Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age

Genome-wide methylation profiles reveal quantitative views of human aging rates

Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270 · see citing works

MethPrimer: designing primers for methylation PCRs

Li, L.-C., & Dahiya, R. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.11.1427 · Cited by 2,741 · see citing works

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390 · see citing works

Epigenetic Predictor of Age

Bocklandt, S., Lin, W., Sehl, M. E., Sánchez, F. J., Sinsheimer, J. S., Horvath, S., & Vilain, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014821 · Cited by 1,012 · see citing works

Brain-derived neurotrophic factor in neurodegenerative diseases

Zuccato, C., & Cattaneo, E. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.54 · Cited by 947 · see citing works

Multidimensional Scaling

Davison, M. L., & Sireci, S. G. (2000) · Elsevier eBooks · doi:10.1016/b978-012691360-6/50013-6 · Cited by 819 · see citing works

REST and stress resistance in ageing and Alzheimer’s disease

Lu, T., Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T.-H., Kim, H., Drake, D., Liu, X., et al. (2014) · Nature · doi:10.1038/nature13163 · Cited by 760 · see citing works

Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters

Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007) · Genomics · doi:10.1016/j.ygeno.2007.05.004 · Cited by 699 · see citing works

Epigenetics and aging: the targets and the marks

Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690 · cited 4× · see citing works

Epigenetic interplay between histone modifications and DNA methylation in gene silencing

Vaissière, T., Sawan, C., & Herceg, Z. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.02.004 · Cited by 635 · see citing works

New insights into brain BDNF function in normal aging and Alzheimer disease

Tapia‐Arancibia, L., Aliaga, E., Silhol, M., & Arancibia, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.007 · Cited by 571 · see citing works

Epigenetics and the environmental regulation of the genome and its function

Zhang, T.-Y., & Meaney, M. J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163625 · Cited by 565 · see citing works

Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects

Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379 · see citing works

Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression

Guilloux, J.-P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K., Tseng, G. C., Lewis, D. A., & Sibille, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.113 · Cited by 378 · see citing works

Is schizophrenia a syndrome of accelerated aging?

Kirkpatrick, B., Messias, E., Harvey, P. D., Fernandez-Egea, E., & Bowie, C. R. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm140 · Cited by 335 · see citing works

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

Rao, J. S., Keleshian, V. L., Klein, S. L., & Рапопорт, С. И. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.55 · Cited by 305 · see citing works

Brain-Derived Neurotrophic Factor Signaling and Subgenual Anterior Cingulate Cortex Dysfunction in Major Depressive Disorder

Tripp, A., Oh, H., Guilloux, J.-P., Martinowich, K., Lewis, D. A., & Sibille, E. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12020248 · Cited by 273 · see citing works

Molecular aging in human prefrontal cortex is selective and continuous throughout adult life

Erraji-Benchekroun, L., Underwood, M. D., Arango, V., Galfalvy, H., Pavlidis, P., Smyrniotopoulos, P., Mann, J. J., & Sibille, E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.034 · Cited by 236 · see citing works

Of sound mind and body: depression, disease, and accelerated aging

Wolkowitz, O. M., Reus, V. I., & Mellon, S. H. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/owolkowitz · Cited by 213 · see citing works

Genome-Wide Methylation Changes in the Brains of Suicide Completers

Labonté, B., Suderman, M., Maussion, G., Lopez, J. P., Navarro-Sánchez, L., Yerko, V., Mechawar, N., Szyf, M., Meaney, M. J., & Turecki, G. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12050627 · Cited by 212 · see citing works

Isolation of neuronal chromatin from brain tissue

Jiang, Y., Matevossian, A., Huang, H.-S., Straubhaar, J., & Akbarian, S. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-42 · Cited by 193 · see citing works

Reduced somatostatin in subgenual anterior cingulate cortex in major depression

Tripp, A., Kota, R. S., Lewis, D. A., & Sibille, E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.014 · Cited by 190 · see citing works

The theory of bipolar disorder as an illness of accelerated aging: implications for clinical care and research

Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183 · see citing works

DNA methylation of the BDNF gene and its relevance to psychiatric disorders

Ikegame, T., Bundo, M., Murata, Y., Kasai, K., Kato, T., & Iwamoto, K. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2013.65 · Cited by 179 · see citing works

BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex

Webster, M. J., Weickert, C. S., Herman, M. M., & Kleinman, J. E. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00540-0 · Cited by 173 · see citing works

Genomic patterns and context specific interpretation of DNA methylation

Baubec, T., & Schübeler, D. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.015 · Cited by 163 · see citing works

Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging

Hayashi, M., Yamashita, A., & Shimizu, K. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01317-0 · Cited by 132 · see citing works

Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

Lin, L., & Sibille, E. L. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00110 · Cited by 115 · see citing works

Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism

Glorioso, C. A., Oh, S., Douillard‐Guilloux, G., & Sibille, E. L. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.016 · Cited by 103 · see citing works

The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species

Seney, M. L., Chang, L.-C., Oh, H., Wang, X., Tseng, G. C., Lewis, D. A., & Sibille, E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00104 · Cited by 78 · see citing works

The Age-by-Disease Interaction Hypothesis of Late-Life Depression

McKinney, B. C., & Sibille, E. L. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.053 · Cited by 69 · see citing works

Quantitation of DNA methylation by melt curve analysis

Smith, E., Jones, M. E., & Drew, P. A. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-123 · Cited by 47 · see citing works

Epigenetic state and expression of imprinted genes in umbilical cord correlates with growth parameters in human pregnancy

Lim, A. L., Ng, S., Leow, S. C. P., Choo, R. W. M., Ito, M., Chan, Y. H., Goh, S. K., Tng, E., Kwek, K. Y. C., Chong, Y. S., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-100858 · Cited by 45 · see citing works

Age-by-disease biological interactions: implications for late-life depression

McKinney, B. C., Oh, H., & Sibille, E. L. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00237 · Cited by 20 · see citing works

Methylation analysis of SST and SSTR4 promoters in the neocortex of Alzheimer's disease patients

Großer, C., Neumann, L. C., Horsthemke, B., et al. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.02.046 · Cited by 12 · see citing works

Region-Specific In Situ Hybridization-Guided Laser-Capture Microdissection on Postmortem Human Brain Tissue Coupled with Gene Expression Quantification

Bernard, R., Burke, S., & Kerman, I. A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-163-5_29 · Cited by 5 · see citing works

Somatostatin Methylation as a Biomarker for Gastric Cancer: Ready for “Prime Time” or for Further Validation?

Goel, A. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1475-z · Cited by 4 · see citing works

Comprehensive functional genomic resource and integrative model for the human brain

Wang, D., Liu, S., Warrell, J., Won, H., Shi, X., Navarro, F. C. P., Clarke, D., Gu, M., Emani, P., Yang, Y. T., et al. (2018) · Science · doi:10.1126/science.aat8464 · Cited by 965 · see citing works

The effect of childhood trauma on serum BDNF in bipolar depression is modulated by the serotonin promoter genotype

Benedetti, F., Ambrée, O., Locatelli, C., Lorenzi, C., Poletti, S., Colombo, C., & Arolt, V. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.043 · Cited by 18 · see citing works

Role of DNA methylation in human age prediction

Goel, N., Karir, P., & Garg, V. K. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.012 · Cited by 60 · see citing works

Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function

Titcombe, P., Murray, R. J. S., Hewitt, M., Antoun, E., Cooper, C. C., Inskip, H. M., Holbrook, J. D., Godfrey, K. M., Lillycrop, K. A., Hanson, M. A., et al. (2021) · Epigenetics · doi:10.1080/15592294.2021.1950990 · Cited by 23 · see citing works

Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice

Tsuchida, A., Nonomura, T., Ono‐Kishino, M., Nakagawa, T., Taiji, M., & Noguchi, H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801678 · Cited by 86 · see citing works

Abstract 160: Identifying differential methylation patterns of benign and tumor prostate tissue in African American and European American prostate cancer patients

Chernoff, M., Demanelis, K., Gillard, M., et al. (2020) · Cancer Research · doi:10.1158/1538-7445.am2020-160 · Cited by 1 · see citing works

Epigenetic in Kidney Transplantation: Characteristic Paired Donor-Recipient DNA Methylation Patterns Correlate With Long-Term Graft Function.

Suh, J., Maluf, D. G., Gehrau, R. C., et al. (2014) · Transplantation · doi:10.1097/00007890-201407151-00653