ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143

Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623

ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors

Boillée, S., Velde, C. V., & Cleveland, D. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.018 · Cited by 1,476

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Dorpe, J. V., Hellings, P., Gorselink, M., Heymans, S., et al. (2001) · Nature Genetics · doi:10.1038/88842 · Cited by 1,007

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

Lambrechts, D., Storkebaum, E., Morimoto, M., Del‐Favero, J., Smet, F. D., Marklund, S. L., Wyns, S., Thijs, V., Andersson, J., van Marion, I., et al. (2003) · Nature Genetics · doi:10.1038/ng1211 · Cited by 853

Neurovascular mechanisms of Alzheimer's neurodegeneration

Zlokovic, B. V. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.02.001 · Cited by 770

Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF

Pun, S., Santos, A. F., Saxena, S., Xu, L., & Caroni, P. (2006) · Nature Neuroscience · doi:10.1038/nn1653 · Cited by 689

Axonal damage markers in cerebrospinal fluid are increased in ALS

Brettschneider, J., Petzold, A., Süßmuth, S. D., Ludolph, A. C., & Tumani, H. (2006) · Neurology · doi:10.1212/01.wnl.0000203120.85850.54 · Cited by 261

Evidence of Compromised Blood-Spinal Cord Barrier in Early and Late Symptomatic SOD1 Mice Modeling ALS

Garbuzova-Davis, S. N., Saporta, S., Haller, E. M., Kolomey, I., Bennett, S. P., Potter, H., & Sanberg, P. R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001205 · Cited by 253

Ultrastructure of blood–brain barrier and blood–spinal cord barrier in SOD1 mice modeling ALS

Garbuzova-Davis, S., Haller, E., Saporta, S., Kolomey, I., Nicosia, S. V., & Sanberg, P. R. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.044 · Cited by 239

Reduction of Circulating Endothelial Cells in Peripheral Blood of ALS Patients

Garbuzova-Davis, S. N., Woods, R. L., Louis, M. K., Zesiewicz, T. A., Kuzmin‐Nichols, N., Sullivan, K. L., Miller, A. M., Hernandez‐Ontiveros, D. G., & Sanberg, P. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010614 · Cited by 41

Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALS

Alami, N. O., Tang, L., Wiesner, D., Commisso, B., Bayer, D., Weishaupt, J. H., Dupuis, L., Wong, P. C., Baumann, B., Wirth, T., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.201900571 · Cited by 40

Implications of blood-brain barrier disruption in ALS

Garbuzova-Davis, S. N., Saporta, S., & Sanberg, P. R. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960802160990 · Cited by 39

Brain-Gut-Microbiota Axis in Amyotrophic Lateral Sclerosis: A Historical Overview and Future Directions

Chen, S., Cai, X., Lao, L., Wang, Y., Su, H., & Sun, H. (2024) · Aging and Disease · doi:10.14336/ad.2023.0524 · Cited by 40

Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway

Rand, D., Ravid, O., Atrakchi, D., Israelov, H., Bresler, Y., Shemesh, C., Omesi, L., Zaltsman, S. L., Gosselet, F., Maskrey, T. S., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030311 · Cited by 39

Multiple systemic transplantations of human amniotic mesenchymal stem cells exert therapeutic effects in an ALS mouse model

Sun, H., Hou, Z., Yang, H., Meng, M., Li, P., Zou, Q., Yang, L., Chen, Y., Chai, H., Zhong, H., et al. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1903-z · Cited by 38

Low Serum Superoxide Dismutase Is Associated With a High Risk of Cognitive Impairment After Mild Acute Ischemic Stroke

Zhang, M., Liang, J.-H., Yang, M., Ren, Y., Cheng, D., Wu, Q., He, Y., & Yin, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.834114 · Cited by 37

T 2 -Weighted MRI Detects Presymptomatic Pathology in the SOD1 Mouse Model of ALS

Evans, M. C., Serres, S., Khrapitchev, A. A., Stolp, H. B., Anthony, D. C., Talbot, K., Turner, M. R., & Sibson, N. R. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.19 · Cited by 37

ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis

Tanaka, H., Shimazawa, M., Takata, M., Kaneko, H., Tsuruma, K., Ikeda, T., Warita, H., Aoki, M., Yamada, M., Takahashi, H., et al. (2013) · Journal of Neurology · doi:10.1007/s00415-013-6877-3 · Cited by 37

Synaptic Failure: Focus in an Integrative View of ALS

Casas, C., Manzano, R., Vaz, A. R., Osta, R., & Brites, D. M. T. O. (2015) · Brain Plasticity · doi:10.3233/bpl-140001 · Cited by 39

Defining novel functions for cerebrospinal fluid in ALS pathophysiology

Kwong, K. C. N. K., Mehta, A. R., Nedergaard, M., & Chandran, S. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01018-0 · Cited by 41

Neural Induction with Neurogenin 1 Enhances the Therapeutic Potential of Mesenchymal Stem Cells in an Amyotrophic Lateral Sclerosis Mouse Model

Choi, C., Lee, Y., Kim, H., Kim, S. H., Kim, S., & Kim, S. (2013) · Cell Transplantation · doi:10.3727/096368912x637019 · Cited by 36

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls

Zhao, W., Beers, D. R., Thonhoff, J. R., Thome, A. D., Faridar, A., Wang, J., Wen, S., Ornelas, L., Sareen, D., Goodridge, H. S., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101192 · Cited by 40

Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis

Laferrière, F., & Polymenidou, M. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14054 · Cited by 43

Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone

Fidler, J. A., Treleaven, C. M., Frakes, A., Tamsett, T. J., McCrate, M., Cheng, S. H., Shihabuddin, L. S., Kaspar, B. K., & Dodge, J. C. (2011) · The FASEB Journal · doi:10.1096/fj.11-190819 · Cited by 39

Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies

Mohamed, L. A., Markandaiah, S. S., Bonanno, S., Pasinelli, P., & Trotti, D. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0120-6 · Cited by 35

In vivo assessment of retinal vessel pathology in amyotrophic lateral sclerosis

Abdelhak, A., Hübers, A., Böhm, K., Ludolph, A. C., Kassubek, J., & Pinkhardt, E. H. (2018) · Journal of Neurology · doi:10.1007/s00415-018-8787-x · Cited by 36

Imaging cellular markers of neuroinflammation in the brain of the rat model of amyotrophic lateral sclerosis

Bataveljić, D., Stamenković, S., Bačić, G., & Andjus, P. (2011) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.98.2011.1.4 · Cited by 38

The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease

Ehtezazi, T., Rahman, K., Davies, R., & Leach, A. G. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220071 · Cited by 37

Unraveling the Complexity of Amyotrophic Lateral Sclerosis: Recent Advances from the Transgenic Mutant SOD1 Mice

Peviani, M., Caron, I., Pizzasegola, C., Gensano, F., Tortarolo, M., & Bendotti, C. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791556096 · Cited by 34

Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury

Salvany, S., Casanovas, A., Piedrafita, L., Tarabal, O., Hernández, S., Calderó, J., & Esquerda, J. E. (2021) · Glia · doi:10.1002/glia.23959 · Cited by 36

Breached Barriers: A Scoping Review of Blood-Central Nervous System Barrier Pathology in Amyotrophic Lateral Sclerosis

Mirian, A., Moszczynski, A. J., Soleimani, S., Aubert, I., Zinman, L. H., & Abrahão, A. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.851563 · Cited by 31

Discrete mitochondrial aberrations in the spinal cord of sporadic ALS patients

Delic, V., Kurien, C., Cruz, J., Zivkovic, S., Barretta, J., Thomson, A., Hennessey, D., Joseph, J., Ehrhart, J. C., Willing, A. E., et al. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24249 · Cited by 34

Decreased signalling of EphA4 improves functional performance and motor neuron survival in the SOD1G93A ALS mouse model

Zhao, J., Cooper, L. T., Boyd, A., & Bartlett, P. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-29845-1 · Cited by 33

Retinal Damage in Amyotrophic Lateral Sclerosis: Underlying Mechanisms

Soldatov, V. O., Kukharsky, M. S., Белых, А. Е., Sobolev, A., & Deykin, A. V. (2021) · Eye and Brain · doi:10.2147/eb.s299423 · Cited by 35

Optimization of Immunosuppressive Therapy for Spinal Grafting of Human Spinal Stem Cells in a Rat Model of ALS

Hefferan, M. P., Johe, K. K., Hazel, T. G., Feldman, E. L., Lunn, J. S., & Maršala, M. (2011) · Cell Transplantation · doi:10.3727/096368910x564553 · Cited by 32

Systemic Dental Pulp Stem Cell Secretome Therapy in a Mouse Model of Amyotrophic Lateral Sclerosis

Jun-mei, W., Zuzzio, K., & Walker, C. L. (2019) · Brain Sciences · doi:10.3390/brainsci9070165 · Cited by 33

Metalloproteinase alterations in the bone marrow of ALS patients

Bossolasco, P., Cova, L., Calzarossa, C., Servida, F., Mencacci, N. E., Onida, F., Polli, E. E., Deliliers, G. L., & Silani, V. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0584-7 · Cited by 32

Phosphorylated neurofilament heavy chain levels in paired plasma and CSF of amyotrophic lateral sclerosis

Li, S., Ren, Y., Zhu, W., Yang, F., Zhang, X., & Huang, X. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.05.062 · Cited by 32

Modeling Neurovascular Disorders and Therapeutic Outcomes with Human-Induced Pluripotent Stem Cells

Bosworth, A. M., Faley, S. L., Bellan, L. M., & Lippmann, E. S. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00087 · Cited by 32

Thrombin and the Coag-Inflammatory Nexus in Neurotrauma, ALS, and Other Neurodegenerative Disorders

Festoff, B. W., & Citron, B. A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00059 · Cited by 31

Leptin receptor deficiency induces early, transient and hyperglycaemia-independent blood-brain barrier dysfunction

Corem, N., Anzi, S., Gelb, S., & Ben‐Zvi, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-39230-1 · Cited by 31

Amyotrophic Lateral Sclerosis Overview

Siddique, N., & Siddique, T. (2015) · Europe PMC (PubMed Central) · Cited by 31

Amyotrophic lateral sclerosis immunoglobulins G enhance the mobility of Lysotracker-labelled vesicles in cultured rat astrocytes

Stenovec, M., Milosevic, M. M., Petrušić, V., Potokar, M., Stević, Z., Prebil, M., Kreft, M., Trkov, S., Anđjus, P. R., & Zorec, R. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02337.x · Cited by 31

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis

Watanabe-Matsumoto, S., Moriwaki, Y., Okuda, T., Ohara, S., Yamanaka, K., Abe, Y., Yasui, M., & Misawa, H. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.11.001 · Cited by 31

Astrocytes: Dissecting Their Diverse Roles in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Valori, C. F., Sulmona, C., Brambilla, L., & Rossi, D. (2023) · Cells · doi:10.3390/cells12111450 · Cited by 30

Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice

Sullivan, J. M., Bagnell, A. M., Alevy, J., Avila, E. M., Mihaljević, L., Saavedra-Rivera, P. C., Kong, L., Huh, J. S., McCray, B. A., Aisenberg, W. H., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk1358 · Cited by 29

Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS

Min, J.-H., Sarlus, H., & Harris, R. A. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1408159 · Cited by 31

Neurodegenerative diseases have genetic hallmarks of autoinflammatory disease

Richards, R. I., Robertson, S. A., & Kastner, D. L. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy139 · Cited by 27

The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis

Schweingruber, C., & Hedlund, E. (2022) · Biology · doi:10.3390/biology11081191 · Cited by 29

Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity

Schreiber, S., Bernal, J., Arndt, P., Schreiber, F., Müller, P., Morton, L., Braun-Dullaeus, R. C., Hernández, M. V., Duarte, R., Wardlaw, J. M., et al. (2023) · Cells · doi:10.3390/cells12060957 · Cited by 30

CSF profiles of angiogenic and inflammatory factors depend on the respiratory status of ALS patients

Moreau, C., Gosset, P., Danel-Brunaud, V., Lassalle, P., Degonne, B., Destée, A., Defebvre, L., & Devos, D. (2009) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960802651725 · Cited by 29

Blood-spinal cord barrier disruption in degenerative cervical myelopathy

Kim, H. W., Hu, Y. S., & Shea, G. K. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00463-y · Cited by 31

The potential roles of aquaporin 4 in amyotrophic lateral sclerosis

Zou, S., Lan, Y., Wang, H., Zhang, B., & Sun, Y. (2019) · Neurological Sciences · doi:10.1007/s10072-019-03877-5 · Cited by 28

Phenotypic characteristics of human bone marrow-derived endothelial progenitor cells in vitro support cell effectiveness for repair of the blood-spinal cord barrier in ALS

Garbuzova-Davis, S. N., Ehrhart, J. C., Mustafa, H., Llauget, A., Boccio, K. J., Sanberg, P. R., Appel, S. H., & Borlongan, C. V. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146428 · Cited by 28

Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration

Quaegebeur, A., & Carmeliet, P. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_83 · Cited by 27

Novel Molecular Biomarkers at the Blood-Brain Barrier in ALS

Bataveljić, D., Milosevic, M. M., Radenović, L., & Anđjus, P. R. (2014) · BioMed Research International · doi:10.1155/2014/907545 · Cited by 28

Transplantation of human bone marrow stem cells into symptomatic ALS mice enhances structural and functional blood-spinal cord barrier repair

Garbuzova-Davis, S. N., Haller, E. M., Navarro, S., Besong, T. E., Boccio, K. J., Hailu, S., Khatib, M., Sanberg, P. R., Appel, S. H., & Borlongan, C. V. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.012 · Cited by 28

The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases

Sharif, A., Mamo, J. C. L., Lam, V., Al‐Salami, H., Mooranian, A., Watts, G. F., Clarnette, R., Luna, G., & Takechi, R. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00398-w · Cited by 29

No evidence of microbleeds in ALS patients at 7 Tesla MRI

Verstraete, E., Biessels, G. J., van den Heuvel, M. P., Visser, F., Luijten, P. R., & van den Berg, L. H. (2010) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482968.2010.513053 · Cited by 26

Expression of the ALS-Causing Variant hSOD1 G93A Leads to an Impaired Integrity and Altered Regulation of Claudin-5 Expression in an in Vitro Blood–Spinal Cord Barrier Model

Meister, S., Storck, S. E., Hameister, E., Behl, C., Weggen, S., Clement, A. M., & Pietrzik, C. U. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.57 · Cited by 27

Self-assembling vascular endothelial growth factor nanoparticles improve function in spinocerebellar ataxia type 1

Hu, Y.-S., Do, J., Edamakanti, C. R., Kini, A. R., Martina, M., Stupp, S. I., & Opal, P. (2019) · Brain · doi:10.1093/brain/awy328 · Cited by 26

Reduction of microhemorrhages in the spinal cord of symptomatic ALS mice after intravenous human bone marrow stem cell transplantation accompanies repair of the blood-spinal cord barrier

Eve, D. J., Steiner, G. A., Mahendrasah, A., Sanberg, P. R., Kurien, C., Thomson, A., Borlongan, C. V., & Garbuzova-Davis, S. N. (2018) · Oncotarget · doi:10.18632/oncotarget.24360 · Cited by 26

Pleiotropic activity of systemically delivered angiogenin in the SOD1G93A mouse model

Crivello, M., O’Riordan, S. L., Woods, I., Cannon, S., Halang, L., Coughlan, K. S., Hogg, M. C., Lewandowski, S. A., & Prehn, J. H. M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.022 · Cited by 26

Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging

Gallego, I., Villate-Beitia, I., del Burgo, L. S., Puras, G., & Pedraz, J. L. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000418 · Cited by 26

Changes of gene expression profiles in the cervical spinal cord by acupuncture in an MPTP-intoxicated mouse model: Microarray analysis

Choi, Y., Yeo, S., Hong, Y., Kim, S., & Lim, S. (2011) · Gene · doi:10.1016/j.gene.2011.03.006 · Cited by 25

Superficial Siderosis Mimicking Amyotrophic Lateral Sclerosis

Driver‐Dunckley, E. D., Hoxworth, J. M., Patel, N. P., Bosch, E. P., & Goodman, B. P. (2010) · Journal of Clinical Neuromuscular Disease · doi:10.1097/cnd.0b013e3181ca3712 · Cited by 24

Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets

Ferraiuolo, L., & Maragakis, N. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135911 · Cited by 28

Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis

Jacob, S. M., Lee, S., Kim, S. H., Sharkey, K. A., Pfeffer, G., & Nguyen, M. D. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00991-7 · Cited by 25

Stem Cells in Amyotrophic Lateral Sclerosis: Motor Neuron Protection or Replacement?

Silani, V., Calzarossa, C., Cova, L., & Ticozzi, N. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791292666 · Cited by 24

Microcirculation of the brain: morphological assessment in degenerative diseases and restoration processes

Kolinko, Y., Krakorová, K., Cendelín, J., Tonar, Z., & Králíčková, M. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0049 · Cited by 28

Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation

Arribas, V., Onetti, Y., Ramiro‐Pareta, M., Villacampa, P., Beck, H., Alberola, M., Esteve‐Codina, A., Merkel, A., Sperandio, M., Martínez-Estrada, O. M., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.177819 · Cited by 21

Neurovascular unit pathology is observed very early in disease progression in the mutant SOD1G93A mouse model of amyotrophic lateral sclerosis

Yoshikawa, M., Aizawa, S., Oppenheim, R. W., & Milligan, C. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114084 · Cited by 22

Flow-metabolism uncoupling in the cervical spinal cord of ALS patients

Yamashita, T., Hatakeyama, T., Sato, K., Fukui, Y., Hishikawa, N., Ohta, Y., Nishiyama, Y., Kawai, N., Tamiya, T., & Abe, K. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2823-y · Cited by 23

VEGF up-regulation by G93A superoxide dismutase and the role of malate–aspartate shuttle inhibition

Mali, Y., & Zisapel, N. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.005 · Cited by 22

Detecting sub-voxel microvasculature with USPIO-enhanced susceptibility-weighted MRI at 7 T

Shen, Y., Hu, J., Eteer, K., Chen, Y., Buch, S., Alhourani, H., Shah, K., Jiang, Q., Ge, Y., & Haacke, E. M. (2020) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2019.12.010 · Cited by 22

Platelet-derived growth factor signalling in neurovascular function and disease

Li, S. Y., Johnson, R. H., Smyth, L. C. D., & Dragunow, M. (2022) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2022.106187 · Cited by 22

Blood brain barrier-on-a-chip to model neurological diseases

Reshma, S. C., Megha, K. B., Amir, S., Rukhiya, S., & Mohanan, P. V. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104174 · Cited by 23

Proteomics and mathematical modeling of longitudinal CSF differentiates fast versus slow ALS progression

Vu, L. T., Garcia‐Mansfield, K., Pompeiano, A., An, J., David‐Dirgo, V., Sharma, R., Venugopal, V., Halait, H., Marcucci, G., Kuo, Y., et al. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51890 · Cited by 22

Natural Compounds Used as Therapies Targeting to Amyotrophic Lateral Sclerosis

Nabavi, S. F., Daglia, M., D’Antona, G., Sobarzo‐Sánchez, E., Talas, Z., & Nabavi, S. F. (2015) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201016666150118132224 · Cited by 22

Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model

Crivello, M., Hogg, M. C., Jirström, E., Halang, L., Woods, I., Rayner, M., Coughlan, K. S., Lewandowski, S. A., & Prehn, J. H. M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040238 · Cited by 25

C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis

Lai, J. D., & Ichida, J. K. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134523 · Cited by 25

Contributions of Drug Transporters to Blood-Brain Barriers

Liu, L., & Liu, X. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7647-4_9 · Cited by 21

Hypercapnia is a Possible Determinant of the Function of the Blood-Cerebrospinal Fluid Barrier in Amyotrophic Lateral Sclerosis

Süßmuth, S. D., Sperfeld, A. D., Ludolph, A. C., & Tumani, H. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0156-9 · Cited by 21

A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery

Wasielewska, J. M., Chaves, J. C. S., Cabral-da-Silva, M. C., Pecoraro, M., Viljoen, S. J., Nguyen, T. H., Bella, V. L., Oikari, L. E., Ooi, L., & White, A. R. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00565-1 · Cited by 22

Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Liu, Z., Zhang, H., Lu, K., Chen, L., Zhang, Y., Xu, Z., Zhou, H., Sun, J., Xu, M., Ouyang, Q., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114660 · Cited by 20

Vascular damage in the central nervous system: a multifaceted role for vascular-derived TGF-β

Beck, K., & Schachtrup, K. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1228-0 · Cited by 20

Molecular Imaging of Brain Lipid Environment of Lymphocytes in Amyotrophic Lateral Sclerosis Using Magnetic Resonance Imaging and SECARS Microscopy

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Astrocytes in Motor Neuron Diseases

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Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model

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Elevated Cerebrospinal Fluid Proteins and Albumin Determine a Poor Prognosis for Spinal Amyotrophic Lateral Sclerosis

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Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases

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Defining Peripheral Nervous System Dysfunction in the SOD-1G93ATransgenic Rat Model of Amyotrophic Lateral Sclerosis

Riva, N., Chaabane, L., Peviani, M., Ungaro, D., Domi, T., Dina, G., Bianchi, F., Spano, G., Cerri, F., Podini, P., et al. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000081 · Cited by 21

Correlation of mRNA Expression and Signal Variability in Chronic Intracortical Electrodes

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ABC efflux transporters at blood-central nervous system barriers and their implications for treating spinal cord disorders

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Endothelial Tpl2 Regulates Vascular Barrier Function Via Tight Junction Protein Claudin-5 Promoting CNS Cell Infiltration and Tumor Metastasis

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Stem cells in amyotrophic lateral sclerosis: state of the art

Mazzini, L., Vercelli, A., Ferrero, I., Mareschi, K., Boido, M., Servo, S., Oggioni, G. D., Testa, L., Monaco, F., & Fagioli, F. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903186956 · Cited by 19

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A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models

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Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

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Feasibility of cell therapy for amyotrophic lateral sclerosis

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A possible haemodynamic mechanism for Amyotrophic Lateral Sclerosis

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Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells

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The Breakdown of Neurovascular Barriers: Molecular Mechanisms of Tight Junction Dysfunction

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ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis

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Effects of Acetyl-L-Carnitine on Oxidative Stress in Amyotrophic Lateral Sclerosis Patients: Evaluation on Plasma Markers and Members of the Neurovascular Unit

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Potential new complication in drug therapy development for amyotrophic lateral sclerosis

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Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis

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The level of homocysteine in amyotrophic lateral sclerosis: a systematic review and meta-analysis

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Immunological Aspects in Amyotrophic Lateral Sclerosis

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Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

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Blood-CNS Barrier Impairment in ALS patients versus an animal model

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Neurovascular unit pathology is observed very early in disease progression in the mutant SOD1G93A mouse model of amyotrophic lateral sclerosis

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Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1

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