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Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells
Abstract
The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows between embryonic day (E) 13.5 and E15.5 while other embryonic NPCs continue to divide rapidly. By allowing H2B-GFP expressed at E9.5 to become diluted in dividing cells until the young adult stage, we determined that a majority of NSCs in the young adult subependymal zone (SEZ) originated from these slowly dividing embryonic NPCs. The cyclin-dependent kinase inhibitor p57 is highly expressed in this embryonic subpopulation, and the deletion of p57 impairs the emergence of adult NSCs. Our results suggest that a substantial fraction of adult SEZ NSCs is derived from a slowly dividing subpopulation of embryonic NPCs and identify p57 as a key factor in generating this embryonic origin of adult SEZ NSCs.
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“Adult V-SVZ NSCs are set aside during embryogenesis, remaining largely quiescent until adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and reside in a complex microenvironment comprising diverse cell types and local and long-range signals (Silva-Vargas et al., 2013).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Furutachi et al., 2015
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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
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“Two recent studies suggested that adult SVZ NSCs are regionally specified at an early embryonic stage and then remain largely quiescent until re-activation postnatally (Fuentealba et al., 2015; Furutachi et al., 2015).”
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Metadata
- Authors
- Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y., & Gotoh, Y.
- Affiliations
- The University of Tokyo (JP)
- Kyoto University (JP)
- Echelon Biosciences (US)
- Kyushu University (JP)
- Corresponding author
- Gotoh, Yukiko
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2015-03-30
- Volume
- 18
- Issue
- 5
- Pages
- 657-665
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2052382060
- Cited by
- 329
- References
- 47
- Citations by year
- 2026: 15 · 2025: 28 · 2024: 33 · 2023: 29 · 2022: 27 · 2021: 30 · 2020: 35 · 2019: 41 · 2018: 28 · 2017: 39 · 2016: 20 · 2015: 4
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- The Molecular Biology Society of Japan
- Funders
- Japan Society for the Promotion of Science (25891008, 15K15086, 25221303)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- adult neural stem cells, subventricular zone, p57, cyclin-dependent kinase inhibitors, stem cell origin, cell cycle progression
- MeSH terms
- Animals, Cell Cycle, Cell Division, Histones, Mice, Inbred C57BL, Mice, Inbred ICR, Nerve Tissue Proteins, Recombinant Fusion Proteins, Telencephalon, Genes, Reporter, Cell Lineage, Cyclin-Dependent Kinase Inhibitor p57, Mice, Neurogenesis, Neural Stem Cells
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