Cited by 329Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, Shohei, Miya, Hiroaki, Watanabe, Tomoyuki, Kawai, Hiroki, Yamasaki, Norihiko, Harada, Yujin, Imayoshi, Itaru, Nelson, Mark, Nakayama, Keiichi I, Hirabayashi, Yusuke, Gotoh, Yukiko·2015·Nature Neuroscience

DOI 10.1038/nn.3989

Open this paper in CoChat — free account

Abstract

The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows between embryonic day (E) 13.5 and E15.5 while other embryonic NPCs continue to divide rapidly. By allowing H2B-GFP expressed at E9.5 to become diluted in dividing cells until the young adult stage, we determined that a majority of NSCs in the young adult subependymal zone (SEZ) originated from these slowly dividing embryonic NPCs. The cyclin-dependent kinase inhibitor p57 is highly expressed in this embryonic subpopulation, and the deletion of p57 impairs the emergence of adult NSCs. Our results suggest that a substantial fraction of adult SEZ NSCs is derived from a slowly dividing subpopulation of embryonic NPCs and identify p57 as a key factor in generating this embryonic origin of adult SEZ NSCs.

Integrity signals

Registry

Crossref · 10.1038/nn.3989

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
SOX2 Functions to Maintain Neural Progenitor Identity
Graham, V., Khudyakov, J. I., Ellis, P., & Pevny, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00497-5 · Cited by 1,344
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054
Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain
Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.004 · Cited by 1,015

Flagged first, then by citations

Show all 47 references

Sorted by citations

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791
“Two recent studies suggested that adult SVZ NSCs are regionally specified at an early embryonic stage and then remain largely quiescent until re-activation postnatally (Fuentealba et al., 2015; Furutachi et al., 2015).”
Background
Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
The cell cycle in stem cell proliferation, pluripotency and differentiation
Liu, L., Michowski, W., Kołodziejczyk, A., & Siciński, P. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0384-4 · Cited by 432
Epigenetic mechanisms in neurogenesis
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 406
Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest
Urbán, N., Blomfield, I. M., & Guillemot, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.026 · Cited by 383
A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis
Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.010 · Cited by 267
Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages
Mizrak, D., Levitin, H. M., Delgado, A. C., Crotet, V., Yuan, J., Chaker, Z., Silva-Vargas, V., Sims, P. A., & Doetsch, F. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.044 · Cited by 248
Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation
Obernier, K., Cebrian-Silla, A., Thomson, M., Parraguez, J. I., Anderson, R., Guinto, C., Rodas Rodriguez, J., Garcia-Verdugo, J.-M., & Alvarez-Buylla, A. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.01.003 · Cited by 250
Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome‐wide expression analysis
Götz, M., Sirko, S., Beckers, J., & Irmler, M. (2015) · Glia · doi:10.1002/glia.22850 · Cited by 237
Notch and Neurogenesis
Engler, A., Zhang, R., & Taylor, V. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-89512-3_11 · Cited by 223
Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling
Yuzwa, S. A., Borrett, M. J., Innes, B. T., Voronova, A., Ketela, T., Kaplan, D. R., Bader, G. D., & Miller, F. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.12.017 · Cited by 205
A mosaic world: puzzles revealed by adult neural stem cell heterogeneity
Chaker, Z., Codega, P., & Doetsch, F. (2016) · WIREs Developmental Biology · doi:10.1002/wdev.248 · Cited by 198
Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis
Khacho, M., Clark, A., Svoboda, D. S., MacLaurin, J. G., Lagace, D. C., Park, D. S., & Slack, R. S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx217 · Cited by 199
High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brainPreprint
Sueda, R., Imayoshi, I., Harima, Y., & Kageyama, R. (2019) · Genes & Development · doi:10.1101/gad.323196.118 · Cited by 184
Onset of differentiation is post-transcriptionally controlled in adult neural stem cells
Baser, A., Skabkin, M. A., Kleber, S., Dang, Y., Balta, G. S. G., Kalamakis, G., Göpferich, M., Ibañez, D. C., Schefzik, R., Lopez, A. S., et al. (2019) · Nature · doi:10.1038/s41586-019-0888-x · Cited by 169
Stem cell quiescence: the challenging path to activation
Urbán, N., & Cheung, T. H. (2021) · Development · doi:10.1242/dev.165084 · Cited by 168
Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis
Cebrián‐Silla, A., Nascimento, M. A., Redmond, S., Mansky, B., Wu, D., Obernier, K., Rodriguez, R. R., González-Granero, S., García‐Verdugo, J. M., Lim, D. A., et al. (2021) · eLife · doi:10.7554/elife.67436 · Cited by 148
Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor
Redmond, S., Figueres‐Oñate, M., Obernier, K., Nascimento, M. A., Parraguez, J. I., López‐Mascaraque, L., Fuentealba, L. C., & Álvarez-Buylla, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.088 · Cited by 128
Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Fu, N. Y., Rios, A. C., Pal, B., Law, C. W., Jamieson, P. R., Liu, R., Vaillant, F., Jackling, F. C., Liu, K. H., Smyth, G. K., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3471 · Cited by 141
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
Álvarez, G., Daclin, M., Shihavuddin, A., Lansade, P., Fortoul, A., Faucourt, M., Clavreul, S., Lalioti, M., Taraviras, S. L., Hippenmeyer, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.051 · Cited by 134
Neurogenesis in the Developing and Adult Brain—Similarities and Key DifferencesPreprint
Götz, M., Nakafuku, M., & Petřík, D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018853 · Cited by 131
Notch2 signaling maintains NSC quiescence in the murine ventricular-subventricular zone
Engler, A., Rolando, C., Giachino, C., Saotome, I., Erni, A., Brien, C., Zhang, R., Zimber-Strobl, U., Radtke, F., Artavanis-Tsakonas, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.094 · Cited by 125
Neural stem cells: developmental mechanisms and disease modeling
Zhao, X., & Moore, D. L. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2738-1 · Cited by 127
Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment
Lee, E. C., Ha, T. W., Lee, D.-H., Hong, D.-Y., Park, S.-W., Lee, J. Y., Lee, M. R., & Oh, J. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158367 · Cited by 122
Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
Zhou, Y. F., Bond, A. M., Shade, J. E., Zhu, Y., Davis, C.-H. O., Wang, X., Su, Y., Yoon, K., Phan, A. T., Chen, W. J., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.005 · Cited by 114
Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
Kobayashi, T., Piao, W., Takamura, T., Kori, H., Miyachi, H., Kitano, S., Iwamoto, Y., Yamada, M., Imayoshi, I., Shioda, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13203-4 · Cited by 111
RNA-binding proteins balance brain function in health and disease
Schieweck, R., Ninkovic, J., & Kiebler, M. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00047.2019 · Cited by 111
Neural Progenitor Cell Polarity and Cortical Development
Arai, Y., & Taverna, E. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00384 · Cited by 112
Glial control of neurogenesis
Falk, S., & Götz, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.025 · Cited by 99
Therapeutic Plasticity of Neural Stem Cells
Ottoboni, L., von Wunster, B., & Martino, G. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00148 · Cited by 105
Regulation of active and quiescent somatic stem cells by Notch signaling
Sueda, R., & Kageyama, R. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12626 · Cited by 88
Area-specific regulation of quiescent neural stem cells by Notch3 in the adult mouse subependymal zone
Kawai, H., Kawaguchi, D., Kuebrich, B. D., Kitamoto, T., Yamaguchi, M., Gotoh, Y., & Furutachi, S. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0001-17.2017 · Cited by 85
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
Chavali, M., Klingener, M., Kokkosis, A. G., Garkun, Y., Felong, S., Maffei, A., & Aguirre, A. A. (2017) · Nature Communications · doi:10.1038/s41467-017-02440-0 · Cited by 85
Regulation of neurogenesis in the adult and aging brain
Katsimpardi, L., & Lledo, P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.07.006 · Cited by 89
Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
Berg, D. A., Bond, A. M., Ming, G.-L., & Song, H. (2018) · F1000Research · doi:10.12688/f1000research.12684.1 · Cited by 89
Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production
Tan, X., Liu, W. A., Zhang, X., Shi, W., Ren, S., Li, Z., Brown, K. N., & Shi, S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.02.023 · Cited by 88
Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development
Storer, M. A., Gallagher, D., Fatt, M. P., Simonetta, J. V., Kaplan, D. R., & Miller, F. D. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.03.008 · Cited by 83
Regulating Endogenous Neural Stem Cell Activation to Promote Spinal Cord Injury Repair
Gilbert, E. A. B., Lakshman, N., Lau, K. S. K., & Morshead, C. M. (2022) · Cells · doi:10.3390/cells11050846 · Cited by 81
Distinct Molecular Signatures of Quiescent and Activated Adult Neural Stem Cells Reveal Specific Interactions with Their Microenvironment
Morizur, L., Chicheportiche, A., Gauthier, L., Daynac, M., Boussin, F. D., & Mouthon, M. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.005 · Cited by 81
Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis
Rizzoti, K., & Lovell-Badge, R. H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.020 · Cited by 79
Adult Neurogenesis and the Promise of Adult Neural Stem Cells
Ghosh, H. S. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519856876 · Cited by 81
Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain
Lepko, T., Pusch, M., Müller, T., Schulte, D., Ehses, J., Kiebler, M. A., Hasler, J., Huttner, H. B., Vandenbroucke, R. E., Vandendriessche, C., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100481 · Cited by 75
Life-Long Neurogenic Activity of Individual Neural Stem Cells and Continuous Growth Establish an Outside-In Architecture in the Teleost Pallium
Furlan, G., Cuccioli, V., Vuillemin, N., Dirian, L., Muntasell, A. J., Coolen, M., Dray, N., Bedu, S., Houart, C., Beaurepaire, E., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.09.052 · Cited by 73
Notch signaling as a master regulator of adult neurogenesis
Lampada, A., & Taylor, V. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1179011 · Cited by 86
An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants
Alonso, S. B., Reinert, J. K., Marichal, N., Massalini, S., Berninger, B., Kuner, T., & Calegari, F. (2019) · The EMBO Journal · doi:10.15252/embj.201798791 · Cited by 71
Quiescent Neural Stem Cells for Brain Repair and Regeneration: Lessons from Model Systems
Otsuki, L., & Brand, A. H. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.02.002 · Cited by 68
Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells
Hu, X.-L., Chen, G., Zhang, S., Zheng, J., Wu, J., Bai, Q., Wang, Y., Li, J., Wang, H., Han, F., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.047 · Cited by 70
Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis
Borrett, M. J., Innes, B. T., Jeong, D., Tahmasian, N., Storer, M. A., Bader, G. D., Kaplan, D. R., & Miller, F. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108022 · Cited by 75
Neurogenesis From Embryo to Adult – Lessons From Flies and Mice
Mira, H., & Morante, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00533 · Cited by 71
Function of neural stem cells in ischemic brain repair processes
Zhang, R., Zhang, Z., & Chopp, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16674487 · Cited by 68
Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation
van den Ameele, J., & Brand, A. H. (2019) · eLife · doi:10.7554/elife.47887 · Cited by 69
Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation
Boareto, M., Iber, D., & Taylor, V. (2017) · Development · doi:10.1242/dev.152520 · Cited by 65
The therapeutic contribution of nanomedicine to treat neurodegenerative diseases via neural stem cell differentiation
Carradori, D., Eyer, J., Saulnier, P., Véronique Préat, A., & Rieux, A. D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.032 · Cited by 66
Adult Neural Stem Cells: Born to Last
Morales, A. V., & Mira, H. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00096 · Cited by 62
Conserved and Divergent Features of Adult Neurogenesis in Zebrafish
Labusch, M., Mancini, L., Morizet, D., & Bally-Cuif, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00525 · Cited by 48
Regulation of CNS precursor function by neuronal chemokines
Watson, A. E. S., Goodkey, K., Footz, T. K., & Voronova, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134533 · Cited by 57
Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
Harada, Y., Yamada, M., Imayoshi, I., Kageyama, R., Suzuki, Y., Kuniya, T., Furutachi, S., Kawaguchi, D., & Gotoh, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-26605-0 · Cited by 56
How a radial glial cell decides to become a multiciliated ependymal cell
Kyrousi, C., Lygerou, Z., & Taraviras, S. L. (2017) · Glia · doi:10.1002/glia.23118 · Cited by 59
Neural Stem Cell Regulation by Adhesion Molecules Within the Subependymal Niche
Morante‐Redolat, J. M., & Porlan, E. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00102 · Cited by 50
Neural stem cell metabolism revisited: a critical role for mitochondria
Scandella, V., Petrelli, F., Moore, D. L., Braun, S. M. G., & Knobloch, M. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.05.008 · Cited by 55
Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis
Bast, L., Calzolari, F., Strasser, M. K., Hasenauer, J., Theis, F. J., Ninkovic, J., & Marr, C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.088 · Cited by 50
Embryonic origin and lineage hierarchies of the neural progenitor subtypes building the zebrafish adult midbrain
Galant, S., Furlan, G., Coolen, M., Dirian, L., Foucher, I., & Bally‐Cuif, L. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.09.022 · Cited by 50
Structured form of DHA prevents neurodegenerative disorders: A better insight into the pathophysiology and the mechanism of DHA transport to the brain
Balakrishnan, J., Kannan, S., & Govindasamy, A. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.12.003 · Cited by 53
Mercury Toxicity and Neurogenesis in the Mammalian Brain
Abbott, L. C., & Nigussie, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147520 · Cited by 51
The Functional Role of Olfactory Bulb Granule Cell Subtypes Derived From Embryonic and Postnatal Neurogenesis
Takahashi, H., Yoshihara, S., & Tsuboi, A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00229 · Cited by 50
Ontogeny of adult neural stem cells in the mammalian brain
Bond, A. M., Ming, G., & Song, H. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.11.002 · Cited by 51
Proneural Genes Define Ground State Rules to Regulate Neurogenic Patterning and Cortical Folding
Han, S., Okawa, S., Wilkinson, G., Ghazale, H., Adnani, L., Dixit, R., Tavares, L., Faisal, I., Brooks, M. J., Cortay, V., et al. (2020) · Neuron · doi:10.1016/j.neuron.2021.07.007 · Cited by 50
Midbrain tectal stem cells display diverse regenerative capacities in zebrafish
Lindsey, B. W., Aitken, G., Tang, J., Khabooshan, M. A., Douek, A. M., Vandestadt, C., & Kaslin, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-40734-z · Cited by 48
New Insights Into the Intricacies of Proneural Gene Regulation in the Embryonic and Adult Cerebral Cortex
Oproescu, A.-M., Han, S., & Schuurmans, C. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.642016 · Cited by 54
Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?
Kase, Y., Shimazaki, T., & Okano, H. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00122-x · Cited by 51
Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium
Higa, T., Okita, Y., Matsumoto, A., Nakayama, S., Oka, T., Sugahara, O., Koga, D., Takeishi, S., Nakatsumi, H., Hosen, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29165-z · Cited by 45
The Symmetry of Neural Stem Cell and Progenitor Divisions in the Vertebrate Brain
Gimeno, G. C., & Paridaen, J. T. M. L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.885269 · Cited by 48
Stars from the darkest night: unlocking the neurogenic potential of astrocytes in different brain regions
Magnusson, J. P., & Frisén, J. (2016) · Development · doi:10.1242/dev.133975 · Cited by 46
Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
Laukoter, S., Beattie, R., Pauler, F. M., Amberg, N., Nakayama, K. I., & Hippenmeyer, S. (2020) · Nature Communications · doi:10.1038/s41467-019-14077-2 · Cited by 45
Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration
Kiyokawa, H., Yamaoka, A., Matsuoka, C., Tokuhara, T., Abe, T., & Morimoto, M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.05.016 · Cited by 45
Adult NSC diversity and plasticity: the role of the niche
Llorens-Bobadilla, E., & Martín-Villalba, A. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.11.008 · Cited by 45
Neural Stem Cell Activation and the Role of Protein Synthesis
Baser, A., Skabkin, M. A., & Martín-Villalba, A. (2017) · Brain Plasticity · doi:10.3233/bpl-160038 · Cited by 43
Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells
Cebrián‐Silla, A., Alfaro‐Cervelló, C., Herranz‐Pérez, V., Kaneko, N., Park, D. H., Sawamoto, K., Álvarez-Buylla, A., Lim, D. A., & García‐Verdugo, J. M. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.024 · Cited by 41
New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells
Kawamura, Y., Takouda, J., Yoshimoto, K., & Nakashima, K. (2018) · Cell Biology and Toxicology · doi:10.1007/s10565-017-9420-y · Cited by 42
Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21
Maeda, Y., Isomura, A., Masaki, T., & Kageyama, R. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112520 · Cited by 40
Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding
Falk, S., Bugeon, S., Ninkovic, J., Pilz, G.-A., Postiglione, M. P., Cremer, H., Knoblich, J. A., & Götz, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.009 · Cited by 39
Molecular Mechanisms Governing the Stem Cell’s Fate in Brain Cancer: Factors of Stemness and Quiescence
Gulaia, V. S., Kumeiko, V. V., Shved, N. A., Cicinskas, E., Александрович, Р. С., Ruzov, A. S., & Kagansky, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00388 · Cited by 39
From Cell States to Cell Fates: How Cell Proliferation and Neuronal Differentiation Are Coordinated During Embryonic Development
Belmonte‐Mateos, C., & Pujades, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.781160 · Cited by 44
Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy
Wang, S., He, Q., Qu, Y., Yin, W., Zhao, R., Wang, X., Yang, Y., & Guo, Z. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.391313 · Cited by 41
Coupling progenitor and neuronal diversity in the developing neocortex
Govindan, S., & Jabaudon, D. (2017) · FEBS Letters · doi:10.1002/1873-3468.12846 · Cited by 40
DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus
Noguchi, H., Murao, N., Kimura, A., Matsuda, T., Namihira, M., & Nakashima, K. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0512-16.2016 · Cited by 38
HES1 protein oscillations are necessary for neural stem cells to exit from quiescence
Marinopoulou, E., Biga, V., Sabherwal, N., Miller, A., Desai, J., Adamson, A. D., & Papalopulu, N. (2021) · iScience · doi:10.1016/j.isci.2021.103198 · Cited by 33
Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice
Boucherie, C., Boutin, C., Jossin, Y., Schakman, O., Goffinet, A. M., Ris, L., Gailly, P. L., & Tissir, F. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.236 · Cited by 37
Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development
Yabut, O., & Pleasure, S. J. (2017) · Brain Plasticity · doi:10.3233/bpl-180064 · Cited by 39
PPARs and Energy Metabolism Adaptation during Neurogenesis and Neuronal Maturation
d’Angelo, M., Antonosante, A., Castelli, V., Catanesi, M., Moorthy, N. K., Iannotta, D., Cimini, A., & Benedetti, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071869 · Cited by 37
Lineage Tracing and Cell Potential of Postnatal Single Progenitor Cells In Vivo
Figueres‐Oñate, M., Sánchez-Villalón, M., Sánchez‐González, R., & López‐Mascaraque, L. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.08.010 · Cited by 37
Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors
Donega, V., van der Geest, A. T., Sluijs, J. A., van Dijk, R. E., Wang, C. C., Başak, O., Pasterkamp, R. J., & Hol, E. M. (2022) · Nature Communications · doi:10.1038/s41467-022-28626-9 · Cited by 36
Bipotent progenitors as embryonic origin of retinal stem cells
Tang, X., Gao, J., Jia, X., Zhao, W., Zhang, Y., Pan, W., & He, J. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611057 · Cited by 36
Role of Astrocytes in the Neurogenic Niches
Schneider, J., Karpf, J., & Beckervordersandforth, R. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9068-9_2 · Cited by 36
Adult hypothalamic neurogenesis and sleep–wake dysfunction in aging
Kostin, A., Alam, A., McGinty, D., & Alam, M. N. (2020) · SLEEP · doi:10.1093/sleep/zsaa173 · Cited by 33
p27, The Cell Cycle and Alzheimer´s Disease
García‐Osta, A., Dong, J., Moreno-Aliaga, M. J., & Ramírez, M. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031211 · Cited by 36
Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells
Noguchi, H., Castillo, J. G., Nakashima, K., & Pleasure, S. J. (2019) · eLife · doi:10.7554/elife.42918 · Cited by 35
GemC1 is a critical switch for neural stem cell generation in the postnatal brain
Lalioti, M., Kaplani, K., Lokka, G., Georgomanolis, T., Kyrousi, C., Dong, W., Dunbar, A., Parlapani, E., Damianidou, E., Spassky, N., et al. (2019) · Glia · doi:10.1002/glia.23690 · Cited by 32
Molecular Mechanisms of Neurogenic Aging in the Adult Mouse Subventricular Zone
Lupo, G., Gioia, R., Nisi, P. S., Biagioni, S., & Cacci, E. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519829040 · Cited by 35

Authors: Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y., & Gotoh, Y.
Affiliations: The University of Tokyo (JP)
Kyoto University (JP)
Echelon Biosciences (US)
Kyushu University (JP)
Corresponding author: Gotoh, Yukiko
ORCID: Watanabe, Tomoyuki
Kawai, Hiroki
Harada, Yujin
Imayoshi, Itaru
Nakayama, Keiichi I
Hirabayashi, Yusuke
Gotoh, Yukiko
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-03-30
Volume: 18
Issue: 5
Pages: 657-665
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3989
OpenAlex: W2052382060
Cited by: 329
References: 47
Citations by year: 2026: 15 · 2025: 28 · 2024: 33 · 2023: 29 · 2022: 27 · 2021: 30 · 2020: 35 · 2019: 41 · 2018: 28 · 2017: 39 · 2016: 20 · 2015: 4
FWCI: 12.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
The Molecular Biology Society of Japan
Funders: Japan Society for the Promotion of Science (25891008, 15K15086, 25221303)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: adult neural stem cells, subventricular zone, p57, cyclin-dependent kinase inhibitors, stem cell origin, cell cycle progression
MeSH terms: Animals, Cell Cycle, Cell Division, Histones, Mice, Inbred C57BL, Mice, Inbred ICR, Nerve Tissue Proteins, Recombinant Fusion Proteins, Telencephalon, Genes, Reporter, Cell Lineage, Cyclin-Dependent Kinase Inhibitor p57, Mice, Neurogenesis, Neural Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks