Childhood trauma and neural responses to personalized stress: favorite-food and neutral-relaxing cues in adolescents
Open accessAbstract
Previous studies have found childhood trauma to be associated with functional and structural abnormalities in corticostriatal-limbic brain regions, which may explain the associations between trauma and negative mental and physical health outcomes. However, functional neuroimaging of maltreatment-related trauma has been limited by largely using generic and predominantly aversive stimuli. Personalized stress, favorite-food, and neutral/relaxing cues during functional magnetic resonance imaging were used to probe the neural correlates of emotional/motivational states in adolescents with varying exposure to maltreatment-related trauma. Sixty-four adolescents were stratified into high- or low-trauma-exposed groups. Cue-related measures of subjective anxiety and craving were collected. Relative to the low-trauma-exposed group, high-trauma-exposed adolescents displayed an increased activation of insula, anterior cingulate, and prefrontal cortex in response to stress cues. Activation in subcortical structures, including the hippocampus, was inversely correlated with subjective anxiety in the high- but not the low-trauma-exposed group. The high-trauma-exposed group displayed hypoactivity of cerebellar regions in response to neutral/relaxing cues. No group differences were observed in response to favorite-food cues. The relationship between trauma exposure and altered cortico-limbic circuitry may in part explain the association between childhood trauma and heightened vulnerability to emotional disturbances and risky behaviour. This may be particularly pertinent during adolescence when such difficulties often emerge. Further work is needed to elucidate the mechanism linking trauma to obesity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Stressful experiences in early childhood make individuals more vulnerable to react intensively to stress in adolescents and adulthood and to develop mental disorders and addictive behaviors.
“Consistent with this notion, stressful experiences in early childhood make individuals more vulnerable to react intensively to stress in adolescents and adulthood (Elsey et al., 2015) and to develop mental disorders (Chen and Baram, 2016) and addictive behaviors (Briand and Blendy, 2010).”
From Integrating psychological and neurobiological considerations regarding the development and maintenance of specific Internet-use disorders: An Interaction of Person-Affect-Cognition-Execution (I-PACE) model (2016) · cites this paper as Elsey et al., 2015
The Discussion reports heightened neural responses to stress cues in adolescents with greater childhood trauma exposure. It also mentions similar findings in adults after cumulative adversity across the lifespan, but this study did not establish that early-childhood stress causes heightened stress reactivity in adulthood. The mental-disorder and addictive-behavior clauses have separate citations and are not assessed here. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820 · see citing works
Handbook of attachment: theory, research, and clinical applications
(1999) · Choice Reviews Online · doi:10.5860/choice.37-1841 · Cited by 5,386 · see citing works
(1988) · Cited by 4,111 · see citing works
Mindfulness-based stress reduction and health benefits
Grossman, P., Niemann, L., Schmidt, S., & Walach, H. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00573-7 · Cited by 3,958 · see citing works
Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876 · see citing works
SHAFFER, D., FISHER, P., LUCAS, C. P., DULCAN, M. K., & SCHWAB-STONE, M. E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200001000-00014 · Cited by 3,505 · see citing works
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · see citing works
Why do many psychiatric disorders emerge during adolescence?
Paus, T., Keshavan, M., & Giedd, J. N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2513 · Cited by 3,123 · see citing works
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works
Rethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520 · see citing works
On the probable error of a coefficient of correlation deduced from a small sample
Fisher, R. A. (1921) · Adelaide Research & Scholarship (AR&S) (University of Adelaide) · Cited by 2,089 · see citing works
Validity of the Childhood Trauma Questionnaire in an Adolescent Psychiatric Population
BERNSTEIN, D. P., AHLUVALIA, T., POGGE, D., & HANDELSMAN, L. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199703000-00012 · Cited by 1,574 · see citing works
Enhancement of MR Images Using Registration for Signal Averaging
Holmes, C. J., Hoge, R. D., Collins, D. L., Woods, R. P., Toga, A. W., & Evans, A. C. (1998) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199803000-00032 · Cited by 1,422 · see citing works
Mindfulness-based stress reduction and health benefits: A meta-analysis
Grossman, P., Niemann, L., Schmidt, S., & Walach, H. (2003) · Focus on Alternative and Complementary Therapies · doi:10.1111/j.2042-7166.2003.tb04008.x · Cited by 1,394 · see citing works
Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., Poulton, R., & Caspi, A. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.214 · Cited by 1,165 · see citing works
Somerville, L. H., Jones, R. M., & Casey, B. J. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.07.003 · Cited by 1,025 · see citing works
Kaufman Assessment Battery for Children
Kaufman, A. S., & Kaufman, N. L. (1983) · PsycTESTS Dataset · doi:10.1037/t27677-000 · Cited by 1,011 · see citing works
Dannlowski, U., Stuhrmann, A., Beutelmann, V., Zwanzger, P., Lenzen, T., Grotegerd, D., Domschke, K., Hohoff, C., Ohrmann, P., Bauer, J., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.021 · Cited by 954 · see citing works
The Human Amygdala: An Evolved System for Relevance Detection
Sander, D., Grafman, J., & Zalla, T. (2003) · Reviews in the Neurosciences · doi:10.1515/revneuro.2003.14.4.303 · Cited by 944 · see citing works
Critchley, H. D., Elliott, R., Mathias, C. J., & Dolan, R. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-03033.2000 · Cited by 813 · see citing works
Andersen, S. L., Tomada, A., Vincow, E. S., Valente, E., Polcari, A., & Teicher, M. H. (2008) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.2008.20.3.292 · Cited by 788 · see citing works
The childhood trauma questionnaire in a community sample: Psychometric properties and normative data
Scher, C. D., Stein, M. B., Asmundson, G. J. G., McCreary, D. R., & Forde, D. R. (2001) · Journal of Traumatic Stress · doi:10.1023/a:1013058625719 · Cited by 726 · see citing works
Dolcos, F., LaBar, K. S., & Cabeza, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409848102 · Cited by 601 · see citing works
Kaufman Assessment Battery for Children
Loomis, D. J., Holt, R. E., Kaufman, J. C., & Kaufman, A. S. (2010) · The Corsini Encyclopedia of Psychology · doi:10.1002/9780470479216.corpsy0486 · Cited by 551 · see citing works
Child maltreatment and attachment theory
Crittenden, P. M., & Ainsworth, M. D. S. (1989) · Child Maltreatment · doi:10.1017/cbo9780511665707.015 · Cited by 527 · see citing works
Black, P. H. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00048-5 · Cited by 502 · see citing works
Early experience and the development of stress reactivity and regulation in children
Loman, M. M., & Gunnar, M. R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.007 · Cited by 489 · see citing works
Fink, L., Bernstein, D. P., Handelsman, L., Foote, J. P., & Lovejoy, M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1329 · Cited by 453 · see citing works
Woon, F. L., & Hedges, D. W. (2008) · Hippocampus · doi:10.1002/hipo.20437 · Cited by 416 · see citing works
Pryce, C. R., Rüedi‐Bettschen, D., Dettling, A. C., Weston, A. A., Russig, H. D., Ferger, B., & Feldon, J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.011 · Cited by 414 · see citing works
Does Depression Cause Obesity?
Blaine, B. E. (2008) · Journal of Health Psychology · doi:10.1177/1359105308095977 · Cited by 372 · see citing works
Clustered pixels analysis for functional MRI activation studies of the human brain
Xiong, J., Gao, J., Lancaster, J. L., & Fox, P. T. (1995) · Human Brain Mapping · doi:10.1002/hbm.460030404 · Cited by 361 · see citing works
Edmiston, E. E. (2011) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2011.565 · Cited by 341 · see citing works
Obesity and Type 2 Diabetes Risk in Midadult Life: The Role of Childhood Adversity
Thomas, C., Hyppönen, E., & Power, C. (2008) · Pediatrics · doi:10.1542/peds.2007-2403 · Cited by 330 · see citing works
Heightened neural reactivity to threat in child victims of family violence
McCrory, E. J., De Brito, S. A., Sebastian, C. L., Mechelli, A., Bird, G., Kelly, P. A., & Viding, E. (2011) · Current Biology · doi:10.1016/j.cub.2011.10.015 · Cited by 327 · see citing works
Self-citationModeling stress and drug craving in the laboratory: implications for addiction treatment development
Sinha, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00134.x · Cited by 314 · see citing works
Self-citationChild abuse and neglect and the development of mental disorders in the general population
COHEN, P., BROWN, J., & SMAILES, E. (2001) · Development and Psychopathology · doi:10.1017/s0954579401004126 · Cited by 309 · see citing works
Paivio, S. C., & Cramer, K. M. (2004) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2004.01.011 · Cited by 306 · see citing works
Attachment theory within a modern evolutionary framework
Simpson, J. A., & Belsky, J. (2008) · BIROn (Birkbeck, University of London) · Cited by 294 · see citing works
Thompson, M. P., Kingree, J. B., & Desai, S. (2004) · American Journal of Public Health · doi:10.2105/ajph.94.4.599 · Cited by 292 · see citing works
Mechanisms Linking Early Experience and the Emergence of Emotions
Pollak, S. D. (2008) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2008.00608.x · Cited by 253 · see citing works
Kelly, P. A., Viding, E. M., Wallace, G. L., Schaer, M., Brito, S. A. D., Robustelli, B. L., & McCrory, E. J. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.020 · Cited by 208 · see citing works
Self-citationNeural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity
Jastreboff, A. M., Sinha, R., Lacadie, C., Small, D. M., Sherwin, R. S., & Potenza, M. N. (2013) · Diabetes Care · doi:10.2337/dc12-1112 · Cited by 204 · see citing works
Self-citationBrain activity during biofeedback relaxation: A functional neuroimaging investigation
Critchley, H. (2001) · Brain · doi:10.1093/brain/124.5.1003 · Cited by 196 · see citing works
A 30‐year Follow‐up of the Effects of Child Abuse and Neglect on Obesity in Adulthood
Bentley, T., & Widom, C. S. (2009) · Obesity · doi:10.1038/oby.2009.160 · Cited by 163 · see citing works
Abnormal T2 relaxation time in the cerebellar vermis of adults sexually abused in childhood:
Anderson, C. M., Teicher, M. H., Polcari, A., & Renshaw, P. F. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00047-6 · Cited by 139 · see citing works
Valentino, K., Toth, S. L., & Cicchetti, D. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02072.x · Cited by 132 · see citing works
Geometric strategies for neuroanatomic analysis from MRI
Duncan, J. S., Papademetris, X., Yang, J., Jackowski, M. P., Zeng, X., & Staib, L. H. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.027 · Cited by 119 · see citing works
Examining Overgeneral Autobiographical Memory as a Risk Factor for Adolescent Depression
Rawal, A., & Rice, F. J. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.02.025 · Cited by 90 · see citing works
The neonatal cerebellum: The highest level of glucocorticoid receptors in the brain
Pavlík, A., & Buresová, M. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90171-8 · Cited by 88 · see citing works
Cumulative adversity sensitizes neural response to acute stress: association with health symptoms
Seo, D., Tsou, K. A., Ansell, E. B., Potenza, M. N., & Sinha, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.250 · Cited by 88 · see citing works
Self-citationEvent-related potentials in cocaine-exposed children during a Stroop task
Mayes, L. C., Molfese, D. L., Key, A. P. F., & Hunter, N. C. (2005) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.05.011 · Cited by 64 · see citing works
Self-citationXMedCon: an open-source medical image conversion toolkit
Nolf, E., Voet, T., Jacobs, F., Dierckx, R., & Lemahieu, I. A. (2003) · Cited by 45 · see citing works
Hommer, R. E., Seo, D., Lacadie, C., Chaplin, T. M., Mayes, L. C., Sinha, R., & Potenza, M. N. (2012) · Human Brain Mapping · doi:10.1002/hbm.22089 · Cited by 43 · see citing works
Self-citationThe Council on Economic Affairs
FINK, P. J. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.309 · Cited by 40 · see citing works
Modeling Relapse Situations in the Human Laboratory
Sinha, R. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_150 · Cited by 32 · see citing works
Self-citationPrenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli
Yip, S. W., Potenza, E. B., Balodis, I. M., Lacadie, C., Sinha, R., Mayes, L. C., & Potenza, M. N. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.133 · Cited by 23 · see citing works
Self-citationModeling Relapse Situations in the Human Laboratory
Sinha, R. (2011) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_150 · Cited by 22 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Brand, M., Young, K. S., Laier, C., Wölfling, K., & Potenza, M. N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.033 · Cited by 2,153 · see citing works
“Consistent with this notion, stressful experiences in arly childhood make individuals more vulnerable to react intenively to stress in adolescents and adulthood (Elsey et al., 2015) and o develop mental disorders (Chen and Baram, 2016) and addicive behaviors (Briand and Blendy, 2010).”
Self-citationMcCrory, E. J., Gerin, M. I., & Viding, E. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12713 · Cited by 402 · see citing works
Self-citationWiss, D. A., & Brewerton, T. D. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112964 · Cited by 273 · see citing works
Trauma, PTSD, and the Developing Brain
Herringa, R. J. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0825-3 · Cited by 248 · see citing works
Wiss, D. A., Avena, N., & Gold, M. (2020) · Nutrients · doi:10.3390/nu12113521 · Cited by 66 · see citing works
- Authors
- Elsey, J., Coates, A., Lacadie, C. M., McCrory, E. J., Sinha, R., Mayes, L. C., & Potenza, M. N.
- Affiliations
- Anna Freud Centre (GB)
- Yale University (US)
- University College London (GB)
- Corresponding author
- Potenza, Marc N
- Venue
- Neuropsychopharmacology
- Published
- 2015-01-08
- Volume
- 40
- Issue
- 7
- Pages
- 1580-1589
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC4915266
- OpenAlex
- W1993765253
- Cited by
- 52
- References
- 59
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 2
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Center for Responsible Gaming
- Korea Electrotechnology Research Institute
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (RL1AA017539)
- National Institute on Drug Abuse (R01DA006025, P50DA016556, R01DA017863, K05DA020091, PL1DA024859)
- National Institute of Dental and Craniofacial Research (UL1DE019586, UL1DE19586)
- Office of Research on Women's Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD003008)
- Common Fund
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- childhood trauma, maltreatment, adolescents, subjective anxiety, craving, insula, anterior cingulate cortex, prefrontal cortex, hippocampus, cerebellum, emotional disturbance, risk-taking
- MeSH terms
- Adolescent, Brain, Child Abuse, Cues, Emotions, Female, Food Preferences, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Oxygen, Stress, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
