Cited by 81Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchIon channel regulation and function

The quest for action potentials in C. elegans neurons hits a plateau

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Lockery, Shawn R, Goodman, Miriam B·2009·Nature Neuroscience

Abstract

The small size and high resistance of C. elegans neurons makes them sensitive to the random opening of single ion channels, probably rendering codes that are based on classical, all-or-none action potentials unworkable. The recent discovery in C. elegans of a special class of regenerative events known as plateau potentials introduces the possibility of digital neural codes. Such codes would solve the problem of representing information in nervous systems in which action potentials are unreliable.

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Authors
Lockery, S. R., & Goodman, M. B.
Affiliations
  • University of Oregon (US)
  • Stanford University (US)
Venue
Nature Neuroscience
Published
2009-04
Volume
12
Issue
4
Pages
377-378
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2060528973
Cited by
81
References
40
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 11 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
2.75
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R21MH112105, R01MH051383)
  • National Institute of Neurological Disorders and Stroke (R01NS047715)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
Caenorhabditis elegans, action potential, plateau potentials, ion channels, neural coding
MeSH terms
Action Potentials, Animals, Neurons, Caenorhabditis elegans

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