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Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering
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Rapid progress in identifying disease biomarkers has increased the importance of creating high-performance detection technologies. Over the last decade, the design of many detection platforms has focused on either the nano or micro length scale. Here, we review recent strategies that combine nano- and microscale materials and devices to produce large improvements in detection sensitivity, speed and accuracy, allowing previously undetectable biomarkers to be identified in clinical samples. Microsensors that incorporate nanoscale features can now rapidly detect disease-related nucleic acids expressed in patient samples. New microdevices that separate large clinical samples into nanocompartments allow precise quantitation of analytes, and microfluidic systems that utilize nanoscale binding events can detect rare cancer cells in the bloodstream more accurately than before. These advances will lead to faster and more reliable clinical diagnostic devices.
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“These results highlight the unique advantages that these functionalized NPs possess for protein enrichment over antibody-based platforms: (a) comparable size and diffusion kinetics to proteins, promoting effective capture of low-abundance proteins within complex mixtures20,47,48; (b) high surface area per volume and high number of flexible binding sites, contributing to high ligand density and”
From Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum (2020) · cites this paper as [20]
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Metadata
- Authors
- Kelley, S. O., Mirkin, C. A., Walt, D. R., Ismagilov, R. F., Toner, M., & Sargent, E. H.
- Affiliations
- University of Toronto (CA)
- Northwestern University (US)
- Tufts University (US)
- California Institute of Technology (US)
- Harvard University (US)
- Corresponding author
- Kelley, Shana O.
- ORCID
- Venue
- Nature Nanotechnology
- Published
- 2014-12
- Volume
- 9
- Issue
- 12
- Pages
- 969-980
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- PMC
- PMC4472305
- OpenAlex
- W2082607189
- Cited by
- 398
- References
- 102
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 23 · 2023: 26 · 2022: 43 · 2021: 24 · 2020: 44 · 2019: 38 · 2018: 48 · 2017: 42 · 2016: 40 · 2015: 37
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Science Foundation
- U.S. Department of Defense (W81XWH1110814, W81XWH-11-1-, W81XWH, BC100510)
- Prostate Cancer Foundation
- Genome Canada
- National Institutes of Health (W81XWH)
- Defense Advanced Research Projects Agency (HR0011-11-2-0006)
- Advanced Research Projects Agency
- Canadian Institutes of Health Research
- National Institute of Biomedical Imaging and Bioengineering (R01EB012946, P41EB002503)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- biomolecule detection, disease biomarkers, nucleic acid detection, microsensors, nanocompartments, microfluidics, clinical diagnostics, detection sensitivity, sample separation
- MeSH terms
- Humans, Neoplasms, Biomarkers, Tumor, Biosensing Techniques, Nanotechnology
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