine–Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus

Moreno, E., Vaz, S. H., Cai, N.-S., Ferrada, C., Quiroz, C., Barodia, S. K., Kabbani, N., Canela, E. I., McCormick, P. J., Lluı́s, C., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0191-11.2011 · Cited by 31 · see citing works

Symptoms and side effects in chronic non-cancer pain: patient report vs. systematic assessment

JONSSON, T., Christrup, L. L., Højsted, J., Villesen, H. H., ALBJERG, T. H., Ravn‐Nielsen, L. V., & Sjøgren, P. (2010) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2010.02329.x · Cited by 29 · see citing works

Reward‐related ventral striatum reactivity mediates gender‐specific effects of a galanin remote enhancer haplotype on problem drinking

Nikolova, Y. S., Singhi, E. K., Drabant, E. M., & Hariri, A. R. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12035 · Cited by 26 · see citing works

Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy

Gu, X., Sun, Y.-G., & Yu, L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.033 · Cited by 26 · see citing works

Up-regulation of galanin and corticotropin-releasing hormone mRNAs in the key hypothalamic and amygdaloid nuclei in a mouse model of visceral pain

Nishii, H., Nomura, M. J., Aono, H., Fujimoto, N., & Matsumoto, T. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2006.12.022 · Cited by 24 · see citing works

Evaluation of study design variables and their impact on food-maintained operant responding in mice

Haluk, D. M., & Wickman, K. D. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.025 · Cited by 22 · see citing works

Galanin and Galanin-Like Peptide Differentially Modulate Neuronal Activities in Rat Arcuate Nucleus Neurons

Dong, Y., Tyszkiewicz, J. P., & Fong, T. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01117.2005 · Cited by 19 · see citing works

Galanin‐induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2

Einstein, E. B., Asaka, Y., Yeckel, M. F., Higley, M. J., & Picciotto, M. R. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12151 · Cited by 15 · see citing works

Galanin, through GalR1 but not GalR2 receptors, decreases motivation at times of high appetitive behavior

Anderson, M. E., Runesson, J., Saar, I., Langel, Ü., & Robinson, J. K. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.045 · Cited by 10 · see citing works

Increase of galanin-like immunoreactivity in rat hypothalamic arcuate neurons after peripheral nerve injury

Imbe, H., Abe, T., Okamoto, K., Sato, M., Ito, H., Kumabe, S., & Senba, E. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.073 · Cited by 9 · see citing works

The neuroscience of placebo effects: connecting context, learning and health

Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844 · see citing works

Nociception, pain, negative moods, and behavior selection

Baliki, M. N., & Apkarian, A. V. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.005 · Cited by 731 · see citing works

Neural circuits for pain: Recent advances and current views

Peirs, C., & Seal, R. P. (2016) · Science · doi:10.1126/science.aaf8933 · Cited by 481 · see citing works

Corticolimbic anatomical characteristics predetermine risk for chronic pain

Vachon‐Presseau, É., Tétreault, P., Petre, B., Huang, L., Berger, S., Torbey, S., Baria, A. T., Mansour, A. R., Hashmi, J. A., Griffith, J. W., et al. (2016) · Brain · doi:10.1093/brain/aww100 · Cited by 387 · see citing works

A thalamic input to the nucleus accumbens mediates opiate dependence

Zhu, Y., Wienecke, C. F. R., Nachtrab, G. T., & Chen, X. (2016) · Nature · doi:10.1038/nature16954 · Cited by 386 · see citing works

Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia

Smith, M. L., Asada, N., & Malenka, R. C. (2021) · Science · doi:10.1126/science.abe3040 · Cited by 368 · see citing works

Diametric neural ensemble dynamics in parkinsonian and dyskinetic states

Parker, J. G., Marshall, J. D., Ahanonu, B., Wu, Y., Kim, T. H., Grewe, B. F., Zhang, Y., Li, J. Z., Ding, J., Ehlers, M., et al. (2018) · Nature · doi:10.1038/s41586-018-0090-6 · Cited by 342 · see citing works

Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain

Kuner, R., & Kuner, T. (2020) · Physiological Reviews · doi:10.1152/physrev.00040.2019 · Cited by 342 · see citing works

A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell

Castro, D. C., & Bruchas, M. R. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.003 · Cited by 287 · see citing works

Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain

Woo, C.-W., Roy, M., Buhle, J. T., & Wager, T. D. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002036 · Cited by 263 · see citing works

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship

Babiloni, A. H., Koninck, B. P. D., Beetz, G., Beaumont, L. D., Martel, M. O., & Lavigne, G. J. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02067-z · Cited by 242 · see citing works

The Emotional Brain as a Predictor and Amplifier of Chronic Pain

Vachon‐Presseau, É., Centeno, M. V., Ren, W., Berger, S., Tétreault, P., Ghantous, M. E., Baria, A. T., Farmer, M., Baliki, M. N., Schnitzer, T. J., et al. (2016) · Journal of Dental Research · doi:10.1177/0022034516638027 · Cited by 241 · see citing works

The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities

Serafini, R. A., Pryce, K. D., & Zachariou, V. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.10.018 · Cited by 237 · see citing works

Brain circuits for pain and its treatment

Lindsay, N. M., Chen, C., Gilam, G., Mackey, S., & Scherrer, G. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7360 · Cited by 234 · see citing works

The molecular and cellular mechanisms of depression: a focus on reward circuitry

Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works

Mesolimbic dopamine signaling in acute and chronic pain

Taylor, A. M. W., Becker, S., Schweinhardt, P., & Cahill, C. M. (2016) · Pain · doi:10.1097/j.pain.0000000000000494 · Cited by 229 · see citing works

Chronic Pain in the Elderly: Mechanisms and Perspectives

Dagnino, A. P. A., & Campos, M. M. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.736688 · Cited by 249 · see citing works

Depression: a decision-theoretic analysis

Huys, Q. J. M., Daw, N. D., & Dayan, P. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033928 · Cited by 221 · see citing works

Quantifying cerebral contributions to pain beyond nociception

Woo, C., Schmidt, L., Krishnan, A., Jepma, M., Roy, M., Lindquist, M. A., Atlas, L. Y., & Wager, T. D. (2017) · Nature Communications · doi:10.1038/ncomms14211 · Cited by 215 · see citing works

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

Ren, W., Centeno, M. V., Berger, S., Wu, Y., Na, X., Liu, X., Kondapalli, J., Apkarian, A. V., Martina, M., & Surmeier, D. J. (2015) · Nature Neuroscience · doi:10.1038/nn.4199 · Cited by 208 · see citing works

Opioids for the Treatment of Chronic Pain: Mistakes Made, Lessons Learned, and Future Directions

Ballantyne, J. C. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002500 · Cited by 203 · see citing works

Pain-induced negative affect is mediated via recruitment of the nucleus accumbens kappa opioid system

Massaly, N., Copits, B. A., Wilson-Poe, A. R., Hipólito, L., Markovic, T., Yoon, H. J., Liu, S., Walicki, M. C., Bhatti, D. L., Sirohi, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.029 · Cited by 200 · see citing works

Reward, motivation, and emotion of pain and its relief

Porreca, F., & Navratilova, E. (2017) · Pain · doi:10.1097/j.pain.0000000000000798 · Cited by 198 · see citing works

Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain

Taylor, A. M. W., Castonguay, A., Taylor, A. J., Murphy, N. P., Ghogha, A., Cook, C. P., Xue, L., Olmstead, M. C., Koninck, Y. D., Evans, C. J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4036-14.2015 · Cited by 190 · see citing works

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

Descalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V. (2017) · Science Signaling · doi:10.1126/scisignal.aaj1549 · Cited by 188 · see citing works

Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum

Creed, M. C., Ntamati, N. R., Chandra, R., Lobo, M. K., & Lüscher, C. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.001 · Cited by 176 · see citing works

How expectations influence pain

Fields, H. L. (2018) · Pain · doi:10.1097/j.pain.0000000000001272 · Cited by 175 · see citing works

Modulation of pain, nociception, and analgesia by the brain reward center

Mitsi, V., & Zachariou, V. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.017 · Cited by 168 · see citing works

Chronic Back Pain Is Associated with Alterations in Dopamine Neurotransmission in the Ventral Striatum

Martikainen, I. K., Nuechterlein, E. B., Pecina, M. M., Love, T., Cummiford, C. M., Green, C. R., Stohler, C. S., & Zubieta, J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4605-14.2015 · Cited by 166 · see citing works

Nucleus Accumbens Modulation in Reward and Aversion

Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163 · see citing works

Neuroimaging-based biomarkers for pain: state of the field and current directions

van der Miesen, M. M., Lindquist, M. A., & Wager, T. D. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000751 · Cited by 137 · see citing works

Layer-specific pain relief pathways originating from primary motor cortex

Gan, Z., Gangadharan, V., Liu, S., Körber, C., Tan, L. L., Li, H., Oswald, M. J., Kang, J., Martín-Cortecero, J., Männich, D., et al. (2022) · Science · doi:10.1126/science.add4391 · Cited by 132 · see citing works

Input- and Output-Specific Regulation of Serial Order Performance by Corticostriatal Circuits

Rothwell, P. E., Hayton, S. J., Sun, G. L., Fuccillo, M. V., Lim, B. K., & Malenka, R. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.035 · Cited by 129 · see citing works

Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior

Markovic, T., Pedersen, C. E., Massaly, N., Vachez, Y. M., Ruyle, B. C., Murphy, C. A., Abiraman, K., Shin, J. H., Garcia, J. J., Yoon, H. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00924-3 · Cited by 129 · see citing works

Boosting efficiency above 28% using effective charge transport layer with Sr 3 SbI 3 based novel inorganic perovskite

Reza, M. S., Rahman, M. F., Kuddus, A., Mohammed, M. K. A., Al-Mousoi, A. K., Islam, M. R., Ghosh, A., Bhattarai, S., Pandey, R., Madan, J., et al. (2023) · RSC Advances · doi:10.1039/d3ra06137j · Cited by 129 · see citing works

An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences

Song, Q., Wei, A., Xu, H., Gu, Y., Jiang, Y. Q., Dong, N., Zheng, C., Wang, Q., Gao, M., Sun, S., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01519-w · Cited by 128 · see citing works

Distinct neural mechanisms for the prosocial and rewarding properties of MDMA

Heifets, B. D., Salgado, J. S., Taylor, M. D., Hoerbelt, P., Cardozo Pinto, D. F., Steinberg, E. E., Walsh, J. J., Sze, J. Y., & Malenka, R. C. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw6435 · Cited by 120 · see citing works

Cognition in the Chronic Pain Experience: Preclinical Insights

Phelps, C. E., Navratilova, E., & Porreca, F. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.01.001 · Cited by 120 · see citing works

Effects of stress on the corticolimbic system: implications for chronic pain

Vachon‐Presseau, É. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.014 · Cited by 113 · see citing works

Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit

Yang, H., de Jong, J. W., Cerniauskas, I., Peck, J. R., Lim, B. K., Gong, H., Fields, H. L., & Lammel, S. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00903-8 · Cited by 113 · see citing works

Does the kappa opioid receptor system contribute to pain aversion?

Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., Morón, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105 · see citing works

The dynamics of the stress neuromatrix

Sousa, N. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.196 · Cited by 105 · see citing works

Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain

Zhang, H., Qian, Y., Li, C., Liu, D., Wang, L., Wang, X., Liu, M., Liu, H., Zhang, S., Guo, X.-Y., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1180 · Cited by 101 · see citing works

Role of Descending Dopaminergic Pathways in Pain Modulation

Li, C., Liu, S., Lu, X., & Tao, F. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190430102531 · Cited by 100 · see citing works

Endogenous opioid systems alterations in pain and opioid use disorder

Higginbotham, J. A., Markovic, T., Massaly, N., & Morón, J. A. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.1014768 · Cited by 94 · see citing works

Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

Makary, M. M., Polosecki, P. I., Cecchi, G., DeAraujo, I. E., Barron, D. S., Constable, R. T., Whang, P. G., Thomas, D.-A. M., Mowafi, H. O., Small, D. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918682117 · Cited by 90 · see citing works

Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain

Reckziegel, D., Vachon‐Presseau, É., Petre, B., Schnitzer, T. J., Baliki, M. N., & Apkarian, A. V. (2019) · Pain · doi:10.1097/j.pain.0000000000001529 · Cited by 89 · see citing works

Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables

Markov, D. D., & Novosadova, E. V. (2022) · Biology · doi:10.3390/biology11111621 · Cited by 95 · see citing works

Role of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance

Lee, J.-Y., You, T., Lee, C.-H., Im, G. H., Seo, H., Woo, C., & Kim, S. (2022) · Current Biology · doi:10.1016/j.cub.2022.04.090 · Cited by 85 · see citing works

Enhanced serotonin and mesolimbic dopamine transmissions in a rat model of neuropathic pain

Sagheddu, C., Aroni, S., Felice, M. D., Lecca, S., Luchicchi, A., Melis, M., Muntoni, A. L., Romano, R., Palazzo, E., Guida, F., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.06.003 · Cited by 86 · see citing works

Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain

Laumet, G. O., Zhou, W., Dantzer, R., Edralin, J. D., Huo, X., Budac, D. P., O’Connor, J. C., Lee, A. W., Heijnen, C. J., & Kavelaars, A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.008 · Cited by 84 · see citing works

Discovery of endogenous opioid systems: what it has meant for the clinician's understanding of pain and its treatment

Ballantyne, J. C., & Sullivan, M. D. (2017) · Pain · doi:10.1097/j.pain.0000000000001043 · Cited by 79 · see citing works

The migraineur’s brain networks: Continuous resting state fMRI over 30 days

Schulte, L. H., Menz, M. M., Haaker, J., & May, A. (2020) · Cephalalgia · doi:10.1177/0333102420951465 · Cited by 80 · see citing works

Current Understanding of the Neural Circuitry in the Comorbidity of Chronic Pain and Anxiety

Chen, T., Wang, J., Wang, Y.-Q., & Chu, Y. (2022) · Neural Plasticity · doi:10.1155/2022/4217593 · Cited by 80 · see citing works

Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?

Fiore, N. T., & Austin, P. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.04.012 · Cited by 80 · see citing works

Brain-derived neurotrophic factor–mediated projection-specific regulation of depressive-like and nociceptive behaviors in the mesolimbic reward circuitry

Liu, D., Tang, Q., Cui, Y., Song, Y., Liu, Y., Yang, J., Liu, H., Zhang, Y., Wu, S., Song, Y., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001083 · Cited by 79 · see citing works

The role of hedonics in the Human Affectome

Becker, S., Bräscher, A., Bannister, S., Bensafi, M., Calma‐Birling, D., Chan, R. C. K., Eerola, T., Ellingsen, D., Ferdenzi, C., Hanson, J. L., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.003 · Cited by 81 · see citing works

Voluntary and evoked behavioral correlates in neuropathic pain states under different social housing conditions

Pitzer, C., Kuner, R., & Tappe‐Theodor, A. (2016) · Molecular Pain · doi:10.1177/1744806916656635 · Cited by 72 · see citing works

Anhedonia in chronic pain and prescription opioid misuse

Garland, E. L., Trøstheim, M., Eikemo, M., Ernst, G., & Leknes, S. (2019) · Psychological Medicine · doi:10.1017/s0033291719002010 · Cited by 72 · see citing works

Therapeutic mechanisms of psychedelics and entactogens

Heifets, B. D., & Olson, D. E. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01666-5 · Cited by 67 · see citing works

Multiple Brain Networks Mediating Stimulus–Pain Relationships in Humans

Geuter, S., Losin, E. A. R., Roy, M., Atlas, L. Y., Schmidt, L., Krishnan, A., Koban, L., Wager, T. D., & Lindquist, M. A. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa048 · Cited by 65 · see citing works

Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell

Wu, X.-B., Jing, P.-B., Zhang, Z.-J., Cao, D.-L., Gao, M.-H., Jiang, B.-C., & Gao, Y.-J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0115-8 · Cited by 68 · see citing works

Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior

Kashima, D. T., & Grueter, B. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705974114 · Cited by 66 · see citing works

Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect

Zhou, H., Martinez, E., Lin, H. H., Yang, R., Dale, J., Liu, K., Huang, D., & Wang, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00240 · Cited by 67 · see citing works

Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

Puighermanal, E., Castell, L., Esteve‐Codina, A., Melser, S., Kaganovsky, K., Zussy, C., Boubaker-Vitre, J., Gut, M., Rialle, S., Kellendonk, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15716-9 · Cited by 59 · see citing works

Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons

Yun, S., Yang, B., Anair, J. D., Martin, M. M., Fleps, S. W., Pamukcu, A., Yeh, N.-H., Contractor, A., Kennedy, A., & Parker, J. G. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01390-9 · Cited by 66 · see citing works

Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats

Chung, G., Kim, C. Y., Yun, Y.-C., Yoon, S. H., Kim, M., Kim, Y. K., & Kim, S. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-09991-8 · Cited by 65 · see citing works

Mindfulness is Associated With Increased Hedonic Capacity Among Chronic Pain Patients Receiving Extended Opioid Pharmacotherapy

Thomas, E. A., & Garland, E. L. (2017) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000379 · Cited by 61 · see citing works

An epigenetic hypothesis for the genomic memory of pain

Alvarado, S. G., Tajerian, M., Suderman, M. J., Machnes, Z. M., Pierfelice, S., Millecamps, M., Stone, L. S., & Szyf, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00088 · Cited by 61 · see citing works

Genetics and the environment affect the relationship between depression and low back pain

Pinheiro, M. B., Ferreira, M. L., Refshauge, K. M., Colodro‐Conde, L., Carrillo, E., Hopper, J. L., Ordoñana, J. R., & Ferreira, P. H. (2015) · Pain · doi:10.1097/01.j.pain.0000460330.56256.25 · Cited by 60 · see citing works

Neuroimaging-based biomarker discovery and validation

Woo, C., & Wager, T. D. (2015) · Pain · doi:10.1097/j.pain.0000000000000223 · Cited by 59 · see citing works

Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience

Turner, B. D., Kashima, D. T., Manz, K. M., Grueter, C. A., & Grueter, B. A. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00420 · Cited by 59 · see citing works

Safety out of control: dopamine and defence

Lloyd, K., & Dayan, P. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0099-7 · Cited by 59 · see citing works

Reward responsiveness in patients with chronic pain

Elvemo, N.-A. L., Landrø, N. I., Borchgrevink, P. C., & Haberg, A. K. (2015) · European Journal of Pain · doi:10.1002/ejp.687 · Cited by 56 · see citing works

Neuroplasticity of Supraspinal Structures Associated with Pathological Pain

Boadas‐Vaello, P., Homs, J., Reina, F., Carrera, A., & Verdú, E. (2017) · The Anatomical Record · doi:10.1002/ar.23587 · Cited by 58 · see citing works

Angiotensin-converting enzyme gates brain circuit–specific plasticity via an endogenous opioid

Trieu, B. H., Remmers, B. C., Toddes, C., Brandner, D. D., Lefevre, E. M., Kocharian, A., Retzlaff, C. L., Dick, R. M., Mashal, M. A., Gauthier, E. A., et al. (2022) · Science · doi:10.1126/science.abl5130 · Cited by 49 · see citing works

Involvement of the nucleus accumbens and dopamine system in chronic pain

Benarroch, E. E. (2016) · Neurology · doi:10.1212/wnl.0000000000003243 · Cited by 52 · see citing works

miR-200a-3p modulates gene expression in comorbid pain and depression: Molecular implication for central sensitization

Satyanarayanan, S. K., Shih, Y.-H., Wen, Y., Palani, M., Lin, Y., Su, H., Gałecki, P., & Su, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.190 · Cited by 50 · see citing works

Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain

Li, Y., Luo, Y., Su, W.-K., Ge, J., Crowther, A., Chen, Z.-K., Wang, L., Lazarus, M., Liu, Z., Qu, W., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.014 · Cited by 52 · see citing works

Psychological Processes in Chronic Pain: Influences of Reward and Fear Learning as Key Mechanisms – Behavioral Evidence, Neural Circuits, and Maladaptive Changes

Nees, F., & Becker, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.051 · Cited by 49 · see citing works

Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain

Botvinik‐Nezer, R., Petre, B., Čeko, M., Lindquist, M. A., Friedman, N. P., & Wager, T. D. (2024) · Nature Communications · doi:10.1038/s41467-024-50103-8 · Cited by 48 · see citing works

A distinct parabrachial–to–lateral hypothalamus circuit for motivational suppression of feeding by nociception

Phua, S. C., Tan, Y. L., Kok, A. M. Y., Senol, E., Chiam, C. J. H., Lee, C.-Y., Peng, Y., Lim, A. T. J., Mohammad, H., Lim, J.-X., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe4323 · Cited by 47 · see citing works

Brain systems at the intersection of chronic pain and self-regulation

Reddan, M. C., & Wager, T. D. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.047 · Cited by 46 · see citing works

Striatal hypofunction as a neural correlate of mood alterations in chronic pain patients

Kim, M., Mawla, I., Albrecht, D., Admon, R., Torrado-Carvajal, Á., Bergan, C., Protsenko, E., Kumar, P., Edwards, R. R., Saha, A., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116656 · Cited by 46 · see citing works

Allostatic dysregulation of natural reward processing in prescription opioid misuse: Autonomic and attentional evidence

Garland, E. L., Froeliger, B., & Howard, M. O. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.01.005 · Cited by 46 · see citing works

Brain activity for tactile allodynia: a longitudinal awake rat functional magnetic resonance imaging study tracking emergence of neuropathic pain

Chang, P., Centeno, M. V., Procissi, D., Baria, A. T., & Apkarian, A. V. (2016) · Pain · doi:10.1097/j.pain.0000000000000788 · Cited by 45 · see citing works

Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain

Schwartz, N., Miller, C. S., & Fields, H. L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.073 · Cited by 42 · see citing works

Altered prefrontal correlates of monetary anticipation and outcome in chronic pain

Martucci, K. T., Borg, N., MacNiven, K. H., Knutson, B. D., & Mackey, S. (2018) · Pain · doi:10.1097/j.pain.0000000000001232 · Cited by 42 · see citing works

The brain on opioids

Ballantyne, J. C. (2018) · Pain · doi:10.1097/j.pain.0000000000001270 · Cited by 44 · see citing works

Identification of traits and functional connectivity-based neurotraits of chronic pain

Vachon‐Presseau, É., Berger, S., Abdullah, T. B., Griffith, J. W., Schnitzer, T. J., & Apkarian, A. V. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000349 · Cited by 44 · see citing works

RGS9-2–controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states

Mitsi, V., Terzi, D., Purushothaman, I., Manouras, L., Gaspari, S., Neve, R. L., Stratinaki, M., Feng, J., Shen, L., & Zachariou, V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504283112 · Cited by 42 · see citing works

Effects of pregabalin on the nociceptive, emotional and cognitive manifestations of neuropathic pain in mice

Porta, C. L., Lara-Mayorga, I. M., Negrete, R., & Maldonado, R. J. (2016) · European Journal of Pain · doi:10.1002/ejp.868 · Cited by 42 · see citing works

Functional connectivity of the amygdala is linked to individual differences in emotional pain facilitation

Gandhi, W., Rosenek, N., Harrison, R. N., & Salomons, T. V. (2019) · Pain · doi:10.1097/j.pain.0000000000001714 · Cited by 40 · see citing works

App-Based Relaxation Exercises for Patients With Chronic Neck Pain: Pragmatic Randomized Trial

Pach, D., Blödt, S., Wang, J., Keller, T., Bergmann, B., Rogge, A. A., Barth, J., Icke, K., Roll, S., & Witt, C. M. (2022) · JMIR mhealth and uhealth · doi:10.2196/31482 · Cited by 40 · see citing works

Behavioral outcomes of complete Freund adjuvant–induced inflammatory pain in the rodent hind paw: a systematic review and meta-analysis

Burek, D., Massaly, N., Yoon, H. J., Doering, M. M., & Morón, J. A. (2021) · Pain · doi:10.1097/j.pain.0000000000002467 · Cited by 40 · see citing works

Psychosocial intervention and the reward system in pain and opioid misuse: new opportunities and directions

Garland, E. L. (2020) · Pain · doi:10.1097/j.pain.0000000000001988 · Cited by 36 · see citing works

The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain

Ziółkowska, B. (2021) · Brain Sciences · doi:10.3390/brainsci11101311 · Cited by 38 · see citing works

Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons

Ibrahim, K. M., Massaly, N., Yoon, H. J., Sandoval, R., Widman, A. J., Heuermann, R. J., Williams, S. B., Post, W., Pathiranage, S., Lintz, T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44836-9 · Cited by 39 · see citing works

BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended

Smith, P. A. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.02.020 · Cited by 38 · see citing works

Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats

Cowen, S. L., Phelps, C. E., Navratilova, E., McKinzie, D. L., Okun, A., Husain, O., Gleason, S. D., Witkin, J. M., & Porreca, F. (2018) · Pain · doi:10.1097/j.pain.0000000000001226 · Cited by 38 · see citing works

Finding motivation in pain

Lewis, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3814

A neuropeptide kills patient's motivation

Stern, P. (2014) · Science · doi:10.1126/science.345.6196.526-d

Calcium-Permeable AMPA Receptors in the Nucleus Accumbens Regulate Depression-Like Behaviors in the Chronic Neuropathic Pain State

Goffer, Y., Xu, D., Eberle, S. E., D’amour, J. A., Lee, M., Tukey, D. S., Froemke, R. C., Ziff, E. B., & Wang, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-13.2013 · Cited by 142 · see citing works

Role and Mechanism of Arcuate Nucleus POMC Neurons in Depression‐Like Behavior of Chronic Pain

Yang, T., Huang, Y., Zhang, K., Diao, H., Yin, Q., Pan, Z., & Gao, J. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70249

Distinct nucleus accumbens neural pathways underlie separate behavioral features of chronic pain and comorbid depression

Liu, D., Xu, F.-X., Yu, Z., Huang, X., Zhu, Y.-B., Wang, L.-J., Wu, C., Zhang, X., Cao, J., & Li, J. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191270 · Cited by 12 · see citing works