The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Sleep and waking modulate spine turnover in the adolescent mouse cortex
Open accessAbstract
Cortical development involves synaptic formation and elimination. Although synaptogenesis predominates in the early stages and pruning in the later stages, the two processes are thought to happen concurrently. In adults, synaptic strength is modulated by behavioral state, and we asked whether synaptic remodeling may be affected by sleep and waking states. Using two-photon microscopy in adolescent mice, we found that waking results in a net increase in cortical spines, whereas sleep is associated with net spine loss.
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“In juvenile mice in vivo, two-photon microscopy in the sensorimotor cortex revealed a net decrease in spine growth across periods of sleep, although there was also significant spine growth at the same time (772).”
From About Sleep's Role in Memory (2013) · cites this paper as [772]
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“In adult mice, no similar changes were observed.”
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“The mechanisms mediating synaptic plasticity during critical periods in essential aspects differ from those during later life (838) and differences in the regulation of synaptic plasticity may still exist between juveniles and adults (772).”
From About Sleep's Role in Memory (2013) · cites this paper as [772]
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Cites
Why do many psychiatric disorders emerge during adolescence?
Paus, T., Keshavan, M., & Giedd, J. N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2513 · Cited by 3,123
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Self-citationStably maintained dendritic spines are associated with lifelong memories
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Self-citationVyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837
Self-citationSynaptic development of the cerebral cortex: implications for learning, memory and mental illness
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Neural activity and the dynamics of central nervous system development
Hua, J. Y., & Smith, S. J. (2004) · Nature Neuroscience · doi:10.1038/nn1218 · Cited by 450
Sleep and Synaptic Homeostasis: Structural Evidence in Drosophila
Bushey, D., Tononi, G., & Cirelli, C. (2011) · Science · doi:10.1126/science.1202839 · Cited by 357
Self-citationDash, M. B., Douglas, C. L., Vyazovskiy, V. V., Cirelli, C., & Tononi, G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5486-08.2009 · Cited by 286
Self-citationInhibitory synaptogenesis in mouse somatosensory cortex
DeFelipe, J. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.7.619 · Cited by 284
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
“sensorimotor cortex revealed a net decrease in spine growth across periods of sleep, although there was also significant spine growth at the same time (772).”
BackgroundTononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356
Self-citationSynaptic Energy Use and Supply
Harris, J. J., Jolivet, R., & Attwell, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.019 · Cited by 1,747
Sleep promotes branch-specific formation of dendritic spines after learning
Yang, G., Lai, C. S. W., Cichon, J., Ma, L., Li, W., & Gan, W.-B. (2014) · Science · doi:10.1126/science.1249098 · Cited by 616
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
de Vivo, L., Bellesi, M., Marshall, W., Bushong, E. A., Ellisman, M. H., Tononi, G., & Cirelli, C. (2017) · Science · doi:10.1126/science.aah5982 · Cited by 574
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Metadata
- Authors
- Maret, S., Faraguna, U., Nelson, A. B., Cirelli, C., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Cirelli, Chiara
- Tononi, Giulio
- Venue
- Nature Neuroscience
- Published
- 2011-10-09
- Volume
- 14
- Issue
- 11
- Pages
- 1418-1420
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3203346
- OpenAlex
- W2045436209
- Cited by
- 315
- References
- 15
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 19 · 2023: 23 · 2022: 23 · 2021: 14 · 2020: 29 · 2019: 26 · 2018: 16 · 2017: 35 · 2016: 21 · 2015: 15 · 2014: 23 · 2013: 28 · 2012: 16
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD000579)
- National Institute of Mental Health (R01MH091326)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- synaptic plasticity, sleep, wakefulness, synaptic pruning, synaptogenesis, synaptic remodeling, adolescent brain development, cortical development, behavioral state
- MeSH terms
- Animals, Animals, Newborn, Bacterial Proteins, Cerebral Cortex, Electroencephalography, Electromyography, Luminescent Proteins, Mice, Transgenic, Motor Activity, Neurons, Sleep, Ultrasonography, Wakefulness, Microscopy, Confocal, Dendritic Spines, Mice
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