The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus, and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear
Open accessAbstract
Current models of conditioned fear expression and extinction involve the basolateral amygdala (BLA), ventral medial prefrontal cortex (vmPFC), and the hippocampus (HPC). There is some disagreement with respect to the specific roles of these structures, perhaps due to subregional differences within each area. For example, growing evidence suggests that infralimbic (IL) and prelimbic (PL) subregions of vmPFC have opposite influences on fear expression. Moreover, it is the ventral HPC (vHPC), rather than the dorsal HPC, that projects to vmPFC and BLA. To help determine regional specificity, we used small doses of the GABA(A) agonist muscimol to selectively inactivate IL, PL, BLA, or vHPC in an auditory fear conditioning and extinction paradigm. Infusions were performed prior to extinction training, allowing us to assess the effects on both fear expression and subsequent extinction memory. Inactivation of IL had no effect on fear expression, but impaired the within-session acquisition of extinction as well as extinction memory. In contrast, inactivation of PL impaired fear expression, but had no effect on extinction memory. Inactivation of the BLA or vHPC impaired both fear expression and extinction memory. Post-extinction inactivations had no effect in any structure. We suggest a model in which amygdala-dependent fear expression is modulated by inputs from PL and vHPC, whereas extinction memory requires extinction-induced plasticity in IL, BLA, and/or vHPC.
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“Thus, stimulation of the infralimbic region should inhibit fear expression, and it does (Sierra-Mercado, Padilla-Coreano, & Quirk, 2011).”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Sierra-Mercado, Padilla-Coreano, & Quirk, 2011
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“Neither is vmPFC generally required for fear extinction (but see [36]), in which cues are presented without reinforcement and the CR diminishes over time [34].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [36]
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Cites
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Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836
Self-citationPhelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Self-citationSmaller hippocampal volume predicts pathologic vulnerability to psychological trauma
Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn958 · Cited by 1,635
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Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
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Research works printed but not linked: 1
- Amano T, Unal CT, Paré D (2009). Synaptic basis of fear extinction in the amygdala: role of intercalated (ITC) neurons. Soc Neurosci Abstr 680: 10.
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Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466
Self-citationLearned helplessness at fifty: Insights from neuroscience.
Maier, S. F., & Seligman, M. E. P. (2016) · Psychological Review · doi:10.1037/rev0000033 · Cited by 1,031
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856
Metadata
- Authors
- Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J.
- Affiliations
- University of Puerto Rico, Medical Sciences Campus (PR)
- Corresponding author
- Quirk, Gregory J
- Venue
- Neuropsychopharmacology
- Published
- 2010-10-20
- Volume
- 36
- Issue
- 2
- Pages
- 529-538
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3005957
- OpenAlex
- W2108888119
- Cited by
- 1,190
- References
- 78
- Citations by year
- 2026: 50 · 2025: 61 · 2024: 80 · 2023: 73 · 2022: 78 · 2021: 109 · 2020: 78 · 2019: 77 · 2018: 90 · 2017: 78 · 2016: 75 · 2015: 90 · 2014: 88 · 2013: 84 · 2012: 50
- FWCI
- 31.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh081975-05)
- National Institute of Mental Health (MH-058883, R01-MH081975, R01MH058883, R37MH058883, MH081975, R36MH089296, R29MH058883)
- National Institute of General Medical Sciences (T34GM007821)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fear conditioning, fear extinction, infralimbic cortex, prelimbic cortex, ventral hippocampus, basolateral amygdala, ventromedial prefrontal cortex, auditory fear conditioning, muscimol inactivation, memory extinction
- MeSH terms
- Amygdala, Animals, Conditioning, Operant, Extinction, Psychological, Fear, Male, Rats, Sprague-Dawley, Prefrontal Cortex, Rats, CA1 Region, Hippocampal
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