Cited by 258Alzheimer's disease research and treatmentsMemory and Neural MechanismsMedicinal Plants and Neuroprotection

Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice

Alamed, Jennifer, Wilcock, Donna M, Diamond, David M, Gordon, Marcia N, Morgan, Dave·2006·Nature Protocols

Abstract

The radial arm water maze (RAWM) contains six swim paths (arms) extending out of an open central area, with an escape platform located at the end of one arm (the goal arm). The goal arm location remains constant for a given mouse. On day 1, mice are trained for 15 trials (spaced over 3 h), with trials alternating between visible and hidden platform. On day 2, mice are trained for 15 trials with the hidden platform. Entry into an incorrect arm is scored as an error. The RAWM has the spatial complexity and performance measurement simplicity of the dry radial arm maze combined with the rapid learning and strong motivation observed in the Morris water maze without requiring foot shock or food deprivation as motivating factors. With two sessions each day, 16 mice can be tested over 2 days.

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Crossref · 10.1038/nprot.2006.275

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Authors
Alamed, J., Wilcock, D. M., Diamond, D. M., Gordon, M. N., & Morgan, D.
Affiliations
University of South Florida (US)
Venue
Nature Protocols
Published
2006-11
Volume
1
Issue
4
Pages
1671-1679
ISSN
  • 1750-2799 (ISSN-L)
  • 1754-2189
OpenAlex
W1990078328
Cited by
256
References
13
Citations by year
2026: 9 · 2025: 6 · 2024: 12 · 2023: 15 · 2022: 28 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 13 · 2017: 20 · 2016: 19 · 2015: 18 · 2014: 17 · 2013: 11 · 2012: 14
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Protocols (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (AG25509, R01AG018478, AG 15490, R01AG025509, AG 25711, R01AG015490, AG18478, P50AG025711)
  • National Institute of Neurological Disorders and Stroke (NS48335, R01NS048335)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
radial arm water maze, spatial learning, spatial memory, transgenic mice, Alzheimer's disease model
MeSH terms
Animals, Memory Disorders, Mice, Transgenic, Statistics as Topic, Swimming, Amyloid beta-Protein Precursor, Maze Learning, Models, Animal, Mice

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