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Cited by 329Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, Shohei, Miya, Hiroaki, Watanabe, Tomoyuki, Kawai, Hiroki, Yamasaki, Norihiko, Harada, Yujin, Imayoshi, Itaru, Nelson, Mark, Nakayama, Keiichi I, Hirabayashi, Yusuke, Gotoh, Yukiko·2015·Nature Neuroscience
DOI 10.1038/nn.3989
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Abstract

The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows between embryonic day (E) 13.5 and E15.5 while other embryonic NPCs continue to divide rapidly. By allowing H2B-GFP expressed at E9.5 to become diluted in dividing cells until the young adult stage, we determined that a majority of NSCs in the young adult subependymal zone (SEZ) originated from these slowly dividing embryonic NPCs. The cyclin-dependent kinase inhibitor p57 is highly expressed in this embryonic subpopulation, and the deletion of p57 impairs the emergence of adult NSCs. Our results suggest that a substantial fraction of adult SEZ NSCs is derived from a slowly dividing subpopulation of embryonic NPCs and identify p57 as a key factor in generating this embryonic origin of adult SEZ NSCs.

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Metadata

Authors
Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y., & Gotoh, Y.
Affiliations
  • The University of Tokyo (JP)
  • Kyoto University (JP)
  • Echelon Biosciences (US)
  • Kyushu University (JP)
Corresponding author
Gotoh, Yukiko
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2015-03-30
Volume
18
Issue
5
Pages
657-665
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn.3989
OpenAlex
W2052382060
Cited by
329
References
47
Citations by year
2026: 15 · 2025: 28 · 2024: 33 · 2023: 29 · 2022: 27 · 2021: 30 · 2020: 35 · 2019: 41 · 2018: 28 · 2017: 39 · 2016: 20 · 2015: 4
FWCI
12.26
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • The Molecular Biology Society of Japan
Funders
Japan Society for the Promotion of Science (25891008, 15K15086, 25221303)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
adult neural stem cells, subventricular zone, p57, cyclin-dependent kinase inhibitors, stem cell origin, cell cycle progression
MeSH terms
Animals, Cell Cycle, Cell Division, Histones, Mice, Inbred C57BL, Mice, Inbred ICR, Nerve Tissue Proteins, Recombinant Fusion Proteins, Telencephalon, Genes, Reporter, Cell Lineage, Cyclin-Dependent Kinase Inhibitor p57, Mice, Neurogenesis, Neural Stem Cells

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