Extinction circuits for fear and addiction overlap in prefrontal cortex

Peters, Jamie; Kalivas, Peter W.; Quirk, Gregory J.

doi:10.1101/lm.1041309

Cited by 736Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Extinction circuits for fear and addiction overlap in prefrontal cortex

Open access

Peters, Jamie, Kalivas, Peter W., Quirk, Gregory J.·2009·Learning & Memory

DOI 10.1101/lm.1041309PMC PMC4527308

Open this paper in CoChat — free account Open PDF

Abstract

Extinction is a form of inhibitory learning that suppresses a previously conditioned response. Both fear and drug seeking are conditioned responses that can lead to maladaptive behavior when expressed inappropriately, manifesting as anxiety disorders and addiction, respectively. Recent evidence indicates that the medial prefrontal cortex (mPFC) is critical for the extinction of both fear and drug-seeking behaviors. Moreover, a dorsal-ventral distinction is apparent within the mPFC, such that the prelimbic (PL-mPFC) cortex drives the expression of fear and drug seeking, whereas the infralimbic (IL-mPFC) cortex suppresses these behaviors after extinction. For conditioned fear, the dorsal-ventral dichotomy is accomplished via divergent projections to different subregions of the amygdala, whereas for drug seeking, it is accomplished via divergent projections to the subregions of the nucleus accumbens. Given that the mPFC represents a common node in the extinction circuit for these behaviors, treatments that target this region may help alleviate symptoms of both anxiety and addictive disorders by enhancing extinction memory.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/lm.1041309

Cites

196 of 196 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Drug-cue extinction is believed to involve neurons in the PFC.
“Like fear extinction, drug-cue extinction is believed to involve neurons in the PFC (59).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [59]
Dysfunction of vmPFC is thought to be critical in anxiety disorders such as PTSD, depression, counterproductive motivation in drug addiction, and dysregulation of autonomic and endocrine systems related to chronic stress and pain.
“Dysfunction of the vmPFC is thought to be critical in anxiety disorders such as PTSD [10] (Figure 1vw), depression [79] (figure 1x), counterproductive motivation in drug addiction [80], and dysregulation of autonomic and endocrine systems related to chronic stress [12] and pain [13].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [80]
Recent evidence links PL and rdACC to appetitive drug-seeking behavior, which argues in favor of a process account of the rdACC/vmPFC distinction.
“Recent evidence linking PL and rdACC to appetitive, drug seeking behavior [80] argues in favor of a process account.”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [80]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128 · see citing works
Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667 · see citing works
The Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627 · see citing works
Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective
Bechara, A. (2005) · Nature Neuroscience · doi:10.1038/nn1584 · Cited by 2,149 · cited 1× · see citing works
“Human addicts resemble patients with vmPFC lesions on certain measures of cognitive inhibitory control (Bechara 2005).”
Background
The prefontral cortex and cognitive control
Miller, E. K. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036228 · Cited by 2,016 · see citing works
Dysfunction in the neural circuitry of emotion regulation–a possible prelude to violence
Davidson, R. J., Putnam, K. M., & Larson, C. L. (2000) · Science · doi:10.1126/science.289.5479.591 · Cited by 1,894 · see citing works
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 3× · see citing works
“Single-unit recordings reveal that CS responsiveness in IL-mPFC neurons develops only after extinction learning has occurred, and correlates with the degree of extinction recall (Milad and Quirk 2002).”
BackgroundSelf-citation
Extinction Learning in Humans
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753 · see citing works
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works
Self-citation
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580 · see citing works
Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin
Sesack, S. R., Deutch, A. Y., Roth, R. H., & Bunney, B. S. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902900205 · Cited by 1,568 · see citing works
Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550 · see citing works
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513 · see citing works
Integrative activity of the brain
Konorski, J. (1967) · Cited by 1,372 · see citing works
Mechanisms of fear extinction
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277 · see citing works
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227 · see citing works
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219 · see citing works
Self-citation
Recall of Fear Extinction in Humans Activates the Ventromedial Prefrontal Cortex and Hippocampus in Concert
Milad, M. R., Wright, C. I., Orr, S. P., Pitman, R. K., Quirk, G. J., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.011 · Cited by 1,197 · see citing works
Self-citation
Putting a spin on the dorsal-ventral divide of the striatum
Voorn, P., Vanderschuren, L. J. M. J., Groenewegen, H. J., Robbins, T. W., & Pennartz, C. M. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.006 · Cited by 1,188 · see citing works
Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex
Bechara, A., Tranel, D., Damasio, H., & Damasio, A. R. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.2.215 · Cited by 1,179 · see citing works
The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro‐gold
Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102 · see citing works
Cognitive Enhancers as Adjuncts to Psychotherapy: Use of D-Cycloserine in Phobic Individuals to Facilitate Extinctionof Fear
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063 · see citing works
Addiction: A Disease of Learning and Memory
Hyman, S. E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1414 · Cited by 980 · see citing works
Switching on and off fear by distinct neuronal circuits
Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950 · see citing works
Activation of memory circuits during cue-elicited cocaine craving.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.12040 · Cited by 936 · see citing works
Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli
Garavan, H., Pankiewicz, J., Bloom, A., Cho, J.-K., Sperry, L., Ross, T. J., Salmeron, B. J., Risinger, R., Kelley, D., & Stein, E. A. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1789 · Cited by 931 · see citing works
Reinstatement of cocaine-reinforced responding in the rat
de Wit, H., & Stewart, J. (1981) · Psychopharmacology · doi:10.1007/bf00432175 · Cited by 928 · see citing works
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924 · see citing works
Frontal lobe and cognitive development
Fuster, J. M. (2002) · Journal of Neurocytology · doi:10.1023/a:1024190429920 · Cited by 916 · see citing works
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905 · see citing works
Self-citation
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · cited 2× · see citing works
“Jamie Peters, Peter W. Kalivas and Gregory J. Quirk cortex Extinction circuits for fear and addiction overlap in prefrontal References http://learnmem.cshlp.org/content/16/5/279.full.html#ref-list-1 This article cites 187 articles, 58 of which can be accessed free at: service Email alerting click…”
Background
Decision-making and addiction (part I): impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences.
Bechara, A., & Damasio, H. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(02)00015-5 · Cited by 889 · see citing works
Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior
McFarland, K., Lapish, C. C., & Kalivas, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03531.2003 · Cited by 884 · see citing works
Self-citation
Amygdaloid projections to the mesencephalon, pons and medulla oblongata in the cat
Hopkins, D. A., & Holstege, G. (1978) · Experimental Brain Research · doi:10.1007/bf00239551 · Cited by 866 · see citing works
Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: Parallel recordings in the freely behaving rat
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808 · see citing works
Self-citation
Regional Cerebral Blood Flow in the Amygdala and Medial PrefrontalCortex During Traumatic Imagery in Male and Female Vietnam Veterans With PTSD
Shin, L. M., Orr, S. P., Carson, M. A., Rauch, S. L., Macklin, M. L., Lasko, N. B., Peters, P. M., Metzger, L. J., Dougherty, D. D., Cannistraro, P. A., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.2.168 · Cited by 790 · see citing works
Memory and Addiction
Kelley, A. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.016 · Cited by 773 · see citing works
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
Baker, D. L., McFarland, K., LAKE, R. W., Shen, H., Tang, X., Toda, S., & Kalivas, P. W. (2003) · Nature Neuroscience · doi:10.1038/nn1069 · Cited by 740 · see citing works
Self-citation
Opioid receptors
Waldhoer, M., Bartlett, S. E., & Whistler, J. L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073940 · Cited by 740 · see citing works
Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study.
Bremner, J., Staib, L., Kaloupek, D., Southwick, S., Soufer, R., & Charney, D. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00297-2 · Cited by 730 · see citing works
Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.
Morgan, M. A., & LeDoux, J. E. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.681 · Cited by 717 · see citing works
Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear
Vidal-Gonzalez, I., Vidal-Gonzalez, B., Rauch, S. L., & Quirk, G. J. (2006) · Learning & Memory · doi:10.1101/lm.306106 · Cited by 705 · see citing works
Self-citation
Stress-induced relapse to heroin and cocaine seeking in rats: a review
Shaham, Y., Erb, S. M., & Stewart, J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00024-2 · Cited by 703 · see citing works
Prefrontal involvement in the regulation of emotion: convergence of rat and human studies
Quirk, G. J., & Beer, J. S. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.07.004 · Cited by 701 · see citing works
Self-citation
Projections of the medial and lateral prefrontal cortices to the amygdala: a Phaseolus vulgaris leucoagglutinin study in the rat
McDonald, A. J., Mascagni, F., & Guo, L. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00417-3 · Cited by 689 · see citing works
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission
Kalivas, P. W., Volkow, N., & Seamans, J. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.005 · Cited by 657 · see citing works
Self-citation
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
Epstein, D., Preston, K., Stewart, J., & Shaham, Y. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0529-6 · Cited by 634 · see citing works
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning
Blair, H. T., Schafe, G. E., Bauer, E. P., Rodrigues, S. M., & LeDoux, J. E. (2001) · Learning & Memory · doi:10.1101/lm.30901 · Cited by 610 · see citing works
Fear extinction in rats: Implications for human brain imaging and anxiety disorders
Milad, M. R., Rauch, S. L., Pitman, R. K., & Quirk, G. J. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.008 · Cited by 597 · cited 2× · see citing works
“Extinction failure in the aversive domain can lead to anxiety disorders (Delgado et al. 2006; Milad et al. 2006), while extinction failure in the appetitive domain can lead to relapse in addicted subjects (Kalivas et al. 2005; Garavan and Hester 2007).”
BackgroundSelf-citation
Activity in Prelimbic Cortex Is Necessary for the Expression of Learned, But Not Innate, Fears
Corcoran, K., & Quirk, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5327-06.2007 · Cited by 580 · see citing works
Self-citation
Augmentation of Exposure Therapy With D-Cycloserine for Social Anxiety Disorder
Hofmann, S. G., Meuret, A. E., Smits, J. A. J., Simon, N. M., Pollack, M. H., Eisenmenger, K., Shiekh, M., & Otto, M. W. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.298 · Cited by 560 · cited 2× · see citing works
“PTSD patients exhibit decreased activity within vmPFC when exposed to traumatic reminders (Bremner et al. 1999; Shin et al. 2004; Phan et al. 2006), suggesting that the vmPFC in humans is analogous to IL-mPFC in the rodent.”
Background
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
Cornish, J. L., & Kalivas, P. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0006.2000 · Cited by 546 · see citing works
Self-citation
Infralimbic Prefrontal Cortex Is Responsible for Inhibiting Cocaine Seeking in Extinguished Rats
Peters, J., LaLumiere, R. T., & Kalivas, P. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1045-08.2008 · Cited by 537 · see citing works
Self-citation
Rethinking the Fear Circuit: The Central Nucleus of the Amygdala Is Required for the Acquisition, Consolidation, and Expression of Pavlovian Fear Conditioning
Wilensky, A. E., Schafe, G. E., Kristensen, M. P., & LeDoux, J. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4316-06.2006 · Cited by 533 · see citing works
Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure
Burgos-Robles, A., Vidal-Gonzalez, I., & Quirk, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0378-09.2009 · Cited by 530 · see citing works
Self-citation
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha, R., Garcia, M., Paliwal, P., Kreek, M. J., & Rounsaville, B. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.324 · Cited by 528 · see citing works
Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior
McFarland, K., Davidge, S. B., Lapish, C. C., & Kalivas, P. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4177-03.2004 · Cited by 524 · see citing works
Self-citation
Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity
Chudasama, Y., Passetti, F., Rhodes, S. E. V., Lopian, D., Desai, A., & Robbins, T. W. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.020 · Cited by 518 · see citing works
The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats
Fuchs, R. A., Evans, K. A., Ledford, C. C., Parker, M. P., Case, J. M., Mehta, R. H., & See, R. E. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300579 · Cited by 517 · see citing works
Consolidation of Fear Extinction Requires NMDA Receptor-Dependent Bursting in the Ventromedial Prefrontal Cortex
Burgos-Robles, A., Vidal-Gonzalez, I., Santini, E., & Quirk, G. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.021 · Cited by 516 · see citing works
Self-citation
Presence and acquired origin of reduced recall for fear extinction in PTSD: Results of a twin study
Milad, M. R., Orr, S. P., Lasko, N. B., Chang, Y., Rauch, S. L., & Pitman, R. K. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.017 · Cited by 512 · see citing works
Neural systems and cue-induced cocaine craving
Bonson, K. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00371-2 · Cited by 507 · cited 2× · see citing works
“Interestingly, deactivation of vmPFC has been observed in addicts exposed to cocaine-related cues using positron emission tomography (PET) for glucose metabolism (Bonson et al. 2002).”
Background
Effects of D-Cycloserine on Extinction: Translation From Preclinical to Clinical Work
Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.084 · Cited by 498 · see citing works
Context-Dependent Human Extinction Memory Is Mediated by a Ventromedial Prefrontal and Hippocampal Network
Kalisch, R., Korenfeld, E., Stephan, K. E., Weiskopf, N., Seymour, B., & Dolan, R. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2021-06.2006 · Cited by 493 · see citing works
A Role for the Human Dorsal Anterior Cingulate Cortex in Fear Expression
Milad, M. R., Quirk, G. J., Pitman, R. K., Orr, S. P., Fischl, B., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.032 · Cited by 485 · see citing works
Self-citation
Consolidation of Fear Extinction Requires Protein Synthesis in the Medial Prefrontal Cortex
Santini, E., Ge, H., Ren, K., de Ortiz, S. P., & Quirk, G. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0786-04.2004 · Cited by 479 · see citing works
Self-citation
Amygdala intercalated neurons are required for expression of fear extinction
Likhtik, E., Popa, D., Apergis-Schoute, J., Fidacaro, G. A., & Paré, D. (2008) · Nature · doi:10.1038/nature07167 · Cited by 474 · see citing works
Brief Uncontrollable Stress Causes Dendritic Retraction in Infralimbic Cortex and Resistance to Fear Extinction in Mice
Izquierdo, A., Wellman, C. L., & Holmes, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0474-06.2006 · Cited by 459 · see citing works
Two different lateral amygdala cell populations contribute to the initiation and storage of memory
Repa, J. C., Muller, J., Apergis, J., Desrochers, T. M., Zhou, Y., & LeDoux, J. E. (2001) · Nature Neuroscience · doi:10.1038/89512 · Cited by 440 · see citing works
A cannabinoid mechanism in relapse to cocaine seeking
Vries, T. J. D., Shaham, Y., Homberg, J. R., Crombag, H. S., Schuurman, K. G., Dieben, J., Vanderschuren, L. J. M. J., & Schoffelmeer, A. N. M. (2001) · Nature Medicine · doi:10.1038/nm1001-1151 · Cited by 433 · see citing works
Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex
Sotres-Bayon, F., Cain, C. K., & LeDoux, J. E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.012 · Cited by 433 · see citing works
Decision-making and impulse control after frontal lobe injuries
Bechara, A., & der Linden, M. V. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000194141.56429.3c · Cited by 426 · see citing works
A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats
Capriles, N., Rodaros, D., Sorge, R. E., & Stewart, J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1283-z · Cited by 414 · see citing works
Cystine/Glutamate Exchange Regulates Metabotropic Glutamate Receptor Presynaptic Inhibition of Excitatory Transmission and Vulnerability to Cocaine Seeking
Moran, M., McFarland, K., Meléndez, R. I., Kalivas, P. W., & Seamans, J. K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1007-05.2005 · Cited by 412 · see citing works
Self-citation
Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory
Milad, M. R., Quinn, B. T., Pitman, R. K., Orr, S. P., Fischl, B., & Rauch, S. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502441102 · Cited by 412 · see citing works
Two transpallidal pathways originating in the rat nucleus accumbens
Zahm, D. S., & Heimer, L. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020302 · Cited by 406 · see citing works
Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste “liking”/“disliking” reactions, place preference/avoidance, and fear
Reynolds, S. M., & Berridge, K. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07308.2002 · Cited by 403 · see citing works
Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200209000-00008 · Cited by 398 · see citing works
Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats
McLaughlin, J., & See, R. E. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1196-x · Cited by 392 · see citing works
Effects of D-cycloserine on extinction of conditioned freezing.
Ledgerwood, L., Richardson, R., & Cranney, J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.341 · Cited by 388 · see citing works
D-Cycloserine Augmented Exposure Therapy for Obsessive-Compulsive Disorder
Kushner, M. G., Kim, S. W., Donahue, C. B., THURAS, P. D., Adson, D. E., Kotlyar, M., McCabe, J., Peterson, J., & Foa, E. B. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.020 · Cited by 384 · see citing works
Spontaneous recovery
Rescorla, R. A. (2004) · Learning & Memory · doi:10.1101/lm.77504 · Cited by 380 · see citing works
Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
Chhatwal, J. P., Davis, M., Maguschak, K. A., & Ressler, K. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300655 · Cited by 376 · see citing works
Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: Reversal by D 1 antagonists
Ciccocioppo, R., Sanna, P. P., & Weiss, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1976 · Cited by 371 · see citing works
Extending animal models of fear conditioning to humans
Delgado, M. R., Olsson, A., & Phelps, E. A. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.006 · Cited by 366 · see citing works
Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking
LaLumiere, R. T., & Kalivas, P. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5129-07.2008 · Cited by 364 · see citing works
Self-citation
Prefrontal Control of the Amygdala
Likhtik, E., Pelletier, J. G., Paz, R., & Paré, D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2314-05.2005 · Cited by 361 · see citing works
Augmentation of Behavior Therapy With <scp>d</scp> -Cycloserine for Obsessive-Compulsive Disorder
Wilhelm, S., Buhlmann, U., Tolin, D. F., Meunier, S. A., Pearlson, G. D., Reese, H. E., Cannistraro, P., Jenike, M. A., & Rauch, S. L. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050776 · Cited by 358 · see citing works
Electrical Stimulation of Medial Prefrontal Cortex Reduces Conditioned Fear in a Temporally Specific Manner.
Milad, M. R., Vidal-Gonzalez, I., & Quirk, G. J. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.2.389 · Cited by 354 · see citing works
Self-citation
Some observations on cortical inputs to the macaque monkey amygdala: An anterograde tracing study
Stefanacci, L., & Amaral, D. G. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10339 · Cited by 345 · see citing works
Direct Interactions between the Basolateral Amygdala and Nucleus Accumbens Core Underlie Cocaine-Seeking Behavior by Rats
Ciano, P. D., & Everitt, B. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1581-04.2004 · Cited by 333 · see citing works
The Role of Cognitive Control in Cocaine Dependence
Garavan, H., & Hester, R. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9034-x · Cited by 327 · see citing works
Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder
Best, M., Williams, J. M., & Coccaro, E. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112604099 · Cited by 325 · see citing works
Prefrontal Cortex Long-Term Potentiation, But Not Long-Term Depression, Is Associated with the Maintenance of Extinction of Learned Fear in Mice
Herry, C., & Garcia, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00577.2002 · Cited by 323 · see citing works
Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour
Sutton, M. A., Schmidt, E. F., Choi, K.-H., Schad, C. A., Whisler, K., Simmons, D. L., Karanian, D. A., Monteggia, L. M., Neve, R. L., & Self, D. W. (2003) · Nature · doi:10.1038/nature01249 · Cited by 322 · see citing works
Addiction and its reward process through polymorphisms of the D2dopamine receptor gene: a review
Noble, E. P. (2000) · European Psychiatry · doi:10.1016/s0924-9338(00)00208-x · Cited by 314 · see citing works
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
Park, W.-K., Bari, A., Jey, A. R., Anderson, S. M., Spealman, R. D., Rowlett, J. K., & Pierce, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02916.2002 · Cited by 310 · see citing works
Negative emotion-driven impulsivity predicts substance dependence problems
Verdejo‐García, A., Bechara, A., Recknor, E. C., & Pérez-Garcı́a, M. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.05.025 · Cited by 307 · see citing works
Neuropeptide S-Mediated Control of Fear Expression and Extinction: Role of Intercalated GABAergic Neurons in the Amygdala
Jüngling, K., Seidenbecher, T., Sosulina, L., Lesting, J., Sangha, S., Clark, S. D., Okamura, N., Duangdao, D. M., Xu, Y.-L., Reinscheid, R. K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.002 · Cited by 299 · see citing works
Blockade of Stress-Induced But Not Cocaine-Induced Reinstatement by Infusion of Noradrenergic Antagonists into the Bed Nucleus of the Stria Terminalis or the Central Nucleus of the Amygdala
Leri, F., Flores, J., Rodaros, D., & Stewart, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05713.2002 · Cited by 292 · see citing works
A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats
Salmaso, N., Rodaros, D., Stewart, J., & Erb, S. (2001) · Psychopharmacology · doi:10.1007/s002130000642 · Cited by 291 · see citing works
Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata
Chiba, T., Kayahara, T., & Nakano, K. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03013-4 · Cited by 290 · see citing works
Noradrenergic Signaling in Infralimbic Cortex Increases Cell Excitability and Strengthens Memory for Fear Extinction
Mueller, D., Porter, J. T., & Quirk, G. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3248-07.2008 · Cited by 284 · see citing works
Self-citation
Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior
Reynolds, S. M., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03261.2001 · Cited by 281 · see citing works
Trauma and substance cue reactivity in individuals with comorbid posttraumatic stress disorder and cocaine or alcohol dependence
Coffey, S. F., Saladin, M. E., Drobes, D. J., Brady, K. T., Dansky, B. S., & Kilpatrick, D. G. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(01)00157-0 · Cited by 270 · see citing works
Allelic association of the D2 dopamine receptor gene with cocaine dependence
Noble, E. P., Blum, K., Khalsa, M. E., Ritchie, T., Montgomery, A., Wood, R. C., Fitch, R. J., Ozkaragoz, T., Sheridan, P. J., Anglin, M. D., et al. (1993) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(93)90113-5 · Cited by 264 · see citing works
Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction
Sierra‐Mercado, D., Corcoran, K. A., Lebrón‐Milad, K., & Quirk, G. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05014.x · Cited by 255 · see citing works
Self-citation
Amygdala depotentiation and fear extinction
Kim, J., Lee, S., Park, K., Hong, I., Song, B., Son, G. H., Park, H., Kim, W. R., Park, E. J., Choe, H. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710548105 · Cited by 252 · see citing works
Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction
Anglada-Figueroa, D., & Quirk, G. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2600-05.2005 · Cited by 238 · see citing works
Self-citation
Activator of G Protein Signaling 3
Bowers, M. S., McFarland, K., LAKE, R. W., Peterson, Y. K., Lapish, C. C., Gregory, M. L., Lanier, S. M., & Kalivas, P. W. (2004) · Neuron · doi:10.1016/s0896-6273(04)00159-x · Cited by 236 · see citing works
Self-citation
Preferential Effects of the Metabotropic Glutamate 2/3 Receptor Agonist LY379268 on Conditioned Reinstatement versus Primary Reinforcement: Comparison between Cocaine and a Potent Conventional Reinforcer
Baptista, M. A. S., Martin‐Fardon, R., & Weiss, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0176-04.2004 · Cited by 235 · see citing works
A Subpopulation of Neurons in the Medial Prefrontal Cortex Encodes Emotional Learning with Burst and Frequency Codes through a Dopamine D4Receptor-Dependent Basolateral Amygdala Input
Laviolette, S. R., Lipski, W. J., & Grace, A. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1168-05.2005 · Cited by 235 · see citing works
Role of ventral medial prefrontal cortex in incubation of cocaine craving
Koya, E., Uejima, J. L., Wihbey, K. A., Bossert, J. M., Hope, B. T., & Shaham, Y. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.022 · Cited by 229 · see citing works
Neural substrates of cocaine-cue associations that trigger relapse
See, R. E. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.034 · Cited by 228 · see citing works
Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication.
Comings, D., Muhleman, D., & Gysin, R. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00519-6 · Cited by 226 · see citing works
RepeatedN-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine
Madayag, A., Lobner, D., Kau, K. S., Mantsch, J. R., Abdulhameed, O., Hearing, M., Grier, M. D., & Baker, D. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2808-07.2007 · Cited by 225 · see citing works
Long-Term Sequelae of Prefrontal Cortex Damage Acquired in Early Childhood
Anderson, S. W., Damásio, H., Tranel, D., & Damásio, A. R. (2000) · Developmental Neuropsychology · doi:10.1207/s1532694202anderson · Cited by 225 · see citing works
Infralimbic cortex activation increases c-fos expression in intercalated neurons of the amygdala
Berretta, S., Pantazopoulos, H., Caldera, M., Pantazopoulos, P., & Paré, D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.020 · Cited by 223 · see citing works
Interactions of the basolateral amygdala with the dorsal hippocampus and dorsomedial prefrontal cortex regulate drug context‐induced reinstatement of cocaine‐seeking in rats
Fuchs, R. A., Eaddy, J. L., Su, Z., & Bell, G. H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05674.x · Cited by 212 · see citing works
The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats
Pamplona, F. A., Prediger, R. D. S., Pandolfo, P., & Takahashi, R. N. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0514-0 · Cited by 211 · see citing works
Bidirectional synaptic plasticity in intercalated amygdala neurons and the extinction of conditioned fear responses
Royer, S., & Paré, D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00455-4 · Cited by 210 · see citing works
Is Cocaine Desire Reduced by N -Acetylcysteine?
LaRowe, S. D., Myrick, H., Hedden, S. L., Mardikian, P. N., Saladin, M. E., McRae‐Clark, A. L., Brady, K. T., Kalivas, P. W., & Malcolm, R. J. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.7.1115 · Cited by 210 · see citing works
Self-citation
LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress
Schoepp, D. D., Wright, R. A., Levine, L. R., Gaydos, B. L., & Potter, W. Z. (2003) · Stress · doi:10.1080/1025389031000146773 · Cited by 207 · see citing works
Fast Spiking and Regular Spiking Neural Correlates of Fear Conditioning in the Medial Prefrontal Cortex of the Rat
Baeg, E. H. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.5.441 · Cited by 205 · see citing works
The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse
Rogers, J. L., Ghee, S. M., & See, R. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.012 · Cited by 204 · see citing works
Dissociable Effects of Lidocaine Inactivation of the Rostral and Caudal Basolateral Amygdala on the Maintenance and Reinstatement of Cocaine-Seeking Behavior in Rats
Kantak, K. M., Black, Y. D., Valencia, E., Green-Jordan, K., & Eichenbaum, H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01126.2002 · Cited by 200 · see citing works
Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats
Vries, T. J. D., Homberg, J. R., Binnekade, R., Raasø, H. S., & Schoffelmeer, A. N. M. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1422-1 · Cited by 197 · see citing works
Evidence for the coexistence of glutamate decar☐ylase and Met-enkephalin immunoreactivities in axon terminals of rat ventral pallidum
Zahm, D. S., Záborszky, L., Alones, V., & Heimer, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90331-2 · Cited by 196 · see citing works
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats
Peters, J., & Kalivas, P. W. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0372-9 · Cited by 190 · see citing works
Self-citation
Single neurons in the medial prefrontal cortex of the rat exhibit tonic and phasic coding during trace fear conditioning.
Gilmartin, M. R., & McEchron, M. D. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.6.1496 · Cited by 183 · see citing works
Evidence that an accumbens to subpallidal GABAergic projection contributes to locomotor activity
Mogenson, G. J., & Nielsen, M. A. (1983) · Brain Research Bulletin · doi:10.1016/0361-9230(83)90166-1 · Cited by 182 · see citing works
The role of mesoaccumbens-pallidal circuitry in novelty-induced behavioral activation
Hooks, M. S., & Kalivas, P. W. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00409-x · Cited by 180 · see citing works
Self-citation
The effects of cocaine: A shifting target over the course of addiction
Porrino, L. J., Smith, H. R., Nader, M. A., & Beveridge, T. J. R. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.040 · Cited by 178 · see citing works
Psychological aspects of traumatic injury in children and adolescents
Caffo, E., & Belaise, C. (2003) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(03)00004-x · Cited by 174 · see citing works
Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution.
Sotres-Bayon, F., Díaz‐Mataix, L., Bush, D. E. A., & LeDoux, J. E. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn099 · Cited by 168 · see citing works
Corticolimbic Blood Flow During Nontraumatic Emotional Processing in Posttraumatic Stress Disorder
Phan, K. L., Britton, J. C., Taylor, S. F., Fig, L. M., & Liberzon, I. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.184 · Cited by 161 · see citing works
Manipulation of dopamine d1-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior
Sanchez, C. J., Bailie, T. M., Wu, W.-R., Li, N., & Sorg, B. A. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00078-2 · Cited by 160 · see citing works
Anger, impulsivity, and anger control in combat-related posttraumatic stress disorder.
Chemtob, C. M., Hamada, R. S., Roitblat, H. L., & Muraoka, M. Y. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.4.827 · Cited by 160 · see citing works
Building and Burying Fear Memories in the Brain
Maren, S. (2005) · The Neuroscientist · doi:10.1177/1073858404269232 · Cited by 160 · see citing works
Orbital and Medial Prefrontal Cortex and Psychostimulant Abuse: Studies in Animal Models
Porrino, L. J. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.326 · Cited by 155 · see citing works
The Rostral Anterior Cingulate Cortex Modulates the Efficiency of Amygdala-Dependent Fear Learning
Bissière, S., Plachta, N., Hoyer, D., McAllister, K. H., Olpe, H.-R., Grace, A. A., & Cryan, J. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.022 · Cited by 151 · see citing works
The distribution and origin of glutamate decar☐ylase and choline acetyltransferase in ventral pallidum and other basal forebrain regions
Walaas, I., & Fonnum, F. (1979) · Brain Research · doi:10.1016/0006-8993(79)90783-2 · Cited by 150 · see citing works
The dopamine D2 receptor gene: a genetic risk factor in substance abuse
Comings, D. E., Muhleman, D. R., Ahn, C. W., Gysin, R., & Flanagan, S. D. (1994) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(94)90154-6 · Cited by 150 · see citing works
d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference
Botreau, F., Paolone, G., & Stewart, J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.012 · Cited by 149 · see citing works
Cocaine-Induced Reinstatement Requires Endogenous Stimulation of μ-Opioid Receptors in the Ventral Pallidum
Tang, X., McFarland, K., Cagle, S., & Kalivas, P. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0685-05.2005 · Cited by 148 · see citing works
Self-citation
Intrinsic connections of the cingulate cortex in the rat suggest the existence of multiple functionally segregated networks
Jones, B. F., Groenewegen, H. J., & Witter, M. P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.063 · Cited by 135 · see citing works
The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining.Preprint
Zimmerman, J. M., Rabinak, C. A., McLachlan, I. G., & Maren, S. (2007) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.607207 · Cited by 131 · see citing works
A role for the prefrontal cortex in recall of recent and remote memories
Blum, S., Hebert, A. E., & Dash, P. (2006) · NeuroReport · doi:10.1097/01.wnr.0000201509.53750.bc · Cited by 127 · see citing works
Hippocampal low-frequency stimulation and chronic mild stress similarly disrupt fear extinction memory in rats.
Garcia, R., Spennato, G., Nilsson-Todd, L., Moreau, J., & Deschaux, O. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.10.005 · Cited by 126 · see citing works
Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning
Hikind, N., & Maroun, M. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.03.003 · Cited by 124 · see citing works
The role of prefrontal cortex D1-like and D2-like receptors in cocaine-seeking behavior in rats
Sun, W., & Rebec, G. V. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1956-x · Cited by 122 · see citing works
Involvement of the Pallidal‐thalamocortical Circuit in Adaptive Behavior
Kalivas, P. W., Churchill, L., & ROMANIDES, A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09261.x · Cited by 120 · see citing works
Self-citation
Substance abuse and panic-related anxiety: A critical review
Cox, B. J., Norton, G. R., Swinson, R. P., & Endler, N. S. (1990) · Behaviour Research and Therapy · doi:10.1016/0005-7967(90)90157-e · Cited by 119 · see citing works
The role of prefrontal cortex CB1 receptors in the modulation of fear memory
Lin, H.-C., Mao, S.-C., Su, C.-L., & Gean, P.-W. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn075 · Cited by 119 · see citing works
Postextinction Infusion of a Mitogen-Activated Protein Kinase Inhibitor Into the Medial Prefrontal Cortex Impairs Memory of the Extinction of Conditioned FearPreprint
Hugues, S., Deschaux, O., & Garcia, R. (2004) · Learning & Memory · doi:10.1101/lm.77704 · Cited by 117 · see citing works
Synaptology of prefrontal cortical projections to the basolateral amygdala: an electron microscopic study in the rat
Brinley-Reed, M., Mascagni, F., & MCDONALD, A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12212-5 · Cited by 114 · see citing works
Childhood maltreatment, perceived stress, and stress-related coping in recently abstinent cocaine dependent adults
Hyman, S. M., Paliwal, P., & Sinha, R. (2007) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.21.2.233 · Cited by 107 · see citing works
Context-dependent prefrontal cortex regulation of cocaine self-administration and reinstatement behaviors in rats
Di Pietro, N. C., Black, Y. D., & Kantak, K. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05193.x · Cited by 107 · see citing works
Altered Prelimbic Cortex Output during Cue-Elicited Drug Seeking
Miller, C. A., & Marshall, J. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1685-04.2004 · Cited by 102 · see citing works
Illicit drug use and anxiety disorders: Findings from two community surveys
Sareen, J., Chartier, M., Paulus, M. P., & Stein, M. B. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2006.01.009 · Cited by 97 · see citing works
The facilitative effects of d-cycloserine on extinction of a cocaine-induced conditioned place preference can be long lasting and resistant to reinstatement
Paolone, G., Botreau, F., & Stewart, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1280-y · Cited by 96 · see citing works
Extinction Memory Improvement by the Metabolic Enhancer Methylene BluePreprint
Gonzalez-Lima, F., & Bruchey, A. K. (2004) · Learning & Memory · doi:10.1101/lm.82404 · Cited by 93 · see citing works
The relationship between anxiety and substance use disorders among individuals with severe affective disorders
Goodwin, R. D., Stayner, D. A., Chinman, M., Wu, P., Tebes, J. K., & Davidson, L. (2002) · Comprehensive Psychiatry · doi:10.1053/comp.2002.33500 · Cited by 90 · see citing works
Clinical Perspectives on Neurobiological Effects of Psychological Trauma
Weber, D. A., & Reynolds, C. R. (2004) · Neuropsychology Review · doi:10.1023/b:nerv.0000028082.13778.14 · Cited by 89 · see citing works
Opposing roles for the ventral prefrontal cortex and the basolateral amygdala on the spontaneous recovery of cocaine-seeking in rats
Peters, J., Vallone, J., Laurendi, K., & Kalivas, P. W. (2007) · Psychopharmacology · doi:10.1007/s00213-007-1034-2 · Cited by 87 · see citing works
Self-citation
A Biologically Realistic Network Model of Acquisition and Extinction of Conditioned Fear Associations in Lateral Amygdala Neurons
Li, G., Nair, S. S., & Quirk, G. J. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90765.2008 · Cited by 86 · see citing works
Self-citation
The role of different subregions of the basolateral amygdala in cue-induced reinstatement and extinction of food-seeking behavior
McLaughlin, R. J., & Floresco, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.025 · Cited by 85 · see citing works
Nucleus accumbens dopamine and learned fear revisited: a review and some new findings
Levita, L., Dalley, J. W., & Robbins, T. W. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00287-5 · Cited by 82 · see citing works
A differential involvement of the shell and core subterritories of the nucleus accumbens of the rats in memory processes.
Jongen‐Rêlo, A. L., Kaufmann, S., & Feldon, J. (2003) · Behavioral Neuroscience · doi:10.1037//0735-7044.117.1.150 · Cited by 73 · see citing works
An infusion of bupivacaine into the nucleus accumbens disrupts the acquisition but not the expression of contextual fear conditioning.
Haralambous, T., & Westbrook, R. F. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.5.925 · Cited by 67 · see citing works
Olfactory identification dysfunction, aggression and impulsivity in war veterans with post-traumatic stress disorder
Dileo, J., Brewer, W., Hopwood, M., Anderson, V., & Creamer, M. (2007) · Psychological Medicine · doi:10.1017/s0033291707001456 · Cited by 66 · see citing works
Attenuation of Cue-Induced Heroin-Seeking Behavior by Cannabinoid CB1 Antagonist Infusions into the Nucleus Accumbens Core and Prefrontal Cortex, but Not Basolateral Amygdala
Alvarez‐Jaimes, L., Polis, I. Y., & Parsons, L. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301630 · Cited by 63 · see citing works
Retrieval and the Extinction of Memory
Cammarota, M., Bevilaqua, L., Barros, D., Vianna, M., Izquierdo, L. A., Medina, J., & Izquierdo, I. (2005) · Cellular and molecular neurobiology · doi:10.1007/s10571-005-4009-z · Cited by 61 · see citing works
Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats
Schwienbacher, I., Fendt, M., Richardson, R., & Schnitzler, H. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.037 · Cited by 59 · see citing works
Involvement of pallidothalamic circuitry in working memory
Kalivas, P. W., Jackson, D., Romanidies, A., Wyndham, L., & Duffy, P. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00054-9 · Cited by 58 · see citing works
Self-citation
Differential involvement of the prelimbic cortex and striatum in conditioned heroin and sucrose seeking following long‐term extinction
Schmidt, E. D., Voorn, P., Binnekade, R., Schoffelmeer, A. N. M., & Vries, T. J. D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04435.x · Cited by 58 · see citing works
A differential involvement of the shell and core subterritories of the nucleus accumbens of the rats in memory processes.
Jongen‐Rêlo, A. L., Kaufmann, S., & Feldon, J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.1.150 · Cited by 58 · see citing works
Posttraining lesions of the medial prefrontal cortex impair performance of Pavlovian eyeblink conditioning but have no effect on concomitant heart rate changes in rabbits (Oryctolagus cuniculus).
Powell, D. A., Skaggs, H., Churchwell, J. C., & McLaughlin, J. (2001) · Behavioral Neuroscience · doi:10.1037//0735-7044.115.5.1029 · Cited by 56 · see citing works
An infusion of bupivacaine into the nucleus accumbens disrupts the acquisition but not the expression of contextual fear conditioning.
Haralambous, T., & Westbrook, R. F. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.925 · Cited by 54 · see citing works
Traumatic events and post-traumatic stress disorder in cocaine users entering private treatment1Interim results from this study were presented at the 54th Annual Scientific Meeting of the College On Problems of Drug Dependence, June 1992, Keystone, CO.1
Wasserman, D. A., Havassy, B. E., & Boles, S. M. (1997) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(97)00048-3 · Cited by 53 · see citing works
Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning
Ovari, J., & Leri, F. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.015 · Cited by 51 · see citing works
Posttraining lesions of the medial prefrontal cortex impair performance of Pavlovian eyeblink conditioning but have no effect on concomitant heart rate changes in rabbits (Oryctolagus cuniculus).
Powell, D. A., Skaggs, H., Churchwell, J. C., et al. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.5.1029 · Cited by 47 · see citing works
Early postnatal stress alters the extinction of context-dependent conditioned fear in adult rats.
Matsumoto, M., Togashi, H., Konno, K., Koseki, H., Hirata, R., Izumi, T., Yamaguchi, T., & Yoshioka, M. (2008) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2007.12.017 · Cited by 43 · see citing works
The isomers of cocaine and tropacocaine: Effect on 3H-catecholamine uptake by rat brain synaptosomes
Komiskey, H. L., Miller, D. D., LaPidus, J. B., et al. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90110-2 · Cited by 43 · see citing works
Is Cocaine Desire Reduced by N -Acetylcysteine?
LaRowe, S. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.7.1115 · Cited by 41 · see citing works
The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA
Torregrossa, M. M., Tang, X.-C., & Kalivas, P. W. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.016 · Cited by 38 · see citing works
Self-citation
Prior cocaine exposure disrupts extinction of fear conditioningPreprint
Burke, K. A., Franz, T. M., Gugsa, N., & Schoenbaum, G. M. (2006) · Learning & Memory · doi:10.1101/lm.216206 · Cited by 36 · see citing works
PERSONALITY DISPOSITIONS IN THE PREDICTION OF POSTTRAUMATIC STRESS REACTIONS
Aidman, E., & Kollaras-Mitsinikos, L. (2006) · Psychological Reports · doi:10.2466/pr0.99.2.569-580 · Cited by 35 · see citing works
Cocaine Use and the Occurrence of Panic Attacks in the Community: A Case-Crossover Approach
O’Brien, M. S., Wu, L.-T. T., & Anthony, J. C. (2005) · Substance Use & Misuse · doi:10.1081/ja-200049236 · Cited by 33 · see citing works
Role of the prelimbic cortex in the acquisition, re-acquisition or persistence of responding for a drug-paired conditioned reinforcer
Ciano, P. D., Benham-Hermetz, J., Fogg, A. P., & Osborne, G. E. C. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.016 · Cited by 30 · see citing works
GABA–opioid interactions in the globus pallidus: [D‐Ala2]‐Met‐enkephalinamide attenuates potassium‐evoked GABA release after nigrostriatal lesion
Schroeder, J. A., & Schneider, J. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01010.x · Cited by 24 · see citing works
PERSONALITY DISPOSITIONS IN THE PREDICTION OF POSTTRAUMATIC STRESS REACTIONS
Aidman, E. (2006) · Psychological Reports · doi:10.2466/pr0.99.6.569-580 · Cited by 9 · see citing works
Editorial: Pragmatics and statistics in psychiatric genetics
Levinson, D. F. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970418)74:2 · Cited by 6 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

LaRowe, S.D., Myrick, H., Malcolm, R., and Kalivas, P. 2005. Cue reactivity and neuroimaging in cocaine-dependent subjects: A double-blind placebo-controlled pilot study involving N-acetylcysteine. In Proceedings of the 35th annual meeting of the Society for Neuroscience. Washington, DC.

Sorted by citations

Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c150015 · Cited by 1,819 · see citing works
The role of medial prefrontal cortex in memory and decision making
Euston, D. R., Gruber, A. J., & McNaughton, B. L. (2012) · Neuron · doi:10.1016/j.neuron.2012.12.002 · Cited by 1,541 · see citing works
From Reactive to Proactive and Selective Control: Developing a Richer Model for Stopping Inappropriate Responses
Aron, A. R. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.024 · Cited by 1,236 · see citing works
The Multifaceted Role of the Ventromedial Prefrontal Cortex in Emotion, Decision Making, Social Cognition, and Psychopathology
Hiser, J., & Koenigs, M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.030 · Cited by 972 · see citing works
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856 · see citing works
Stress-induced obesity and the emotional nervous system
Dallman, M. F. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.004 · Cited by 814 · see citing works
Investigating the phenomenological matrix of mindfulness-related practices from a neurocognitive perspective.
Lutz, A., Jha, A. P., Dunne, J. D., & Saron, C. D. (2015) · American Psychologist · doi:10.1037/a0039585 · Cited by 697 · see citing works
The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis
Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598 · see citing works
Self-citation
A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and Relapse
Xue, Y.-X., Luo, Y.-X., Wu, P., Shi, H.-S., Xue, L.-F., Chen, C., Zhu, W.-L., Ding, Z.-B., Bao, Y.-P., Shi, J., et al. (2012) · Science · doi:10.1126/science.1215070 · Cited by 511 · see citing works
The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear
Giustino, T. F., & Maren, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00298 · Cited by 519 · see citing works
Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking
Chen, B. T., Yau, H.-J., Hatch, C., Kusumoto-Yoshida, I., Cho, S. L., Hopf, F. W., & Bonci, A. (2013) · Nature · doi:10.1038/nature12024 · Cited by 498 · see citing works
The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
Bossert, J. M., Marchant, N. J., Calu, D. J., & Shaham, Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3120-y · Cited by 453 · see citing works
Goal-directed learning and obsessive-compulsive disorder
Gillan, C. M., & Robbins, T. W. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0475 · Cited by 348 · see citing works
LET'S GET PHYSICAL: A CONTEMPORARY REVIEW OF THE ANXIOLYTIC EFFECTS OF EXERCISE FOR ANXIETY AND ITS DISORDERS: Review: Exercise and Anxiety Reduction
Asmundson, G. J. G., Fetzner, M. G., DeBoer, L. B., Powers, M. B., Otto, M. W., & Smits, J. A. J. (2013) · Depression and Anxiety · doi:10.1002/da.22043 · Cited by 361 · see citing works
Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders
Myers-Schulz, B., & Koenigs, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.88 · Cited by 333 · see citing works
A dual operator view of habitual behavior reflecting cortical and striatal dynamics
Smith, K. S., & Graybiel, A. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.038 · Cited by 324 · see citing works
Overlapping neural systems mediating extinction, reversal and regulation of fear
Schiller, D., & Delgado, M. R. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.002 · Cited by 294 · see citing works
Environmental Enrichment Confers Stress Resiliency to Social Defeat through an Infralimbic Cortex-Dependent Neuroanatomical Pathway
Lehmann, M. L., & Herkenham, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0577-11.2011 · Cited by 234 · see citing works
Aberrant learning and memory in addiction
Torregrossa, M. M., Corlett, P. R., & Taylor, J. R. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.014 · Cited by 223 · see citing works
Improving translation of animal models of addiction and relapse by reverse translation
Venniro, M., Banks, M. L., Heilig, M., Epstein, D. H., & Shaham, Y. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0378-z · Cited by 212 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Removal of Perineuronal Nets in the Medial Prefrontal Cortex Impairs the Acquisition and Reconsolidation of a Cocaine-Induced Conditioned Place Preference Memory
Slaker, M., Churchill, L., Todd, R. P., Blacktop, J. M., Zuloaga, D. G., Raber, J., Darling, R. A., Brown, T. E., & Sorg, B. A. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3592-14.2015 · Cited by 208 · see citing works
Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood
Gass, J. T., Glen, W. B., McGonigal, J. T., Trantham-Davidson, H., Lopez, M. F., Randall, P. K., Yaxley, R., Floresco, S. B., & Chandler, L. J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.109 · Cited by 197 · see citing works
Going and stopping: dichotomies in behavioral control by the prefrontal cortex
Gourley, S. L., & Taylor, J. R. (2016) · Nature Neuroscience · doi:10.1038/nn.4275 · Cited by 195 · see citing works
PTSD and gene variants: new pathways and new thinking
Skelton, K., Ressler, K. J., Norrholm, S. D., Jovanovic, T., & Bradley-Davino, B. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.013 · Cited by 191 · see citing works
Reversible online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex
Smith, K. S., Virkud, A., Deisseroth, K., & Graybiel, A. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216264109 · Cited by 173 · see citing works
Learning to forget: manipulating extinction and reconsolidation processes to treat addiction
Torregrossa, M. M., & Taylor, J. R. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2750-9 · Cited by 172 · see citing works
How expectations influence pain
Fields, H. L. (2018) · Pain · doi:10.1097/j.pain.0000000000001272 · Cited by 175 · see citing works
Context, emotion, and the strategic pursuit of goals: interactions among multiple brain systems controlling motivated behavior
Gruber, A. J., & McDonald, R. J. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00050 · Cited by 173 · see citing works
Psychedelics and Other Psychoplastogens for Treating Mental Illness.
Vargas, M. V., Meyer, R., Avanes, A. A., Rus, M., & Olson, D. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727117 · Cited by 166 · see citing works
Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum
van Kerkhof, L. W., Damsteegt, R., Trezza, V., Voorn, P., & Vanderschuren, L. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.83 · Cited by 161 · see citing works
The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex
Pattwell, S. S., Bath, K. G., Perez-Castro, R., Lee, F. S., Chao, M. V., & Ninan, I. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5205-11.2012 · Cited by 156 · see citing works
Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models
Orsini, C. A., Moorman, D. E., Young, J. W., Setlow, B., & Floresco, S. B. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.009 · Cited by 153 · see citing works
Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex
Pfarr, S., Meinhardt, M. W., Klee, M. L., Hansson, A. C., Vengeliene, V., Schonig, K., Bartsch, D., Hope, B. T., Spanagel, R., & Sommer, W. H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0684-15.2015 · Cited by 143 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist
Shirayama, Y., Yang, C., Zhang, J.-C., Ren, Q., Yao, W., & Hashimoto, K. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.002 · Cited by 137 · see citing works
Amygdala and bed nucleus of the stria terminalis circuitry: Implications for addiction-related behaviors
Stamatakis, A. M., Sparta, D. R., Jennings, J. H., McElligott, Z. A., Decot, H., & Stuber, G. D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.046 · Cited by 132 · see citing works
dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients
Manitt, C., Eng, C., Pokinko, M., Ryan, R. T., Torres-Berrío, A., Lopez, J. P., Yogendran, S. V., Daubaras, M. J. J., Grant, A., Schmidt, E. R. E., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.105 · Cited by 125 · see citing works
The learning of fear extinction
Furini, C., Myskiw, J., & Izquierdo, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.016 · Cited by 124 · see citing works
Efficacy of invasive and non-invasive brain modulation interventions for addiction
Luigjes, J., Segrave, R., de Joode, N., Figee, M., & Denys, D. (2019) · Neuropsychology Review · doi:10.1007/s11065-018-9393-5 · Cited by 125 · see citing works
Repetitive Transcranial Magnetic Stimulation in Alcohol Dependence: A Randomized, Double-Blind, Sham-Controlled Proof-of-Concept Trial Targeting the Medial Prefrontal and Anterior Cingulate Cortices
Harel, M., Perini, I., Kämpe, R., Alyagon, U., Shalev, H., Besser, I., Sommer, W. H., Heilig, M., & Zangen, A. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.020 · Cited by 115 · see citing works
Bridging the interval: Theory and neurobiology of trace conditioning
Raybuck, J. D., & Lattal, K. M. (2014) · Behavioural Processes · doi:10.1016/j.beproc.2013.08.016 · Cited by 114 · see citing works
Psychosocial stress is associated with in vivo dopamine release in human ventromedial prefrontal cortex: A positron emission tomography study using [18F]fallypride
Lataster, J., Collip, D., Ceccarini, J., Haas, D., Booij, L., van Os, J., Pruessner, J., Van Laere, K., & Myin-Germeys, I. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.030 · Cited by 109 · see citing works
The neural correlates of regulating positive and negative emotions in medication-free major depression
Greening, S. G., Osuch, E. A., Williamson, P. C., & Mitchell, D. G. V. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst027 · Cited by 99 · see citing works
Oxytocin in the medial prefrontal cortex regulates maternal care, maternal aggression and anxiety during the postpartum period
Sabihi, S., Dong, S. M., Durosko, N. E., & Leuner, B. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00258 · Cited by 101 · see citing works
Olanzapine treatment of adolescent rats causes enduring specific memory impairments and alters cortical development and function
Milstein, J. A., Elnabawi, A., Vinish, M., Swanson, T., Enos, J. K., Bailey, A. M., Kolb, B., & Frost, D. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057308 · Cited by 57 · see citing works
Methylphenidate and Atomoxetine Inhibit Social Play Behavior through Prefrontal and Subcortical Limbic Mechanisms in Rats
Achterberg, E. J. M., van Kerkhof, L. W. M., Damsteegt, R., Trezza, V., & Vanderschuren, L. J. M. J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2945-14.2015 · Cited by 58 · see citing works
Modulation of defensive behavior by transient receptor potential vanilloid type-1 (TRPV1) channels
Aguiar, D. C., Moreira, F. A., Terzian, A. L., Fogaça, M. V., Lisboa, S. F., Wotjak, C. T., & Guimaraes, F. S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.026 · Cited by 57 · see citing works
Prefrontal Dopaminergic Mechanisms of Extinction in Adolescence Compared to Adulthood in Rats
Zbukvic, I. C., Park, C. H. J., Ganella, D. E., Lawrence, A. J., & Kim, J. H. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00032 · Cited by 57 · see citing works
Anti-relapse neurons in the infralimbic cortex of rats drive relapse-suppression by drug omission cues
Laque, A., L. De Ness, G., Wagner, G. E., Nedelescu, H., Carroll, A., Watry, D., M. Kerr, T., Koya, E., Hope, B. T., Weiss, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11799-1 · Cited by 43 · see citing works
Exposure therapy vs lifestyle intervention to reduce food cue reactivity and binge eating in obesity: A pilot study
Schyns, G., van den Akker, K., Roefs, A., Houben, K., & Jansen, A. (2020) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2019.01.005 · Cited by 44 · see citing works
Cue exposure and response prevention with heavy smokers: a laboratory-based randomised placebo-controlled trial examining the effects of D-cycloserine on cue reactivity and attentional bias
Kamboj, S. K., Joye, A., Das, R. K., Gibson, A. J. W., Morgan, C. J. A., & Curran, H. V. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2571-2 · Cited by 44 · see citing works
Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex
Christianson, J. P., Flyer-Adams, J. G., Drugan, R. C., Amat, J., Daut, R. A., Foilb, A. R., Watkins, L. R., & Maier, S. F. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00348 · Cited by 39 · see citing works
Enhancing the salience of dullness: behavioral and pharmacological strategies to facilitate extinction of drug-cue associations in adolescent rats
Brenhouse, H. C., Dumais, K., & Andersen, S. L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.063 · Cited by 38 · see citing works
Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory
Alaghband, Y., Kwapis, J. L., López, A. J., White, A. O., Aimiuwu, O. V., Al-Kachak, A., Bodinayake, K. K., Oparaugo, N. C., Dang, R., Astarabadi, M., et al. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.09.001 · Cited by 34 · see citing works
Chronic nicotine exposure produces lateralized, age‐dependent dendritic remodeling in the rodent basolateral amygdala
Bergstrom, H. C., Smith, R. F., Mollinedo, N. S., & McDonald, C. G. (2010) · Synapse · doi:10.1002/syn.20783 · Cited by 31 · see citing works
The role of the cerebellum in drug‐cue associative memory: functional interactions with the medial prefrontal cortex
Gil‐Miravet, I., Guarque‐Chabrera, J., Carbo‐Gas, M., Olucha‐Bordonau, F., & Miquel, M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14187 · Cited by 26 · see citing works
Enhanced Operant Extinction and Prefrontal Excitability in a Mouse Model of Angelman Syndrome
Sidorov, M. S., Judson, M. C., Kim, H., Rougie, M., Ferrer, A. I., Nikolova, V. D., Riddick, N. V., Moy, S. S., & Philpot, B. D. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.2828-17.2018 · Cited by 25 · see citing works
Adolescence alcohol exposure impairs fear extinction and alters medial prefrontal cortex plasticity
Lawson, K., Scarlata, M. J., Cho, W. C., Mangan, C., Petersen, D., Thompson, H. M., Ehnstrom, S., Mousley, A. L., Bezek, J. L., & Bergstrom, H. C. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109048 · Cited by 16 · see citing works

Spontaneous brain activity following fear reminder of fear conditioning by using resting-state functional MRI
Feng, P., Zheng, Y., & Feng, T. (2015) · Scientific Reports · doi:10.1038/srep16701 · Cited by 24 · see citing works
Inhibition of projections from the basolateral amygdala to the entorhinal cortex disrupts the acquisition of contextual fear
Sparta, D. R., Smithuis, J., Stamatakis, A. M., Jennings, J. H., Kantak, P. A., Ung, R. L., & Stuber, G. D. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00129 · Cited by 75 · see citing works
Fear conditioning and the basolateral amygdala
Sun, Y., Gooch, H., & Sah, P. (2020) · F1000Research · doi:10.12688/f1000research.21201.1 · Cited by 104 · see citing works
Encoding Fear of Heights by Basolateral Amygdala NeuronsPreprint
Liu, J., Lin, L., & Wang, D. V. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.13.990671
Resting-state functional connectivity between amygdala and the ventromedial prefrontal cortex following fear reminder predicts fear extinction
Feng, P., Zheng, Y., & Feng, T. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw031 · Cited by 48 · see citing works

Authors: Peters, J., Kalivas, P. W., & Quirk, G. J.
Affiliations: University of Puerto Rico, Medical Sciences Campus (PR)
Medical University of South Carolina (US)
ORCID: Peters, Jamie
Kalivas, Peter W.
Quirk, Gregory J.
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2009-04-20
Volume: 16
Issue: 5
Pages: 279-288
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.1041309
PMC: PMC4527308
OpenAlex: W2100804779
Cited by: 736
References: 196
Citations by year: 2026: 20 · 2025: 25 · 2024: 24 · 2023: 25 · 2022: 42 · 2021: 47 · 2020: 48 · 2019: 52 · 2018: 58 · 2017: 54 · 2016: 55 · 2015: 51 · 2014: 67 · 2013: 49 · 2012: 46
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1f32da005369-01, 5r01mh081975-05, MH058883)
National Institute of Mental Health (MH05383, MH-058883, R01-MH081975, F32MH085383, R01MH058883, R37MH058883, MH081975, R29MH058883)
National Institute on Drug Abuse (DA012513, R01DA012513, DA005369)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: extinction learning, fear extinction, medial prefrontal cortex, prelimbic cortex, infralimbic cortex, amygdala projections, anxiety disorders, addiction, memory extinction, inhibitory learning
MeSH terms: Animals, Brain Mapping, Extinction, Psychological, Fear, Humans, Neural Pathways, Prefrontal Cortex, Substance-Related Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Extinction circuits for fear and addiction overlap in prefrontal cortex

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks