Cited by 1,084Ubiquitin and proteasome pathwaysCancer-related Molecular PathwaysProtein Degradation and Inhibitors

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Welcker, Markus, Clurman, Bruce E.·2008·Nature Reviews Cancer

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Abstract

FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN. FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies. Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis. This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer.

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Authors: Welcker, M., & Clurman, B. E.
Affiliations: Fred Hutch Cancer Center (US)
University of Washington (US)
Corresponding author: Welcker, Markus
ORCID: Welcker, Markus
Clurman, Bruce E.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2008-02
Volume: 8
Issue: 2
Pages: 83-93
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2290
OpenAlex: W2142183096
Cited by: 1,084
References: 120
Citations by year: 2026: 33 · 2025: 34 · 2024: 34 · 2023: 38 · 2022: 53 · 2021: 67 · 2020: 64 · 2019: 69 · 2018: 67 · 2017: 68 · 2016: 74 · 2015: 77 · 2014: 73 · 2013: 82 · 2012: 76
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL084205)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
Keywords: FBXW7, SCF ubiquitin ligase, tumour suppressor, MYC degradation, cyclin E, notches, c-Jun, chromosomal instability, carcinogenesis, cancer-associated mutations, cell division, cell growth, cell differentiation
MeSH terms: F-Box-WD Repeat-Containing Protein 7, Animals, Cell Differentiation, Cell Division, Humans, Models, Biological, Mutation, Neoplasms, Gene Expression Regulation, Neoplastic, Cell Cycle Proteins, Dimerization, Cyclin E, Ubiquitin-Protein Ligases, F-Box Proteins, Cell Proliferation, Mice

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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