FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Welcker, Markus, Clurman, Bruce E.·2008·Nature Reviews Cancer

DOI 10.1038/nrc2290

Cited by (1,000)

Items 101–200 of 1,000

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase
Stephen M. Orlicky, Xiaojing Tang, Victor Neduva, Nadine H. Elowe, Eric D. Brown, Frank Sicheri, Mike Tyers · 2010 · Nature Biotechnology
The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation
Dong Hong Zhao, Hanqiu Zheng, Zhongmei Zhou, Ceshi Chen · 2010 · Cancer Research
Notch in fibrosis and as a target of anti-fibrotic therapy
Biao Hu, Sem Hin Phan · 2016 · Pharmacological Research
Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase
Sang Hyun Min, Alan W. Lau, Tae Ho Lee, Hiroyuki Inuzuka, Shuo Wei, Pengyu Huang, Shavali Shaik, Daniel Yenhong Lee, Greg Finn, Martin Balaštík et al. · 2012 · Molecular Cell
SCF E3 Ubiquitin Ligases as Anticancer Targets
Lijun Jia, Yi Sun · 2011 · Current Cancer Drug Targets
An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance
Ningning Li, Roya Babaei‐Jadidi, Federica Lorenzi, Bradley Spencer‐Dene, Philip A. Clarke, Enric Domingo, Eugene M. Tulchinsky, Robert G.J. Vries, David James Kerr, Yihang Pan et al. · 2019 · Oncogenesis
Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer
Catherine Elizabeth Caldon, Elizabeth A. Musgrove · 2010 · Cell Division
Degradation of Activated Protein Kinases by Ubiquitination
LU Zhi-min, Hunter Tony · 2009 · Annual Review of Biochemistry
Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammation
Jia He, Yinjing Song, Gaopeng Li, Peng Xiao, Yang Liu, Yue Xue, Qian Cao, Xintao Tu, Ting Shuang Pan, Zhinong Jiang et al. · 2019 · Journal of Clinical Investigation
Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significance
Masaaki Iwatsuki, Koshi Mimori, Hideshi Ishii, Takehiko Yokobori, Yasushi Takatsuno, Tetsuya Sato, Hiroyuki Toh, Ichiro Onoyama, Keiichi I. Nakayama, Hideo Andreas Baba et al. · 2009 · International Journal of Cancer
The SnRK2-APC/CTE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways
Qibing Lin, Fuqing Wu, Peike Sheng, Zhe Zhang, Xin Zhang, Xiuping Guo, Jiulin Wang, Zhijun Cheng, Jie Wang, Haiyang Wang et al. · 2015 · Nature Communications
Degrons in cancer
Bálint Mészáros, Manjeet Kumar, Toby J. Gibson, Bora Uyar, Zsuzsanna Dosztányi · 2017 · Science Signaling
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer
Shunrong Ji, Yi Qin, Si Shi, Xiangyuan Liu, Hongli Hu, Hu Zhou, Jing Gao, Bo Zhang, Wenyan Xu, Jiang Liu et al. · 2015 · Cell Research
Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma
Junji Kurashige, M Watanabe, Masaaki Iwatsuki, Kouichi Kinoshita, Seiya Saito, Yukiharu Hiyoshi, HANAE KAMOHARA, Yoshifumi Baba, Koshi Mimori, Hideo Andreas Baba · 2011 · British Journal of Cancer
DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells
Naoe Taira, Rei Mimoto, Morito Kurata, Tomoko Yamaguchi, Masanobu Kitagawa, Yoshio Miki, Kiyotsugu Yoshida · 2012 · Journal of Clinical Investigation
F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor
Rocı́o Sancho, Anett Jandke, Hayley L. Belnoue-Davis, Markus E. Diefenbacher, Ian P.M. Tomlinson, Axel Behrens · 2010 · Gastroenterology
The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia
Marc R. Mansour, Takaomi Sanda, Lee N. Lawton, Xiaoyu Li, Taras Kreslavsky, Carl D. Novina, Marjorie Brand, Alejandro Gutiérrez, Michelle A. Kelliher, Catriona H. M. Jamieson et al. · 2013 · The Journal of Experimental Medicine
F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner
Kanae Yumimoto, Sayuri Akiyoshi, Hiroki Ueo, Yasuaki Sagara, Ichiro Onoyama, Hiroaki Ueo, Shinji Ohno, Masaki Mori, Koshi Mimori, Keiichi I. Nakayama · 2015 · Journal of Clinical Investigation
Combined Mutation of Apc, Kras , and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer
Sakai, Eri, Nakayama, Mizuho, Oshima, Hiroko, Kouyama, Yuta, Niida, Atsushi, Fujii, Satoshi, Ochiai, Atsushi, Nakayama, Keiichi I., Mimori, Koshi, Suzuki, Yutaka et al. · 2018 · Cancer Research
Identification of human haploinsufficient genes and their genomic proximity to segmental duplications
Vinh T Dang, Karin S. Kassahn, Andrés Esteban Marcos, Mark A. Ragan · 2008 · European Journal of Human Genetics
Novel Evidence for Curcumin and Boswellic Acid–Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer
Shusuke Toden, Yoshinaga Okugawa, Constanze Buhrmann, Durgha Nattamai, Esperanza Anguiano, Nicole E. Baldwin, Mehdi Shakibaei, Clement Richard Boland, Ajay Goel · 2015 · Cancer Prevention Research
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4
Qiang Zhang, David M. Karnak, Mingjia Tan, Theodore Steven Lawrence, Meredith Ann Morgan, Yi Sun · 2016 · Molecular Cell
FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2
Fei Xu, Jiajia Li, Mengdong Ni, Jingyi Cheng, Haiyun Zhao, Shanshan Wang, Xiang Yu Zhou, Xiaohua Wu · 2021 · Molecular Cancer
Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells
Rocı́o Sancho, Ralph Gruber, Guoqiang Gu, Axel Behrens · 2014 · Cell stem cell
The heat-shock, or HSF1-mediated proteotoxic stress, response in cancer: from proteomic stability to oncogenesis
Chengkai Dai · 2017 · Philosophical Transactions of the Royal Society B Biological Sciences
The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis.
Yaqin Tu, Cai Chen, Junru Pan, Junfa Xu, Zhiguang Zhou, Cong‐Yi Wang · 2012 · Europe PMC (PubMed Central)
WT1 mutations in T-ALL
Valeria Tosello, Marc R. Mansour, Kelly Barnes, Maddalena Paganin, Maria Luisa Sulis, Sarah Jenkinson, Christopher G. Allen, Rosemary E. Gale, David C. Linch, Teresa Palomero et al. · 2009 · Blood
Notch as a hub for signaling in angiogenesis
Rui Benedito, Mats Hellström · 2013 · Experimental Cell Research
F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check
Víctor M. Diaz, Antonio Garcı́a de Herreros · 2015 · Seminars in Cancer Biology
Myc and its interactors take shape
William B. Tu, Sara Helander, Robert Pilstål, K. Ashley Hickman, Corey Lourenco, Igor Jurišica, Brian Raught, Björn Wallner, Maria Sunnerhagen, Linda Z. Penn · 2014 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
LncRNA‐MIF, a c‐Myc‐activated long non‐coding RNA, suppresses glycolysis by promoting Fbxw7‐mediated c‐Myc degradation
Pengfei Zhang, Limian Cao, Pingsheng Fan, Yide Mei, Mian Wu · 2016 · EMBO Reports
ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence
Lijun Jia, Marı́a S. Soengas, Yi Sun · 2009 · Cancer Research
Vitamin D receptor as a master regulator of the c-MYC/MXD1 network
Reyhaneh Salehi-Tabar, Loan Nguyen‐Yamamoto, Luz E. Tavera-Mendoza, Thomas Quail, Vassil Dimitrov, Beum‐Soo An, Leon Glass, David Goltzman, John H. White · 2012 · Proceedings of the National Academy of Sciences
Eya1 Interacts with Six2 and Myc to Regulate Expansion of the Nephron Progenitor Pool during Nephrogenesis
Jin Xu, Elaine Y.M. Wong, Chunming Cheng, Jun Li, Mohammad Tofael Kabir Sharkar, Chelsea Y. Xu, Binglai Chen, Jianbo Sun, Dongzhu Jing, Pin‐Xian Xu · 2014 · Developmental Cell
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
Linsey B. Reavie, Giusy Della Gatta, Kelly Moran-Crusio, Beatriz Aranda-Orgillés, Shannon M. Buckley, Benjamin J. Thompson, Eugine Lee, Jie Gao, Andrea L. Bredemeyer, Beth Ann Helmink et al. · 2010 · Nature Immunology
Biological roles of LSD1 beyond its demethylase activity
Feiying Gu, Yuxin Lin, Zhun Wang, Xiaoxin Wu, Zhenyue Ye, Yuezhen Wang, Huiyin Lan · 2020 · Cellular and Molecular Life Sciences
Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy
Carmen Herling, Marion Klaumuenzer, Cristiano Krings Rocha, Janine Altmüller, Hölger Thiele, Jasmin Bahlo, Sandra Kluth, Giuliano Crispatzu, Marco Herling, Joanna Schiller et al. · 2016 · Blood
Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding
Cecilia Andrésen, Sara Helander, Alexander S. Lemak, Christophe Farès, Veronika Csizmók, Jonas Carlsson, Linda Z. Penn, Julie Deborah Forman-Kay, C.H. Arrowsmith, Patrik Lundström et al. · 2012 · Nucleic Acids Research
Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase
Jonathan E. Grim, Michael P. Gustafson, Roli K. Hirata, Amanda Hagar, Jherek Swanger, Markus Welcker, Harry C. Hwang, Johan Ericsson, David W. Russell, Bruce E. Clurman · 2008 · The Journal of Cell Biology
Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCFFBXL17 in NRF2 Activation via BACH1 Repressor Turnover
Meng-Kwang Marcus Tan, Hui-Jun Lim, Eric J. Bennett, Yang Shi, J. Wade Harper · 2013 · Molecular Cell
Ubiquitin becomes ubiquitous in cancer
Dingding Shi, Steven R. Grossman · 2010 · Cancer Biology & Therapy
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
Ichiro Onoyama, Atsushi Suzuki, Akinobu Matsumoto, Kengo Tomita, Hideki Katagiri, Yuichi Oike, Keiko Nakayama, Keiko Nakayama · 2010 · Journal of Clinical Investigation
Spotlight on the role of COP1 in tumorigenesis
Jean‐Christophe Marine · 2012 · Nature reviews. Cancer
MiR-223 promotes the cisplatin resistance of human gastric cancer cells via regulating cell cycle by targeting FBXW7
Xiaoying Zhou, Wujuan Jin, Hongyan Jia, Yan Jin, Guoxin Zhang · 2015 · Journal of Experimental & Clinical Cancer Research
The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs
Ning Liu, Hui Li, Shuangxi Li, Mingyue Shen, Ning Xiao, Yunfei Chen, Yan Wang, Weichao Wang, Rui Wang, Qian Wang et al. · 2010 · Journal of Biological Chemistry
Wnt‐induced deubiquitination FoxM1 ensures nucleus β‐catenin transactivation
Yaohui Chen, Li Yu, Jianfei Xue, Aihua Gong, Guanzhen Yu, Aidong Zhou, Kangyu Lin, Sicong Zhang, Nu Zhang, Cara J. Gottardi et al. · 2016 · The EMBO Journal
FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth
Wenxia Wei, Baifu Qin, Weijie Wen, Boyu Zhang, Haidan Luo, Yuzhi Wang, Hui Xu, Xiaoshan Xie, Sicheng Liu, Xin Jian Jiang et al. · 2023 · Signal Transduction and Targeted Therapy
miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7
Chuanyi Zhou, Liangfang Shen, Lei Mao, Bing Wang, Yang Li, Huizhi Yu · 2015 · Biochemical and Biophysical Research Communications
Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics
Mark Larance, Yasmeen Ahmad, Kathryn J Kirkwood, Tony Ly, Angus I. Lamond · 2012 · Molecular & Cellular Proteomics
ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination
Mario R. Capecchi, Amir Pozner · 2015 · Nature Communications
The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer
Omar M. Khan, Joana Carvalho, Bradley Spencer‐Dene, Richard Mitter, David Frith, Ambrosius P. Snijders, Stephen A. Wood, Axel Behrens · 2018 · Journal of Clinical Investigation
Fbxw7-dependent Degradation of Notch Is Required for Control of “Stemness” and Neuronal-Glial Differentiation in Neural Stem Cells
Akinobu Matsumoto, Ichiro Onoyama, Takehiko Sunabori, Ryoichiro Kageyama, Hideyuki Okano, Keiichi I. Nakayama · 2011 · Journal of Biological Chemistry
The Fbw7 and BetaTRCP E3 ubiquitin ligases and their roles in tumorigenesis
Alan, W Lau · 2012 · Frontiers in bioscience
The SCF–Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator
Michael A. Davis, Elizabeth A. Larimore, Brian M. Fissel, Jherek Swanger, Dylan J. Taatjes, Bruce E. Clurman · 2013 · Genes & Development
The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation
Kelly Moran-Crusio, B King, Linsey B. Reavie, Iannis Aifantis · 2010 · Oncogene
Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases
Weihua Zhou, Wenyi Wei, Yi Sun · 2013 · Cell Research
MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
Beatriz Aranda-Orgillés, Ricardo Saldaña-Meyer, Eric Wang, Eirini Trompouki, Anne Fassl, Stephanie Lau, Jasper Mullenders, Pedro P. Rocha, Ramya Raviram, María Guillamot et al. · 2016 · Cell stem cell
NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
Amy Oh, Makayla R Pardo, Anaelena Rodriguez, Connie Yu, Lisa Nguyen, Olin D. Liang, Anna Dorota Chorzalska, Patrycja M. Dubielecka · 2023 · Cell Communication and Signaling
Notch signaling: genetics and structure
Iva Greenwald · 2013 · WormBook
Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers
Libero Santarpia, Yuan Qi, Katherine Stemke‐Hale, Bailiang Wang, Elliana J. Young, Daniel J. Booser, Frankie Ann Holmes, Joyce O’Shaughnessy, Beth A. Hellerstedt, John Pippen et al. · 2012 · Breast Cancer Research and Treatment
The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis
Kuppusamy Balamurugan, Ju‐Ming Wang, Hsin-Hwa Tsai, Shikha Sharan, Miriam R. Anver, Robert M. Leighty, Esta Sterneck · 2010 · The EMBO Journal
Crosstalk between Nrf2 and Notch signaling
Nobunao Wakabayashi, Dionysios V. Chartoumpekis, Thomas W. Kensler · 2015 · Free Radical Biology and Medicine
A star is born: new insights into the mechanism of astrogenesis
Regina Kanski, Miriam E. van Strien, Paula van Tijn, Elly M. Hol · 2013 · Cellular and Molecular Life Sciences
Unraveling the molecular genetics of head and neck cancer through genome-wide approaches
Nadeem Riaz, Luc G.T. Morris, William Lee, Timothy An-thy Chan · 2014 · Genes & Diseases
The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases
Khai M. Nguyen, Luca Busino · 2020 · Advances in experimental medicine and biology
Role of the ubiquitin ligase Fbw7 in cancer progression
Yabin Cheng, Gang Li · 2011 · Cancer and Metastasis Reviews
Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression
Jianxia Wei, Mengna Li, Changning Xue, Shipeng Chen, Lemei Zheng, Hongyu Deng, Faqing Tang, Guiyuan Li, Wei Xiong, Zhaoyang Zeng et al. · 2023 · Journal of Experimental & Clinical Cancer Research
Recent insight into the role of FBXW7 as a tumor suppressor
Kanae Yumimoto, Keiichi I. Nakayama · 2020 · Seminars in Cancer Biology
A Gene Expression Signature from Human Breast Cancer Cells with Acquired Hormone Independence Identifies MYC as a Mediator of Antiestrogen Resistance
Todd W. Miller, Justin Micah Balko, Zara F. Ghazoui, Anita K. Dunbier, H Anderson, Mitch Dowsett, Ana Maria Gonzalez-Angulo, Gordon Brent Mills, William R. Miller, Huiyun Wu et al. · 2011 · Clinical Cancer Research
Abscisic acid promotes proteasome‐mediated degradation of the transcription coactivator NPR 1 in Arabidopsis thaliana
Yezhang Ding, Matthew Dommel, Zhonglin Mou · 2016 · The Plant Journal
CARMA1‐mediated NF‐κB and JNK activation in lymphocytes
Marzenna Blonska, Xin Lin · 2009 · Immunological Reviews
CDK5/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion
Xin Jin, Chong Yang, Ping Fan, Jun Xiao, Wanli Zhang, Sudong Zhan, Tao Liu, Dejie Wang, Heshui Wu · 2017 · Journal of Biological Chemistry
Targeting deubiquitinase USP28 for cancer therapy
Xiaofang Wang, Zhiyi Liu, Li Zhang, Zhaozhi Yang, Xingxing Chen, Jurui Luo, Zhirui Zhou, Xin Mei, Xiaoli Yu, Zhimin Shao et al. · 2018 · Cell Death and Disease
It's T-ALL about Notch
Renée M. Demarest, F Ratti, Anthony J. Capobianco · 2008 · Oncogene
The diverse roles of SPOP in prostate cancer and kidney cancer
Zhiwei Peter Wang, Yizuo Song, Miaomiao Ye, Xiaoming Dai, Xueqiong Zhu, Wenyi Wei · 2020 · Nature Reviews Urology
Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1–associated adult T-cell leukemia
Joanna Pancewicz, John M. Taylor, Abhik Datta, Hicham Hachem Baydoun, Thomas A. Waldmann, Olivier Hermine, Christophe Nicot · 2010 · Proceedings of the National Academy of Sciences
Myc's other life: stem cells and beyond
Elisa Laurenti, Anne Wilson, Andreas Trumpp · 2009 · Current Opinion in Cell Biology
Targeting Ubiquitination for Cancer Therapies
John Kenneth Morrow, Hui‐Kuan Lin, Shao‐Cong Sun, Shuxing Zhang · 2015 · Future Medicinal Chemistry
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
Fengting Su, Andreas Koeberle · 2023 · Cancer and Metastasis Reviews
Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis
Huilin Huang, Hengyou Weng, Lu‐Qin Wang, Chun-Hong Yu, Qiao-Juan Huang, Panpan Zhao, Jun-Zhi Wen, Hui Zhou, Liang‐Hu Qu · 2012 · Molecular Cancer Therapeutics
Viral oncogenesis in cancer: from mechanisms to therapeutics
Qing Xiao, Yi Liu, Tingting Li, Chaoyu Wang, Sanxiu He, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yongzhong Wu, Yao Liu · 2025 · Signal Transduction and Targeted Therapy
Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening
Antonella Sistigu, Martina Musella, Claudia Galassi, Ilio Vitale, Ruggero D. Maria · 2020 · Frontiers in Immunology
mTORC1 signaling governs hematopoietic stem cell quiescence
Boyi Gan, Ronald Anthony DePinho · 2009 · Cell Cycle
FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4
Kuppusamy Balamurugan, Shikha Sharan, Kimberly D. Klarmann, Youhong Zhang, Vincenzo Coppola, Glenn H. Summers, Thierry Roger, Deborah K. Morrison, Jonathan R. Keller, Esta Sterneck · 2013 · Nature Communications
Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer
Jonathan E. Grim, Sue E. Knoblaugh, Katherine Adams Guthrie, Amanda Hagar, Jherek Swanger, Jessica Hespelt, Jeffrey J. Delrow, Tom Small, William M. Grady, Keiichi I. Nakayama et al. · 2012 · Molecular and Cellular Biology
Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer Targets
Dong Wei, Yubing Sun · 2010 · Genes & Cancer
Ubiquitin networks in cancer
Vladimir Kirkin, Ivan Đikić · 2010 · Current Opinion in Genetics & Development
FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer
Shunrong Ji, Yi Qin, Chen Liang, Run Huang, Si Shi, Jiang Liu, Kaizhou Jin, Dingkong Liang, Wenyan Xu, Bo Zhang et al. · 2016 · Clinical Cancer Research
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis
Jinfang Zhang, Lixin Wan, Xiangpeng Dai, Yi Sun, Wenyi Wei · 2014 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Candidate Genes on Chromosome 9q33-34 Involved in the Progression of Childhood Ependymomas
Stéphanie Puget, Jacques Grill, Alexander Valent, Ivan Bièche, Carmela Dantas-Barbosa, Audrey Kauffmann, Philippe Dessen, Ludovic Lacroix, Birgit Geoerger, Bastien Job et al. · 2009 · Journal of Clinical Oncology
Roles of ubiquitin signaling in transcription regulation
Ian Hammond-Martel, Helen Yu, El Bachir Affar · 2011 · Cellular Signalling
Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways
Jiaxin Liu, Yicheng Cheng, Ming Zheng, Bingxiao Yuan, Zimu Wang, Xinying Li, Jie Yin, Mingxiang Ye, Yong Song · 2021 · Signal Transduction and Targeted Therapy
FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7
Zeran Wang, Yueyong Liu, Pengju Zhang, Weiguo Zhang, Weijing Wang, Kenneth A. Curr, Guangwei Wei, Jian‐Hua Mao · 2013 · Oncotarget
Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies
Xavier Lucas, Alessio Ciulli · 2017 · Current Opinion in Structural Biology
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc
Xiao‐Xin Sun, Yingxiao Chen, Yulong Su, Xiaoyan Wang, Krishna M. Chauhan, Juan Liang, Colin J. Daniel, Rosalie C. Sears, Mu‐Shui Dai · 2018 · Proceedings of the National Academy of Sciences
MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation
Francesco Galli, Mariangela Rossi, Yuri D’Alessandra, Marco Claudio De Simone, Teresa Lopardo, Ygal Haupt, Osnat Alsheich-Bartok, Shira Anzi, Eitan Shaulian, Viola Calabrò et al. · 2010 · Journal of Cell Science
SCF FBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation
Meng-Kwang Marcus Tan, Hui-Jun Lim, J. Wade Harper · 2011 · Molecular and Cellular Biology
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma
Vincent L. Cannataro, Stephen G. Gaffney, Tomoaki Sasaki, Natalia Issaeva, Nicholas Grewal, Jennifer Rubin Grandis, Wendell Gray Yarbrough, Barbara Ann Burtness, Karen S. Anderson, Jeffrey P. Townsend · 2019 · Oncogene
The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations
Xavier Bisteau, Matias J. Caldez, Philipp Kaldis · 2014 · Cancers
CHIP/Stub1 functions as a tumor suppressor and represses NF- B-mediated signaling in colorectal cancer
Y. Wang, F. Ren, Y. Wang, Yue Feng, Dongxiao Wang, Baoqing Jia, Ying Qiu, Shiyan Wang, Jun Qing Yu, Joseph J.�Y. Sung et al. · 2013 · Carcinogenesis