Ubiquitin ligases: cell-cycle control and cancer

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661

Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex

Zachariae, W., Schwab, M., Nasmyth, K., & Seufert, W. (1998) · Science · doi:10.1126/science.282.5394.1721 · Cited by 511

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

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Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

Mao, J.-H., Perez-losada, J., Wu, D., DelRosario, R., Tsunematsu, R., Nakayama, K. I., Brown, K., Bryson, S., & Balmain, A. (2004) · Nature · doi:10.1038/nature03155 · Cited by 390

β-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases

Kanemori, Y., Uto, K., & Sagata, N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501873102 · Cited by 128

Cell cycle, CDKs and cancer: a changing paradigm

Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957

On the Dependency of Cellular Protein Levels on mRNA Abundance

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Proteogenomics connects somatic mutations to signalling in breast cancer

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Welcker, M., & Clurman, B. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2290 · Cited by 1,084

The role of ubiquitination in tumorigenesis and targeted drug discovery

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Global Protein Stability Profiling in Mammalian Cells

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Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities

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SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

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The PROTACtable genome

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Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

Bulatov, E., & Ciulli, A. (2015) · Biochemical Journal · doi:10.1042/bj20141450 · Cited by 237

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy

Soucy, T. A., Dick, L. R., Smith, P. G., Milhollen, M. A., & Brownell, J. E. (2010) · Genes & Cancer · doi:10.1177/1947601910382898 · Cited by 225

Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks

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CHIP-Mediated Degradation and DNA Damage-Dependent Stabilization Regulate Base Excision Repair Proteins

Parsons, J. L., Tait, P. S., Finch, D., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.027 · Cited by 165

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer

Daou, S., Hammond-Martel, I., Mashtalir, N., Barbour, H., Gagnon, J., Iannantuono, N. G., Nkwe, N. S., Motorina, A., Pak, H., Yu, H., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.661553 · Cited by 146

Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity

Frank, C. L., & Tsai, L.-H. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.029 · Cited by 118

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein

Okuhira, K., Ohoka, N., Sai, K., Nishimaki-Mogami, T., Itoh, Y., Ishikawa, M., Hashimoto, Y., & Naito, M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.019 · Cited by 118

Regulatory mechanisms of one-carbon metabolism enzymes

Petrova, B., Maynard, A. G., Wang, P., & Kanarek, N. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105457 · Cited by 103

Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1

Lin, Z., Tan, C., Qiu, Q., Kong, S., Yang, H., Zhao, F., Liu, Z., Li, J., Kong, Q., Gao, B., et al. (2015) · Cell Discovery · doi:10.1038/celldisc.2015.28 · Cited by 90

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.

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Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer

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High-Throughput Screening AlphaScreen Assay for Identification of Small-Molecule Inhibitors of Ubiquitin E3 Ligase SCFSkp2-Cks1

Ungermannova, D., Lee, J., Zhang, G., Dallmann, H. G., McHenry, C. S., & Liu, X. (2013) · SLAS Discovery · doi:10.1177/1087057113485789 · Cited by 70

Sequential replication-coupled destruction at G1/S ensures genome stability

Coleman, K. E., Grant, G. D., Haggerty, R. A., Brantley, K., Shibata, E., Workman, B. D., Dutta, A., Varma, D., Purvis, J. E., & Cook, J. G. (2015) · Genes & Development · doi:10.1101/gad.263731.115 · Cited by 51

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.018 · Cited by 46

Mechanisms of tolvaptan-induced toxicity in HepG2 cells

Wu, Y., Beland, F. A., Chen, S., Liu, F., Guo, L., & Fang, J.-L. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.03.015 · Cited by 41

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

Krenning, L., Sonneveld, S., & Tanenbaum, M. E. (2022) · eLife · doi:10.7554/elife.71356 · Cited by 41

Cell Cycle Regulation and Apoptotic Cell Death in Experimental Colon Carcinogenesis: Intervening with Cyclooxygenase-2 Inhibitors

Saini, M. K., & Sanyal, S. N. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1015743 · Cited by 37

Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7

Boretto, M., Geurts, M. H., Gandhi, S., Ma, Z., Staliarova, N., Celotti, M., Lim, S., He, G.-W., Millen, R., Driehuis, E., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309902121 · Cited by 30

Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis

Yu, Y., & Munger, K. (2013) · Virology · doi:10.1016/j.virol.2013.08.013 · Cited by 15