The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division
Open accessAbstract
Oligodendrocytes in the mammalian brain are continuously generated from NG2 cells throughout postnatal life. However, it is unclear when the decision is made for NG2 cells to self-renew or differentiate into oligodendrocytes after cell division. Using a combination of in vivo and ex vivo imaging and fate analysis of proliferated NG2 cells in fixed tissue, we demonstrate that in the postnatal developing mouse brain, the majority of divided NG2 cells differentiate into oligodendrocytes during a critical age-specific temporal window of 3–8 d. Notably, within this time period, damage to myelin and oligodendrocytes accelerated oligodendrocyte differentiation from divided cells, and whisker removal decreased the survival of divided cells in the deprived somatosensory cortex. These findings indicate that during the critical temporal window of plasticity, the fate of divided NG2 cells is sensitive to modulation by external signals.
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Cites
Cell death and control of cell survival in the oligodendrocyte lineage
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Self-citationPDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
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A critical period for social experience-dependent oligodendrocyte maturation and myelination
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Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
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Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
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Self-citationImpaired adult myelination in the prefrontal cortex of socially isolated mice
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Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain
Hill, R. A., Li, A. M., & Grutzendler, J. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0120-6 · Cited by 467
Self-citationCell Densities in the Mouse Brain: A Systematic Review
Keller, D., Erö, C., & Markram, H. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00083 · Cited by 380
Preservation of a remote fear memory requires new myelin formation
Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R., & Kheirbek, M. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0582-1 · Cited by 365
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Metadata
- Authors
- Hill, R. A., Patel, K. D., Goncalves, C. M., Grutzendler, J., & Nishiyama, A.
- Venue
- Nature Neuroscience
- Published
- 2014-09-28
- Volume
- 17
- Issue
- 11
- Pages
- 1518-1527
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2019571068
- Cited by
- 188
- References
- 16
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- green
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