The DOI matches its Crossref record; 108 of the 109 references it cites were found in a registry or an index.
The neural basis of puberty and adolescence
Abstract
The pubertal transition to adulthood involves both gonadal and behavioral maturation. A developmental clock, along with permissive signals that provide information on somatic growth, energy balance and season, time the awakening of gonadotropin releasing hormone (GnRH) neurons at the onset of puberty. High-frequency GnRH release results from disinhibition and activation of GnRH neurons at puberty onset, leading to gametogenesis and an increase in gonadal steroid hormone secretion. Steroid hormones, in turn, both remodel and activate neural circuits during adolescent brain development, leading to the development of sexual salience of sensory stimuli, sexual motivation, and expression of copulatory behaviors in specific social contexts. These influences of hormones on reproductive behavior depend in part on changes in the adolescent brain that occur independently of gonadal maturation. Reproductive maturity is therefore the product of developmentally timed, brain-driven and recurrent interactions between steroid hormones and the adolescent nervous system.
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In the citing paper
“animal studies indicate that increases in reward-seeking are coincident with pubertal maturation”
From A dual systems model of adolescent risk‐taking (2010) · cites this paper as Sisk & Foster, 2004
In the citing paper
“The results for selfreported pubertal changes concur with prior research on pubertal development showing that puberty starts earlier in girls than boys (Carskadon and Acebo, 1993;Sisk and Foster, 2004;Shirtcliff et al., 2009).”
From Longitudinal Changes in Adolescent Risk-Taking: A Comprehensive Study of Neural Responses to Rewards, Pubertal Development, and Risk-Taking Behavior (2015) · cites this paper as Sisk and Foster, 2004
In the citing paper
“that some are indirectly attributable to them (in that the presence of gonadal hormones may catalyze other processes)”
From A behavioral scientist looks at the science of adolescent brain development (2010) · cites this paper as Sisk & Foster, 2004
In the citing paper
“that some are merely coincident with them, perhaps programmed to unfold along a developmental schedule established long before adolescence”
From A behavioral scientist looks at the science of adolescent brain development (2010) · cites this paper as Sisk & Foster, 2004
In the citing paper
“Animal studies suggest that some of the changes in dopaminergic activity are directly attributable to the hormonal changes of puberty”
From A behavioral scientist looks at the science of adolescent brain development (2010) · cites this paper as Sisk & Foster, 2004
In the citing paper
“These processes of restructuring in the pubertal brain are argued to be driven by hormonal changes (Sisk and Foster 2004;Sisk and Zehr 2005;Schulz et al. 2009) and to carry functional consequences on higher order brain functions such as executive functions and social cognition”
From Developmental Changes in Organization of Structural Brain Networks (2013) · cites this paper as Sisk and Foster 2004
In the citing paper
“Sexual behavior develops according to a species-specific, genetically controlled, maturational plan in which the age at first reproduction occurs within a specific age range (87).”
From Emerging Adulthood, a Pre-adult Life-History Stage (2020) · cites this paper as [87]
In the citing paper
“Traditionally, puberty is defined as the process leading to the attainment of sexual maturation [181], beginning with the activation of the HPG axis, and ending with reproductive competency [153, 178].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [178]
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Items 401–500 of 995
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Haller, S. P., Kadosh, K. C., & Lau, J. Y. F. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00846 · Cited by 36
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BackgroundAdolescents: which risks for their life and health?
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“In addition, cell morphology, neural transmitter and receptor density also change drastically during early brain development (Sisk and Foster, 2004; Sisk and Zehr, 2005).”
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“Puberty — via its hormonal effects — impacts both physical maturation — resulting in the development of secondary sexual characteristics — and reproductive behaviors (Sisk and Foster, 2004).”
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“The mean age for initiation of abuse is 15 years [15], and it is estimated that a large portion of teenagers take AAS throughout adolescence at a time when the brain is still developing and highly hormone-sensitive [16–18].”
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“Puberty in many species involves reduced sensitivity of the hypothalamo-pituitary axis to steroid negative feedback [3–5, 29].”
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Pangelinan, M. M., Leonard, G. T., Perron, M., Pike, G. B., Richer, L., Veillette, S., Pausová, Z., & Paus, T. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0956-9 · Cited by 31
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“The onset of puberty is marked by hormonal changes directed by neuronal signals that result in activation of the hypothalamic-pituitary-gonadal axis and reproductive maturity [30].”
BackgroundKiSS‐1: A Likely Candidate for the Photoperiodic Control of Reproduction in Seasonal Breeders
Revel, F. G., Saboureau, M., Masson‐Pévet, M., Pévet, P., Mikkelsen, J. D., & Simonneaux, V. (2006) · Chronobiology International · doi:10.1080/07420520500521939 · Cited by 31
“In most mammals, the HPG axis experiences episodes of activation/inactivation throughout lifetime; it is transiently activated around birth and then becomes quiescent until puberty, when GnRH secretion increases again to stimulate final gonadal maturation (Sisk and Foster, 2004).”
BackgroundGlucocorticoids and the Development of Agonistic Behaviour during Puberty in Male Golden Hamsters
Wommack, J. C., Salinas, A. G., & Delville, Y. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01369.x · Cited by 31
“The lack of involvement of the gonadal steroids in pubertal changes in behaviour has led some authors to hypothesise that these maturational processes are regulated by nonsteroidal mechanisms ( 32 ).”
BackgroundKisspeptin and neurokinin B: roles in reproductive health
Koysombat, K., Tsoutsouki, J., Patel, A., Comninos, A. N., Dhillo, W. S., & Abbara, A. (2025) · Physiological Reviews · doi:10.1152/physrev.00015.2024 · Cited by 39
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“These two time points are critical to the development of neurological disorders and particularly susceptible to disturbances from the environment (Bale et al., 2010; Holder and Blaustein, 2014; Rice and Barone, 2000; Roth and Sweatt, 2010; Schneider, 2013; Sisk and Foster, 2004).”
BackgroundReview: Puberty as a time of remodeling the adult response to ovarian hormones
Blaustein, J. D., Ismail, N., & Holder, M. K. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.05.007 · Cited by 30
“Puberty refers to the developmental transition to a mature, reproductive state, while adolescence, a period of development distinct from puberty, refers to social and cognitive maturation that accompanies the reproductive maturation (4;5).”
BackgroundCircadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge
Tonsfeldt, K. J., Mellon, P. L., & Hoffmann, H. M. (2021) · Endocrinology · doi:10.1210/endocr/bqab268 · Cited by 36
Gonadectomy increases neurogenesis in the male adolescent rhesus macaque hippocampus
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Fujiwara, M., Aoyama, I., Hino, T., Teramoto, T., & Ishihara, T. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.058 · Cited by 30
Palomo, P., Borrego, A., Cebolla, A., Lloréns, R., Demarzo, M., & Baños, R. (2017) · Consciousness and Cognition · doi:10.1016/j.concog.2017.10.014 · Cited by 31
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Lane, P. H. (2005) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2005.07.009 · Cited by 29
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Genc, S., Raven, E. P., Drakesmith, M., Blakemore, S., & Jones, D. K. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac515 · Cited by 31
“Sex steroid hormones can cross the blood–brain barrier and act as trophic factors impacting the development of axons and supporting cells in the brain (Sisk and Foster 2004).”
Backgroundvan Batenburg‐Eddes, T., & Jolles, J. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00673 · Cited by 28
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“Pubertal maturation, which contributes to DAergic changes in adolescence (Kuhn et al., 2010; Ladouceur et al., 2019; Sárvári et al., 2014; Sisk and Foster, 2004; Sisk and Zehr, 2005) and the development of inhibitory control networks (Bramen et al.”
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“In fact, adolescence is a developmental period across species where the mere presence of peers affects decision-making processes (Sisk and Foster, 2004; Sato et al. , 2008; Spear, 2009).”
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“In vertebrates, GnRH neurons control reproduction by directing the activity of the HPG axis through the integration of a multitude of external and internal stimuli 20 .”
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“During puberty, the hippocampus undergoes significant dendritic pruning and reorganization [43, 44] that plays a critical role in regulating cognitive and affective behavior in adulthood [35, 45].”
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“However, our understanding of the detailed regulatory mechanism of the timing of puberty is still far from complete (Sisk & Foster 2004).”
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“Introduction Puberty is a period of brain remodeling by sex steroid hormones, as animals develop reproductive maturity (Levitt, 2003;Schulz et al., 2009;Sisk and Foster, 2004).”
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“During critical stages of development, structural and functional neuronal circuits that follow sexspecific spatiotemporal patterns are built (Casey and Jones, 2010) and it has been proposed that disturbances of this maturational process might cause abnormal behavioral and cognitive function in later life (Sisk and Fos…”
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“…tremendous changes in social reasoning and susceptibility to social influences, and develop a greater capacity for impulse control and mature social reasoning (Sisk & Foster, 2004; Steinberg, 2004, 2010; Steinberg, Albert, Cauffman, Banich, Graham, & Woolard, 2008; Steinberg, & Monahan, 2007).”
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Adolescent TBI‐induced hypopituitarism causes sexual dysfunction in adult male rats
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Pathology or Normal Variant: What Constitutes a Delay in Puberty?
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“The substantial neural and behavioral development that occurs during adolescence (Sisk & Foster, 2004; Spear, 2000) likely modulates the effects of drugs of abuse taken during this time (Anderson, Bari, & Pierce, 2003).”
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Mindfulness training enhances students’ executive functioning and social emotional skills
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“Pathways that are not reinforced are “pruned” during this critical developmental stage (Sisk & Foster, 2004).”
Lye, M.-S., Krishnarajah, I., & Jahanfar, S. (2013) · Indian journal of human genetics · doi:10.4103/0971-6866.116127 · Cited by 26
“[29,30] Early age of menarche is therefore introduced as a life predictor of breast cancer risk.”
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Steroidogenic Factor 1 and the Central Nervous System
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Molecular causes of hypogonadotropic hypogonadism
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“Elevated circulating concentrations of testosterone resulting from gonadal maturation have enduring effects on brain morphology and activate neural pathways involved in the control of male sexual behavior (Balthazart, et al., 2004; Schulz and Sisk, 2006; Sisk and Foster, 2004).”
BackgroundKang, S., Wu, M. M., Galvez, R., & Gulley, J. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.044 · Cited by 29
“Rat adolescence also involves numerous neural and behavioral changes that are noted as early as P28 and are similar to those seen in humans (Sisk and Foster, 2004; Spear, 2011).”
BackgroundEffect of LPS treatment on tyrosine hydroxylase expression and Parkinson-like behaviors
Girard-Joyal, O., & Ismail, N. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.12.009 · Cited by 28
“While adolescence is characterized by the social, emotional, cognitive, and behavioral changes from childhood to adulthood (Schneider, 2008; Sisk and Foster, 2004; Spear, 2000), puberty is a short period within adolescence and it represents an organism's transition from a non-reproductive to a reproductive state (Perf…”
BackgroundTakahashi, A., Islam, M. S., Abe, H., Okubo, K., Akazome, Y., Kaneko, T., Hioki, H., & Oka, Y. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23883 · Cited by 26
“GnRH peptides, released from GnRH neurons in the hypothalamus (hypothalamic GnRH neurons), act on pituitary gonadotropes and stimulate the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (Sisk and Foster, 2004).”
BackgroundConstantin, S., & Wray, S. (2008) · Endocrinology · doi:10.1210/en.2007-1508 · Cited by 26
“GnRH-1 can be regulated by external and internal cues (17).”
BackgroundA Comparative, Developmental, and Clinical Perspective of Neurobehavioral Sexual Dimorphisms
Viveros, M., Mendrek, A., Paus, T., López-Rodríguez, A. B., Marco, E. M., Yehuda, R., Cohen, H., Lehrner, A. L., & Wagner, E. J. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00084 · Cited by 26
“But as pointed out by others, adolescence does not equal puberty: “puberty refers to the activation of the hypothalamic-pituitary-gonadal axis that culminates in gonadal maturation” while “adolescence refers to the maturation of adult social and cognitive behaviors” (Sisk and Foster, 2004).”
BackgroundThe journey through the world of adolescent sleep
Darchia, N., & Červená, K. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0065 · Cited by 28
“Gonadal maturation and behavioral maturation are closely interrelated processes, and the end point of these two processes is the mature adult with reproductive capabilities (Sisk and Foster, 2004; Blakemore et al., 2010).”
BackgroundInfluentialSexual Differentiation of Brain and Behavior
McCarthy, M. M. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10017-4 · Cited by 25
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López-Ojeda, W., & Hurley, R. A. (2021) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20100269 · Cited by 24
“These take place subsequent to the remodeling of cortical and limbic system neuroanatomical structures (27 – 29).”
The development of sensorimotor cortical oscillations is mediated by pubertal testosterone
Fung, M. H., Heinrichs‐Graham, E., Taylor, B. K., Frenzel, M. R., Eastman, J. A., Wang, Y., Calhoun, V. D., Stephen, J. M., & Wilson, T. W. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119745 · Cited by 25
“Introduction The pubertal period of development consists of many physiologial changes, including increased production of the sex steroids testoserone and estradiol, which facilitate sex-specific developmental proesses ( Sisk and Foster, 2004 ).”
BackgroundNeurokinin B signaling in puberty: Human and animal studies
Topaloglu, A. K. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.020 · Cited by 25
“The timing of gonadal ctivation is conceptualized to be determined by an elusive develpmental clock whose signals integrate with internal and external ues to modulate “a passive downstream mechanism governing nRH synthesis and release” (Sisk and Foster, 2004).”
Androgen Physiology, Pharmacology, and Abuse
Handelsman, D. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00137-4 · Cited by 26
Neuroendocrine regulation of puberty in fish: Insights from the grey mullet (Mugil cephalus) model
Nocillado, J. N., & Elizur, A. (2007) · Molecular Reproduction and Development · doi:10.1002/mrd.20744 · Cited by 25
Kentner, A. C., Lima, E., Migliore, M. M., Shin, J., & Scalia, S. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.035 · Cited by 23
Cortisol changes in healthy children and adolescents during the COVID-19 pandemic
Fung, M. H., Taylor, B. K., Embury, C. M., Spooner, R. K., Johnson, H. J., Willett, M. P., Frenzel, M. R., Badura-Brack, A. S., White, S. F., & Wilson, T. W. (2022) · Stress · doi:10.1080/10253890.2022.2125798 · Cited by 27
“Adolescence is a unique period of social and cognitive behavioral maturation (Sisk & Foster, 2004).”
BackgroundWommack, J. C., & Delville, Y. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.11.007 · Cited by 24
Scents of Adolescence: The Maturation of the Olfactory Phenotype in a Free-Ranging Mammal
Caspers, B. A., Schroeder, F. C., Franke, S., & Voigt, C. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021162 · Cited by 24
“This process of maturation extends well beyond morphological and physiological changes [1], and also includes the olfactory phenotype [2].”
BackgroundO’Leary, J. D., Kozareva, D. A., Hueston, C. M., O’Leary, O. F., Cryan, J. F., & Nolan, Y. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.022 · Cited by 24
“The mammalian brain continues to develop after birth, throughout childhood and into adulthood [16, 17].”
BackgroundEffect of Overcrowding on Hair Corticosterone Concentrations in Juvenile Male Wistar Rats.
Uarquin, D. G., Meyer, J. S., Cárdenas, F. P., & Rojas, M. J. (2016) · PubMed Central · Cited by 24
Ashrap, P., Meeker, J. D., Sánchez, B. N., Basu, N., Tamayo‐Ortiz, M., Solano-González, M., Mercado‐García, A., Téllez‐Rojo, M. M., Peterson, K. E., & Watkins, D. J. (2020) · Environmental Health · doi:10.1186/s12940-020-00672-0 · Cited by 24
Early-Life Experiences: Enduring Behavioral, Neurological, and Endocrinological Consequences
Romeo, R. D., Tang, A. C., & Sullivan, R. M. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00062-0 · Cited by 25
“While puberty has long been regarded as a period of rapid physical growth and reproductive maturation, more recently it is also regarded as an additional critical period of neurobehavioral developmental vulnerabilities (Andersen, 2003; Dahl, 2004; Kleinert, 2007; Patton and Viner, 2007; Romeo, 2003; Sisk and Foster, 2…”
BackgroundSubramaniam, M., Vaingankar, J. A., Tan, B., Abdin, E., Chang, S. H. S., Tan, Y., Samari, E., Archana, S., Chua, Y., Lee, J., et al. (2025) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2025.104405 · Cited by 27
Approche neuroéconomique de la prise de risque à l’adolescence
Barbalat, G., Domenech, P., Vernet, M., & Fourneret, P. (2009) · L Encéphale · doi:10.1016/j.encep.2009.06.004 · Cited by 29
Nutritional status affects the microRNA profile of the hypothalamus of female sheep
Yang, H., Lin, S., Lei, X., Yuan, C., Yu, Y., Zhao, Z., & Chen, J. (2018) · Reproduction Fertility and Development · doi:10.1071/rd17179 · Cited by 23
Labouesse, M. A., Polesel, M., Clementi, E., Müller, F., Markkanen, E., Mouttet, F., Cattaneo, A., & Richetto, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-26631-x · Cited by 24
Ranjan, A. K., Choubey, M., Yada, T., & Krishna, A. (2019) · Journal of Molecular Histology · doi:10.1007/s10735-019-09846-8 · Cited by 23
Distinctions between sex and time in patterns of DNA methylation across puberty
Moore, S. R., Humphreys, K. L., Colich, N. L., Davis, E., Lin, D. T. S., MacIsaac, J. L., Kobor, M. S., & Gotlib, I. H. (2020) · BMC Genomics · doi:10.1186/s12864-020-06789-3 · Cited by 25
ERα Signaling in GHRH/Kiss1 Dual-Phenotype Neurons Plays Sex-Specific Roles in Growth and Puberty
García-Galiano, D., Cara, A. L., Tata, Z., Allen, S. J., Myers, M. G., Schipani, E., & Elias, C. F. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2069-20.2020 · Cited by 24
Physical maturation, peer environment, and the ontogenesis of substance use disorders
Kirillova, G. P., Vanyukov, M. M., Kirisci, L., & Reynolds, M. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.02.017 · Cited by 23
“In this research, we did not concurrently study the role of other hormones and numerous factors that contribute to pubertal development and brain remodeling in adolescence, forming basis for behavior regulation involved in CD and SUD risk (Sisk and Foster, 2004).”
BackgroundInhibitory Control and Drug Abuse Prevention
Bardo, M. T., Fishbein, D. H., & Milich, R. S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1268-8 · Cited by 66
O’Donoghue, S., Green, T., ROSS, J. L., Hallmayer, J. F., Lin, X., Jo, B., Huffman, L. C., Hong, D. S., & Reiss, A. L. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.032 · Cited by 23
“Based on animal studies, it has been posited that a second restructuring occurs during pubertal “hormonal events” (25, 43), where sex steroid hormones have been related to restructuring of the visual cortex in animals (44).”
BackgroundOlivares, E. L., da Silveira, A. L. B., Fonseca, F. V., Almeida, C. D. S., Côrtes, R. S., Pereira-Junior, P. P., Nascimento, J. H. M., & Reis, L. C. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.12.006 · Cited by 23
Adolescence, créativité et transformation de Soi
Barbot, B., & Lubart, T. (2012) · Enfance · doi:10.4074/s0013754512003059 · Cited by 33
on behalf of the Partners Demonstration Project Team, Musinguzi, N., Kidoguchi, L., Mugo, N., Ngure, K., Katabira, E. T., Celum, C., Baeten, J. M., Heffron, R. A., & Haberer, J. E. (2020) · BMC Public Health · doi:10.1186/s12889-020-09712-3 · Cited by 22
The social modulation of behavioural development
Sachser, N., & Kaiser, S. (2010) · Springer eBooks · doi:10.1007/978-3-642-02624-9_17 · Cited by 22
Dalmida, S. G., Aduloju-Ajijola, N., Clayton-Jones, D. L., Thomas, T. L., Erazo-Toscano, R., Lewis, R., Fleming, T., Taylor, S., & Lunyong, M. (2016) · Journal of Transcultural Nursing · doi:10.1177/1043659616678660 · Cited by 23
“Changes in social information processing network connectivity may contribute to increased sexual motivation (Sisk & Foster, 2004) and sexuality, increased peer orientation, and decreased parent/family orientation, but the details of these changes and effects remain poorly understood (Nelson,…”
BackgroundDevelopment of the Stress Axis: Maternal and Environmental Influences
Walker, C., & McCormick, C. M. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00061-9 · Cited by 23
Neurobiology of resilience to early life stress
Torres‐Berrío, A., Bortolami, A., Peña, C. J., & Nestler, E. J. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02158-4 · Cited by 24
Trova, S., Bovetti, S., Bonzano, S., Marchis, S. D., & Peretto, P. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157984 · Cited by 23
“these hormones significantly rise at the onset of puberty [39–42], and in parallel, sex-specific morphological traits and behaviors start to appear [34].”
BackgroundEndocannabinoid system contributions to sex-specific adolescent neurodevelopment
Simone, J. J., Green, M. R., & McCormick, C. M. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110438 · Cited by 25
The impact of pubertal DHEA on the development of visuospatial oscillatory dynamics
Fung, M. H., Rahman, R. L., Taylor, B. K., Frenzel, M. R., Eastman, J. A., Wang, Y., Calhoun, V. D., Stephen, J. M., & Wilson, T. W. (2022) · Human Brain Mapping · doi:10.1002/hbm.25991 · Cited by 20
“…in the synthesis of testosterone and estradiol, hormones that characteristically rise later in adolescence to uniquely facilitate sexually dimorphic patterns of development during gonadarche (Blakemore et al., 2010; Nguyen et al., 2013; Reman & Carr, 2004; Sisk & Foster, 2004; Witte et al., 2010).”
BackgroundMuscatello, R. A., Rafatjoo, E., Mirpuri, K. K., Kim, A., Vandekar, S., & Corbett, B. A. (2022) · Molecular Autism · doi:10.1186/s13229-022-00515-4 · Cited by 23
“While often used interchangeably in describing adolescence, puberty uniquely refers to biological maturation, particularly that of sexual systems, and the physiological effects of resultant changes to the endocrine system, including activation of the HPG axis [5].”
Background
Metadata
- Authors
- Sisk, C. L., & Foster, D. L.
- Affiliations
- Michigan State University (US)
- University of Michigan (US)
- Corresponding author
- Sisk, Cheryl L
- ORCID
- Sisk, Cheryl L
- Venue
- Nature Neuroscience
- Published
- 2004-09-27
- Volume
- 7
- Issue
- 10
- Pages
- 1040-1047
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2094109313
- Cited by
- 1,085
- References
- 109
- Citations by year
- 2026: 40 · 2025: 37 · 2024: 50 · 2023: 46 · 2022: 60 · 2021: 58 · 2020: 59 · 2019: 50 · 2018: 75 · 2017: 43 · 2016: 59 · 2015: 62 · 2014: 56 · 2013: 74 · 2012: 57
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- puberty, adolescence, GnRH neurons, steroid hormones, adolescent brain development, sexual motivation, sexual behavior, reproductive maturation, neural circuits, gonadal maturation
- MeSH terms
- Adolescent, Animals, Biological Clocks, Brain, Gonads, Humans, Hypothalamo-Hypophyseal System, Gonadotropin-Releasing Hormone, Puberty, Sexual Behavior, Sex Characteristics, Sexual Maturation
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