The detection of motion by blind subjects with the epiretinal 60-electrode (Argus II) retinal prosthesis
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OBJECTIVE: To investigate the ability of 28 blind subjects implanted with a 60-electrode Argus II (Second Sight Medical Products Inc) retinal prosthesis system to detect the direction of a moving object. METHODS: Blind subjects (bare light perception or worse in both eyes) with retinitis pigmentosa were implanted with the Argus II prosthesis as part of a phase 1/2 feasibility study at multiple clinical sites worldwide. The experiment measured their ability to detect the direction of motion of a high-contrast moving bar on a flatscreen monitor in 3 conditions: with the prosthesis system on and a 1-to-1 mapping of spatial information, with the system off, and with the system on but with randomly scrambled spatial information. RESULTS: Fifteen subjects (54%) were able to perform the task significantly better with their prosthesis system than they were with their residual vision, 2 subjects had significantly better performance with their residual vision, and no difference was found for 11 subjects. Of the 15 better-performing subjects, 11 were available for follow-up testing, and 10 of them had significantly better performance with normal rather than with scrambled spatial information. CONCLUSIONS: This work demonstrates that blind subjects implanted with the Argus II retinal prosthesis were able to perform a motion detection task they could not do with their native vision, confirming that electrical stimulation of the retina provides spatial information from synchronized activation of multiple electrodes. TRIAL REGISTRATION: clinicaltrials.gov Identifier:NCT00407602
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Argus II users also improved on object localization and motion discrimination tasks.
“Their performance also improved for object localization and motion discrimination tasks (Ahuja et al. 2011; Barry, Dagnelie, and Argus II Study Group 2012; Dorn et al. 2013; Dagnelie et al. 2017).”
From Sequential epiretinal stimulation improves discrimination in simple shape discrimination tasks only (2022) · cites this paper as Dorn et al. 2013
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Self-citation
- Authors
- Dorn, J. D., Ahuja, A. K., Caspi, A., da Cruz, L., Dagnelie, G., Sahel, J.-A., Greenberg, R. J., McMahon, M. J., & Argus II Study Group, F. T.
- Affiliations
- Second Sight Medical Products (US)
- University of Southern California (US)
- Corresponding author
- Dorn, Jessy D.
- Venue
- JAMA Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2013-02-01
- Volume
- 131
- Issue
- 2
- Pages
- 183
- ISSN
- 2168-6165 (ISSN-L)
- PMC
- PMC3924899
- OpenAlex
- W2024323852
- Cited by
- 177
- References
- 12
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 14 · 2018: 16 · 2017: 17 · 2016: 22 · 2015: 13 · 2014: 20 · 2013: 9
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Eye Institute (R24EY012893, EY012893, R01EY012893, R01EY021220)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- Argus II, retinal prosthesis, motion direction detection, retinitis pigmentosa, blindness, spatial mapping, visual prosthesis
- MeSH terms
- Adult, Aged, Blindness, Electrodes, Implanted, Electric Stimulation Therapy, Feasibility Studies, Female, Humans, Male, Microelectrodes, Middle Aged, Motion Perception, Perceptual Disorders, Retina, Retinitis Pigmentosa, Sensory Thresholds, Treatment Outcome, Prosthesis Implantation, Visual Prosthesis
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