FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

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SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

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Quality control of protein complex composition

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Proteostasis and Its Role in Disease Development

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Role of key regulators of the cell cycle in maintenance of hematopoietic stem cells

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Targeting Notch degradation system provides promise for breast cancer therapeutics

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Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer

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A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression

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FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15

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MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation

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Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases

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Genome evolution predicts genetic interactions in protein complexes and reveals cancer drug targets

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Fbxw7 Limits Myelination by Inhibiting mTOR Signaling

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Turn It Down a Notch

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Loss of the Nuclear Pool of Ubiquitin Ligase CHIP/STUB1 in Breast Cancer Unleashes the MZF1-Cathepsin Pro-oncogenic Program

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Targeting SCF E3 Ligases for Cancer Therapies

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Nucleolar Targeting of the Fbw7 Ubiquitin Ligase by a Pseudosubstrate and Glycogen Synthase Kinase 3

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FBXW7 Mutation Analysis and its Correlation with Clinicopathological Features and Prognosis in Colorectal Cancer Patients

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miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7

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Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

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The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response

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A structural view of PA2G4 isoforms with opposing functions in cancer

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Targeted Therapy in Uterine Serous Carcinoma: An Aggressive Variant of Endometrial Cancer

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SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegronPreprint

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Characterization of novel CTNNB1 mutation in Craniopharyngioma by whole-genome sequencing

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Genetic profiles of cervical tumors by high‐throughput sequencing for personalized medical care

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Fbw7 Targets GATA3 through Cyclin-Dependent Kinase 2-Dependent Proteolysis and Contributes to Regulation of T-Cell Development

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Synthetic lethality-based targets for discovery of new cancer therapeutics.

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Targeted next-generation sequencing of cancer genes in poorly differentiated thyroid cancer

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Principles of tumorigenesis and emerging molecular drivers of SHH ‐activated medulloblastomas

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Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

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miR ‐223‐3p targets FBXW7 to promote epithelial‐mesenchymal transition and metastasis in breast cancer

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Characterization of Genomic Alterations in Colorectal Liver Metastasis and Their Prognostic Value

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KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc

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A complex molecular switch directs stress-induced cyclin C nuclear release through SCFGrr1-mediated degradation of Med13

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FBXO2, a novel marker for metastasis in human gastric cancer

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Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell cycle and ubiquitin ligase genes

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Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling

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Cooperative action of JNK and AKT/mTOR in 1‐methyl‐4‐phenylpyridinium‐induced autophagy of neuronal PC12 cells

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CRL2LRR-1 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Caenorhabditis elegans Germline

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The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1‐βTrCP2‐Cdc25A‐mediated mitotic entry to ensure neurogenesis

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Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1

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Drug Discovery Approaches to Target E3 Ligases

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Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR

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Murine Models of Acute Leukemia: Important Tools in Current Pediatric Leukemia Research

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PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity

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Molecular Dynamics Reveal the Essential Role of Linker Motions in the Function of Cullin–RING E3 Ligases

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Ubiquitin-dependent regulation of transcription in development and disease

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Phosphorylation prevents C/EBPβ from the calpain-dependent degradation

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Prognostic impact of RING box protein-1 (RBX1) expression in gastric cancer

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RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival

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States of G0 and the proliferation-quiescence decision in cells, tissues and during development

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Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis

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B-cell receptor configuration and mutational analysis of patients with chronic lymphocytic leukaemia and trisomy 12 reveal recurrent molecular abnormalities

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Uveal melanoma hepatic metastases mutation spectrum analysis using targeted next-generation sequencing of 400 cancer genes

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Regulating Fbw7 on the road to cancer

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Tumor suppressor Fbxw7 antagonizes WNT signaling by targeting β-catenin for degradation in pancreatic cancer

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Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7

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SCFFbxw7/hCdc4 targets cyclin E2 for ubiquitin-dependent proteolysis

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FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection

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The Repressing Function of the Oncoprotein BCL-3 Requires CtBP, while Its Polyubiquitination and Degradation Involve the E3 Ligase TBLR1

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KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8

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USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity

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Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer

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Exome Sequencing Identifies Potentially Druggable Mutations in Nasopharyngeal Carcinoma

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Serial profiling of circulating tumor DNA for optimization of anti‐VEGF chemotherapy in metastatic colorectal cancer patients

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FGFBP1, a downstream target of the FBW7/c-Myc axis, promotes cell proliferation and migration in pancreatic cancer.

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E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc

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Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy

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The FBXO4 Tumor Suppressor Functions as a Barrier to Braf V600E -Dependent Metastatic Melanoma

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GLIPR1 Suppresses Prostate Cancer Development through Targeted Oncoprotein Destruction

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Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc

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Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery

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Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer

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Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling

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FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis

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Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP

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SCFFBXW7/GSK3β-Mediated GFI1 Degradation Suppresses Proliferation of Gastric Cancer Cells

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Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

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HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53

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Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1

Biswas, M., Kwong, E. K., Park, E., Nagra, P., & Chan, J. Y. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.04.013 · Cited by 34

The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis

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Regulation of BRAF protein stability by a negative feedback loop involving the MEK–ERK pathway but not the FBXW7 tumour suppressor

Aguilar-Hernández, M., PATEL, B., Hey, F., Giblett, S. M., Belnoue-Davis, H. L., & Pritchard, C. A. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.02.009 · Cited by 34

FBXW 7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy

Xiao, Y., Yin, C., Wang, Y., Lv, H., Wang, W., Huang, Y., Pérez‐Losada, J., Snijders, A. M., Mao, J., & Zhang, P. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12200 · Cited by 34

Genetic mutations in human rectal cancers detected by targeted sequencing

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Molecular characterization of oral squamous cell carcinoma using targeted next‐generation sequencing

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Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD

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Regulation of F-box proteins by noncoding RNAs in human cancers

Lin, M., Xu, Y., Gao, Y., Pan, C., Zhu, X., & Wang, Z. P. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.09.008 · Cited by 33

Xanthohumol suppresses glioblastoma via modulation of Hexokinase 2 -mediated glycolysis

Yuan, J., Peng, G., Xiao, G., Yang, Z., Huang, J., Liu, Q., Yang, Z., & Liu, D. (2020) · Journal of Cancer · doi:10.7150/jca.33045 · Cited by 33

Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40

Salzberg, Y., Pechuk, V., Gat, A., Setty, H., Sela, S., & Oren‐Suissa, M. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.002 · Cited by 33

Honokiol antagonizes doxorubicin resistance in human breast cancer via miR-188-5p/FBXW7/c-Myc pathway

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Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation

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FBW 7 is associated with prognosis, inhibits malignancies and enhances temozolomide sensitivity in glioblastoma cells

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FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer

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Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism

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A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation

Peng, D., Wang, Z., Huang, A., Zhao, Y. B., & Qin, F. X.-F. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601009 · Cited by 32

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells

Saffie, R., Zhou, N., Rolland, D. C. M., Önder, Ö., Basrur, V., Campbell, S. L., Wellen, K. E., Elenitoba‐Johnson, K. S. J., Capell, B. C., & Busino, L. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2247 · Cited by 32

Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis

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Isoform‐Specific SCFFbw7 Ubiquitination Mediates Differential Regulation of PGC‐1α

Trausch‐Azar, J. S., Abed, M., Orian, A., & Schwartz, A. L. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24812 · Cited by 32

FBW7: the substrate recognition component of SCF-type ubiquitin ligase

Xie, F. (2008) · Shengming de Huaxue

Tumor Suppressor Function and Mechanism of Ubiquitin Ligase FBW7

Xiao, G. (2011) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao

Role of the ubiquitin ligase Fbw7 in cancer progression

Cheng, Y., & Li, G. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9330-z · Cited by 105

Mechanisms of Tumor Suppression by the SCFFbw7

Minella, A. C., & Clurman, B. E. (2005) · Cell Cycle · doi:10.4161/cc.4.10.2058 · Cited by 115

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities

Davis, R. J., Welcker, M., & Clurman, B. E. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.013 · Cited by 343