Cited by 2,229Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationFetal and Pediatric Neurological Disorders

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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

Noctor, Stephen C, Martínez-Cerdeño, Verónica, Ivic, Lidija, Kriegstein, Arnold R·2004·Nature Neuroscience

DOI 10.1038/nn1172

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Abstract

Precise patterns of cell division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult cerebral cortex. Using time-lapse imaging of clonal cells in rat cortex over several generations, we show here that neurons are generated in two proliferative zones by distinct patterns of division. Neurons arise directly from radial glial cells in the ventricular zone (VZ) and indirectly from intermediate progenitor cells in the subventricular zone (SVZ). Furthermore, newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate. These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration.

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
Self-citation
Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
Luskin, M. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90281-u · Cited by 1,803
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462
Neurons in Rhesus Monkey Visual Cortex: Systematic Relation between Time of Origin and Eventual Disposition
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons
Miyata, T., Kawaguchi, A., Okano, H., & Ogawa, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00420-2 · Cited by 892
Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis
Chenn, A., & McConnell, S. K. (1995) · Cell · doi:10.1016/0092-8674(95)90035-7 · Cited by 766
Characterization of CNS Precursor Subtypes and Radial Glia
Hartfuss, E., Galli, R., Heins, N., & Götz, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9962 · Cited by 755
Origin of GABAergic neurons in the human neocortex
Letinić, K., Zoncu, R., & RAKIC, P. T. (2002) · Nature · doi:10.1038/nature00779 · Cited by 730

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Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal‐Retzius cells
Barber, M., & Pierani, A. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22363 · Cited by 76
Development of the Nervous System
(2012) · Elsevier eBooks · doi:10.1016/c2009-0-02132-1 · Cited by 76
Mitotic Spindle Asymmetry: A Wnt/PCP-Regulated Mechanism Generating Asymmetrical Division in Cortical Precursors
Delaunay, D., Cortay, V., Patti, D., Knoblauch, K., & Dehay, C. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.026 · Cited by 75
The Phosphatase PP4c Controls Spindle Orientation to Maintain Proliferative Symmetric Divisions in the Developing Neocortex
Xie, Y., Jüschke, C., Esk, C., Hirotsune, S., & Knoblich, J. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.027 · Cited by 75
Characterization of Adult Neural Stem Cells and Their Relation to Brain Tumors
Jackson, E. L., & Álvarez-Buylla, A. (2008) · Cells Tissues Organs · doi:10.1159/000114541 · Cited by 75
MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex
Weimer, J. M., Yokota, Y., Stanco, A., Stumpo, D. J., Blackshear, P. J., & Anton, E. S. (2009) · Development · doi:10.1242/dev.036616 · Cited by 75
Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells
Sakai, D., Dixon, J., Dixon, M. J., & Trainor, P. A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002566 · Cited by 75
Hippocampal Pyramidal Neurons Switch from a Multipolar Migration Mode to a Novel “Climbing” Migration Mode during Development
Kitazawa, A., Kubo, K., Hayashi, K., Matsunaga, Y., Ishii, K., & Nakajima, K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2254-13.2014 · Cited by 75
Evolution of Cerebral Cortical Development
Molnár, Z. (2011) · Brain Behavior and Evolution · doi:10.1159/000327325 · Cited by 75
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Santana, J., & Marzolo, M. (2017) · Biochemical Journal · doi:10.1042/bcj20160628 · Cited by 76
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Zhou, X., Zhong, S., Peng, H., Liu, J., Ding, W., Sun, L., Ma, Q., Liu, Z., Chen, R., Wu, Q., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17890-2 · Cited by 74
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Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex
Toma, K., & Hanashima, C. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00274 · Cited by 74
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Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here
Hamilton, L. K., Joppé, S. E., Cochard, L. M., & Fernandes, K. J. L. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12207 · Cited by 74
CLoNe is a new method to target single progenitors and study their progeny in mouse and chick
García‐Moreno, F., Vasistha, N. A., Begbie, J., & Molnár, Z. (2014) · Development · doi:10.1242/dev.105254 · Cited by 74
Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse
Stolp, H. B., Turnquist, C., Dzięgielewska, K. M., Saunders, N. R., Anthony, D. C., & Molnár, Z. (2011) · Brain · doi:10.1093/brain/awr237 · Cited by 74
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Tajbakhsh, S., Rocheteau, P., & Roux, I. L. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175415 · Cited by 74
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Taverna, E., Mora‐Bermúdez, F., Strzyz, P. J., Florio, M., Icha, J., Haffner, C., Norden, C., Wilsch‐Bräuninger, M., & Huttner, W. Β. (2016) · Scientific Reports · doi:10.1038/srep21206 · Cited by 74
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Rash, B. G., Ackman, J. B., & RAKIC, P. T. (2016) · Science Advances · doi:10.1126/sciadv.1501733 · Cited by 74
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Sakurai, M., Ayukawa, K., Setsuie, R., Nishikawa, K., Hara, Y., Ohashi, H., Nishimoto, M., Abe, T., Kudo, Y., Sekiguchi, M., et al. (2005) · Journal of Cell Science · doi:10.1242/jcs.02716 · Cited by 74
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Mora‐Bermúdez, F., Matsuzaki, F., & Huttner, W. Β. (2014) · eLife · doi:10.7554/elife.02875 · Cited by 73
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Wang, H., Xiao, Z., Zheng, J., Wu, J., Hu, X.-L., Yang, X., & Shen, Q. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.081 · Cited by 73
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Self-citation
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Notch, Neural Stem Cells, and Brain TumorsPreprint
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Liu, X., Sun, L., Torii, M., & RAKIC, P. T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205880109 · Cited by 71
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Li, X., Xiao, J., Fröhlich, H., Tu, X., Li, L., Xu, Y., Cao, H., Qu, J., Rappold, G., & Chen, J.-G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127671 · Cited by 70
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Costa, M. R., Kessaris, N., Richardson, W. D., Götz, M., & Hedin‐Pereira, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2418-07.2007 · Cited by 69
Scuola Normale Superiore
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Staal, J. A., Alexander, S. R., Liu, Y., Dickson, T. D., & Vickers, J. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022040 · Cited by 68
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Ecker, C., Shahidiani, A., Feng, Y., Daly, E., Murphy, C., D’Almeida, V., Deoni, S., Williams, S., Gillan, N., Gudbrandsen, M., et al. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1207-1 · Cited by 68
Lineage-dependent circuit assembly in the neocortex
Gao, P., Sultan, K. T., Zhang, X., & Shi, S. (2013) · Development · doi:10.1242/dev.087668 · Cited by 68
Function of neural stem cells in ischemic brain repair processes
Zhang, R., Zhang, Z., & Chopp, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16674487 · Cited by 68
Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice
Fan, L., Lu, Y., Shen, X., Shao, H., Suo, L., & Wu, Q. (2018) · eLife · doi:10.7554/elife.35242 · Cited by 68
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Gonçalves, J. C., Quintremil, S., Yi, J., & Vallee, R. B. (2020) · Current Biology · doi:10.1016/j.cub.2020.05.091 · Cited by 68
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Krienen, F. M., Levandowski, K. M., Zaniewski, H., del Rosario, R. C. H., Schroeder, M. E., Goldman, M., Wienisch, M., Lutservitz, A., Beja-Glasser, V. F., Chen, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adk3986 · Cited by 67
Nuclear factor one B regulates neural stem cell differentiation and axonal projection of corticofugal neurons
Betancourt, J., Katzman, S. J., & Chen, B. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23373 · Cited by 67
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Ueno, M., Katayama, K., Yamauchi, H., Nakayama, H., & Doi, K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.042 · Cited by 67
Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesis
Duggan, A., Madathany, T., de Castro, S. C., Gerrelli, D., Guddati, K., & Garcı́a-Añoveros, J. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21629 · Cited by 67
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Kostović, I., Išasegi, I. Ž., & Krsnik, Ž. (2018) · Journal of Anatomy · doi:10.1111/joa.12920 · Cited by 67
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Kostic, M., Paridaen, J. T. M. L., Long, K. R., Kalebic, N., Langen, B., Grübling, N., Wimberger, P., Kawasaki, H., Namba, T., & Huttner, W. Β. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.091 · Cited by 67
Bcl11 Transcription Factors Regulate Cortical Development and Function
Simon, R., Wiegreffe, C., & Britsch, S. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00051 · Cited by 66
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Allen, D. E., Donohue, K. C., Cadwell, C. R., Shin, D., Keefe, M. G., Sohal, V. S., & Nowakowski, T. J. (2022) · Science · doi:10.1126/science.abm5224 · Cited by 67
Three phases of DiGeorge/22q11 deletion syndrome pathogenesis during brain development: Patterning, proliferation, and mitochondrial functions of 22q11 genes
Meechan, D. W., Maynard, T. M., Tucker, E. S., & LaMantia, A. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.005 · Cited by 66
Molecular genetic determinants of human brain size
Tang, B. L. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.040 · Cited by 66
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Wang, Q., Yang, L., Alexander, C. M., & Temple, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042883 · Cited by 66
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Imayoshi, I., & Kageyama, R. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.006 · Cited by 66
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Yamamoto, S., Yoshino, I., Shimazaki, T., Murohashi, M., Hevner, R. F., Lax, I., Okano, H., Shibuya, M., Schlessinger, J., & Gotoh, N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507961102 · Cited by 66
Myc increases self-renewal in neural progenitor cells through Miz-1
Kerosuo, L., Piltti, K. M., Fox, H., Angers‐Loustau, A., Häyry, V., Eilers, M., Sariola, H. V., & Wartiovaara, K. (2008) · Journal of Cell Science · doi:10.1242/jcs.024802 · Cited by 66
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Axin Directs the Amplification and Differentiation of Intermediate Progenitors in the Developing Cerebral Cortex
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Self-citation
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Authors: Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R.
Affiliations: Columbia University (US)
Corresponding author: Noctor, Stephen C
ORCID: Noctor, Stephen C
Kriegstein, Arnold R
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-01-04
Volume: 7
Issue: 2
Pages: 136-144
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1172
OpenAlex: W2127220436
Cited by: 2,229
References: 51
Citations by year: 2026: 43 · 2025: 69 · 2024: 91 · 2023: 91 · 2022: 101 · 2021: 97 · 2020: 130 · 2019: 114 · 2018: 121 · 2017: 115 · 2016: 108 · 2015: 109 · 2014: 127 · 2013: 123 · 2012: 127
FWCI: 21.49
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r37ns038658-07)
National Institute of Neurological Disorders and Stroke (NS-35710, NS 38658, NS-21223, R01NS021223)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords: cortical neuron migration, cortical neurogenesis, radial glia, intermediate progenitor cells, ventricular zone, subventricular zone, symmetric cell division, asymmetric cell division, retrograde migration, cortical plate, cortical development
MeSH terms: Animals, Cell Differentiation, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Immunohistochemistry, Neurons, Organ Culture Techniques, Stem Cells, Patch-Clamp Techniques, Microscopy, Confocal, Rats

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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

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