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Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering
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Rapid progress in identifying disease biomarkers has increased the importance of creating high-performance detection technologies. Over the last decade, the design of many detection platforms has focused on either the nano or micro length scale. Here, we review recent strategies that combine nano- and microscale materials and devices to produce large improvements in detection sensitivity, speed and accuracy, allowing previously undetectable biomarkers to be identified in clinical samples. Microsensors that incorporate nanoscale features can now rapidly detect disease-related nucleic acids expressed in patient samples. New microdevices that separate large clinical samples into nanocompartments allow precise quantitation of analytes, and microfluidic systems that utilize nanoscale binding events can detect rare cancer cells in the bloodstream more accurately than before. These advances will lead to faster and more reliable clinical diagnostic devices.
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“These results highlight the unique advantages that these functionalized NPs possess for protein enrichment over antibody-based platforms: (a) comparable size and diffusion kinetics to proteins, promoting effective capture of low-abundance proteins within complex mixtures20,47,48; (b) high surface area per volume and high number of flexible binding sites, contributing to high ligand density and”
From Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum (2020) · cites this paper as [20]
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Cites
Chemistry and Properties of Nanocrystals of Different Shapes
Burda, C., Chen, X., Narayanan, R., & El-Sayed, M. A. (2005) · Chemical Reviews · doi:10.1021/cr030063a · Cited by 7,230
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Self-citationIsolation of rare circulating tumour cells in cancer patients by microchip technology
Nagrath, S., Sequist, L. V. D., Maheswaran, S., Bell, D. W., Irimia, D., Ulkus, L., Smith, M. R., Kwak, E. L., Digumarthy, S. R., Muzikansky, A., et al. (2007) · Nature · doi:10.1038/nature06385 · Cited by 3,595
Self-citationAllard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G. J., Uhr, J. W., & Terstappen, L. W. M. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0378 · Cited by 2,542
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476
Self-citationNanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins
Nam, J., Thaxton, C. S., & Mirkin, C. A. (2003) · Science · doi:10.1126/science.1088755 · Cited by 2,391
Self-citationMicrofluidic Large-Scale Integration
Thorsen, T., Maerkl, S. J., & Quake, S. R. (2002) · Science · doi:10.1126/science.1076996 · Cited by 2,265
Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214
Rissin, D. M., Kan, C. W., Campbell, T. G., Howes, S. C., Fournier, D. R., Song, L., Piech, T., Patel, P. P., Chang, L., Rivnak, A. J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1641 · Cited by 2,119
Self-citationNanoparticle-Based Bio-Barcodes for the Ultrasensitive Detection of Proteins*
Nam, J., Thaxton, C. S., & Mirkin, C. A. (2020) · Spherical Nucleic Acids · doi:10.1201/9781003056713-94 · Cited by 2,038
Self-citation
Cited by
Sorted by citations
Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules
Labib, M., Sargent, E. H., & Kelley, S. O. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00220 · Cited by 994
Self-citationA review on graphene-based nanocomposites for electrochemical and fluorescent biosensors
Krishnan, S. K., Singh, E. J., Singh, P., Meyyappan, M., & Nalwa, H. S. (2019) · RSC Advances · doi:10.1039/c8ra09577a · Cited by 798
Ultrasensitive surface-enhanced Raman scattering detection in common fluids
Yang, S., Dai, X., Stogin, B. B., & Wong, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518980113 · Cited by 703
Dai, Y., Somoza, R. A., Wang, L., Welter, J. F., Li, Y., Caplan, A. I., & Liu, C.-C. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201910772 · Cited by 667
Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip
Zhang, P., Zhou, X., He, M., Shang, Y., Tetlow, A. L., Godwin, A., & Zeng, Y. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0356-9 · Cited by 505
Recent progress on highly sensitive perovskite photodetectors
Miao, J., & Zhang, F. (2019) · Journal of Materials Chemistry C · doi:10.1039/c8tc06089d · Cited by 442
Lin, M., Song, P., Zhou, G., Zuo, X., Aldalbahi, A. K., Lou, X., Shi, J., & Fan, C. (2016) · Nature Protocols · doi:10.1038/nprot.2016.071 · Cited by 390
Highly Narrowband Photomultiplication Type Organic Photodetectors
Wang, W., Zhang, F., Du, M., Li, L., Zhang, M., Wang, K., Wang, Y., Hu, B., Fang, Y. Z., & Huang, J. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b05418 · Cited by 378
Advances in the Application of Magnetic Nanoparticles for Sensing
Gloag, L., Mehdipour, M., Chen, D., Tilley, R. D., & Gooding, J. J. (2019) · Advanced Materials · doi:10.1002/adma.201904385 · Cited by 368
Metal-Polydopamine Framework: An Innovative Signal-Generation Tag for Colorimetric Immunoassay
Ren, R., Cai, G., Yu, Z., Zeng, Y., & Tang, D. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03538 · Cited by 362
Chiu, D. T., deMello, A. J., Carlo, D. D., Doyle, P. S., Hansen, C. L., Maceiczyk, R. M., & Wootton, R. C. R. (2017) · Chem · doi:10.1016/j.chempr.2017.01.009 · Cited by 343
Challenges and Solutions in Developing Ultrasensitive Biosensors
Wu, Y., Tilley, R. D., & Gooding, J. J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b09397 · Cited by 307
Quantitative and Sensitive SERS Platform with Analyte Enrichment and Filtration Function
Ding, Q., Wang, J., Chen, X., Liu, H., Li, Q., Wang, Y., & Yang, S. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c02683 · Cited by 296
Rationally Engineered Nucleic Acid Architectures for Biosensing Applications
Xiao, M., Lai, W., Man, T., Chang, B., Li, L., Chandrasekaran, A. R., & Pei, H. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00121 · Cited by 291
Reaction–diffusion processes at the nano- and microscales
Epstein, I. R., & Xu, B. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.41 · Cited by 285
Recent Progress on Photomultiplication Type Organic Photodetectors
Miao, J., & Zhang, F. (2018) · Laser & Photonics Review · doi:10.1002/lpor.201800204 · Cited by 286
An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum
Das, J., Ivanov, I., Montermini, L., Rak, J. W., Sargent, E. H., & Kelley, S. O. (2015) · Nature Chemistry · doi:10.1038/nchem.2270 · Cited by 276
Self-citationConfined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells
Yu, R., Ying, Y., Gao, R., & Long, Y. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201803229 · Cited by 255
Artificial intelligence aids in development of nanomedicines for cancer management
Tan, P., Chen, X., Zhang, H., Wei, Q., & Luo, K. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.01.005 · Cited by 256
CRISPR Mediated Biosensing Toward Understanding Cellular Biology and Point‐of‐Care Diagnosis
Dai, Y., Wu, Y., Liu, G., & Gooding, J. J. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202005398 · Cited by 244
Recent advances in lab-on-a-chip for biosensing applications
Lafleur, J., Jönsson, A., Senkbeil, S., & Kutter, J. P. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.08.003 · Cited by 242
Liao, Z., Zhang, Y., Li, Y., Miao, Y., Gao, S., Lin, F., Deng, Y., & Geng, L. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.11.032 · Cited by 238
Pashchenko, O. I., Shelby, T., Banerjee, T., & Santra, S. (2018) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.8b00023 · Cited by 239
Biomolecular sensors for advanced physiological monitoring
Flynn, C. D., Chang, D., Mahmud, A., Yousefi, H., Das, J., Riordan, K. T., Sargent, E. H., & Kelley, S. O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00067-z · Cited by 226
Self-citationFuture cancer research priorities in the USA: a Lancet Oncology Commission
Jaffee, E. M., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., Barker, A. D., Bastani, R., Bhatia, S. N., Bluestone, J. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30698-8 · Cited by 212
DNA Clutch Probes for Circulating Tumor DNA Analysis
Das, J., Ivanov, I., Sargent, E. H., & Kelley, S. O. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b05679 · Cited by 206
Self-citationXi, J., Xie, C., Zhang, Y., Wang, L., Xiao, J. Z., Duan, X., Ren, J., Xiao, F., & Wang, S. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b05561 · Cited by 196
Xu, W., Jin, T., Dai, Y., & Liu, C.-C. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112100 · Cited by 195
Wang, W., Du, M., Zhang, M., Miao, J., Fang, Y. Z., & Zhang, F. (2018) · Advanced Optical Materials · doi:10.1002/adom.201800249 · Cited by 185
Tailored Graphitic Carbon Nitride Nanostructures: Synthesis, Modification, and Sensing Applications
Chen, L., & Song, J. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201702695 · Cited by 183
Mechanistic Challenges and Advantages of Biosensor Miniaturization into the Nanoscale
Soleymani, L., & Li, F. (2017) · ACS Sensors · doi:10.1021/acssensors.7b00069 · Cited by 177
Advances in biological applications of self-assembled DNA tetrahedral nanostructures
Li, S., Tian, T., Zhang, T., Cai, X., & Lin, Y. (2018) · Materials Today · doi:10.1016/j.mattod.2018.08.002 · Cited by 177
2D Nanomaterial-Based Surface Plasmon Resonance Sensors for Biosensing Applications
Singh, S., Singh, P. K., Umar, A., Lohia, P., Albargi, H. B., Castañeda, L., & Dwivedi, D. K. (2020) · Micromachines · doi:10.3390/mi11080779 · Cited by 176
Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles
Zhou, Y., Mohamadi, R. M., Poudineh, M., Kermanshah, L., Ahmed, S. U., Safaei, T. S., Stojcic, J., Nam, R. K., Sargent, E. H., & Kelley, S. O. (2015) · Small · doi:10.1002/smll.201502365 · Cited by 176
Self-citationSharafeldin, M., Bishop, G. W., Bhakta, S., El‐Sawy, A. M., Suib, S. L., & Rusling, J. F. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.12.052 · Cited by 170
Integrated Electrochemical Microsystems for Genetic Detection of Pathogens at the Point of Care
Hsieh, K., Ferguson, B. S., Eisenstein, M. S., Plaxco, K. W., & Soh, H. T. (2015) · Accounts of Chemical Research · doi:10.1021/ar500456w · Cited by 158
A Highly Sensitive Narrowband Nanocomposite Photodetector with Gain
Shen, L., Fang, Y., Wei, H., Yuan, Y., & Huang, J. (2016) · Advanced Materials · doi:10.1002/adma.201503774 · Cited by 156
Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework
Song, P., Shen, J., Ye, D., Dong, B., Wang, F., Pei, H., Wang, J., Shi, J., Wang, L., Xue, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14664-8 · Cited by 150
Li, C., Lu, J., Zhao, Y., Sun, L., Wang, G., Ma, Y., Zhang, S., Zhou, J., Shen, L., & Huang, W. (2019) · Small · doi:10.1002/smll.201903599 · Cited by 145
Zhang, P., Wu, X., Gardashova, G., Yang, Y., Zhang, Y., Xu, L., & Zeng, Y. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz2878 · Cited by 147
Direct DNA Analysis with Paper-Based Ion Concentration Polarization
Gong, M. M., Nosrati, R., Gabriel, M. C. S., Zini, A. S., & Sinton, D. A. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b08523 · Cited by 144
High‐Performance Near‐IR Photodetector Using Low‐Bandgap MA0.5FA0.5Pb0.5Sn0.5I3 Perovskite
Xu, X., Chueh, C., Jing, P., Yang, Z., Shi, X., Zhao, T., Lin, L. Y., & Jen, A. K. ‐. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201701053 · Cited by 140
Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes
Xia, Y., Zhang, R., Wang, Z., Tian, J., & Chen, X. S. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00675b · Cited by 139
Recent advances in microfluidic chip integrated electronic biosensors for multiplexed detection
Liao, Z., Wang, J., Zhang, P., Zhang, Y., Miao, Y., Gao, S., Deng, Y., & Geng, L. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.08.061 · Cited by 136
DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development
Ye, D., Zuo, X., & Fan, C. (2018) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061417-010007 · Cited by 134
Organic Photodetectors: Materials, Structures, and Challenges
Liu, J., Wang, Y., Wen, H., Bao, Q., Shen, L., & Ding, L. (2020) · Solar RRL · doi:10.1002/solr.202000139 · Cited by 134
Bhattacharjee, R., Tanaka, S., Moriam, S., Masud, M. K., Lin, J., Alshehri, S. M., Ahamad, T., Salunkhe, R. R., Nguyen, N., Yamauchi, Y., et al. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01132j · Cited by 134
Dai, Y., Somoza, R. A., Wang, L., Welter, J. F., Li, Y., Caplan, A. I., & Liu, C.-C. (2019) · Angewandte Chemie · doi:10.1002/ange.201910772 · Cited by 133
Photonic Crystal Microbubbles as Suspension Barcodes
Shang, L., Fu, F., Cheng, Y., Wang, H., Liu, Y., Zhao, Y., & Gu, Z. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b10612 · Cited by 131
Framework-Nucleic-Acid-Enabled Biosensor Development
Yang, F., Li, Q., Wang, L., Zhang, G., & Fan, C. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00257 · Cited by 131
Zhao, Y., Li, C., Jiang, J., Wang, B., & Shen, L. (2020) · Small · doi:10.1002/smll.202001534 · Cited by 130
Fu, K. X., Seo, J., Kesler, V., Maganzini, N., Wilson, B. D., Eisenstein, M. S., Murmann, B., & Soh, H. T. (2021) · Advanced Science · doi:10.1002/advs.202102495 · Cited by 129
Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine
Li, J., Baird, M. A., Davis, M. A., Tai, W., Zweifel, L. S., Waldorf, K. M. A., Gale, M., Rajagopal, L., Pierce, R. H., & Gao, X. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0082 · Cited by 132
SERS based point-of-care detection of food-borne pathogens
Mungroo, N. A., Oliveira, G. V., & Neethirajan, S. R. (2015) · Microchimica Acta · doi:10.1007/s00604-015-1698-y · Cited by 122
Mechano‐Based Transductive Sensing for Wearable Healthcare
Wang, T., Yang, H., Qi, D., Liu, Z., Cai, P., Zhang, H., & Chen, X. (2018) · Small · doi:10.1002/smll.201702933 · Cited by 121
Tang, C. K., Vaze, A., Shen, M., & Rusling, J. F. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00256 · Cited by 118
Zhao, Y., Yin, X., Li, P., Ren, Z., Gu, Z., Zhang, Y., & Song, Y. (2023) · Nano-Micro Letters · doi:10.1007/s40820-023-01161-y · Cited by 117
Li, T., Liu, L., Li, Y., Xie, J., & Wu, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201502047 · Cited by 115
Xu, Q., Yuan, H. S., Dong, X., Zhang, Y., Asif, M., Dong, Z., He, W., Ren, J., Sun, Y., & Xiao, F. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.02.026 · Cited by 113
Multiplex Immunosensor Arrays for Electrochemical Detection of Cancer Biomarker Proteins
Munge, B. S., Stracensky, T. S., Kathleen, G., DiBiase, D., & Rusling, J. F. (2016) · Electroanalysis · doi:10.1002/elan.201600183 · Cited by 112
Zhan, Y., Wang, Y., Cheng, Q., Li, C., Li, K., Li, H., Peng, J., Lü, B., Wang, Y., Song, Y., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908743 · Cited by 112
Digital immunoassay for biomarker concentration quantification using solid-state nanopores
He, L., Tessier, D. R., Briggs, K., Tsangaris, M., Charron, M., McConnell, E. M., Lomovtsev, D., & Tabard‐Cossa, V. (2021) · Nature Communications · doi:10.1038/s41467-021-25566-8 · Cited by 115
Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis
D’Agata, R., Giuffrida, M., & Spoto, G. (2017) · Molecules · doi:10.3390/molecules22111951 · Cited by 113
Lossless enrichment of trace analytes in levitating droplets for multiphase and multiplex detection
Chen, X., Ding, Q., Bi, C., Ruan, J., & Yang, S. (2022) · Nature Communications · doi:10.1038/s41467-022-35495-9 · Cited by 110
Díez, A. G., Rincón‐Iglesias, M., Lanceros-Méndez, S., Reguera, J., & Lizundia, E. (2022) · Materials Today Chemistry · doi:10.1016/j.mtchem.2022.101220 · Cited by 112
Valency‐Controlled Framework Nucleic Acid Signal Amplifiers
Liu, Q., Ge, Z., Mao, X., Zhou, G., Zuo, X., Shen, J., Shi, J., Li, J., Wang, L., Chen, X., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201802701 · Cited by 99
A fully-automated, six-plex single molecule immunoassay for measuring cytokines in blood
Rivnak, A. J., Rissin, D. M., Kan, C. W., Song, L., Fishburn, M. W., Piech, T., Campbell, T. G., DuPont, D. R., Gardel, M., Sullivan, S., et al. (2015) · Journal of Immunological Methods · doi:10.1016/j.jim.2015.04.017 · Cited by 98
Yang, F., Zuo, X., Fan, C., & Zhang, X. (2018) · National Science Review · doi:10.1093/nsr/nwx134 · Cited by 95
Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome
Gardner, L., Kostarelos, K., Mallick, P., Dive, C., & Hadjidemetriou, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00645-x · Cited by 96
Bruno, G., Trani, N. D., Hood, R. L., Zabre, E., Filgueira, C. S., Canavese, G., Jain, P., Smith, Z. W., Demarchi, D., Hosali, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04133-8 · Cited by 92
Ali, M. A., Hu, C., Yuan, B., Jahan, S., Saleh, M. S., Guo, Z., Gellman, A. J., & Panat, R. P. (2021) · Nature Communications · doi:10.1038/s41467-021-27361-x · Cited by 92
Liu, L., Lü, H., Shi, R., Peng, X., Xiang, Q., Wang, B., Wan, Q.-Q., Sun, Y., Yang, F., & Zhang, G. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03622 · Cited by 88
Li, X., Falcone, N., Hossain, M. N., Kraatz, H., Chen, X., & Huang, H. (2021) · Talanta · doi:10.1016/j.talanta.2021.122183 · Cited by 89
Huang, Q., Wang, Y., Chen, X., Wang, Y., Li, Z., Du, S., Wang, L., & Chen, S. (2017) · Nanotheranostics · doi:10.7150/ntno.22091 · Cited by 88
Tang, C. K., Vaze, A., & Rusling, J. F. (2017) · Lab on a Chip · doi:10.1039/c6lc01238h · Cited by 87
High‐Performance Nucleic Acid Sensors for Liquid Biopsy Applications
Das, J., & Kelley, S. O. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201905005 · Cited by 87
Self-citationSaleem, M. I., Kyaw, A. K. K., & Hur, J. (2024) · Advanced Optical Materials · doi:10.1002/adom.202401625 · Cited by 93
High-Curvature Nanostructuring Enhances Probe Display for Biomolecular Detection
Luna, P. D., Mahshid, S. S., Das, J., Luan, B., Sargent, E. H., Kelley, S. O., & Zhou, R. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b05153 · Cited by 84
Self-citationHuang, M., Gu, Z., Zhang, J., Zhang, D., Zhang, H., Yang, Z., & Qu, J. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00410g · Cited by 82
Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
Tiambeng, T. N., Roberts, D. S., Brown, K. A., Zhu, Y., Chen, B., Wu, Z., Mitchell, S. D., Guardado-Alvarez, T. M., Jin, S., & Ge, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-17643-1 · Cited by 76
Das, J., Ivanov, I., Safaei, T. S., Sargent, E. H., & Kelley, S. O. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201800455 · Cited by 77
Self-citationLi, Y., Xuan, J., Song, Y., Qi, W., He, B., Wang, P., & Qin, L. (2015) · ACS Nano · doi:10.1021/acsnano.5b07357 · Cited by 77
Passaes, C., Bruel, T., Decalf, J., David, A., Angin, M., Monceaux, V., Müller-Trutwin, M. C., Noël, N., Bourdic, K., Lambotte, O., et al. (2017) · Journal of Virology · doi:10.1128/jvi.02296-16 · Cited by 76
Kadimisetty, K., Malla, S., Bhalerao, K. S., Mosa, I. M., Bhakta, S., Lee, N. H., & Rusling, J. F. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01198 · Cited by 75
Strand Displacement Strategies for Biosensor Applications
Dai, Y., Furst, A. L., & Liu, C.-C. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.10.001 · Cited by 74
Qu, X., Yang, F., Chen, H., Li, J., Zhang, H., Zhang, G., Li, L., Wang, L., Song, S., Tian, Y., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03645 · Cited by 73
Biosensors for liquid biopsy: circulating nucleic acids to diagnose and treat cancer
Bellassai, N., & Spoto, G. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9806-3 · Cited by 71
The sustainability of emerging technologies for use in pharmaceutical manufacturing
Weaver, E., O’Hagan, C., & Lamprou, D. A. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2093857 · Cited by 70
“tion level can still be as sparse as parts per million (ppm) [88].”
BackgroundSun, D., Lü, J., Chen, D., Jiang, Y., Wang, Z., Qin, W., Yu, Y., Chen, Z., & Zhang, Y. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.04.142 · Cited by 70
Critical Review: digital resolution biomolecular sensing for diagnostics and life science research
Huang, Q., Li, N., Zhang, H., Che, C., Sun, F., Xiong, Y., Canady, T. D., & Cunningham, B. T. (2020) · Lab on a Chip · doi:10.1039/d0lc00506a · Cited by 72
Homogeneous Entropy-Driven Amplified Detection of Biomolecular Interactions
Kim, D., Garner, O. B., Özcan, A., & Carlo, D. D. (2016) · ACS Nano · doi:10.1021/acsnano.6b02060 · Cited by 70
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de Oliveira, R. A. G., Materón, E. M., Melendez, M. E., Carvalho, A. L., & Faria, R. C. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03350 · Cited by 70
Sharafeldin, M., Chen, T., Özkaya, G. U., Choudhary, D., Molinolo, A., Gutkind, J. S., & Rusling, J. F. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112681 · Cited by 69
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Barek, J. (2021) · Chemosensors · doi:10.3390/chemosensors9010012 · Cited by 69
Chen, P., Huang, N., Chung, M. T., Cornell, T. T., & Kurabayashi, K. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.005 · Cited by 68
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Bhattarai, P., & Hameed, S. (2020) · Wiley eBooks · doi:10.1002/9783527345137.ch1 · Cited by 71
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Clack, K., Soda, N., Kasetsirikul, S., Mahmudunnabi, R. G., Nguyen, N., & Shiddiky, M. J. A. (2023) · Small · doi:10.1002/smll.202205856 · Cited by 68
Zhang, X., Zheng, E., Esopi, M. R., Cai, C., & Yu, Q. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b06861 · Cited by 63
Ouyang, W., & Han, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904513116 · Cited by 64
Metadata
- Authors
- Kelley, S. O., Mirkin, C. A., Walt, D. R., Ismagilov, R. F., Toner, M., & Sargent, E. H.
- Affiliations
- University of Toronto (CA)
- Northwestern University (US)
- Tufts University (US)
- California Institute of Technology (US)
- Harvard University (US)
- Corresponding author
- Kelley, Shana O.
- ORCID
- Venue
- Nature Nanotechnology
- Published
- 2014-12
- Volume
- 9
- Issue
- 12
- Pages
- 969-980
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- PMC
- PMC4472305
- OpenAlex
- W2082607189
- Cited by
- 398
- References
- 102
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 23 · 2023: 26 · 2022: 43 · 2021: 24 · 2020: 44 · 2019: 38 · 2018: 48 · 2017: 42 · 2016: 40 · 2015: 37
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Science Foundation
- U.S. Department of Defense (W81XWH1110814, W81XWH-11-1-, W81XWH, BC100510)
- Prostate Cancer Foundation
- Genome Canada
- National Institutes of Health (W81XWH)
- Defense Advanced Research Projects Agency (HR0011-11-2-0006)
- Advanced Research Projects Agency
- Canadian Institutes of Health Research
- National Institute of Biomedical Imaging and Bioengineering (R01EB012946, P41EB002503)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- biomolecule detection, disease biomarkers, nucleic acid detection, microsensors, nanocompartments, microfluidics, clinical diagnostics, detection sensitivity, sample separation
- MeSH terms
- Humans, Neoplasms, Biomarkers, Tumor, Biosensing Techniques, Nanotechnology
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