The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
Abstract
Precise patterns of cell division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult cerebral cortex. Using time-lapse imaging of clonal cells in rat cortex over several generations, we show here that neurons are generated in two proliferative zones by distinct patterns of division. Neurons arise directly from radial glial cells in the ventricular zone (VZ) and indirectly from intermediate progenitor cells in the subventricular zone (SVZ). Furthermore, newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate. These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration.
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“IPCs can undergo 1–3 proliferation cycles before differentiation to neurons [97, 98].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [97]
In the citing paper
“The newly generated cell can differentiate into a neuron, or become an IPC [97].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [97]
Citations
Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
Self-citationLuskin, M. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90281-u · Cited by 1,803
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons
Miyata, T., Kawaguchi, A., Okano, H., & Ogawa, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00420-2 · Cited by 892
Chenn, A., & McConnell, S. K. (1995) · Cell · doi:10.1016/0092-8674(95)90035-7 · Cited by 766
Characterization of CNS Precursor Subtypes and Radial Glia
Hartfuss, E., Galli, R., Heins, N., & Götz, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9962 · Cited by 755
Origin of GABAergic neurons in the human neocortex
Letinić, K., Zoncu, R., & RAKIC, P. T. (2002) · Nature · doi:10.1038/nature00779 · Cited by 730
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Kohno, T., Ishii, K., Hirota, Y., Honda, T., Makino, M., Kawasaki, T., Nakajima, K., & Hattori, M. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1907-20.2020 · Cited by 30
Choi, J., Park, S., & Sockanathan, S. (2014) · Development · doi:10.1242/dev.104505 · Cited by 19
Matho, K. S., Huilgol, D., Galbavy, W., He, M., Kim, G., An, X., Lu, J., Wu, P., Di Bella, D. J., Shetty, A. S., et al. (2020) · doi:10.1101/2020.04.22.054064 · Cited by 20
Singh, P., Ray, K., Fujita, D., & Bandyopadhyay, A. (2019) · Lecture Notes in Electrical Engineering · doi:10.1007/978-981-13-1642-5_63 · Cited by 20
Belzil, C., Asada, N., Ishiguro, K.-I., Nakaya, T., Parsons, K., Pendolino, V., Neumayer, G., Mapelli, M., Nakatani, Y., Sanada, K., et al. (2014) · Biology Open · doi:10.1242/bio.20147807 · Cited by 15
Huang, C., Liu, T., Wang, Q., Hou, W., Zhou, C., Song, Z., Shi, Y. S., Gao, X., Chen, G., Yin, Z., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa042 · Cited by 14
Metadata
- Authors
- Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R.
- Affiliations
- Columbia University (US)
- Corresponding author
- Noctor, Stephen C
- Venue
- Nature Neuroscience
- Published
- 2004-01-04
- Volume
- 7
- Issue
- 2
- Pages
- 136-144
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2127220436
- Cited by
- 2,229
- References
- 51
- Citations by year
- 2026: 43 · 2025: 69 · 2024: 91 · 2023: 91 · 2022: 101 · 2021: 97 · 2020: 130 · 2019: 114 · 2018: 121 · 2017: 115 · 2016: 108 · 2015: 109 · 2014: 127 · 2013: 123 · 2012: 127
- FWCI
- 21.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7r37ns038658-07)
- National Institute of Neurological Disorders and Stroke (NS-35710, NS 38658, NS-21223, R01NS021223)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- cortical neuron migration, cortical neurogenesis, radial glia, intermediate progenitor cells, ventricular zone, subventricular zone, symmetric cell division, asymmetric cell division, retrograde migration, cortical plate, cortical development
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Immunohistochemistry, Neurons, Organ Culture Techniques, Stem Cells, Patch-Clamp Techniques, Microscopy, Confocal, Rats
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