Cited by 625Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolMemory and Neural Mechanisms

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Early life experience alters response of adult neurogenesis to stress

Mirescu, Christian, Peters, Jennifer D, Gould, Elizabeth·2004·Nature Neuroscience

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Abstract

Maternal deprivation produces persistent abnormalities in behavioral and neuroendocrine functions associated with the hippocampus, a brain region that shows considerable structural change in response to experience throughout life. Here we show that adverse experience early in life affects the regulation of adult neurogenesis in the hippocampus. More specifically, a decrease in cell proliferation and immature neuron production are observed in the dentate gyrus of adult rats that are maternally separated as pups. Although maternally separated rats show normal basal levels of corticosterone, the suppression of cell proliferation in these rats can be reversed by lowering corticosterone below the control value. In addition, normal stress-induced suppression of cell proliferation and neurogenesis, despite normal activation of the hypothalamic pituitary adrenal (HPA) axis, is not observed in maternally separated rats. Our results suggest that early adverse experience inhibits structural plasticity via hypersensitivity to glucocorticoids and diminishes the ability of the hippocampus to respond to stress in adulthood.

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“…during early neurodevelopment in rodent and nonhuman primates, such as early maternal separation and poor postnatal care, has been linked specifically with long-term changes in structure and function of the brain (Kaffman and Meaney, 2007; Meaney, 2001; Mirescu et al., 2004; Sanchez, 2006).”
BackgroundResultInfluential
Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation.
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The impact of maternal separation on adult mouse behaviour and on the total neuron number in the mouse hippocampus
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Authors: Mirescu, C., Peters, J. D., & Gould, E.
Affiliations: Princeton University (US)
Corresponding author: Gould, Elizabeth
ORCID: Mirescu, Christian
Gould, Elizabeth
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-07-25
Volume: 7
Issue: 8
Pages: 841-846
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1290
OpenAlex: W1964173716
Cited by: 625
References: 45
Citations by year: 2026: 8 · 2025: 9 · 2024: 23 · 2023: 18 · 2022: 16 · 2021: 14 · 2020: 19 · 2019: 31 · 2018: 18 · 2017: 22 · 2016: 34 · 2015: 37 · 2014: 36 · 2013: 34 · 2012: 24
FWCI: 9.43
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH059740, P50MH058922, MH58922, MH-59740)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: childhood adversity, maternal separation, adult neurogenesis, hippocampus, dentate gyrus, cell proliferation, corticosterone, glucocorticoid sensitivity, stress response, hypothalamic-pituitary-adrenal axis, structural plasticity
MeSH terms: Animals, Cell Division, Corticosterone, Female, Hippocampus, Hypothalamo-Hypophyseal System, Immunohistochemistry, Maternal Deprivation, Neuronal Plasticity, Pituitary-Adrenal System, Stress, Psychological, Rats

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Early life experience alters response of adult neurogenesis to stress

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