DNA methylation of the BDNF gene and its relevance to psychiatric disorders

Trk Receptors: Roles in Neuronal Signal Transduction

Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · see citing works

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent <i>Bdnf</i> Gene Regulation

Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405 · see citing works

Lasting epigenetic influence of early-life adversity on the BDNF gene

Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273 · see citing works

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232 · see citing works

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works

Regional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.

Hofer, M., Pagliusi, S. R., Hohn, A., Leibrock, J., & Barde, Y. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07423.x · Cited by 1,017 · see citing works

ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75^NTRand Sortilin

Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013 · see citing works

A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression

Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works

Mouse and rat <i>BDNF</i> gene structure and expression revisited

Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L., & Lee, F. S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0348-04.2004 · Cited by 874 · see citing works

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works

Multiple promoters direct tissue-specific expression of the rat BDNF gene

Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858 · see citing works

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815 · see citing works

Epigenetic Regulation of <i>bdnf</i> Gene Transcription in the Consolidation of Fear Memory

Lubin, F. D., Roth, T. L., & Sweatt, J. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1786-08.2008 · Cited by 793 · see citing works

Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis

Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works

Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters

Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007) · Genomics · doi:10.1016/j.ygeno.2007.05.004 · Cited by 699 · see citing works

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r43 · Cited by 630 · see citing works

Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus

Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I.-C., Desai, P., Malone, L. M., & Sweatt, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511767200 · Cited by 615 · see citing works

The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system

Dechant, G., & Barde, Y. (2002) · Nature Neuroscience · doi:10.1038/nn1102-1131 · Cited by 606 · see citing works

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

Weickert, C. S., Hyde, T. M., Lipska, B. K., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001308 · Cited by 533 · see citing works

Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations

Maisonpierre, P. C., Beau, M. M. L., Espinosa, R., Ip, N. Y., Belluscio, L., de la Monte, S. M., Squinto, S. P., Furth, M. E., & Yancopoulos, G. D. (1991) · Genomics · doi:10.1016/0888-7543(91)90436-i · Cited by 511 · see citing works

Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR

Bibel, M., Hoppe, E., & Barde, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.616 · Cited by 476 · see citing works

Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis

Green, M. J., Matheson, S. L., Shepherd, A., Weickert, C. S., & Carr, V. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.88 · Cited by 453 · see citing works

Brain-Derived Neurotrophic Factor Val66Met and Psychiatric Disorders: Meta-Analysis of Case-Control Studies Confirm Association to Substance-Related Disorders, Eating Disorders, and Schizophrenia

Gratacòs, M., González, J. R., Mercader, J. M., de Cid, R., Urretavizcaya, M., & Estivill, X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.025 · Cited by 428 · see citing works

Relationship of Brain-Derived Neurotrophic Factor and Its Receptor TrkB to Altered Inhibitory Prefrontal Circuitry in Schizophrenia

Hashimoto, T., Bergen, S. E., Nguyen, Q. L., Xu, B., Monteggia, L. M., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4035-04.2005 · Cited by 384 · see citing works

Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects

Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379 · see citing works

DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression

Fuchikami, M., Morinobu, S., Segawa, M., Okamoto, Y., Yamawaki, S., Ozaki, N., Inoue, T., Kusumi, I., Koyama, T., Tsuchiyama, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023881 · Cited by 378 · see citing works

Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation

Szeszko, P. R., Lipsky, R. H., Mentschel, C., Robinson, D. G., Gunduz‐Bruce, H., Sevy, S. M., Ashtari, M., Napolitano, B. A., Bilder, R. M., Kane, J. M., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001656 · Cited by 373 · see citing works

Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses

Durany, N., Michel, T. M., Zöchling, R., Boissl, K. W., Cruz-Sánchez, F., Riederer, P. F., & Thome, J. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00084-0 · Cited by 363 · see citing works

Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders

Ray, M. T., Weickert, C. S., Wyatt, E. J., & Webster, M. J. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100048 · Cited by 354 · see citing works

Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients

Takahashi, M., Shirakawa, O., Toyooka, K., Kitamura, N., Hashimoto, T., Maeda, K., Koizumi, S., Wakabayashi, K., Takahashi, H., Someya, T., et al. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000718 · Cited by 340 · see citing works

Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder

Roth, T. L., Zoladz, P. R., Sweatt, J. D., & Diamond, D. M. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.013 · Cited by 321 · see citing works

Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene

Perroud, N., Salzmann, A., Prada, P., Nicastro, R., Hoeppli, M.-E., Furrer, S., Ardu, S., Krejci, I., Karege, F., & Malafosse, A. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.140 · Cited by 320 · see citing works

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

Rao, J. S., Keleshian, V. L., Klein, S. L., & Рапопорт, С. И. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.55 · Cited by 305 · see citing works

Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine

Liu, Q., Lü, L., Zhu, X.-G., Gong, J.-P., Shaham, Y., & Uhl, G. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.004 · Cited by 297 · see citing works

Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury

Onishchenko, N. R., Karpova, N. N., Sabri, F., Ċastrén, E., & Ceccatelli, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05484.x · Cited by 263 · see citing works

Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress

Unternaehrer, E., Luers, P., Mill, J., Dempster, E., Meyer, A. H., Staehli, S., Lieb, R., Hellhammer, D. H., & Meinlschmidt, G. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.77 · Cited by 250 · see citing works

Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders

Rutten, B. P. F., & Mill, J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp104 · Cited by 244 · see citing works

Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease

Liu, Q., Walther, D. M., Drgon, T., Polesskaya, O. O., Lesnick, T. G., Strain, K. J., de Andrade, M., Bower, J. H., Maraganore, D. M., & Uhl, G. R. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30109 · Cited by 227 · see citing works

Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients

Kim, H., Rapoport, S. I., & Rao, J. S. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.010 · Cited by 210 · see citing works

Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia

Weickert, C. S., Ligons, D. L., Romanczyk, T. B., Ungaro, G., Hyde, T. M., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001678 · Cited by 199 · see citing works

The role of BDNF in the pathophysiology and treatment of schizophrenia

Favalli, G. P. D. S., Li, J., Belmonte-de-Abreu, P. S., Wong, A. H. C., & Daskalakis, Z. J. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.022 · Cited by 197 · see citing works

Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII

D'Addario, C., Dell'Osso, B., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.10 · Cited by 192 · see citing works

Maternal smoking during pregnancy is associated with epigenetic modifications of the brain‐derived neurotrophic factor‐6 exon in adolescent offspring

Toledo‐Rodriguez, M., Lotfipour, S., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Pausová, Z., & Paus, T. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31109 · Cited by 176 · see citing works

An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease

Murer, M. G., Boissière‐Michot, F., Yan, Q., Hunot, S., Villares, J., Faucheux, B. A., Agid, Y., Hirsch, É. C., & Raisman‐Vozari, R. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00219-x · Cited by 176 · see citing works

Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice

Ernfors, P., Kučera, J., Lee, K., Loring, J. M., & Jaenisch, R. (1995) · The International Journal of Developmental Biology · doi:10.1387/ijdb.8645564 · Cited by 149 · see citing works

Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype.

Marini, A. M., Jiang, X., Wu, X., Tian, F., Zhu, D., Okagaki, P., & Lipsky, R. H. (2004) · PubMed · Cited by 129 · see citing works

Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans

Molteni, R., Cattaneo, A., Calabrese, F., Macchi, F., Olivier, J. D. A., Racagni, G., Ellenbroek, B. A., Gennarelli, M., & Riva, M. A. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.014 · Cited by 126 · see citing works

Whither proBDNF?

Barker, P. A. (2009) · Nature Neuroscience · doi:10.1038/nn0209-105 · Cited by 110 · see citing works

A systematic review and meta‐analysis on the association between BDNF val 66 met and hippocampal volume—A genuine effect or a winners curse?

Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Kaimatzoglou, A., Voshaar, R. C. O., Penninx, B. W. J. H., van IJzendoorn, M. H., & Elzinga, B. M. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32078 · Cited by 107 · see citing works

Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains

Iritani, S., Niizato, K., Nawa, H., Ikeda, K., & Emson, P. C. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00112-x · Cited by 101 · see citing works

Epigenetic Modulation of BDNF Gene in Patients with Major Depressive Disorder

D’Addario, C., Dell’Osso, B. M., Galimberti, D., Palazzo, C., Benatti, B., Francesco, A. D., Scarpini, E. A., Altamura, A. C., & Maccarrone, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.009 · Cited by 96 · see citing works

Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia

Wong, J., Hyde, T. M., Cassano, H., Deep‐Soboslay, A., Kleinman, J. E., & Weickert, C. S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.037 · Cited by 91 · see citing works

A longitudinal study of BDNF promoter methylation and genotype with poststroke depression

Kim, J., Stewart, R. J., Kang, H., Kim, S., Kim, S., Shin, I., Park, M., Kim, H., Shin, M., Cho, K.-H., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.008 · Cited by 91 · see citing works

Primary Structure and Biological Activity of Human Brain-Derived Neurotrophic Factor

Rosenthal, A., Goeddel, D. V., NGUYEN, T., Martin, E., Burton, L., Shih, A., Laramee, G. R., Wurm, F. M., MASON, A., Nikolics, K., et al. (1991) · Endocrinology · doi:10.1210/endo-129-3-1289 · Cited by 89 · see citing works

Human neuroblastomas with unfavorable biologies express high levels of brain-derived neurotrophic factor mRNA and a variety of its variants

Aoyama, M., Asai, K., Shishikura, T., Kawamoto, T., Miyachi, T., Yokoi, T., Togari, H., Wada, Y., Kato, T., & Nakagawara, A. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00715-1 · Cited by 85 · see citing works

DNA methylation changes in schizophrenia and bipolar disorder

Connor, C., & Akbarian, S. (2008) · Epigenetics · doi:10.4161/epi.3.2.5938 · Cited by 84 · see citing works

DNA methylation and expression profiles of the brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in patients with schizophrenia

Kordi-Tamandani, D. M., Sahranavard, R., & Torkamanzehi, A. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1986-0 · Cited by 77 · see citing works

Brain‐Derived Neurotrophic Factor Is More Highly Conserved in Structure and Function than Nerve Growth Factor During Vertebrate Evolution

Götz, R., Raulf, F., & Schartl, M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09389.x · Cited by 77 · see citing works

Depolarization induces downregulation of DNMT1 and DNMT3 in primary cortical cultures

Sharma, R. P., Tun, N., & Grayson, D. R. (2008) · Epigenetics · doi:10.4161/epi.3.2.6103 · Cited by 63 · see citing works

TrkB gene expression and DNA methylation state in Wernicke area does not associate with suicidal behavior

Keller, S., Sarchiapone, M., Zarrilli, F., Tomaiuolo, R., Carli, V., Angrisano, T., Videtič, A., Amato, F., Pero, R., di Giannantonio, M., et al. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.003 · Cited by 56 · see citing works

Darkness Reduces BDNF Expression in the Visual Cortex and Induces Repressive Chromatin Remodeling at the BDNF Gene in Both Hippocampus and Visual Cortex

Karpova, N. N., Rantamäki, T., Lieto, A. D., Lindemann, L., Hoener, M. C., & Ċastrén, E. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9544-6 · Cited by 51 · see citing works

Chromosomal mapping of brain-derived neurotrophic factor and neurotrophin-3 genes in man and mouse

Özçelık, T., Rosenthal, A., & Francke, U. (1991) · Genomics · doi:10.1016/0888-7543(91)90437-j · Cited by 48 · see citing works

Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2′-deoxycytidine in Neuro-2a cells

Ishimaru, N., Fukuchi, M., Hirai, A., Chiba, Y., Tamura, T., Takahashi, N., Tabuchi, A., Tsuda, M., & Shiraishi, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.139 · Cited by 47 · see citing works

Measurement Methods of BDNF Levels in Major Depression: A Qualitative Systematic Review of Clinical Trials

Teche, S. P., Nuernberg, G. L., Sordi, A. O., de Souza, L. H., Remy, L., Ceresér, K. M. M., & da Rocha, N. S. (2013) · Psychiatric Quarterly · doi:10.1007/s11126-013-9261-7 · Cited by 39 · see citing works

BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress

Baj, G., & Tongiorgi, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.033316 · Cited by 28 · see citing works

Alternative splicing variants and DNA methylation status of BDNF in inbred chicken lines

Yu, Y., Zhang, H., Byerly, M. S., Bacon, L. D., Porter, T. E., Liu, G. E., & Song, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.071 · Cited by 18 · see citing works

BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress

Baj, G., & Tongiorgi, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.03506 · Cited by 13 · see citing works

Epigenetic mechanisms in neurogenesis

Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 392 · see citing works

DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain

Smith, A. K., Kilaru, V., Klengel, T., Mercer, K. B., Bradley, B., Conneely, K. N., Ressler, K. J., & Binder, E. B. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32278 · Cited by 355 · see citing works

Epigenetic basis of mental illness

Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342 · see citing works

Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality

García-Gutiérrez, M. S., Navarrete, F., Sala, F., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00432 · Cited by 331 · see citing works

Prenatal stressors in rodents: Effects on behavior

Weinstock, M. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.004 · Cited by 264 · see citing works

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167 · see citing works

Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders

Jawahar, M. C., Murgatroyd, C., Harrison, E. L., & Baune, B. T. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0156-3 · Cited by 165 · see citing works

Brain-Derived Neurotrophic Factor Epigenetic Modifications Associated with Schizophrenia-like Phenotype Induced by Prenatal Stress in Mice

Dong, E., Dzitoyeva, S., Matrisciano, F., Tueting, P. A., Grayson, D. R., & Guidotti, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.012 · Cited by 162 · see citing works

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

Lai, C.-Y., Scarr, E., Udawela, M., Everall, I., Chen, W. J., & Dean, B. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i1.102 · Cited by 153 · see citing works

Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review

Frank, D., Gruenbaum, B. F., Zlotnik, A. A., Semyonov, M., Frenkel, A., & Boyko, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315114 · Cited by 154 · see citing works

Brain-derived neurotrophic factor and mental disorders

Lin, C.-C., & Huang, T.-L. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.01.001 · Cited by 143 · see citing works

Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility

Gundacker, C., Forsthuber, M., Szigeti, T., Kakucs, R., Mustieles, V., Fernandez, M. F., Bengtsen, E., Vogel, U., Hougaard, K. S., & Saber, A. T. (2021) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2021.113855 · Cited by 135 · see citing works

Brain derived neurotrophic factor: Epigenetic regulation in psychiatric disorders

Mitchelmore, C., & Gede, L. B. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.037 · Cited by 129 · see citing works

BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis

Zheleznyakova, G. Y., Cao, H., & Schiöth, H. B. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0101-4 · Cited by 127 · see citing works

Lifestyle and Chronic Pain across the Lifespan: An Inconvenient Truth?

Nijs, J., D'Hondt, E., Clarys, P., Deliens, T., Polli, A., Malfliet, A., Coppieters, I., Willaert, W., Tumkaya Yilmaz, S., Elma, Ö., et al. (2020) · PM&amp;R · doi:10.1002/pmrj.12244 · Cited by 121 · see citing works

Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus

Zheng, Y., Fan, W., Zhang, X., & Dong, E. (2016) · Epigenetics · doi:10.1080/15592294.2016.1146850 · Cited by 111 · see citing works

Theranostic Biomarkers for Schizophrenia

Perković, M. N., Erjavec, G. N., Štrac, D. Š., Uzun, S., Kozumplik, O., & Pivac, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040733 · Cited by 97 · see citing works

A Flexible, Efficient Binomial Mixed Model for Identifying Differential DNA Methylation in Bisulfite Sequencing Data

Lea, A. J., Tung, J., & Zhou, X. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005650 · Cited by 103 · see citing works

Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers

Khavari, B., & Cairns, M. J. (2020) · Cells · doi:10.3390/cells9081837 · Cited by 106 · see citing works

Frontal cortex transcriptome analysis of mice exposed to electronic cigarettes during early life stages

Lauterstein, D., Tijerina, P., Corbett, K., Akgol Oksuz, B., Shen, S., Gordon, T., Klein, C., & Zelikoff, J. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13040417 · Cited by 99 · see citing works

Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression

Jin, H., Pei, L., Li, Y., Zheng, H. W., Yang, S., Wan, Y., Mao, L., Xia, Y., He, Q., Li, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13929-5 · Cited by 96 · see citing works

NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms

Snyder, M. A., & Gao, W. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.03.010 · Cited by 93 · see citing works

Epigenetic mechanisms in schizophrenia

Akbarian, S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/sakbarian · Cited by 89 · see citing works

DNA Methylation and Psychiatric Disorders

Liu, C., Jiao, C., Wang, K., & Yuan, N. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.01.006 · Cited by 85 · see citing works

DNA methylation and antipsychotic treatment mechanisms in schizophrenia: Progress and future directions

Ovenden, E. S., McGregor, N. W., Emsley, R. A., & Warnich, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.004 · Cited by 85 · see citing works

Brain-derived neurotrophic factor (BDNF)—Epigenetic regulation in unipolar and bipolar affective disorder

Carlberg, L., Scheibelreiter, J., Hassler, M. R., Schloegelhofer, M., Schmoeger, M., Ludwig, B., Kasper, S. F., Aschauer, H. N., Egger, G., & Schosser, A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.022 · Cited by 84 · see citing works

Ratio of mBDNF to proBDNF for Differential Diagnosis of Major Depressive Disorder and Bipolar Depression

Zhao, G., Zhang, C., Chen, J., Su, Y., Zhou, R., Wang, F., Xia, W., Huang, J., Wang, Z., Hu, Y., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0098-6 · Cited by 84 · see citing works

Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs

Dong, E., Tueting, P. A., Matrisciano, F., Grayson, D. R., & Guidotti, A. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.191 · Cited by 80 · see citing works

Epigenetic alterations of the <i><scp>BDNF</scp></i> gene in combat‐related post‐traumatic stress disorder

Kim, T. Y., Kim, S. J., Chung, H. G., Choi, J. H., Kim, S. H., & Kang, J. I. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12675 · Cited by 76 · see citing works

A brief review of exercise, bipolar disorder, and mechanistic pathways

Thomson, D., Turner, A., Lauder, S., Gigler, M. E., Berk, L., Singh, A., Pasco, J. A., Berk, M., & Sylvia, L. G. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00147 · Cited by 79 · see citing works

An Update on the Epigenetics of Psychotic Diseases and Autism

Abdolmaleky, H. M., Zhou, J., & Thiagalingam, S. (2015) · Epigenomics · doi:10.2217/epi.14.85 · Cited by 75 · see citing works

Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples

Aberg, K. A., Dean, B., Shabalin, A. A., Chan, R. F., Han, L. K. M., Zhao, M., van Grootheest, G., Xie, L. Y., Milaneschi, Y., Clark, S. L., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0247-6 · Cited by 73 · see citing works

Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet

Tyagi, E., Zhuang, Y., Agrawal, R., Ying, Z., & Gómez‐Pinilla, F. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.09.014 · Cited by 70 · see citing works

Advances in Biomarkers of Major Depressive Disorder

Huang, T., & Lin, C.-C. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.11.003 · Cited by 67 · see citing works

Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder

Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 65 · see citing works

Chronic Pain and Psychiatric Conditions

Johnston, K. J. A., & Huckins, L. M. (2022) · Complex Psychiatry · doi:10.1159/000527041 · Cited by 71 · see citing works

Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats

Wu, J., Bie, B., & Naguib, M. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000981 · Cited by 65 · see citing works

Schizophrenia: A review of potential biomarkers

Rodrígues-Amorím, D., Baltanás, T. R., López, M., Spuch, C., Olivares, J. M., & Agís‐Balboa, R. C. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.05.009 · Cited by 62 · see citing works

Predator-based psychosocial stress animal model of PTSD: Preclinical assessment of traumatic stress at cognitive, hormonal, pharmacological, cardiovascular and epigenetic levels of analysis

Zoladz, P. R., & Diamond, D. M. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.003 · Cited by 61 · see citing works

The European Proceedings of Social & Behavioural Sciences

Căpiță, L. E., Huijgen, T., & Căpiță, C. (2016) · Cited by 60 · see citing works

Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time

Forest, M., O’Donnell, K. J., Voisin, G., Gaudreau, H., MacIsaac, J. L., McEwen, L. M., Silveira, P. P., Steiner, M. S., Kobor, M. S., Meaney, M. J., et al. (2018) · Epigenetics · doi:10.1080/15592294.2017.1411443 · Cited by 59 · see citing works

Toward the Identification of Peripheral Epigenetic Biomarkers of Schizophrenia

Guidotti, A., Auta, J., Davis, J. M., Dong, E., Gavin, D. P., Grayson, D. R., Sharma, R. P., Smith, R. C., Tueting, P. A., & Zhubi, A. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2014.892485 · Cited by 54 · see citing works

The hidden link between circadian entropy and mental health disorders

Alachkar, A., Lee, J., Asthana, K., Monfared, R. V., Chen, J., Alhassen, S., Samad, M., Wood, M., Mayer, E., & Baldi, P. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02028-3 · Cited by 65 · see citing works

DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD

Ding, K.-J., Yang, J.-Z., Reynolds, G., Chen, B., Shao, J., Liu, R.-X., Qian, Q., Liu, H., Yang, R.-X., Wen, J.-F., et al. (2017) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1224928 · Cited by 55 · see citing works

Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor

Jiang, H., Zhang, X., Lü, J., Meng, H., Sun, Y., Yang, X., Zhao, B., & Bao, T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00102 · Cited by 54 · see citing works

Select Prenatal Environmental Exposures and Subsequent Alterations of Gene-Specific and Repetitive Element DNA Methylation in Fetal Tissues

Green, B. B., & Marsit, C. J. (2015) · Current Environmental Health Reports · doi:10.1007/s40572-015-0045-0 · Cited by 52 · see citing works

Epigenetic Mechanisms in Autism Spectrum Disorder

Zhubi, A., Cook, E. H., Guidotti, A., & Grayson, D. R. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801311-3.00006-8 · Cited by 51 · see citing works

Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu

Buoso, E., Masi, M., Limosani, R. V., Oliviero, C., Saeed, S., Iulini, M., Passoni, F. C., Racchi, M., & Corsini, E. (2025) · Journal of Xenobiotics · doi:10.3390/jox15010013 · Cited by 50 · see citing works

Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder

D’Addario, C., Bellia, F., Benatti, B., Grancini, B. M., Vismara, M. E. M., Pucci, M., Carlo, V. D., Viganò, C. A., Galimberti, D., Fenoglio, C., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.04.006 · Cited by 47 · see citing works

S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review

Cuomo, A., Crescenzi, B. B., Bolognesi, S., Goracci, A., Koukouna, D., Rossi, R., & Fagiolini, A. M. (2020) · Annals of General Psychiatry · doi:10.1186/s12991-020-00298-z · Cited by 48 · see citing works

Brain-derived neurotrophic factor and early-life stress: Multifaceted interplay

Bondar, N. P., & Merkulova, T. I. (2016) · Journal of Biosciences · doi:10.1007/s12038-016-9648-3 · Cited by 48 · see citing works

Abnormal Brain-Derived Neurotrophic Factor Exon IX Promoter Methylation, Protein, and mRNA Levels in Patients with Major Depressive Disorder

Hsieh, M.-T., Lin, C.-C., Lee, C., & Huang, T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050568 · Cited by 45 · see citing works

Developmental conditions modulate DNA methylation at the glucocorticoid receptor gene with cascading effects on expression and corticosterone levels in zebra finches

Jimeno, B., Hau, M., Gómez‐Díaz, E., & Verhulst, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-52203-8 · Cited by 42 · see citing works

Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance

Humińska‐Lisowska, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111602 · Cited by 52 · see citing works

Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region

Vangeel, E. B., Eede, F. V. D., Hompes, T., Izzi, B., Del‐Favero, J., Moorkens, G. H., Lambrechts, D., Freson, K., & Claes, S. J. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000224 · Cited by 44 · see citing works

When Environment Meets Genetics: A Clinical Review of the Epigenetics of Pain, Psychological Factors, and Physical Activity

Polli, A., Ickmans, K., Godderis, L., & Nijs, J. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2018.09.118 · Cited by 44 · see citing works

DNA methylation analysis of Homeobox genes implicatesHOXB7hypomethylation as risk factor for neural tube defects

Rochtus, A. M., Izzi, B., Vangeel, E. B., Louwette, S., Wittevrongel, C., Lambrechts, D., Moreau, Y., Winand, R., Verpoorten, C., Jansen, K., et al. (2015) · Epigenetics · doi:10.1080/15592294.2014.998531 · Cited by 44 · see citing works

Maternal Chronic Folate Supplementation Ameliorates Behavior Disorders Induced by Prenatal High‐Fat Diet Through Methylation Alteration of BDNF and Grin2b in Offspring Hippocampus

Yan, Z., Jiao, F., Yan, X., & Ou, H. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700461 · Cited by 43 · see citing works

Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia

Morishita, H., Kundakovic, M., Bicks, L., Mitchell, A., & Akbarian, S. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.03.005 · Cited by 42 · see citing works

Sex-specific DNA methylation: impact on human health and development

Govender, P., Ghai, M., & Okpeku, M. (2022) · Molecular Genetics and Genomics · doi:10.1007/s00438-022-01935-w · Cited by 42 · see citing works

New insights into the neurobiological mechanisms of major depressive disorders

Fakhoury, M. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.01.005 · Cited by 41 · see citing works

BDNF as a potential mediator between childhood BPA exposure and behavioral function in adolescent boys from the INMA-Granada cohort

Mustieles, V., Rodríguez‐Carrillo, A., Vela-Soria, F., D’Cruz, S. C., David, A., Smagulova, F. O., Mundo-López, A., Olivas-Martínez, A., Reina-Pérez, I., Olea, N., et al. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.150014 · Cited by 41 · see citing works

Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models

Bhattacharya, S., Fontaine, A., MacCallum, P. E., Drover, J., & Blundell, J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00113 · Cited by 40 · see citing works

Epigenetic regulation of the neural transcriptome and alcohol interference during development

Resendiz, M., Mason, S., Lo, C., & Zhou, F. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00285 · Cited by 39 · see citing works

Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy

Dadkhah, M., Saadat, M., Ghorbanpour, A. M., & Moradikor, N. (2023) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2023.100017 · Cited by 38 · see citing works

BDNF polymorphisms are associated with schizophrenia onset and positive symptoms

Zhang, X. Y., Chen, D., Tan, Y., Tan, S., Luο, X., Zuo, L., & Soares, J. C. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.11.009 · Cited by 38 · see citing works

Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1

Vangeel, E. B., Pishva, E., Hompes, T., van den Hove, D., Lambrechts, D., Allegaert, K., Freson, K., Izzi, B., & Claes, S. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0408-5 · Cited by 38 · see citing works

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

Álvarez-Mon, M. Á., Ortega, M. A., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Lahera, G., Mora, F., Rodríguez-Quiroga, A., Fernández-Rojo, S., Quintero, J., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14080821 · Cited by 36 · see citing works

Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age

McKinney, B. C., Lin, C.-W., Oh, H., Tseng, G. C., Lewis, D. A., & Sibille, E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.107 · Cited by 34 · see citing works

Dysregulation of BDNF in Prefrontal Cortex in Alzheimer’s Disease

Aarons, T., Bradburn, S., Robinson, A., Payton, A., Pendleton, N., & Murgatroyd, C. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190049 · Cited by 31 · see citing works

Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats

Seo, M. K., Kim, Y. H., McIntyre, R. S., Mansur, R. B., Lee, Y. L., Carmona, N. E., Choi, A. J., Kim, G.-M., Lee, J. G., & Park, S. W. (2018) · Neural Plasticity · doi:10.1155/2018/2682037 · Cited by 31 · see citing works

Transgenerational transmission of neurodevelopmental disorders induced by maternal exposure to PM2.5

Zhou, Y., Zhang, M., Liu, W. Y., Li, Y., Qin, Y., & Xu, Y. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126920 · Cited by 30 · see citing works

New Paradigms of Old Psychedelics in Schizophrenia

Mahmood, D., Alenezi, S. K., Anwar, M. J., Azam, F., Qureshi, K. A., & Jaremko, M. (2022) · Pharmaceuticals · doi:10.3390/ph15050640 · Cited by 29 · see citing works

Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity

Bai, I., Keyser, C., Zhang, Z., Rosolia, B. J., Hwang, J.-Y., Zukin, R. S., & Yan, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1322842 · Cited by 30 · see citing works

The epigenetic legacy of illicit drugs: developmental exposures and late-life phenotypes

Flack, N., Colwell, M., & Faulk, C. D. (2019) · Current Zoology · doi:10.1093/eep/dvz022 · Cited by 28 · see citing works

Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood

Li, Y., Ma, Q., Dasgupta, C., Halavi, S., Hartman, R. E., Xiao, D., & Zhang, L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9957-4 · Cited by 28 · see citing works

Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep

Huang, H., Zhu, Y. L., Eliot, M., Knopik, V. S., McGeary, J. E., Carskadon, M. A., & Hart, A. C. (2017) · SLEEP · doi:10.1093/sleep/zsx063 · Cited by 26 · see citing works

Epigenetic Mechanisms of Rapid-Acting Antidepressants

Inserra, A., Campanale, A., Rezai, T., Romualdi, P., & Rubino, T. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03055-y · Cited by 27 · see citing works

Epigenetic modification impacting brain functions: Effects of physical activity, micronutrients, caffeine, toxins, and addictive substances

Mallick, R., & Duttaroy, A. K. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105627 · Cited by 26 · see citing works

Glioma in Schizophrenia: Is the Risk Higher or Lower?

Gao, X., Mi, Y., Guo, N., Xu, H., Jiang, P., Zhang, R., Xu, L., & Gou, X. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00289 · Cited by 26 · see citing works

The Potential Utility of Pharmacogenetic Testing in Psychiatry

Gardner, K. R., Brennan, F. X., Scott, R., & Lombard, J. (2014) · Psychiatry Journal · doi:10.1155/2014/730956 · Cited by 23 · see citing works

Quantitative leukocyte BDNF promoter methylation analysis in bipolar disorder

Strauss, J. S., Khare, T., Luca, V. D., Jeremian, R., Kennedy, J. L., Vincent, J. B., & Petronis, A. (2013) · International Journal of Bipolar Disorders · doi:10.1186/2194-7511-1-28 · Cited by 23 · see citing works

BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications

Fu, X., Wang, J., Du, J., Sun, J., Baranova, A. V., & Zhang, F. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.564277 · Cited by 22 · see citing works

The effect of childhood trauma on serum BDNF in bipolar depression is modulated by the serotonin promoter genotype

Benedetti, F., Ambrée, O., Locatelli, C., Lorenzi, C., Poletti, S., Colombo, C., & Arolt, V. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.043 · Cited by 18 · see citing works

Dysbindin-1, BDNF, and GABAergic Transmission in Schizophrenia

Jun, R. A., Zhang, W., Beacher, N. J., Zhang, Y., Li, Y., & Lin, D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.876749 · Cited by 21 · see citing works

Thymocyte‐derived BDNF influences T‐cell maturation at the DN3/DN4 transition stage

Linker, R. A., Lee, D., Flach, A., Litke, T., van den Brandt, J., Reichardt, H. M., Lingner, T., Bommhardt, U., Sendtner, M., Gold, R., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201444985 · Cited by 21 · see citing works

The role of Twist1 in mutant huntingtin–induced transcriptional alterations and neurotoxicity

Pan, Y., Zhu, Y., Yang, W., Tycksen, E., Liu, S., Palucki, J., Zhu, L., Sasaki, Y., Sharma, M. K., Kim, A. H., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001211 · Cited by 21 · see citing works

Identification of Biomarkers in Neuropsychiatric Disorders Based on Systems Biology and Epigenetics

Peedicayil, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00985 · Cited by 21 · see citing works

The role of BDNF methylation and Val66Met in amygdala reactivity during emotion processing

Redlich, R., Schneider, I., Kerkenberg, N., Opel, N., Bauhaus, J., Enneking, V., Repple, J., Leehr, E. J., Grotegerd, D., Flint, C., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24825 · Cited by 21 · see citing works

BDNF exon IV promoter methylation and antidepressant action: a complex interplay

Pathak, H., Borchert, A., Garaali, S., Burkert, A., & Frieling, H. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01415-3 · Cited by 20 · see citing works

Population Difference in the Associations of KLOTH Promoter Methylation with Mild Cognitive Impairment in Xinjiang Uygur and Han Populations

Luo, M., Zhou, X., Ji, H., Ma, W., Liu, G., Dai, D., Li, J., Chang, L. Y., Xu, L., Jiang, L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132156 · Cited by 19 · see citing works

DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects

Keller, S., Errico, F., Zarrilli, F., Florio, E., Punzo, D., Mansueto, S., Angrisano, T., Pero, R., Lembo, F., Castaldo, G., et al. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.08.022 · Cited by 19 · see citing works

Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence

Iamjan, S.-A., Thanoi, S., Watiktinkorn, P., Fachim, H., Dalton, C., Nudmamud‐Thanoi, S., & Reynolds, G. P. (2021) · Epigenomics · doi:10.2217/epi-2020-0463 · Cited by 20 · see citing works

Neurosustainability

Khalil, M. H. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1436179 · Cited by 19 · see citing works

DNA methylation and gene expression of the chemokine (C-X-C motif) ligand 1 in patients with deficit and non-deficit schizophrenia

Zhou, C., Chen, J., Tang, X., Feng, X., Yu, M., Sha, W., Wang, X., Zhang, X., Yi, H., & Zhang, X. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.06.067 · Cited by 18 · see citing works

Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats

Burgos, H., Hernández, A., Constandil, L., Ríos, M., Flores, O., Puentes, G. C., Hernández, K., Morgan, C., Valladares, L., Castillo, A., et al. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.001 · Cited by 18 · see citing works

Risk Factor Genes in Patients with Dystonia: A Comprehensive Review

Siokas, V., Aloizou, A., Tsouris, Z., Michalopoulou, A., Mentis, A. A., & Dardiotis, E. (2018) · Europe PMC (PubMed Central) · doi:10.7916/d8h438gs · Cited by 18 · see citing works

Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic–ischemic injury in neonatal rats

Li, Y., Ma, Q., Halavi, S., Concepcion, K. R., Hartman, R. E., Obenaus, A., Xiao, D., & Zhang, L. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.10.007 · Cited by 17 · see citing works

Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain

Hamdaoui, Q., Zekri, Y., Richard, S., Aubert, D., Guyot, R., Markossian, S., Gauthier, K. C., Gaie-Levrel, F., Bencsik, A. A., & Flamant, F. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.132253 · Cited by 17 · see citing works

Acute Brain-Derived Neurotrophic Factor DNA Methylation Trajectories in Cerebrospinal Fluid and Associations With Outcomes Following Severe Traumatic Brain Injury in Adults

Treble‐Barna, A., Heinsberg, L. W., Puccio, A. M., Shaffer, J. R., Okonkwo, D. O., Beers, S. R., Weeks, D. E., & Conley, Y. P. (2021) · Neurorehabilitation and neural repair · doi:10.1177/15459683211028245 · Cited by 15 · see citing works

BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis

Zheleznyakova, G. Y., Cao, H., & Schiöth, H. B. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0101-4 · Cited by 127 · see citing works

DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients

Ikegame, T., Bundo, M., Sunaga, F., Asai, T., Nishimura, F., Yoshikawa, A., Kawamura, Y., Hibino, H., Tochigi, M., Kakiuchi, C., et al. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.08.004 · Cited by 129 · see citing works

P-699 - Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients vs controls and potential influence of pharmacological treatments

Dell’Osso, B. M., D’Addario, C., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E. F., Galimberti, D., Fenoglio, C., Cortini, F., Dobrea, C., et al. (2012) · European Psychiatry · doi:10.1016/s0924-9338(12)74866-6

Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII

D'Addario, C., Dell'Osso, B., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.10 · Cited by 192 · see citing works

Alterations in DNA methylation rates of brain-derived neurotrophic factor in patients with schizophrenia

Nojima, S., Fuchikami, M., Kataoka, T., Araki, M., Omura, J., Miyagi, T., Okamoto, Y., Hishimoto, A., & Morinobu, S. (2021) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2020.08.003 · Cited by 3 · see citing works