The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Adolescent Alcohol Exposure Reduces Behavioral Flexibility, Promotes Disinhibition, and Increases Resistance to Extinction of Ethanol Self-Administration in Adulthood
Open accessAbstract
The prefrontal cortex (PFC) is a brain region that is critically involved in cognitive function and inhibitory control of behavior, and adolescence represents an important period of continued PFC development that parallels the maturation of these functions. Evidence suggests that this period of continued development of the PFC may render it especially vulnerable to environmental insults that impact PFC function in adulthood. Experimentation with alcohol typically begins during adolescence when binge-like consumption of large quantities is common. In the present study, we investigated the effects of repeated cycles of adolescent intermittent ethanol (AIE) exposure (postnatal days 28-42) by vapor inhalation on different aspects of executive functioning in the adult rat. In an operant set-shifting task, AIE-exposed rats exhibited deficits in their ability to shift their response strategy when the rules of the task changed, indicating reduced behavioral flexibility. There were no differences in progressive ratio response for the reinforcer suggesting that AIE did not alter reinforcer motivation. Examination of performance on the elevated plus maze under conditions designed to minimize stress revealed that AIE exposure enhanced the number of entries into the open arms, which may reflect either reduced anxiety and/or disinhibition of exploratory-like behavior. In rats that trained to self-administer ethanol in an operant paradigm, AIE increased resistance to extinction of ethanol-seeking behavior. This resistance to extinction was reversed by positive allosteric modulation of mGluR5 during extinction training, an effect that is thought to reflect promotion of extinction learning mechanisms within the medial PFC. Consistent with this, CDPPB was also observed to reverse the deficits in behavioral flexibility. Finally, diffusion tensor imaging with multivariate analysis of 32 brain areas revealed that while there were no differences in the total brain volume, the volume of a subgroup of regions (hippocampus, thalamus, dorsal striatum, neocortex, and hypothalamus) were significantly different in AIE-exposed adults compared with litter-matched Control rats. Taken together, these findings demonstrate that binge-like exposure to alcohol during early to middle adolescence results in deficits in PFC-mediated behavioral control in adulthood.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Similar adult deficits in behavioral flexibility, due to adolescent ethanol exposure, have also been observed using the Morris water maze (Coleman et al. 2011) and set shifting models (Gass et al. 2014).”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Gass et al. 2014
In the citing paper
“Moreover, binge-like alcohol exposure in adolescent rats reduces adult hippocampus, thalamus, dorsal striatum (STR), and cortex volumes compared to littermate controls (Gass et al., 2014; see Gulley and Juraska, 2013 for further review).”
From Sensitive periods of substance abuse: Early risk for the transition to dependence (2017) · cites this paper as Gass et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433
Chambers, R. A., Taylor, J. R., & Potenza, M. N. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1041 · Cited by 1,719
Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat
Birrell, J. M., & Brown, V. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04320.2000 · Cited by 1,421
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
Petanjek, Z., Judaš, M., Šimić, G., Rašin, M. R., Uylings, H. B. M., Rakic, P., & Kostović, I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105108108 · Cited by 1,411
Richardson, N. R., & Roberts, D. C. S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00153-0 · Cited by 1,373
Ethopharmacological analysis of rat behavior on the elevated plus-maze
Cruz, A. P. D. M., Frei, F., & Graeff, F. G. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90472-3 · Cited by 822
Extinction circuits for fear and addiction overlap in prefrontal cortex
Peters, J., Kalivas, P. W., & Quirk, G. J. (2009) · Learning & Memory · doi:10.1101/lm.1041309 · Cited by 736
Cited by
Sorted by citations
Effects of adolescent alcohol consumption on the brain and behaviour
Spear, L. P. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.10 · Cited by 519
Sensitive periods of substance abuse: Early risk for the transition to dependence
Jordan, C. J., & Andersen, S. L. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.10.004 · Cited by 455
Effect of alcohol use on the adolescent brain and behavior
Lees, B., Meredith, L. R., Kirkland, A. E., Bryant, B. E., & Squeglia, L. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172906 · Cited by 411
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior
Crews, F. T., Vetreno, R. P., Broadwater, M., & Robinson, D. L. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012138 · Cited by 356
Charlton, A. J., May, C., Luikinga, S. J., Burrows, E. L., Kim, J. H., Lawrence, A. J., & Perry, C. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-55095-w · Cited by 315
Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models
Zahr, N. M. (2017) · Alcohol research · doi:10.35946/arcr.v38.2.04 · Cited by 231
Pandey, S. C., Sakharkar, A. J., Tang, L., & Zhang, H. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.019 · Cited by 191
Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System
Montesinos, J., Alfonso‐Loeches, S., & Guerri, C. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13208 · Cited by 191
Crews, F. T., Robinson, D. L., Chandler, L. J., Ehlers, C. L., Mulholland, P. J., Pandey, S. C., Rodd, Z. A., SPEAR, L. P., Swartzwelder, H. S., & Vetreno, R. P. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14154 · Cited by 174
Self-citationConsequences of adolescent use of alcohol and other drugs: Studies using rodent models
SPEAR, L. P. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.026 · Cited by 154
The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse
Mooney-Leber, S. M., & Gould, T. J. (2018) · Learning & Memory · doi:10.1101/lm.046672.117 · Cited by 140
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence
Moorman, D. E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.010 · Cited by 114
The impact of junk foods on the adolescent brain
Reichelt, A. C., & Rank, M. M. (2017) · Birth Defects Research · doi:10.1002/bdr2.1173 · Cited by 102
Trantham‐Davidson, H., Centanni, S. W., Garr, S. C., New, N., Mulholland, P. J., Gass, J. T., Glover, E. J., Floresco, S., Crews, F. T., Krishnan, H. R., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.190 · Cited by 101
Self-citationAdolescent neurodevelopment and substance use: receptor expression and behavioral consequences
Thorpe, H. H. A., Hamidullah, S., Jenkins, B. W., & Khokhar, J. Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107431 · Cited by 97
Reichelt, A. C. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00189 · Cited by 101
Neuroimaging in alcohol use disorder: From mouse to man
Fritz, M., Klawonn, A. M., & Zahr, N. M. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24423 · Cited by 89
Evidence for incentive salience sensitization as a pathway to alcohol use disorder
Cofresí, R. U., Bartholow, B. D., & Piasecki, T. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.009 · Cited by 94
Kyzar, E. J., Floreani, C. V., Teppen, T. L., & Pandey, S. C. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00222 · Cited by 93
Salling, M. C., Skelly, M. J., Avegno, E., Regan, S., Zeric, T., Nichols, E., & Harrison, N. L. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0550-18.2018 · Cited by 89
Varlinskaya, E. I., Hosová, D., Towner, T. T., Werner, D. F., & SPEAR, L. P. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112292 · Cited by 87
Fernandez, G. M., Lew, B. J., Vedder, L. C., & Savage, L. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.045 · Cited by 77
Impact of neuroimmune activation induced by alcohol or drug abuse on adolescent brain development
Guerri, C., & Pascual, M. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.11.006 · Cited by 78
Sakharkar, A. J., Kyzar, E. J., Gavin, D. P., Zhang, H., Chen, Y., Krishnan, H. R., Grayson, D. R., & Pandey, S. C. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107679 · Cited by 75
Conflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task
Hu, S., Ide, J. S., Zhang, S., Sinha, R., & Li, C. R. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.03.008 · Cited by 74
Pascual, M., Montesinos, J., & Guerri, C. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24203 · Cited by 71
Broadwater, M., Lee, S., Yu, Y., Hongtu Zhu, B., Crews, F. T., Robinson, D. L., & Shih, Y. I. (2017) · Addiction Biology · doi:10.1111/adb.12530 · Cited by 74
Fernandez, G. M., & Savage, L. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.013 · Cited by 68
Wolstenholme, J. T., Mahmood, T., Harris, G. M., Abbas, S., & Miles, M. F. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00307 · Cited by 64
Chronic Ethanol During Adolescence Impacts Corticolimbic Dendritic Spines and Behavior
Jury, N. J., Pollack, G. A., Ward, M. J., Bezek, J. L., Ng, A. J., Pinard, C. R., Bergstrom, H. C., & Holmes, A. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13422 · Cited by 57
Ma, T., Huang, Z., Xie, X., Cheng, Y., Zhuang, X., Childs, M., Gangal, H., Wang, X., Smith, L., Smith, R., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci154969 · Cited by 53
Bidirectional causality between addiction and cognitive deficits
Melugin, P. R., Nolan, S. O., & Siciliano, C. A. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.11.001 · Cited by 59
Aloi, J. M., Blair, K. S., Crum, K. I., Meffert, H., White, S. F., Tyler, P. M., Thornton, L. C., Mobley, A. M., Killanin, A. D., Adams, K. O., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.06.005 · Cited by 55
Sex and Adolescent Ethanol Exposure Influence Pavlovian Conditioned Approach
Madayag, A. C., Stringfield, S. J., Reissner, K. J., Boettiger, C. A., & Robinson, D. L. (2017) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13354 · Cited by 50
Barker, J. M., Bryant, K. G., Osborne, J. I., & Chandler, L. J. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00450 · Cited by 49
Self-citationFernandez, G. M., Stewart, W. N., & Savage, L. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149987 · Cited by 48
Macht, V. A., Elchert, N., & Crews, F. T. (2020) · Brain Sciences · doi:10.3390/brainsci10110785 · Cited by 48
Sengmany, K., & Gregory, K. J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13281 · Cited by 48
Vetreno, R. P., Patel, Y. N., Patel, U., Walter, T. J., & Crews, F. T. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.018 · Cited by 48
Binge drinking impacts dorsal striatal response during decision making in adolescents
Jones, S. A., Cservenka, A., & Nagel, B. J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.01.044 · Cited by 45
Montesinos, J., Gil, A., & Guerri, C. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13416 · Cited by 49
Centanni, S. W., Burnett, E. J., Trantham‐Davidson, H., & Chandler, L. J. (2016) · Addiction Biology · doi:10.1111/adb.12353 · Cited by 45
Self-citationTapia‐Rojas, C., Mira, R. G., Torres, A. K., Jara, C., Maria Jose Perez, J., Vergara, E. H., Cerpa, W. F., & Quintanilla, R. A. (2017) · Birth Defects Research · doi:10.1002/bdr2.1172 · Cited by 44
Kasten, C. R., Carzoli, K. L., Sharfman, N. M., Henderson, T., Holmgren, E. B., Lerner, M. R., Miller, M. C., & Wills, T. A. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0670-7 · Cited by 43
Adolescent rats are resistant to forming ethanol seeking habits
Serlin, H., & Torregrossa, M. M. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.12.002 · Cited by 41
Alcohol Consumption in Adolescence: a Translational Perspective
SPEAR, L. P. (2016) · Current Addiction Reports · doi:10.1007/s40429-016-0088-9 · Cited by 40
Stress Facilitates the Development of Cognitive Dysfunction After Chronic Ethanol Exposure
Rodberg, E. M., den Hartog, C. R., Anderson, R. I., Becker, H. C., Moorman, D. E., & Vazey, E. M. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13444 · Cited by 37
Tapia‐Rojas, C., Torres, A. K., & Quintanilla, R. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.03.018 · Cited by 36
Cannady, R., McGonigal, J. T., Newsom, R. J., Woodward, J. J., Mulholland, P. J., & Gass, J. T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2873-16.2017 · Cited by 34
Self-citationNentwig, T. B., Starr, E. M., Chandler, L. J., & Glover, E. J. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.01.006 · Cited by 38
Self-citationThe thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy
der Weel, M. J. D.-V., & Witter, M. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.033 · Cited by 37
Nippert, K. E., Rowland, C. P., Vazey, E. M., & Moorman, D. E. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110114 · Cited by 35
Galaj, E., Kipp, B. T., Floresco, S., & Savage, L. M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.062 · Cited by 37
Self-citationAdolescent intermittent ethanol impairs behavioral flexibility in a rat foraging task in adulthood
Sey, N. Y. A., Gómez‐A, A., Madayag, A., Boettiger, C. A., & Robinson, D. L. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112085 · Cited by 32
Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity
Towner, T. T., & Varlinskaya, E. I. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00045 · Cited by 31
Dannenhoffer, C. A., Gómez‐A, A., Macht, V. A., Jawad, R., Sutherland, E. B., Vetreno, R. P., Crews, F. T., Boettiger, C. A., & Robinson, D. L. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14810 · Cited by 36
Alcohol Withdrawal and the Associated Mood Disorders—A Review
Ngui, H. H. L., Kow, A. S. F., Lai, S., Tham, C. L., Ho, Y., & Lee, M. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314912 · Cited by 35
Robinson, D. L., Amodeo, L. R., Chandler, L. J., Crews, F. T., Ehlers, C. L., Gómez‐A, A., Healey, K. L., Kuhn, C. M., Macht, V. A., Marshall, S. A., et al. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.07.007 · Cited by 30
Self-citationSun, W., Li, X., Tang, C., & An, L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01439 · Cited by 29
Glover, E. J., Khan, F., Clayton-Stiglbauer, K., & Chandler, L. J. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108393 · Cited by 29
Self-citationKim, E. U., Varlinskaya, E. I., Dannenhoffer, C. A., & SPEAR, L. P. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.05.002 · Cited by 30
Behavioral Flexibility in Alcohol‐Drinking Monkeys: The Morning After
Shnitko, T. A., Gonzales, S. W., Newman, N., & Grant, K. A. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14289 · Cited by 28
Hamidullah, S., Lutelmowski, C. D., Creighton, S. D., Luciani, K. R., Frie, J. A., Winters, B. D., & Khokhar, J. Y. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110141 · Cited by 28
Van Hees, L., Didone, V., Charlet‐Briart, M., Van Ingelgom, T., Alexandre, A., Quertemont, E., Nguyen, L., & Laguesse, S. (2022) · Addiction Biology · doi:10.1111/adb.13102 · Cited by 27
Calpe-López, C., García-Pardo, M. P., Martínez-Caballero, M. Á., Santos-Ortíz, A., & Aguilar, M. A. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00278 · Cited by 27
Obray, J. D., Landin, J. D., Vaughan, D. T., Scofield, M. D., & Chandler, L. J. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100044 · Cited by 25
Self-citationCrews, F. T., Coleman, L. G., Macht, V. A., & Vetreno, R. P. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000710 · Cited by 27
Sheynikhovich, D., Otani, S., Bai, J., & Arleo, A. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1068271 · Cited by 31
Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?
Shields, C. N., & Gremel, C. M. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14441 · Cited by 26
Pucci, M., Bonaventura, M. V. M. D., Wille‐Bille, A., Fernández, M. S., Maccarrone, M., Pautassi, R. M., Cifani, C., & D’Addario, C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.004 · Cited by 27
Binge Drinking's Effects on the Developing Brain-Animal Models.
Hiller-Sturmhöfel, S., & SPEAR, L. P. (2018) · Europe PMC (PubMed Central) · Cited by 25
Chandler, L. J., Vaughan, D. T., & Gass, J. T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.837657 · Cited by 24
Self-citationMorud, J., Strandberg, J., Andrén, A., Ericson, M., Söderpalm, B., & Adermark, L. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.10.002 · Cited by 24
Seemiller, L. R., & Gould, T. J. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107234 · Cited by 23
Consequences of adolescent alcohol use on adult hippocampal neurogenesis and hippocampal integrity
(2021) · International Review of Neurobiology · doi:10.1016/bs.irn.2021.08.005 · Cited by 23
Dannenhoffer, C. A., Robertson, M. M., Macht, V. A., Mooney, S. M., Boettiger, C. A., & Robinson, D. L. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.07.004 · Cited by 28
Gass, J. T., McGonigal, J. T., & Chandler, L. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.005 · Cited by 24
Self-citationSiemsen, B. M., Landin, J. D., McFaddin, J. A., Hooker, K. N., Chandler, L. J., & Scofield, M. D. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24683 · Cited by 26
Self-citationFalco, E. D., White, S., Morningstar, M. D., Ma, B., Nkurunziza, L. T., Ahmed‐Dilibe, A., Wellman, C. L., & Lapish, C. C. (2021) · Addiction Biology · doi:10.1111/adb.13004 · Cited by 25
Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry
Sicher, A. R., Duerr, A., Starnes, W. D., & Crowley, N. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.896880 · Cited by 25
Fisher, H., Bright, N., Gallo, M., Pajser, A., & Pickens, C. L. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000331 · Cited by 22
Maldonado‐Devincci, A. M., Makdisi, J. G., Hill, A. M., Waters, R. C., Hall, N. I., Shobande, M. J., & Kumari, A. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.24814 · Cited by 21
Coleman, L. G., Crews, F. T., & Vetreno, R. P. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.08.001 · Cited by 26
Risky choice and brain CRF after adolescent ethanol vapor exposure and social stress in adulthood
Boutros, N., Der‐Avakian, A., Semenova, S., Lee, S., & Markou, A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.038 · Cited by 21
Matthews, D. B., Novier, A., Diaz‐Granados, J. L., Skike, C. E. V., Ornelas, L. C., & Mittleman, G. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.012 · Cited by 23
Smiley, C. E., McGonigal, J. T., Valvano, T., Newsom, R. J., Otero, N. K. H., & Gass, J. T. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05622-9 · Cited by 20
Self-citationChronic activation of fear engrams induces extinction‐like behavior in ethanol‐exposed mice
Cincotta, C., Murawski, N. J., Grella, S. L., McKissick, O. P., Doucette, E., & Ramirez, S. (2020) · Hippocampus · doi:10.1002/hipo.23263 · Cited by 19
Natividad, L. A., Steinman, M. Q., Laredo, S. A., Irimia, C., Polis, I. Y., Lintz, R., Buczynski, M. W., Martin‐Fardon, R., Roberto, M., & Parsons, L. H. (2017) · Addiction Biology · doi:10.1111/adb.12568 · Cited by 22
Marcolin, M. L., Baumbach, J. L., Hodges, T. E., & McCormick, C. M. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.08.003 · Cited by 19
Johnson, K. A., & Lovinger, D. M. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.02.002 · Cited by 18
Elton, A., Faulkner, M. L., Robinson, D. L., & Boettiger, C. A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-00993-9 · Cited by 20
Beas, B. S., Setlow, B., & Bizon, J. L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4321-y · Cited by 18
Kipp, B. T., Nunes, P. T., Galaj, E., Hitchcock, B., Nasra, T., Poynor, K. R., Heide, S., Reitz, N. L., & Savage, L. M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.08.014 · Cited by 18
Gómez‐A, A., Dannenhoffer, C. A., Elton, A., Lee, S., Ban, W., Shih, Y. I., Boettiger, C. A., & Robinson, D. L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.778884 · Cited by 16
Chiu, H., & Vargo, E. J. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04085-w · Cited by 28
Ho, A. M., Peyton, M. P., Scaletty, S. J., Trapp, S., Schreiber, A. C., Madden, B. J., Choi, D., & Matthews, D. B. (2022) · ACS Omega · doi:10.1021/acsomega.2c04528 · Cited by 17
Cognitive Alterations in Addictive Disorders: A Translational Approach
Gasparyan, A., Sanchez, D. M., Navarrete, F., Sión, A., Navarro, D., García‐Gutiérrez, M. S., Rubio, G., Barba, R. J., & Manzanares, J. (2023) · Biomedicines · doi:10.3390/biomedicines11071796 · Cited by 18
Crews, F. T., Macht, V. A., & Vetreno, R. P. (2024) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2024.12094 · Cited by 19
Jacobsen, J. H. W., Buisman‐Pijlman, F. T. A., Mustafa, S., Rice, K. C., & Hutchinson, M. R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.028 · Cited by 18
Orbitofrontal cortex subregion inhibition during binge-like and aversion-resistant alcohol drinking
Schuh, K. M., Sneddon, E. A., Nader, A. M., Muench, M. A., & Radke, A. K. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.11.004 · Cited by 15
Metadata
- Authors
- Gass, J. T., Glen, W. B., McGonigal, J. T., Trantham-Davidson, H., Lopez, M. F., Randall, P. K., Yaxley, R., Floresco, S. B., & Chandler, L. J.
- Affiliations
- Medical University of South Carolina (US)
- University of North Carolina at Chapel Hill (US)
- University of British Columbia (CA)
- Corresponding author
- Gass, Justin T
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2014-05-13
- Volume
- 39
- Issue
- 11
- Pages
- 2570-2583
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC4207336
- OpenAlex
- W2059163032
- Cited by
- 197
- References
- 65
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 14 · 2023: 19 · 2022: 19 · 2021: 22 · 2020: 23 · 2019: 18 · 2018: 15 · 2017: 22 · 2016: 15 · 2015: 4 · 2014: 1
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (5u54ca151652-05)
- Canadian Institutes of Health Research (MOP102478, 89861_1)
- National Institute on Alcohol Abuse and Alcoholism (U01AA019967, U01AA020023, K99AA020537, R01AA010983, R00AA020537, K01AA022475, F32AA021642, U24AA020024, U24AA020023, P50AA010761)
- National Cancer Institute (U54CA151652-01-04, U54‐CA151652, P30CA016086-35-37, P30CA016086)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- adolescent intermittent ethanol exposure, binge drinking, prefrontal cortex development, behavioral flexibility, set-shifting, disinhibition, ethanol self-administration, extinction resistance, mGluR5, CDPPB, executive function, anxiety, brain structure, hippocampus, dorsal striatum, medial prefrontal cortex
- MeSH terms
- Administration, Inhalation, Ethanol, Animals, Anxiety, Benzamides, Brain, Central Nervous System Agents, Central Nervous System Depressants, Conditioning, Operant, Exploratory Behavior, Extinction, Psychological, Male, Motivation, Pyrazoles, Reinforcement Schedule, Self Administration, Maze Learning, Rats, Long-Evans, Diffusion Tensor Imaging, Executive Function, Drug-Seeking Behavior, Receptor, Metabotropic Glutamate 5
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
