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Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus, and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear
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Current models of conditioned fear expression and extinction involve the basolateral amygdala (BLA), ventral medial prefrontal cortex (vmPFC), and the hippocampus (HPC). There is some disagreement with respect to the specific roles of these structures, perhaps due to subregional differences within each area. For example, growing evidence suggests that infralimbic (IL) and prelimbic (PL) subregions of vmPFC have opposite influences on fear expression. Moreover, it is the ventral HPC (vHPC), rather than the dorsal HPC, that projects to vmPFC and BLA. To help determine regional specificity, we used small doses of the GABA(A) agonist muscimol to selectively inactivate IL, PL, BLA, or vHPC in an auditory fear conditioning and extinction paradigm. Infusions were performed prior to extinction training, allowing us to assess the effects on both fear expression and subsequent extinction memory. Inactivation of IL had no effect on fear expression, but impaired the within-session acquisition of extinction as well as extinction memory. In contrast, inactivation of PL impaired fear expression, but had no effect on extinction memory. Inactivation of the BLA or vHPC impaired both fear expression and extinction memory. Post-extinction inactivations had no effect in any structure. We suggest a model in which amygdala-dependent fear expression is modulated by inputs from PL and vHPC, whereas extinction memory requires extinction-induced plasticity in IL, BLA, and/or vHPC.
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“Thus, stimulation of the infralimbic region should inhibit fear expression, and it does (Sierra-Mercado, Padilla-Coreano, & Quirk, 2011).”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Sierra-Mercado, Padilla-Coreano, & Quirk, 2011
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“Neither is vmPFC generally required for fear extinction (but see [36]), in which cues are presented without reinforcement and the CR diminishes over time [34].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [36]
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Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836
Self-citationPhelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Self-citationSmaller hippocampal volume predicts pathologic vulnerability to psychological trauma
Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn958 · Cited by 1,635
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227
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- Amano T, Unal CT, Paré D (2009). Synaptic basis of fear extinction in the amygdala: role of intercalated (ITC) neurons. Soc Neurosci Abstr 680: 10.
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Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007
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Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466
Self-citationLearned helplessness at fifty: Insights from neuroscience.
Maier, S. F., & Seligman, M. E. P. (2016) · Psychological Review · doi:10.1037/rev0000033 · Cited by 1,031
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856
Amygdala Microcircuits Controlling Learned Fear
Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751
Cannabidiol as a Potential Treatment for Anxiety Disorders
Blessing, E., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0387-1 · Cited by 752
Temporal evolution of cortical ensembles promoting remote memory retrieval
DeNardo, L. A., Liu, C. D., Allen, W. E., Adams, E. L., Friedmann, D., Dadgar‐Kiani, E., Fu, L., Guenthner, C. J., Lee, J. H., Tessier‐Lavigne, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0318-7 · Cited by 646
Mahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 643
Long-range connectivity defines behavioral specificity of amygdala neurons
Senn, V., Wolff, S. B. E., Herry, C., Grenier, F., Ehrlich, I., Gründemann, J., Fadok, J. P., Müller, C., Letzkus, J. J., & Lüthi, A. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.006 · Cited by 522
The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear
Giustino, T. F., & Maren, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00298 · Cited by 519
A temporal shift in the circuits mediating retrieval of fear memory
Do-Monte, F. H., Quiñones-Laracuente, K., & Quirk, G. J. (2015) · Nature · doi:10.1038/nature14030 · Cited by 491
Self-citationBasomedial amygdala mediates top-down control of anxiety and fear
Adhikari, A., Lerner, T. N., Finkelstein, J., Pak, S., Jennings, J. H., Davidson, T. J., Ferenczi, E., Gunaydin, L. A., Mirzabekov, J. J., Ye, L., et al. (2015) · Nature · doi:10.1038/nature15698 · Cited by 485
Padilla-Coreano, N., Bolkan, S. S., Pierce, G. M., Blackman, D. R., Hardin, W. D., Garcia-Garcia, A. L., Spellman, T. J., & Gordon, J. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.011 · Cited by 463
Self-citationContext Processing and the Neurobiology of Post-Traumatic Stress Disorder
Liberzon, I., & Abelson, J. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.039 · Cited by 489
The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders
Gilpin, N. W., Herman, M. A., & Roberto, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.008 · Cited by 457
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
Fenster, R. J., Lebois, L. A. M., Ressler, K. J., & Suh, J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0039-7 · Cited by 456
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453
Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs
Sotres-Bayón, F., Sierra‐Mercado, D., Pardilla‐Delgado, E., & Quirk, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.028 · Cited by 467
Self-citationHerringa, R. J., Birn, R. M., Ruttle, P. L., Burghy, C. A., Stodola, D. E., Davidson, R. J., & Essex, M. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310766110 · Cited by 426
Neural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429
Felix‐Ortiz, A. C., Burgos-Robles, A., Bhagat, N. D., Leppla, C. A., & Tye, K. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.041 · Cited by 434
Maren, S., & Holmes, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.180 · Cited by 412
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390
“…into the BLA (Laurent & Westbrook, 2008; Laurent et al., 2008; Sierra-Mercado et al., 2011), mPFC/IL (Laurent & Westbrook, 2008, 2009; Sierra-Mercado et al., 2011) and HPC [(Corcoran et al., 2005; Sierra-Mercado et al., 2011), see Table 5 for a summary] disrupt extinction learning…”
BackgroundInfluentialBehavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
Bouton, M. E., Maren, S., & McNally, G. P. (2020) · Physiological Reviews · doi:10.1152/physrev.00016.2020 · Cited by 440
The role of serotonin 5-HT2A receptors in memory and cognition
Zhang, G., & Stackman, R. W. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00225 · Cited by 398
Revisiting the Role of Infralimbic Cortex in Fear Extinction with Optogenetics
Do-Monte, F. H., Manzano-Nieves, G., Quiñones-Laracuente, K., Ramos-Medina, L., & Quirk, G. J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3137-14.2015 · Cited by 385
Self-citationSex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones
Maeng, L. Y., & Milad, M. R. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.04.002 · Cited by 406
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Alexandra Kredlow, M., Fenster, R. J., Laurent, E. S., Ressler, K. J., & Phelps, E. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01155-7 · Cited by 346
“Pharmacological inactivation of PL and IL with agents such as the GABA agonist muscimol further suggested opposing roles for these structures in threat conditioning and threat extinction, respectively [33].”
BackgroundAmygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment
Burgos-Robles, A., Kimchi, E. Y., Izadmehr, E. M., Porzenheim, M. J., Ramos-Guasp, W. A., Nieh, E. H., Felix-Ortiz, A. C., Namburi, P., Leppla, C. A., Presbrey, K. N., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4553 · Cited by 318
Circuit organization of the rodent medial prefrontal cortex
Anastasiades, P. G., & Carter, A. G. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.03.006 · Cited by 314
Synaptic plasticity in depression: Molecular, cellular and functional correlates
Marsden, W. N. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.012 · Cited by 323
The age of anxiety: role of animal models of anxiolytic action in drug discovery
Cryan, J. F., & Sweeney, F. F. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01362.x · Cited by 327
Fear and safety engage competing patterns of theta-gamma coupling in the basolateral amygdala
Stujenske, J. M., Likhtik, E., Topiwala, M. A., & Gordon, J. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.026 · Cited by 303
High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
Mahn, M., Gibor, L., Patil, P., Malina, K. C.-K., Oring, S., Printz, Y., Levy, R., Lampl, I., & Yizhar, O. (2018) · Nature Communications · doi:10.1038/s41467-018-06511-8 · Cited by 279
Rethinking avoidance: Toward a balanced approach to avoidance in treating anxiety disorders
Hofmann, S. G., & Hay, A. C. (2018) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2018.03.004 · Cited by 361
Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283
“Further studies are thus needed to address differential roles for these two mPFC subregions, which have been shown to produce opposite effects in other behavioral domains (Sierra-Mercado et al., 2011; BurgosRobles et al., 2013; Richard and Berridge, 2013).”
BackgroundLebrón‐Milad, K., & Milad, M. R. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-3 · Cited by 319
Orsini, C. A., Kim, J. H., Knapska, E., & Maren, S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4095-11.2011 · Cited by 315
FAAH genetic variation enhances fronto-amygdala function in mouse and human
Dincheva, I., Drysdale, A. T., Hartley, C. A., Johnson, D. C., Jing, D., King, E. C., Ra, S., Gray, J. M., Yang, R., DeGruccio, A. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7395 · Cited by 289
McKlveen, J. M., Myers, B., & Herman, J. P. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12272 · Cited by 273
Fuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414728112 · Cited by 265
Active Avoidance Learning Requires Prefrontal Suppression of Amygdala-Mediated Defensive Reactions
Moscarello, J. M., & LeDoux, J. E. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2596-12.2013 · Cited by 277
Fear extinction and BDNF: translating animal models of PTSD to the clinic
Andero, R., & Ressler, K. J. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00801.x · Cited by 282
Callaghan, B. L., & Tottenham, N. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.204 · Cited by 268
The cannabinoid system and pain
Woodhams, S. G., Chapman, V., Finn, D. P., Hohmann, A. G., & Neugebauer, V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.015 · Cited by 285
The mouse that roared: neural mechanisms of social hierarchy
Wang, F., Kessels, H. W. H. G., & Hu, H. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.005 · Cited by 276
Seeking a Spotless Mind: Extinction, Deconsolidation, and Erasure of Fear Memory
Maren, S. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.023 · Cited by 259
“Other work has shown that pharmacological manipulation of the vmPFC influences the consolidation of extinction memory (Hugues et al., 2006; Laurent and Westbrook, 2008, 2009; Mueller et al., 2010; Sierra-Mercado et al., 2011), suggesting that the vmPFC may also play a role in establishing extinction memories (as oppos…”
BackgroundAmygdala Inhibitory Circuits Regulate Associative Fear Conditioning
Krabbe, S., Gründemann, J., & Lüthi, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.006 · Cited by 268
Reber, S. O., Siebler, P. H., Donner, N. C., Morton, J. T., Smith, D. G., Kopelman, J. M., Lowe, K. R., Wheeler, K. J., Fox, J. H., Hassell, J. E., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600324113 · Cited by 233
Muscatell, K. A., Dedovic, K., Slavich, G. M., Jarcho, M. R., Breen, E. C., Bower, J. E., Irwin, M. R., & Eisenberger, N. I. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.06.201 · Cited by 240
Neural structures mediating expression and extinction of platform-mediated avoidance
Bravo-Rivera, C., Roman-Ortiz, C., Brignoni-Perez, E., Sotres-Bayon, F., & Quirk, G. J. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0191-14.2014 · Cited by 206
Self-citationPrefrontal inputs to the amygdala instruct fear extinction memory formation
Bukalo, O., Pinard, C. R., Silverstein, S., Brehm, C., Hartley, N. D., Whittle, N., Colacicco, G., Busch, E., Patel, S., Singewald, N., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500251 · Cited by 234
Thompson, J. M., & Neugebauer, V. (2017) · Pain Research and Management · doi:10.1155/2017/8296501 · Cited by 238
Differential roles of medial prefrontal subregions in the regulation of drug seeking
Moorman, D. E., James, M. H., McGlinchey, E. M., & Aston‐Jones, G. (2014) · Brain Research · doi:10.1016/j.brainres.2014.12.024 · Cited by 230
Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding
Holmes, A., Fitzgerald, P. J., MacPherson, K. P., DeBrouse, L., Colacicco, G., Flynn, S. M., Masneuf, S., Pleil, K. E., Li, C., Marcinkiewcz, C. A., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3204 · Cited by 218
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208
Sex‐specific mechanisms for responding to stress
Bangasser, D. A., & Wicks, B. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23812 · Cited by 210
Amygdala microcircuits mediating fear expression and extinction
Pare, D., & Duvarci, S. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.02.014 · Cited by 193
Prefrontal cortical regulation of fear learning
Gilmartin, M. R., Balderston, N. L., & Helmstetter, F. J. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.05.004 · Cited by 207
Robinson, O. J., Charney, D. R., Overstreet, C. M., Vytal, K. E., & Grillon, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.096 · Cited by 212
The Fear Circuit Revisited: Contributions of the Basal Amygdala Nuclei to Conditioned Fear
Amano, T., Duvarci, S., Popa, D., & Paré, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3410-11.2011 · Cited by 208
Going and stopping: dichotomies in behavioral control by the prefrontal cortex
Gourley, S. L., & Taylor, J. R. (2016) · Nature Neuroscience · doi:10.1038/nn.4275 · Cited by 195
Amygdala–prefrontal interactions in (mal)adaptive learning
Likhtik, E., & Paz, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.007 · Cited by 198
Li, X., Wei, W., Zhao, Q., Widagdo, J., Baker‐Andresen, D., Flavell, C. R., D’Alessio, A. C., Zhang, Y., & Bredy, T. W. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318906111 · Cited by 192
Functional anatomy of neural circuits regulating fear and extinction
Knapska, E., Macias, M., Mikosz, M., Nowak, A., Owczarek, D., Wawrzyniak, M., Pieprzyk, M., Cymerman, I. A., Werka, T., Sheng, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202087109 · Cited by 187
Hippocampal–Prefrontal BDNF and Memory for Fear Extinction
Rosas-Vidal, L. E., Do-Monte, F. H., Sotres-Bayon, F., & Quirk, G. J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.64 · Cited by 184
Self-citationExercise, Stress Resistance, and Central Serotonergic Systems
Greenwood, B. N., & Fleshner, M. (2011) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31821f7e45 · Cited by 183
A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex
Xu, H., Liu, L., Tian, Y., Wang, J., Li, J., Zheng, J., Zhao, H., He, M., Xu, T.-L., Duan, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.026 · Cited by 181
Cortico-limbic pain mechanisms
Thompson, J. M., & Neugebauer, V. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.037 · Cited by 190
Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex
Klavir, O., Prigge, M., Sarel, A., Paz, R., & Yizhar, O. (2017) · Nature Neuroscience · doi:10.1038/nn.4523 · Cited by 179
Stevens, J. S., Kim, Y. J., Galatzer-Levy, I. R., Reddy, R., Ely, T. D., Nemeroff, C. B., Hudak, L. A., Jovanovic, T., Rothbaum, B. O., & Ressler, K. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.015 · Cited by 177
Peña, D. F., Childs, J. E., Willett, S., Vital, A., McIntyre, C. K., & Kroener, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00327 · Cited by 165
Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions
Hamilton, D. A., & Brigman, J. L. (2015) · Genes, Brain and Behavior · doi:10.1111/gbb.12191 · Cited by 168
Social Behavior Is Modulated by Valence-Encoding mPFC-Amygdala Sub-circuitry
Huang, W., Zucca, A., Levy, J., & Page, D. T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107899 · Cited by 171
Inhibitory gain modulation of defense behaviors by zona incerta
Chou, X.-L., Wang, X., Zhang, Z., Shen, L., Zingg, B., Huang, J., Zhong, W., Mesik, L., Zhang, L. I., & Tao, H. W. (2018) · Nature Communications · doi:10.1038/s41467-018-03581-6 · Cited by 159
Prefrontal microcircuit underlies contextual learning after hippocampal loss
Zelikowsky, M., Bissière, S., Hast, T. A., Bennett, R. Z., Abdipranoto, A., Vissel, B., & Fanselow, M. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301691110 · Cited by 170
Gut Vagal Afferents Differentially Modulate Innate Anxiety and Learned Fear
Klarer, M., Arnold, M., Günther, L., Winter, C., Langhans, W., & Meyer, U. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0252-14.2014 · Cited by 159
Fear conditioning and extinction across development: Evidence from human studies and animal models
Shechner, T., Hong, M., Britton, J. C., Pine, D. S., & Fox, N. A. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.04.001 · Cited by 170
Learning to learn – Intrinsic plasticity as a metaplasticity mechanism for memory formation
Sehgal, M., Song, C., Ehlers, V. L., & Moyer, J. R. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.008 · Cited by 161
Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review
Quiñones-Cordero, M. M., Gallegos, A. M., Lin, F. V., & Heffner, K. L. (2020) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-020-00782-9 · Cited by 172
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Gruene, T. M., Roberts, E., Thomas, V., Ronzio, A., & Shansky, R. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.014 · Cited by 169
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Metadata
- Authors
- Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J.
- Affiliations
- University of Puerto Rico, Medical Sciences Campus (PR)
- Corresponding author
- Quirk, Gregory J
- Venue
- Neuropsychopharmacology
- Published
- 2010-10-20
- Volume
- 36
- Issue
- 2
- Pages
- 529-538
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3005957
- OpenAlex
- W2108888119
- Cited by
- 1,190
- References
- 78
- Citations by year
- 2026: 50 · 2025: 61 · 2024: 80 · 2023: 73 · 2022: 78 · 2021: 109 · 2020: 78 · 2019: 77 · 2018: 90 · 2017: 78 · 2016: 75 · 2015: 90 · 2014: 88 · 2013: 84 · 2012: 50
- FWCI
- 31.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh081975-05)
- National Institute of Mental Health (MH-058883, R01-MH081975, R01MH058883, R37MH058883, MH081975, R36MH089296, R29MH058883)
- National Institute of General Medical Sciences (T34GM007821)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fear conditioning, fear extinction, infralimbic cortex, prelimbic cortex, ventral hippocampus, basolateral amygdala, ventromedial prefrontal cortex, auditory fear conditioning, muscimol inactivation, memory extinction
- MeSH terms
- Amygdala, Animals, Conditioning, Operant, Extinction, Psychological, Fear, Male, Rats, Sprague-Dawley, Prefrontal Cortex, Rats, CA1 Region, Hippocampal
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