A functional link between area MSTd and heading perception based on vestibular signals
Open accessAbstract
Recent findings of vestibular responses in part of the visual cortex--the dorsal medial superior temporal area (MSTd)--indicate that vestibular signals might contribute to cortical processes that mediate the perception of self-motion. We tested this hypothesis in monkeys trained to perform a fine heading discrimination task solely on the basis of inertial motion cues. The sensitivity of the neuronal responses was typically lower than that of psychophysical performance, and only the most sensitive neurons rivaled behavioral performance. Responses recorded in MSTd were significantly correlated with perceptual decisions, and the correlations were strongest for the most sensitive neurons. These results support a functional link between MSTd and heading perception based on inertial motion cues. These cues seem mainly to be of vestibular origin, as labyrinthectomy produced a marked elevation of psychophysical thresholds and abolished MSTd responses. This study provides evidence that links single-unit activity to spatial perception mediated by vestibular signals, and supports the idea that the role of MSTd in self-motion perception extends beyond optic flow processing.
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Vestibular and visual signals are combined in macaque MSTd.
“Neurophysiological work in macaque monkeys indicates that vestibular and visual signals are combined on the dorsal subdivision of the medial superior temporal area (MSTd) (6–11) and in the ventral intraparietal area (VIP) (12, 13).”
From How multisensory neurons solve causal inference. (2021) · cites this paper as [7]
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“The hypothesis that MSTd contributes to the non-visual perception of heading is supported by recent findings that MSTd neurons show directional tuning in the absence of visual stimulation, presumably reflecting vestibular input”
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Self-citationNeural correlates of reliability-based cue weighting during multisensory integration
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InfluentialThe vestibular system: a spatial reference for bodily self-consciousness.
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Sulpizio, V., Strappini, F., Fattori, P., Galati, G., Galletti, C., Pecchinenda, A., & Pitzalis, S. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02549-z · Cited by 12 · see citing works
- Authors
- Gu, Y., DeAngelis, G. C., & Angelaki, D. E.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Angelaki, Dora E
- Venue
- Nature Neuroscience
- Published
- 2007-07-08
- Volume
- 10
- Issue
- 8
- Pages
- 1038-1047
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2430983
- OpenAlex
- W2125690951
- Cited by
- 297
- References
- 2
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 8 · 2021: 14 · 2020: 18 · 2019: 11 · 2018: 17 · 2017: 12 · 2016: 11 · 2015: 17 · 2014: 20 · 2013: 22 · 2012: 21
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY017866, EY-017866, EY-016178, R01EY016178)
- National Institute on Deafness and Other Communication Disorders (DC04260., R01DC004260)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Keywords
- heading perception, self-motion perception, vestibular signals, single-unit activity, visual cortex, labyrinthectomy, perceptual decision making, optical flow, spatial perception
- MeSH terms
- Action Potentials, Animals, Choice Behavior, Discrimination, Psychological, Eye Movements, Labyrinth Diseases, Macaca mulatta, Male, Motion Perception, Orientation, Photic Stimulation, Psychophysics, Reaction Time, Temporal Lobe, Vestibule, Labyrinth, Head Movements, Dominance, Ocular
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