The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Early life experience alters response of adult neurogenesis to stress
Abstract
Maternal deprivation produces persistent abnormalities in behavioral and neuroendocrine functions associated with the hippocampus, a brain region that shows considerable structural change in response to experience throughout life. Here we show that adverse experience early in life affects the regulation of adult neurogenesis in the hippocampus. More specifically, a decrease in cell proliferation and immature neuron production are observed in the dentate gyrus of adult rats that are maternally separated as pups. Although maternally separated rats show normal basal levels of corticosterone, the suppression of cell proliferation in these rats can be reversed by lowering corticosterone below the control value. In addition, normal stress-induced suppression of cell proliferation and neurogenesis, despite normal activation of the hypothalamic pituitary adrenal (HPA) axis, is not observed in maternally separated rats. Our results suggest that early adverse experience inhibits structural plasticity via hypersensitivity to glucocorticoids and diminishes the ability of the hippocampus to respond to stress in adulthood.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“BCAA may mediate effects of fatigue during exercise by modifying certain brain neurotransmitters [50]”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [50]
In the citing paper
“Stress seems to inhibit adult neurogenesis by having a suppressive action on the proliferation of radial stem cells and amplifying progenitors, leading to a reduction in neuroblasts (Dagytė et al., 2009; Mirescu et al., 2004; Opendak et al., 2016) (Table 1).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Mirescu et al., 2004
In the citing paper
“Some previous studies have reported that early life adversity reduces the production of new neurons in the dentate gyrus (37)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [37]
In the citing paper
“Previous work showed maternal separation stress reduced adult neurogenesis in the rat hippocampus (37; 62–64), although other studies failed to show this (65).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [37]
Citations
Cites
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
Self-citationHippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
Cameron, H. A., & Mckay, R. D. G. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1040 · Cited by 1,585
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496
Self-citationGould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3168 · Cited by 1,395
Self-citationSheline, Y. I., Sanghavi, M., Mintun, M. A., & Gado, M. H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05034.1999 · Cited by 1,382 · cited 1×
“Stress-related neuropsychiatric disorders such as depression have been associated with reductions in hippocampal volum”
BackgroundEnhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 618
Constitutive Neurogenesis in the Brain of Different Vertebrate Groups
Stukaneva, M. E., & Pushchina, E. V. (2020) · Neurophysiology · doi:10.1007/s11062-021-09904-6 · Cited by 3
Marazziti, D., Crowther, L. F., & Arone, A. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2355259 · Cited by 3
Olateju, O. I., Ihunwo, A. O., & Manger, P. R. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.12.006 · Cited by 3
Influence of Vagus Nerve Stimulation on Mood and Associated Disorders
Bottari, S. A., Rodriguez, A., & Williamson, J. B. (2023) · Neuromethods · doi:10.1007/978-1-0716-3465-3_7 · Cited by 4
Neuron Division or Enucleation
Сотников, О. С., Лактионова, А. А., Solovieva, I. A., & Krasnova, T. V. (2010) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-010-9339-8 · Cited by 3
Social Inequalities, Family Relationships, and Child Health
Flinn, M. V. (2010) · National symposium on family issues · doi:10.1007/978-1-4419-7361-0_14 · Cited by 3
Animal Models of Mood Disorders
Alcantara, L. F., Parise, E. M., & Bolaños‐Guzmán, C. A. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0026 · Cited by 3
Deciphering Adult Neural Stem Cells with Single-Cell Sequencing
Liu, Y., Zhu, Y., Shi, Y., Liu, X., Su, W., & Zhuo, Y. (2023) · Stem Cells and Development · doi:10.1089/scd.2022.0234 · Cited by 3
Dönmez, R. A., Candansayar, S., Derinöz, O., Gülbahar, Ö., & Bolay, H. (2016) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1502-39 · Cited by 3
Mother–Infant Interaction in the Variable Foraging Demand Model
Coplan, J. D., Kral, J. G., Smith, E. L., & Rosenblum, L. A. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00089-9 · Cited by 3
Marmendal, M. (2005) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 3
Schoenfeld, T. J., & Gould, E. (2011) · Wiley eBooks · doi:10.1002/9781118083222.ch7 · Cited by 4
Self-citationCalado, C. M. S. D. S., Manhães‐de‐Castro, R., Gouveia, H. J. C. B., Nogueira, R. M. T. B. L., Souza, V. D. S., de Lira, A. V. S. M., Merencio, S. M. D. A., Lima, B. M. P., de Oliveira, M. V. P., & Toscano, A. E. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149924 · Cited by 3
Fernandes, R. A., de Oliveira, M. S., de Castro, O. W., & Santos, V. R. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111553 · Cited by 2
Jones, K., Teliska, L. H., Mirrione, M. M., & Betz, A. J. (2025) · Experimental Brain Research · doi:10.1007/s00221-025-07204-7 · Cited by 3
Larrieu, T., Grieco, F., Carron, C., Vilademunt, M., Weber, C., Ginggen, K., Delacrétaz, A., Gallart‐Ayala, H., Tsuda, M. C., Cameron, H. A., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69240-3 · Cited by 3
Salmina, A. B., Uspenskaya, Y. A., Panina, Y. A., Gorina, Y. V., & Lopatina, O. L. (2023) · Cell and Tissue Biology · doi:10.1134/s1990519x23040119 · Cited by 2
Hormone Regulation of Neurogenesis Across the Lifespan
Duarte‐Guterman, P., Yagi, S., Epp, J. R., Brummelte, S., Wainwright, S. R., Barha, C. K., Chow, C., Barker, J. M., & Galea, L. A. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00108-5 · Cited by 2
Epilepsy and Psychiatric Comorbidities: New Approaches and Perspectives
Gargiulo, Á. J. M., Scévola, L., Sarudiansky, M., Kochen, S. S., & D’Alessio, L. (2021) · Springer eBooks · doi:10.1007/978-3-030-61721-9_38 · Cited by 2
Koehl, M., Moal, M. L., & Abrous, D. N. (2011) · Springer eBooks · doi:10.1007/978-4-431-53945-2_4 · Cited by 2
Neurosteroids in Cortical Development and the Etiology of Schizophrenia
Gizerian, S. S. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6854-6_15 · Cited by 2
Early-Life Stress Restricts the Capacity of Adult Progenitor Cells to Differentiate into Neurons
Kaffman, A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.008 · Cited by 2
Brake, A. D., Yang, X., Lee, C., Lee, P., Keselman, P., Eller, O. C., Choi, I.-Y., Harris, J. L., & Christianson, J. A. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.809944 · Cited by 2
Ramírez-Rodríguez, G. B., Laguna-Chimal, J., Vega‐Rivera, N. M., Ortíz‐López, L., Méndez-Cuesta, L. A., Estrada-Camarena, E. M., & Babu, H. (2011) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 2
Hormones and adult neurogenesis in mammals
Richardson, S. J., Almeida, O. F. X., & DEMENEIX, B. A. (2007) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2.2.261 · Cited by 2
Corruble, E. (2006) · L Encéphale · doi:10.1016/s0013-7006(06)76277-7 · Cited by 2
FACULTE MIXTE DE MEDECINE ET DE PHARMACIE DE ROUEN
Eltchaninoff, H., Lacroix, D., & Savoure, D. A. (2013) · Cited by 2
Stress Effects on the Brain System Underlying Explicit Memory
Carver, L. J., & Clüver, A. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195326932.003.0011 · Cited by 2
Early Life Stress, Drug Abuse, Exercise Effects on BDNF and Sex-influenced Excercise Differences
Dold, K. (2013) · Digital Scholarship - UNLV (University of Nevada Reno) · Cited by 2
Stress effects on adult hippocampal neurogenesis and sexual reproductive function
Kirby, E. D. (2011) · eScholarship (California Digital Library) · Cited by 2
Effects of the Maternal Environment on Early Postnatal Development in OXYS Rats
Igonina, T. N., Voronkova, O. M., Ragaeva, D. S., Brusentsev, E. Y., Рожкова, И. Н., Kolosova, N. G., & Amstislavsky, S. Y. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01378-9 · Cited by 1
Алексеевич, М. В., Андреевич, Г. М., & Владимирович, К. А. (2023) · Patient-Oriented Medicine and Pharmacy · doi:10.37489/2949-1924-0012 · Cited by 1
Yavaş, S. E., & Ersoy, S. (2025) · Pamukkale Medical Journal · doi:10.31362/patd.1657975 · Cited by 1
Developmental Scarcity Induces Sex Differences in Social Recognition and CA2 Perineuronal Nets
Waters, R. C., Gore, I. R., Brown, C. J., Skweres-Gilmartin, A. L., Rathaur, A. B., & Gould, E. (2026) · eNeuro · doi:10.1523/eneuro.0199-26.2026 · Cited by 1
Self-citationMaternal programming of defensive responses through sustained effects on gene expression
Diorio, J. C., & Meaney, M. J. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0728 · Cited by 2
de Sá, N. F., Assad, N., Camarini, R., & Suchecki, D. (2026) · Neurobiology of Stress · doi:10.1016/j.ynstr.2026.100800 · Cited by 1
Anderson, L., Dwork, A. J., Keegan, K. A., Thirumangalakudi, L., Lipira, C. M., Lange, C., Higley, J. D., Rosoklija, G. B., Coplan, J. D., & Perera, T. D. (2011) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(11)70673-3 · Cited by 1
Epigenetic effects of environment and diet
Brant, J. O., & Yang, T. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-799958-6.00015-9 · Cited by 1
Épistémologie et méthodologie en psychanalyse et en psychiatrie
Cohen, D. (2017) · Érès eBooks · doi:10.3917/eres.golse.2017.01.0195 · Cited by 1
Arboleda, S. R. (2022) · Cultura y Droga · doi:10.17151/culdr.2022.27.34.2 · Cited by 1
CCKergic System, Hypothalamus-Pituitary-Adrenal (HPA) Axis, and Early-Life Stress (ELS)
Tang, M., Joseph, A. M., Chen, Q., Jiao, J., & Tang, Y. (2012) · InTech eBooks · doi:10.5772/52042 · Cited by 1
Las zonas neurogénicas en el adulto y su relación con las enfermedades neuropsiquiátricas
Ramírez-Rodríguez, G. B., Silva‐Lucero, M., Gomez‐Virgilio, L., Ocaña-Fernández, M. D. Á., Ortíz‐López, L., Torres-Pérez, M. O., & Meraz‐Ríos, M. A. (2013) · Salud Mental · doi:10.17711/sm.0185-3325.2013.026 · Cited by 1
Sindeeva, O. A., Borisova, E. G., Abdurashitov, A. S., Zhinchenko, E., Gekalyuk, A., Ulanova, M., Shareef, A. E., Razubaeva, V., Serov, S. I., Ludmila, Y., et al. (2015) · Journal of Biomedical Photonics & Engineering · doi:10.18287/jbpe-2015-1-4-248 · Cited by 1
You Need Guts to Make New Neurons
Wolf, S. A., & Mattei, D. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0127-4 · Cited by 1
Cui, W., Gong, L., Chen, C., Tang, J. Y., Jin, X., Li, Z., Jing, L., & Wen, G. (2023) · PubMed Central · doi:10.12122/j.issn.1673-4254.2023.06.22 · Cited by 1
Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats
Erasso, D. M. (2011) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1
Common Neural Adaptations and Bidirectional Influences of Stress and Addiction
Eisch, A. J. (2005) · Journal of Dual Diagnosis · doi:10.1300/j374v01n03_04 · Cited by 1
Anhuaman, L. A. L. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.59.2014.tde-03042014-174324 · Cited by 1
Adult Neurogenesis and Central Nervous System Cell Cycle Analysis
Eisch, A. J., & Mandyam, C. D. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-021-8_25 · Cited by 1
Does interleukin 1β play a role in rat pups with neonatal seizure and concomitant neonatal stress?
Huang, L. (2008) · Bioscience hypotheses · doi:10.1016/j.bihy.2008.09.005 · Cited by 1
Effects of semi-natural environmental conditions on phenotypic plasticity in Rattus norvegicus
Margerum, L. A. (2013) · eScholarship (California Digital Library) · Cited by 1
Croy, S. (2017) · Minerva Access (University of Melbourne) · Cited by 1
Developmental approaches to the memory process
Markham, J. A., Black, J., & Greenough, W. T. (2007) · Elsevier eBooks · doi:10.1016/b978-012372540-0/50003-0 · Cited by 1
Effects of Early Life and Adult Chronic Stress on Behavior and Physiology
Weiss, A. (2018) · The Knowledge Bank (The Ohio State University) · Cited by 1
Environmental Influences on Adult Neurogenesis
Glasper, E. R., Morton, J. C., & Gould, E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-045396-5.00241-4 · Cited by 1
Self-citationPadilha, C. B. (2007) · Americanae (AECID Library)
Chronic stress during the peripartum period: Implications for mother and offspring
Hillerer, K. M. (2013) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.23680
The Neurobiology of Stress Throughout the Life Cycle
Kay, J. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0748-6_3
Jans, L. A. W. (2008) · Research Publications (Maastricht University) · doi:10.26481/dis.20080530lj
Murray, L. (2014) · eSource (Dublin Business School)
Introductory and Basic Aspects
López‐Ríos, F., Martín, S. G., & Moreno, A. M. M. (2007) · Wiley eBooks · doi:10.1002/9783527619337.ch11
Anxiety as signal, symptom, and syndrome
Glick, R. A., & Roose, S. P. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777578.007
New insights into TRPV1 function in the brain under physiological and pathological conditions
Stock, K. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-4718
Semrud‐Clikeman, M., & Ellison, P. A. T. (2009) · Springer eBooks · doi:10.1007/978-0-387-88963-4_10
Schizofrenia, Plasticità Neuronale e Farmaci Antipsicotici
Biggio, G. (2006) · Giornale italiano di psicopatologia/Journal of psychopathology/Italian journal of psychopathology
The potential of exercise to reverse stress induced abnormalities in the rat brain
Marais, L. (2010) · SUNScholar (Stellenbosch University)
Dranovsky, A., & Hen, R. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn020
Towards a new understanding of psychological suffering
Taylor-Moore, K. E. (2009) · UC Research Repository (University of Canterbury) · doi:10.26021/7710
Forster, A. (2015) · Library, Museums and Press - UDSpace (University of Delaware)
Understanding the Mechanism Involved in Immune-mediated Cognitive Functioning
Palu, M. L. (2013) · Figshare
The endogenous repair capacity of the parkinsonian brain
van den Berge, S. A. (2011)
Benton, C. S. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/1143-ay27
Florian, M. L. (2010) · Americanae (AECID Library)
Depression and Gene-Environment Interaction
Korean, J., Assoc, N., & Kim, Y. (2010) · 신경정신의학
The Role of Hormones in the Evolution of Human Sociality
Flinn, M. V., & Ward, C. V. (2015) · Wiley eBooks · doi:10.1002/9781119125563.evpsych124
Nagai, T., Yun, J., Ibi, D., Koike, H., Hibi, Y., & Yamada, K. (2012) · Folia Pharmacologica Japonica · doi:10.1254/fpj.139.147
Stress hos höns : Effekter av domesticaring och tidig stress på beteende och välfärd
Ericsson, M. (2016) · Linköping University Electronic Press eBooks · doi:10.3384/diss.diva-126236
[Emotional stress and functional development of the rat brain].
Yoshioka, M., Togashi, H., Yamaguchi, T., & Matsumoto, M. (2005) · Folia Pharmacologica Japonica · doi:10.1254/fpj.125.77
Social instability, hippocampal plasticity and resilience
Opendak, M. M. (2015)
Neurohormetic Properties of the Phytochemical Resveratrol
Holme, A. L., & Pervaiz, S. (2009) · Oxidative stress and disease · doi:10.1201/9781420073522.ch21
Biological and Social Causation of Serious Mental Illness
McKenzie, K. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-420190-3.00026-0
Lau, D. (2013) · UWSpace (University of Waterloo)
Realmuto, G. M., & Klimes‐Dougan, B. (2012) · Wiley eBooks · doi:10.1002/9781119962229.ch3
Merlo, S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-17012015-134343
Migration, Flucht und Trauma – Erkenntnisse aus psychoanalytischen Frühpräventionsprojekten
Fischmann, T. (2017) · Vandenhoeck & Ruprecht eBooks · doi:10.13109/9783666402845.235
Hippocampal neuroplasticity and neurogenesis in major depressive disorder: a high field MRI study
Huang, Y. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3qm0k
Bogin, B. A. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511781193.027
Stress effects on astrocyte communication and regulation of adult hippocampal neural stem cells
Covarrubias, D. (2015) · eScholarship (California Digital Library)
D’Costa, N. (2019) · UWSpace (University of Waterloo)
Molecular aspects of regeneration and neuroprotection in neurodegenerative diseases
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821711-5.00007-3
Bustamante, F. A., Méndez-Ruette, M., Wyneken, Ú., Bátiz, L. F., & Henzi, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813156-5.00017-0
Chaniotakis, I., Diamantakos, E., Rizou, V., Moltsanidou, E., Kotopoulis, C., Thavarajah, M., Polissidis, A., & Kostomitsopoulos, N. G. (2020) · Pet Behaviour Science · doi:10.21071/pbs.vi10.12480
Stephan, M., Skripuletz, T., & von Hörsten, S. (2006) · Springer eBooks · doi:10.1007/978-0-387-48334-4_12
Effects of developmental fluoxetine exposure on neurobehavioral outcomes
Rayen, I. (2013) · Research Publications (Maastricht University) · doi:10.26481/dis.20131023ir
(2008) · Wiley eBooks · doi:10.1002/9781118265666.refs
Metadata
- Authors
- Mirescu, C., Peters, J. D., & Gould, E.
- Affiliations
- Princeton University (US)
- Corresponding author
- Gould, Elizabeth
- Venue
- Nature Neuroscience
- Published
- 2004-07-25
- Volume
- 7
- Issue
- 8
- Pages
- 841-846
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1964173716
- Cited by
- 625
- References
- 45
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 23 · 2023: 18 · 2022: 16 · 2021: 14 · 2020: 19 · 2019: 31 · 2018: 18 · 2017: 22 · 2016: 34 · 2015: 37 · 2014: 36 · 2013: 34 · 2012: 24
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH059740, P50MH058922, MH58922, MH-59740)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- childhood adversity, maternal separation, adult neurogenesis, hippocampus, dentate gyrus, cell proliferation, corticosterone, glucocorticoid sensitivity, stress response, hypothalamic-pituitary-adrenal axis, structural plasticity
- MeSH terms
- Animals, Cell Division, Corticosterone, Female, Hippocampus, Hypothalamo-Hypophyseal System, Immunohistochemistry, Maternal Deprivation, Neuronal Plasticity, Pituitary-Adrenal System, Stress, Psychological, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review