Temporally Dependent Changes in Cocaine-Induced Synaptic Plasticity in the Nucleus Accumbens Shell are Reversed by D1-Like Dopamine Receptor Stimulation
Open accessAbstract
Dopaminergic and glutamatergic inputs to the nucleus accumbens shell have a central role in reward processing. Non-contingent cocaine administration generates a number of long-term AMPA receptor-dependent changes in synaptic efficacy. However, the synaptic consequences of cocaine self-administration and the potential role of dopamine in these processes remain unclear. Here, we examined the influence of D1 dopamine receptor (D1DR) activation on excitatory synaptic plasticity in the accumbens shell of adult rats following cocaine self-administration. Our results indicated that during the first 2 days following cocaine exposure both pre- and post-synaptic mechanisms contribute to a net decrease in AMPA receptor-mediated signaling. This is reflected by decreased frequency of miniature EPSCs (mEPSCs) attributable to enhanced cannabinoid receptor activity, decreased mEPSC amplitude, and increased paired-pulse ratio of evoked EPSCs. In contrast, the only changes observed in the shell 3-4 weeks following cocaine self-administration were increased mEPSCs amplitudes and AMPA/NMDA ratios. We further found that although these cocaine-induced neuroadaptations during early and late abstinence have different synaptic expression mechanisms, they were normalized by stimulation of D1DRs. Thus, pre-exposure to the D1DR agonist, SKF38393, during the initial period of abstinence increased excitatory synaptic strength, but reduced excitatory signaling after weeks of abstinence. Taken together, these results indicate that the direction of changes in excitatory transmission induced by cocaine self-administration switches over the first few weeks of abstinence. Moreover, D1DRs gate the stability of these cocaine-induced changes at glutamatergic synapses in the accumbens shell by utilizing multiple temporally distinct mechanisms, which has implications for the treatment of cocaine craving and addiction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Numerous studies have identified pro-susceptibility neural and molecular factors whose removal promotes stress resilience.
“numerous studies have identified pro–susceptibility neural and molecular factors, which, if removed, promote stress resilience52–54.”
From Neurobiology of resilience (2012) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,529 · see citing works
Pierce, R. C., & Kumaresan, V. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.016 · Cited by 913 · see citing works
Self-citationFormation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790 · see citing works
Drug Addiction as a Pathology of Staged Neuroplasticity
Kalivas, P. W., & O’Brien, C. P. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301564 · Cited by 735 · see citing works
Manabe, T., Wyllie, D. J., Perkel, D. J., & Nicoll, R. A. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.4.1451 · Cited by 666 · see citing works
Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.027 · Cited by 660 · see citing works
Thomas, M. J., Beurrier, C., Bonci, A., & Malenka, R. C. (2001) · Nature Neuroscience · doi:10.1038/nn757 · Cited by 629 · see citing works
Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies.
Levey, A. I., Hersch, S. M., Rye, D. B., Sunahara, R. K., Niznik, H. B., Kitt, C. A., Price, D. L., Maggio, R., Brann, M. R., & Ciliax, B. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8861 · Cited by 625 · see citing works
Brain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613 · see citing works
Molecular Mechanisms of Drug Reinforcement and Addiction
Self, D. W., & Nestler, E. J. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.002335 · Cited by 565 · see citing works
Yung, K. K. L., Bolam, J. P., Smith, A. D., Hersch, S. M., Ciliax, B. J., & Levey, A. I. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00536-e · Cited by 543 · see citing works
Impaired Spatial Learning after Saturation of Long-Term Potentiation
Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M. (1998) · Science · doi:10.1126/science.281.5385.2038 · Cited by 505 · see citing works
Hersch, S. M., Ciliax, B. J., Gutekunst, C., Rees, H., Heilman, C. J., Yung, K. K. L., Bolam, J. P., Ince, E., Yi, H. L., & Levey, A. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05222.1995 · Cited by 483 · see citing works
Boudreau, A. C., & Wolf, M. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2252-05.2005 · Cited by 481 · see citing works
Murase, K., Ryu, P. D., & Randić, M. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90485-0 · Cited by 435 · see citing works
Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens
Kourrich, S., Rothwell, P. E., Klug, J. R., & Thomas, M. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1859-07.2007 · Cited by 429 · see citing works
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
Mameli, M., Halbout, B., Creton, C., Engblom, D., Parkitna, J. M. R., Spanagel, R., & Lüscher, C. (2009) · Nature Neuroscience · doi:10.1038/nn.2367 · Cited by 340 · see citing works
Stell, B. M., & Módy, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-j0003.2002 · Cited by 328 · see citing works
McNaughton, B. L., Barnes, C. A., RAO, G. R., Baldwin, J., & Rasmussen, M. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-02-00563.1986 · Cited by 327 · see citing works
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
Anderson, S. M., Famous, K. R., Sadri-Vakili, G., Kumaresan, V., Schmidt, H. D., Bass, C. E., Terwilliger, E. F., Cha, J.-H. J., & Pierce, R. C. (2008) · Nature Neuroscience · doi:10.1038/nn2054 · Cited by 295 · see citing works
Self-citationBoudreau, A. C., Reimers, J. M., Milovanovic, M., & Wolf, M. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2163-07.2007 · Cited by 277 · see citing works
AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine
Wolf, M. E., & Ferrario, C. R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.013 · Cited by 271 · see citing works
Controversies in translational research: drug self-administration.
Haney, M., & Spealman, R. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1079-x · Cited by 270 · see citing works
Cocaine‐induced neuroadaptations in glutamate transmission
Schmidt, H. D., & Pierce, R. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05144.x · Cited by 254 · see citing works
Self-citationThe Bermuda Triangle of cocaine-induced neuroadaptations
Wolf, M. E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.06.003 · Cited by 228 · see citing works
Bowers, M. S., Chen, B. T., & Bonci, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.004 · Cited by 218 · see citing works
Nicola, S. M., Kombian, S. B., & Malenka, R. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01591.1996 · Cited by 212 · see citing works
Anderson, S. M., & Pierce, R. C. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.12.004 · Cited by 200 · see citing works
Self-citationCaillé, I., Dumartin, B., & Bloch, B. (1996) · Brain Research · doi:10.1016/0006-8993(96)00424-6 · Cited by 188 · see citing works
Pennartz, C. M. A., der Weel, M. J. D.-V., Kitai, S. T., & Lopes, F. H. D. S. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.5.1325 · Cited by 186 · see citing works
McCutcheon, J. E., Wang, X., Tseng, K. Y., Wolf, M. E., & Marinelli, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0350-11.2011 · Cited by 184 · see citing works
Mangiavacchi, S., & Wolf, M. E. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02248.x · Cited by 164 · see citing works
Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
Fernández‐Ruíz, J., Hernández, M., & Ramos, J. A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00144.x · Cited by 163 · see citing works
Xi, Z., Gilbert, J. G., Peng, X., Pak, A. C., Li, X., & Gardner, E. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0726-06.2006 · Cited by 162 · see citing works
Patel, S., Rademacher, D. J., & Hillard, C. J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054270 · Cited by 153 · see citing works
Schilström, B., Yaka, R., Argilli, E., Suvarna, N. U., Schumann, J., Chen, B. T., Carman, M., Singh, V., Mailliard, W. S., Dorit Ron, A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5179-05.2006 · Cited by 147 · see citing works
Cell Type-Specific Alterations in the Nucleus Accumbens by Repeated Exposures to Cocaine
Kim, J., Park, B.-H., Lee, J. H., Park, S. K., & Kim, J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.013 · Cited by 134 · see citing works
Kourrich, S., & Thomas, M. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3028-09.2009 · Cited by 131 · see citing works
D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neurons
Chao, S. Z., Ariano, M. A., Peterson, D. A., & Wolf, M. E. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01164.x · Cited by 126 · see citing works
Schmidt, H. D., Anderson, S. M., & Pierce, R. C. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04524.x · Cited by 119 · see citing works
Self-citationMu, P., Moyer, J. T., Ishikawa, M., Zhang, Y., Panksepp, J., Sorg, B. A., Schlüter, O. M., & Dong, Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4063-09.2010 · Cited by 118 · see citing works
Kuepper, R., Morrison, P. D., van Os, J., Murray, R. M., Kenis, G., & Henquet, C. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.05.031 · Cited by 116 · see citing works
Ghasemzadeh, M., Mueller, C. R., & Vasudevan, P. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.027 · Cited by 113 · see citing works
Harvey, J., & Lacey, M. G. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021296 · Cited by 111 · see citing works
Ferrario, C. R., Loweth, J. A., Milovanovic, M., Ford, K. A., Galiñanes, G. L., Heng, L., Tseng, K. Y., & Wolf, M. E. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.021 · Cited by 109 · see citing works
Dobi, A., Seabold, G. K., Christensen, C. H., Bock, R., & Alvarez, V. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5375-10.2011 · Cited by 102 · see citing works
Schumann, J., & Yaka, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1329-09.2009 · Cited by 102 · see citing works
The Time Course of Signaling at Central Glutamatergic Synapses
Jónás, P. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.2.83 · Cited by 96 · see citing works
André, V. M., Cepeda, C., Cummings, D. M., Jocoy, E. L., Fisher, Y. E., Yang, X. W., & Levine, M. S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07047.x · Cited by 94 · see citing works
Boudreau, A. C., Ferrario, C. R., Glucksman, M., & Wolf, M. E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06140.x · Cited by 85 · see citing works
The Role of Glutamate Receptor Redistribution in Locomotor Sensitization to Cocaine
Ferrario, C. R., Li, X., Wang, X., Reimers, J. M., Uejima, J. L., & Wolf, M. E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.190 · Cited by 83 · see citing works
Sara, Y., Bal, M., Adachi, M., Monteggia, L. M., & Kavalali, E. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5234-10.2011 · Cited by 82 · see citing works
Li, X., Hoffman, A. F., Peng, X., Lupica, C. R., Gardner, E. L., & Xi, Z. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1432-0 · Cited by 74 · see citing works
Ryman-Rasmussen, J. P., Nichols, D. E., & Mailman, R. B. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012153 · Cited by 68 · see citing works
Cocaine Self-Administration Reduces Excitatory Responses in the Mouse Nucleus Accumbens Shell
Schramm‐Sapyta, N. L., Olsen, C. M., & Winder, D. G. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300918 · Cited by 56 · see citing works
Homeostatic changes of the endocannabinoid system in Parkinson's disease
Pisani, V., Madeo, G., Tassone, A., Sciamanna, G., Maccarrone, M., Stanzione, P., & Pisani, A. (2010) · Movement Disorders · doi:10.1002/mds.23457 · Cited by 54 · see citing works
Dumartin, B., Doudnikoff, É., Gonon, F., & Bloch, B. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.04.034 · Cited by 51 · see citing works
Neuroadaptive Changes in NMDAR1 Gene Expression after Extinction of Cocaine Self‐Administration
CRESPO, J. A., Oliva, J. M., Ghasemzadeh, M. B., Kalivas, P. W., & Ambrosio, E. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04153.x · Cited by 51 · see citing works
Johansen, P. A., Hu, X., & White, F. J. (1991) · Journal of Neural Transmission · doi:10.1007/bf01250571 · Cited by 46 · see citing works
Hevers, W., & Lüddens, H. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(01)00158-7 · Cited by 43 · see citing works
The Role of Endogenous Cannabinoid System in Drug Addiction
Parolaro, D., & Rubino, T. (2008) · Drug News & Perspectives · doi:10.1358/dnp.2008.21.3.1203411 · Cited by 35 · see citing works
Ramiro-Fuentes, S., Ortiz, Ó., Moratalla, R., & Fernández‐Espejo, E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.019 · Cited by 20 · see citing works
Flagged first, then by citations
1 of the 63 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works
Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598 · see citing works
Synaptic mechanisms underlying persistent cocaine craving
Wolf, M. E. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.39 · Cited by 389 · see citing works
Contrasting forms of cocaine-evoked plasticity control components of relapse
Pascoli, V., Terrier, J. E., Espallergues, J., Valjent, E., O’Connor, E. C., & Lüscher, C. (2014) · Nature · doi:10.1038/nature13257 · Cited by 396 · see citing works
Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization
Lewitus, G. M., Konefal, S., Greenhalgh, A. D., Pribiag, H., Augereau, K., & Stellwagen, D. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.030 · Cited by 244 · see citing works
Wolf, M. E., & Tseng, K. Y. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00072 · Cited by 199 · see citing works
Dopamine and addiction: what have we learned from 40 years of research
Solinas, M., Belujon, P., Fernagut, P., Jaber, M., & Thiriet, N. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1957-2 · Cited by 155 · see citing works
Rapid, transient synaptic plasticity in addiction
Gipson, C. D., Kupchik, Y. M., & Kalivas, P. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.032 · Cited by 145 · see citing works
Loweth, J. A., Tseng, K. Y., & Wolf, M. E. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.061 · Cited by 139 · see citing works
Terrier, J. E., Lüscher, C., & Pascoli, V. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.345 · Cited by 117 · see citing works
Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling
Hearing, M. C., Graziane, N., Dong, Y., & Thomas, M. J. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.12.004 · Cited by 89 · see citing works
Psychostimulant-Induced Neuroadaptations in Nucleus Accumbens AMPA Receptor TransmissionPreprint
Pierce, R. C., & Wolf, M. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012021 · Cited by 87 · see citing works
Self-citationPurgianto, A., Scheyer, A. F., Loweth, J. A., Ford, K. A., Tseng, K. Y., & Wolf, M. E. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.78 · Cited by 80 · see citing works
Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?
Johnson, K. A., & Lovinger, D. M. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00264 · Cited by 66 · see citing works
Jedynak, J., Hearing, M. C., Ingebretson, A. E., Ebner, S. R., Kelly, M. T., Fischer, R. A., Kourrich, S., & Thomas, M. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.168 · Cited by 61 · see citing works
Madayag, A., Gomez, D. M., Anderson, E. M., Ingebretson, A. E., Thomas, M. J., & Hearing, M. C. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01903-y · Cited by 53 · see citing works
Martín‐García, E., Bourgoin, L., Cathala, A., Kasanetz, F., Mondésir, M., Gutiérrez‐Rodrίguez, A., Reguero, L., Fiancette, J.-F., Grandes, P., Spampinato, U., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.351 · Cited by 55 · see citing works
Ortinski, P. I., Turner, J. R., & Pierce, R. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5730-12.2013 · Cited by 42 · see citing works
Self-citationCocaine-Induced Changes in NMDA Receptor Signaling
Ortinski, P. I. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8636-6 · Cited by 40 · see citing works
Self-citationDingess, P. M., Darling, R. A., Derman, R. C., Wulff, S. S., Hunter, M. L., Ferrario, C. R., & Brown, T. E. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.57 · Cited by 38 · see citing works
Dopamine Triggers CTCF-Dependent Morphological and Genomic Remodeling of Astrocytes
Galloway, A. L., Adeluyi, A., O’Donovan, B., Fisher, M. L., Rao, C. N., Critchfield, P., Sajish, M., Turner, J. R., & Ortinski, P. I. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3349-17.2018 · Cited by 36 · see citing works
Self-citationBenneyworth, M. A., Hearing, M. C., Asp, A. J., Madayag, A., Ingebretson, A. E., Schmidt, C. E., Silvis, K. A., Larson, E. B., Ebner, S. R., & Thomas, M. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.3020-17.2019 · Cited by 34 · see citing works
Briand, L. A., Kimmey, B. A., Ortinski, P. I., Huganir, R. L., & Pierce, R. C. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.265 · Cited by 34 · see citing works
Self-citationDeletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine
Backer, J. D., Monlezun, S., Detraux, B., Gazan, A., Vanopdenbosch, L., Chéron, J., Cannazza, G., Valverde, S., Cantacorps, L., Nassar, M., et al. (2018) · EMBO Reports · doi:10.15252/embr.201745089 · Cited by 33 · see citing works
Liu, X., Liu, Y. U., Zhong, P., Wilkinson, B., Qi, J., Olsen, C. M., Bayer, K. U., & Liu, Q.-S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.299 · Cited by 33 · see citing works
Oral oxycodone self‐administration leads to features of opioid misuse in male and female mice
Slivicki, R. A., Earnest, T., Chang, Y. A., Pareta, R., Casey, E., Li, J., Tooley, J. R., Abiraman, K., Vachez, Y. M., Wolf, D. K., et al. (2022) · Addiction Biology · doi:10.1111/adb.13253 · Cited by 28 · see citing works
Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic TransmissionPreprint
Wright, W. J., & Dong, Y. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039255 · Cited by 26 · see citing works
Higginbotham, J. A., Wang, R., Richardson, B. D., Shiina, H., Tan, S. M., Presker, M. A., Rossi, D. J., & Fuchs, R. A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1390-20.2020 · Cited by 25 · see citing works
Do Alcohol-Related AMPA-Type Glutamate Receptor Adaptations Promote Intake?
Hopf, F. W., & Mangieri, R. A. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_105 · Cited by 23 · see citing works
Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics
Wolf, M. E. (2024) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061724-080548 · Cited by 22 · see citing works
Higginbotham, J. A., Jones, N. M., Wang, R., Christian, R. J., Ritchie, J. L., McLaughlin, R. J., & Fuchs, R. A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00919-x · Cited by 20 · see citing works
O’Donovan, B., Neugornet, A., Neogi, R., Xia, M., & Ortinski, P. I. (2021) · Addiction Biology · doi:10.1111/adb.13042 · Cited by 18 · see citing works
Self-citationSwinford-Jackson, S. E., Huffman, P. J., Knouse, M. C., Thomas, A. S., Rich, M. T., Mankame, S., Worobey, S. J., Sarmiento, M., Coleman, A., & Pierce, R. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01495-y · Cited by 18 · see citing works
Self-citationInbar, K., Levi, L. A., & Kupchik, Y. M. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01285-6 · Cited by 17 · see citing works
Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine‐seeking behavior
Gutman, A. L., Cosme, C. V., Noterman, M. F., Worth, W. R., Wemmie, J. A., & LaLumiere, R. T. (2018) · Addiction Biology · doi:10.1111/adb.12690 · Cited by 17 · see citing works
Hopf, F. W., Seif, T., Chung, S., & Civelli, O. (2013) · PeerJ · doi:10.7717/peerj.61 · Cited by 16 · see citing works
Ingebretson, A. E., Hearing, M. C., Huffington, E. D., & Thomas, M. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.011 · Cited by 10 · see citing works
Domi, A., Lucente, E., Cadeddu, D., & Adermark, L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1105388 · Cited by 8 · see citing works
Neural Circuit Plasticity in Addiction
Anderson, E., & Hearing, M. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00004-x · Cited by 8 · see citing works
Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function
Mittal, N., Minasyan, A., Romaneschi, N., Hakimian, J. K., Gonzalez-Fernandez, G., Albert, R., Desai, N., Mendez, I. A., Schallert, T. J., Ostlund, S. B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185796 · Cited by 6 · see citing works
Sex-dependent fear memory impairment in cocaine-sired rat offspring
Rich, M. T., Worobey, S. J., Mankame, S., Pang, Z. P., Swinford-Jackson, S. E., & Pierce, R. C. (2023) · Science Advances · doi:10.1126/sciadv.adf6039 · Cited by 6 · see citing works
Self-citationRavichandran, P., Bach, S. V., Phillips, R. A., Valentine, M. R., Eagles, N. J., Du, Y., Rosario, I. D., AlGrain, H. A., Maguire, S. E., Miller, R. A., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.06.002 · Cited by 5 · see citing works
Swinford-Jackson, S. E., Rich, M. T., Huffman, P. J., Knouse, M. C., Thomas, A. S., Mankame, S., Worobey, S. J., & Pierce, R. C. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100133 · Cited by 3 · see citing works
Self-citationModeling features of addiction with an oral oxycodone self-administration paradigmPreprint
Murphy, C. A., Chang, Y. A., Pareta, R., Li, J., Slivicki, R. A., Earnest, T., Tooley, J. R., Abiraman, K., Vachez, Y. M., Gereau, R. W., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.08.430180 · Cited by 3 · see citing works
Endocannabinoid-Dependent Synaptic Plasticity in the Striatum
Atwood, B. K., & Lovinger, D. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_5 · Cited by 2 · see citing works
Allen, R. M., Mandt, B. H., Jaskunas, J., Hackley, A., Schickedanz, A., & Bergkamp, D. J. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.11.027 · Cited by 1 · see citing works
White, S. (2013) · ScholarlyCommons (University of Pennsylvania)
Oral oxycodone self-administration leads to features of opioid addiction in male and female micePreprint
Slivicki, R. A., Earnest, T., Chang, Y. A., Pareta, R., Casey, E., Li, J., Tooley, J. R., Abiraman, K., Vachez, Y. M., Wolfe, D. K., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.19.500655
Swinford-Jackson, S. E., Rich, M. T., Huffman, P. J., Knouse, M. C., Thomas, A. S., Mankame, S., Worobey, S. J., & Pierce, R. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.23.524956
Self-citationSocio-communicative and nucleus accumbens core dysfunctions in fragile X syndrome
Giua, G. (2023) · theses.fr (ABES) · doi:10.70675/e45d048ez2538z4905zba74z1de16201406a
- Authors
- Ortinski, P. I., Vassoler, F. M., Carlson, G. C., & Pierce, R. C.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Ortinski, Pavel I
- Venue
- Neuropsychopharmacology
- Published
- 2012-03-14
- Volume
- 37
- Issue
- 7
- Pages
- 1671-1682
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3358735
- OpenAlex
- W2054667632
- Cited by
- 53
- References
- 63
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 10 · 2012: 3
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (K02 DA18678, R01DA022339, K01DA031747, R01 DA22339, K02DA018678)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- cocaine self-administration, nucleus accumbens shell, dopamine D1 receptor, synaptic plasticity, AMPA receptors, miniature EPSCs, cannabinoid receptors, paired-pulse ratio, cocaine abstinence, cocaine craving, cocaine dependence, glutamatergic synapses, reward processing
- MeSH terms
- Animals, Cocaine, Male, Microinjections, Synaptic Transmission, Neuronal Plasticity, Nucleus Accumbens, Self Administration, Synapses, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, AMPA, Dopamine Agonists, Dopamine Uptake Inhibitors, Excitatory Postsynaptic Potentials, Rats, Miniature Postsynaptic Potentials
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review