Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
Abstract
The radial arm water maze (RAWM) contains six swim paths (arms) extending out of an open central area, with an escape platform located at the end of one arm (the goal arm). The goal arm location remains constant for a given mouse. On day 1, mice are trained for 15 trials (spaced over 3 h), with trials alternating between visible and hidden platform. On day 2, mice are trained for 15 trials with the hidden platform. Entry into an incorrect arm is scored as an error. The RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors. With two sessions each day, 16 mice can be tested over 2 days.
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Other common tasks of murine spatial working memory are the Radial Arm Water Maze and the Barnes Maze.
“Other common tasks of murine spatial working memory are the Radial Arm Water Maze (RAWM) and the Barnes Maze (Barnes, 1979; Diamond et al., 1999; Alamed et al., 2006).”
From Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014) · cites this paper as Alamed et al., 2006
Cites
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works
Self-citationHolcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works
Self-citationLewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Murphy, M. P., Baker, M., Yu, X., et al. (2000) · Nature Genetics · doi:10.1038/78078 · Cited by 1,371 · see citing works
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
Dodart, J.-C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M., et al. (2002) · Nature Neuroscience · doi:10.1038/nn842 · Cited by 858 · see citing works
Retinal degeneration mutants in the mouse
Chang, B., Hawes, N. L., Hurd, R. E., Davisson, M. T., Nusinowitz, S., & Heckenlively, J. R. (2002) · Vision Research · doi:10.1016/s0042-6989(01)00146-8 · Cited by 840 · see citing works
Wilcock, D. M., Rojiani, A. M., Rosenthal, A., Subbarao, S., Freeman, M. J., Gordon, M. N., & Morgan, D. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-24 · Cited by 388 · see citing works
Self-citationEstradiol facilitates performance as working memory load increases.
Bimonte, H. A., & Denenberg, V. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00068-7 · Cited by 310 · see citing works
Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice
Gordon, M. N., King, D. L., Diamond, D. M., Jantzen, P. T., Boyett, K. W., Hope, C. E., Hatcher-Martin, J. M., DiCarlo, G., Gottschall, W. P. E., Morgan, D., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00249-9 · Cited by 199 · see citing works
Self-citationWilcock, D. M., Alamed, J., Gottschall, P. E., Grimm, J., Rosenthal, A., Pons, J., Ronan, V., Symmonds, K., Gordon, M. N., & Morgan, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0695-06.2006 · Cited by 154 · see citing works
Self-citationImpaired conditioned taste aversion learning in APP transgenic mice
Janus, C., Welzl, H., Hanna, A., Lovasic, L., Lane, N., St. George-Hyslop, P., & Westaway, D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.007 · Cited by 51 · see citing works
Clapcote, S. J., Lazar, N. L., Bechard, A. R., Wood, G. A., & Roder, J. (2005) · PubMed · Cited by 51 · see citing works
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The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935 · see citing works
Self-citationWebster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755 · see citing works
“Other common tasks of murine spatial working memory are the Radial Arm Water Maze (RAWM) and the Barnes Maze (Barnes, 1979; Diamond et al., 1999; Alamed et al., 2006).”
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615 · see citing works
Assessing Spatial Learning and Memory in Rodents
Vorhees, C. V., & Williams, M. T. (2014) · ILAR Journal · doi:10.1093/ilar/ilu013 · Cited by 543 · see citing works
Horowitz, A. M., Fan, X., Bieri, G., Smith, L. K., Sanchez-Diaz, C. I., Schroer, A. B., Gontier, G., Casaletto, K. B., Kramer, J. H., Williams, K. E., et al. (2020) · Science · doi:10.1126/science.aaw2622 · Cited by 496 · see citing works
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Smith, L. K., He, Y., Park, J.-S., Bieri, G., Snethlage, C. E., Lin, K., Gontier, G., Wabl, R., Plambeck, K. E., Udeochu, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3898 · Cited by 500 · see citing works
Baruch, K., Rosenzweig, N., Kertser, A., Deczkowska, A., Sharif, A. M., Spinrad, A., Tsitsou-Kampeli, A., Sarel, A., Cahalon, L., & Schwartz, M. (2015) · Nature Communications · doi:10.1038/ncomms8967 · Cited by 491 · see citing works
Baruch, K., Deczkowska, A., Rosenzweig, N., Tsitsou-Kampeli, A., Sharif, A. M., Matcovitch-Natan, O., Kertser, A., David, E., Amit, I., & Schwartz, M. (2016) · Nature Medicine · doi:10.1038/nm.4022 · Cited by 425 · see citing works
Exercise and time-dependent benefits to learning and memory
Berchtold, N. C., Castello, N. A., & Cotman, C. W. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.050 · Cited by 371 · see citing works
Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory
Othman, M. Z., Hassan, Z., & Has, A. T. C. (2022) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.21-0120 · Cited by 375 · see citing works
A critical review of chronic stress effects on spatial learning and memory
Conrad, C. D. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.003 · Cited by 335 · see citing works
A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice
Wolf, A., Bauer, B., Abner, E. L., Ashkenazy-Frolinger, T., & Hartz, A. M. S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0147733 · Cited by 281 · see citing works
“…in learning memory (Morris and radial arm water maze), working memory (alternation), object discrimination (novel object recognition), spatial memory (Morris and radial arm water maze), long-term memory (radial arm water maze), and episodic-like memory (radial arm water maze) [24, 29, 35, 51 – 53].”
BackgroundExtracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
Fà, M., Puzzo, D., Piacentini, R., Staniszewski, A., Zhang, H., Baltrons, M. A., Puma, D. D. L., Chatterjee, I., Li, J., Saeed, F., et al. (2016) · Scientific Reports · doi:10.1038/srep19393 · Cited by 274 · see citing works
Deczkowska, A., Matcovitch-Natan, O., Tsitsou-Kampeli, A., Ben-Hamo, S., Dvir-Szternfeld, R., Spinrad, A., Singer, O., David, E., Winter, D. R., Smith, L. K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00769-0 · Cited by 260 · see citing works
Morganti, J. M., Jopson, T. D., Liu, S., Riparip, L.-K., Guandique, C. K., Gupta, N., Ferguson, A. R., & Rosi, S. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2405-14.2015 · Cited by 253 · see citing works
Platelet factors attenuate inflammation and rescue cognition in ageing
Schroer, A. B., Ventura, P. B., Sucharov, J., Misra, R., Chui, M. K. K., Bieri, G., Horowitz, A. M., Smith, L. K., Encabo, K., Tenggara, I., et al. (2023) · Nature · doi:10.1038/s41586-023-06436-3 · Cited by 252 · see citing works
Rosenzweig, N., Dvir-Szternfeld, R., Tsitsou-Kampeli, A., Keren‐Shaul, H., Ben-Yehuda, H., Weill-Raynal, P., Cahalon, L., Kertser, A., Baruch, K., Amit, I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08352-5 · Cited by 224 · see citing works
Chang, J., Rimando, A. M., Pallàs, M., Camins, A., Porquet, D., Reeves, J., Shukitt‐Hale, B., Smith, M. A., Joseph, J. A., & Casadesús, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.08.015 · Cited by 217 · see citing works
Exercise improves cognition and hippocampal plasticity in <i>APOE</i> ɛ4 mice
Nichol, K., Deeny, S. P., Seif, J., Camaclang, K., & Cotman, C. W. (2009) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2009.02.006 · Cited by 213 · see citing works
Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines
Puzzo, D., Lee, L. S., Palmeri, A., Calabrese, G., & Arancio, O. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.011 · Cited by 214 · see citing works
Wilcock, D. M., Lewis, M. R., Nostrand, W. E. V., Davis, J., Previti, M. L., Gharkholonarehe, N., Vitek, M. P., & Colton, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5066-07.2008 · Cited by 187 · see citing works
Self-citationDevelopment of an in-vivo active reversible butyrylcholinesterase inhibitor
Košak, U., Brus, B., Knez, D., Šink, R., Žakelj, S., Trontelj, J., Pišlar, A. H., Šlenc, J., Gobec, M., Živin, M., et al. (2016) · Scientific Reports · doi:10.1038/srep39495 · Cited by 176 · see citing works
Arginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease
Kan, M. J., Lee, J. E., Wilson, J. G., Everhart, A. L., Brown, C. M., Hoofnagle, A. N., Jansen, M., Vitek, M. P., Gunn, M. D., & Colton, C. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4668-14.2015 · Cited by 174 · see citing works
Small molecule cognitive enhancer reverses age-related memory decline in mice
Krukowski, K., Nolan, A., Frias, E. S., Boone, M., Ureta, G., Grue, K. A., Paladini, M. S., Elizarraras, E., Delgado, L. M., Bernales, S., et al. (2020) · eLife · doi:10.7554/elife.62048 · Cited by 161 · see citing works
Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse
Nichol, K. E., Parachikova, A. I., & Cotman, C. W. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.06.027 · Cited by 160 · see citing works
Brownlow, M. L., Benner, L., D’Agostino, D. P., Gordon, M. N., & Morgan, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075713 · Cited by 153 · see citing works
Self-citationPrice, B. R., Sudduth, T. L., Weekman, E. M., Johnson, S. N., Hawthorne, D., Woolums, A. E., & Wilcock, D. M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01915-0 · Cited by 142 · see citing works
Self-citationPhelan, K. D., Shwe, U. T., Abramowitz, J., Wu, H., Rhee, S. W., Howell, M. D., Gottschall, P. E., Freichel, M., Flockerzi, V., Birnbaumer, L., et al. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.082271 · Cited by 143 · see citing works
Sudduth, T. L., Powell, D. K., Smith, C. D., Greenstein, A. W., & Wilcock, D. M. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.1 · Cited by 142 · see citing works
Self-citationSelenica, M. B., Benner, L., Housley, S. B., Manchec, B., Lee, D. C., Nash, K. R., Kalin, J. H., Bergman, J. A., Kozikowski, A. P., Gordon, M. N., et al. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt241 · Cited by 142 · see citing works
Self-citationWebster, S. J., Bachstetter, A. D., & Eldik, L. J. V. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt182 · Cited by 140 · see citing works
Fitz, N. F., Cronican, A. A., Saleem, M., Fauq, A. H., Chapman, R., Lefterov, I. M., & Koldamova, R. P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1937-12.2012 · Cited by 138 · see citing works
Ghafarimoghadam, M., Mashayekh, R., Gholami, M., Fereydani, P., Shelley-Tremblay, J. F., Kandezi, N., Sabouri, E., & Motaghinejad, M. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113652 · Cited by 133 · see citing works
Hsp90 activator Aha1 drives production of pathological tau aggregates
Shelton, L. B., Baker, J. D., Zheng, D., Sullivan, L. E., Solanki, P. K., Webster, J. M., Sun, Z., Sabbagh, J. J., Nordhues, B. A., Koren, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707039114 · Cited by 128 · see citing works
Baranger, K., Marchalant, Y., Bonnet, A., Crouzin, N., Carreté, A., Paumier, J.-M., Py, N., Bernard, A., Bauer, C., Charrat, E., et al. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1992-1 · Cited by 110 · see citing works
Sompol, P. M., Furman, J. L., Pleiss, M. M., Kraner, S. D., Artiushin, I. A., Batten, S. R., Quintero, J. E., Simmerman, L. A., Beckett, T. L., Lovell, M. A., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0877-17.2017 · Cited by 122 · see citing works
Lockrow, J. P., Boger, H. A., Bimonte‐Nelson, H. A., & Granholm, A. C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.036 · Cited by 116 · see citing works
Fiorito, J., Saeed, F., Zhang, H., Staniszewski, A., Feng, Y., Francis, Y. I., Rao, S. R., Thakkar, D. M., Deng, S., Landry, D. W., et al. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.12.009 · Cited by 113 · see citing works
Wahl, D., Coogan, S. C. P., Solon‐Biet, S. M., de Cabo, R., Haran, J. B., Raubenheimer, D., Cogger, V. C., Mattson, M. P., Simpson, S. J., & Couteur, D. G. L. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s145247 · Cited by 111 · see citing works
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy
Nash, K. R., Lee, D. C., Hunt, J. B., Morganti, J. M., Selenica, M.-L., Moran, P., Reid, P., Brownlow, M., Guang-Yu Yang, C., Savalia, M., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.011 · Cited by 108 · see citing works
Self-citationBioluminescence imaging of Aβ deposition in bigenic mouse models of Alzheimer's disease
Watts, J. C., Giles, K., Grillo, S. K., Lemus, A., DeArmond, S. J., & Prusiner, S. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019034108 · Cited by 109 · see citing works
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain
Wheatley, E. G., Albarran, E., White, C. W., Bieri, G., Sanchez-Diaz, C., Pratt, K., Snethlage, C. E., Ding, J. B., & Villeda, S. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.003 · Cited by 107 · see citing works
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Sabbagh, J. J., O’Leary, J. C., Blair, L. J., Klengel, T., Nordhues, B. A., Fontaine, S. N., Binder, E. B., & Dickey, C. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107241 · Cited by 102 · see citing works
Mori, T., Koyama, N., Tan, J., Segawa, T., Maeda, M., & Town, T. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004280 · Cited by 99 · see citing works
Cronican, A. A., Fitz, N. F., Carter, A., Saleem, M., Shiva, S., Barchowsky, A., Koldamova, R. P., Schug, J., & Lefterov, I. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053478 · Cited by 99 · see citing works
Stewart, S., Cacucci, F., & Lever, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101827 · Cited by 94 · see citing works
The Effects of NOS2 Gene Deletion on Mice Expressing Mutated Human AβPP
Colton, C. A., Wilcock, D. M., Wink, D. A., Davis, J., Nostrand, W. E. V., & Vitek, M. P. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15405 · Cited by 92 · see citing works
Self-citationWilcock, D. M., Gharkholonarehe, N., Nostrand, W. E. V., Davis, J., Vitek, M. P., & Colton, C. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1339-09.2009 · Cited by 97 · see citing works
Self-citationHutchinson, K. M., McLaughlin, K. J., Wright, R. L., Ortiz, J. B., Anouti, D. P., Mika, A., Diamond, D. M., & Conrad, C. D. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.01.003 · Cited by 91 · see citing works
Self-citationKrukowski, K., Nolan, A., Becker, M., Picard, K., Vernoux, N., Frias, E. S., Feng, X., Tremblay, M., & Rosi, S. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.210 · Cited by 86 · see citing works
Validation of a 2-day water maze protocol in mice
Gulinello, M. E., Gertner, M. J., Mendoza, G., Schoenfeld, B. P., Oddo, S., LaFerla, F. M., Choi, C. H., McBride, S. M. J., & Faber, D. S. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.002 · Cited by 83 · see citing works
Chou, A., Krukowski, K., Morganti, J. M., Riparip, L., & Rosi, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061616 · Cited by 78 · see citing works
Landel, V., Millet, P., Baranger, K., Loriod, B., & Feron, F. P. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0087-2 · Cited by 79 · see citing works
Webster, S. J., Van Eldik, L. J., Watterson, D. M., & Bachstetter, A. D. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0291-15.2015 · Cited by 80 · see citing works
Mori, T., Koyama, N., Yokoo, T., Segawa, T., Maeda, M., Sawmiller, D. R., Tan, J., & Town, T. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012330 · Cited by 78 · see citing works
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Otsuka, S., Konno, K., Abe, M., Motohashi, J., Kohda, K., Sakimura, K., Watanabe, M., & Yuzaki, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0322-16.2016 · Cited by 78 · see citing works
McIntire, L. B., Berman, D. E., Myaeng, J., Staniszewski, A., Arancio, O., Paolo, G. D., & Kim, T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2034-12.2012 · Cited by 75 · see citing works
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Brownlow, M. L., Joly‐Amado, A., Azam, S., Elza, M., Selenica, M. B., Pappas, C. A., Small, B. J., Engelman, R. W., Gordon, M. N., & Morgan, D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.001 · Cited by 73 · see citing works
Self-citationPhysically intelligent autonomous soft robotic maze escaper
Zhao, Y., Hong, Y., Li, Y., Qi, F., Qing, H., Su, H., & Yin, J. (2023) · Science Advances · doi:10.1126/sciadv.adi3254 · Cited by 73 · see citing works
Sudduth, T. L., Weekman, E. M., Price, B. R., Gooch, J. L., Woolums, A. E., Norris, C. M., & Wilcock, D. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.024 · Cited by 71 · see citing works
Self-citationStriatal‐enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory
Venkitaramani, D. V., de Moura, P. J., Picciotto, M. R., & Lombroso, P. J. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07687.x · Cited by 68 · see citing works
Cortese, G. P., Olin, A., O’Riordan, K. J., Hullinger, R., & Bürger, C. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.11.004 · Cited by 71 · see citing works
Acquarone, E., Argyrousi, E. K., van den Berg, M., Gulisano, W., Fà, M., Staniszewski, A., Calcagno, E., Zuccarello, E., D'adamio, L., Deng, S.-X., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0326-4 · Cited by 68 · see citing works
Accessible analysis of longitudinal data with linear mixed effects models
Murphy, J. I., Weaver, N. E., & Hendricks, A. (2020) · bioRxiv · doi:10.1242/dmm.048025 · Cited by 63 · see citing works
Zou, Y., Corniola, R. S., Leu, D., Khan, A., Sahbaie, P., Chakraborti, A., Clark, J. D., Fike, J. R., & Huang, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216913110 · Cited by 63 · see citing works
Hoffman, A. N., Krigbaum, A. M., Ortiz, J. B., Mika, A., Hutchinson, K. M., Bimonte‐Nelson, H. A., & Conrad, C. D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07820.x · Cited by 63 · see citing works
Human cyclophilin 40 unravels neurotoxic amyloids
Baker, J. D., Shelton, L. B., Zheng, D., Favretto, F., Nordhues, B. A., Darling, A. L., Sullivan, L. E., Sun, Z., Solanki, P. K., Martin, M. D., et al. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2001336 · Cited by 63 · see citing works
Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice
Buhusi, M. C., Etheredge, C., Granholm, A., & Buhusi, C. V. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00284 · Cited by 64 · see citing works
Fiorito, J., Vendôme, J., Saeed, F., Staniszewski, A., Zhang, H., Yan, S., Deng, S., Arancio, O., & Landry, D. W. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00979 · Cited by 61 · see citing works
Tran, T. T., Srivareerat, M., & Alkadhi, K. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.016 · Cited by 60 · see citing works
Hascup, E. R., Broderick, S. O., Russell, M. K., Fang, Y., Bartke, A., Boger, H. A., & Hascup, K. N. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14634 · Cited by 59 · see citing works
Nicholls, R. E., Sontag, J.-M., Zhang, H., Staniszewski, A., Yan, S., Kim, C. Y., Yim, M., Woodruff, C. M., Arning, E., Wasek, B., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521018113 · Cited by 56 · see citing works
Simoes, S., Guo, J., Buitrago, L., Qureshi, Y. H., Feng, X., Kothiya, M., Cortes, E. P., Patel, V. M., Kannan, S., Kim, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110182 · Cited by 55 · see citing works
Sudduth, T. L., Weekman, E. M., Brothers, H. M., Braun, K. J., & Wilcock, D. M. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt262 · Cited by 55 · see citing works
Self-citationA Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism
Lyons, D. N., Vekaria, H., Macheda, T., Bakshi, V., Powell, D. K., Gold, B. T., Lin, A.-L., Sullivan, P. G., & Bachstetter, A. D. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5663 · Cited by 55 · see citing works
Zakirova, Z., Crynen, G. C., Hassan, S., Abdullah, L. I., Horne, L., Mathura, V. S., Crawford, F., & Ait‐Ghezala, G. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00071 · Cited by 53 · see citing works
Medina, D. X., Orr, M. E., & Oddo, S. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.006 · Cited by 51 · see citing works
Sandusky‐Beltran, L. A., Kovalenko, A., Ma, C., Calahatian, J. I. T., Placides, D. S., Watler, M., Hunt, J. B., Darling, A. L., Baker, J. D., Blair, L. J., et al. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0507-y · Cited by 51 · see citing works
Self-citationKrukowski, K., Grue, K. A., Becker, M., Elizarraras, E., Frias, E. S., Halvorsen, A. T., Koenig-Zanoff, M., Frattini, V., Nimmagadda, H., Feng, X., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg6702 · Cited by 51 · see citing works
Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome
Hamlett, E. D., Boger, H. A., Ledreux, A., Kelley, C. M., Mufson, E. J., Falangola, M. F., Guilfoyle, D. N., Nixon, R. A., Patterson, D., Duval, N., et al. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150921095505 · Cited by 51 · see citing works
Mori, T., Koyama, N., Segawa, T., Maeda, M., Maruyama, N., Kinoshita, N., Hou, H., Tan, J., & Town, T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.568212 · Cited by 49 · see citing works
Darlington, D., Deng, J., Giunta, B. N., Hou, H., Sanberg, C. D., Kuzmin‐Nichols, N., Zhou, H., Mori, T., Ehrhart, J. C., Sanberg, P. R., et al. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0345 · Cited by 46 · see citing works
Apparent Behavioral Benefits of Tau Overexpression in P301L Tau Transgenic Mice
Morgan, D., Munireddy, S., Alamed, J., DeLeon, J., Diamond, D. M., Bickford, P. C., Hutton, M. L., Lewis, J. M., McGowan, E. M., & Gordon, M. N. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15407 · Cited by 46 · see citing works
Self-citationSałat, K., Podkowa, A., Mogilski, S., Zaręba, P., Kulig, K., Sałat, R., Malikowska‐Racia, N., & Filipek, B. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.04.018 · Cited by 45 · see citing works
Dvir-Szternfeld, R., Castellani, G., Arad, M., Cahalon, L., Colaiuta, S. P., Keren‐Shaul, H., Croese, T., Burgaletto, C., Baruch, K., Ulland, T. K., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00149-w · Cited by 42 · see citing works
Adeosun, S. O., Hou, X., Zheng, B., Stockmeier, C. A., Ou, X., Paul, I. A., Mosley, T. H., Weisgraber, K. H., & Wang, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497909 · Cited by 44 · see citing works
Davis, K. E., Burnett, K., & Gigg, J. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.005 · Cited by 44 · see citing works
Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice
Mishra, M., Huang, J., Lee, Y. Y., Chua, D. S. K., Lin, X., Hu, J., & Heese, K. (2011) · BioScience Trends · doi:10.5582/bst.2011.v5.3.129 · Cited by 44 · see citing works
Sudduth, T. L., Wilson, J. G., Everhart, A. L., Colton, C. A., & Wilcock, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031993 · Cited by 43 · see citing works
Self-citationAdegoke, O. O., Qiao, F., Liu, Y., Longley, K. R., Feng, S., & Wang, H. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170173 · Cited by 43 · see citing works
Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity
Evans, E. E., Mishra, V. A., Mallow, C. L., Gersz, E. M., Balch, L., Howell, A. P., Reilly, C. A., Smith, E., Fisher, T. L., & Zauderer, M. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02509-8 · Cited by 42 · see citing works
Hou, Y., Wang, Y., Zhao, J., Li, X., Cui, J., Ding, J., Wang, Y., Zeng, X., Ling, Y., Shen, X., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111215 · Cited by 42 · see citing works
Gerstein, H., O’Riordan, K. J., Osting, S., Schwarz, M. K., & Bürger, C. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.009 · Cited by 40 · see citing works
Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease
Velázquez, R., Shaw, D. M., Caccamo, A., & Oddo, S. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0118-z · Cited by 40 · see citing works
Wolf, G., Lotan, A., Lifschytz, T., Ben-Ari, H., Kreisel, T., Tatarskyy, P., Valitzky, M., Mernick, B., Avidan, E., Koroukhov, N., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00191 · Cited by 39 · see citing works
Ben-Ari, H., Lifschytz, T., Wolf, G., Rigbi, A., Blumenfeld‐Katzir, T., Kreisel, T., Koroukhov, N., Lotan, A., & Lerer, B. (2019) · Brain Research · doi:10.1016/j.brainres.2019.01.017 · Cited by 40 · see citing works
Chan, E. S., Shetty, M. S., Sajikumar, S., Chen, C., Soong, T. W., & Wong, B.-S. (2016) · Scientific Reports · doi:10.1038/srep26119 · Cited by 39 · see citing works
Weekman, E. M., Sudduth, T. L., Caverly, C. N., Kopper, T. J., Phillips, O. W., Powell, D. K., & Wilcock, D. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1762-16.2016 · Cited by 37 · see citing works
Self-citation
- Authors
- Alamed, J., Wilcock, D. M., Diamond, D. M., Gordon, M. N., & Morgan, D.
- Affiliations
- University of South Florida (US)
- Venue
- Nature Protocols
- Published
- 2006-11
- Volume
- 1
- Issue
- 4
- Pages
- 1671-1679
- ISSN
- 1750-2799 (ISSN-L)
- 1754-2189
- OpenAlex
- W1990078328
- Cited by
- 256
- References
- 13
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 12 · 2023: 15 · 2022: 28 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 13 · 2017: 20 · 2016: 19 · 2015: 18 · 2014: 17 · 2013: 11 · 2012: 14
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Protocols (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG25509, R01AG018478, AG 15490, R01AG025509, AG 25711, R01AG015490, AG18478, P50AG025711)
- National Institute of Neurological Disorders and Stroke (NS48335, R01NS048335)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- radial arm water maze, spatial learning, spatial memory, transgenic mice, Alzheimer's disease model
- MeSH terms
- Animals, Memory Disorders, Mice, Transgenic, Statistics as Topic, Swimming, Amyloid beta-Protein Precursor, Maze Learning, Models, Animal, Mice
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