FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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1. Fbw7 dimerization determines the specificity and robustness of substrate degradation
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2. Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway
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3. SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions
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4. Dual Regulation of Fbw7 Function and Oncogenic Transformation by Usp28
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5. SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction
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6. Molecular Genetics of Acute Lymphoblastic Leukemia
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7. Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo
   Alex C. Minella, Keith R. Loeb, Andrea Knecht, Markus Welcker, Barbara Varnum‐Finney, Irwin D. Bernstein, James M. Roberts, Bruce E. Clurman · 2008 · Genes & Development
8. The Multiple Layers of Ubiquitin-Dependent Cell Cycle Control
   Katherine E. Wickliffe, Adam P. Williamson, Lingyan Jin, Michael Rapé · 2009 · Chemical Reviews
9. Aberrant regulation of FBW7 in cancer
   Lixia Wang, Xiantao Ye, Yueyong Liu, Wenyi Wei, Zhiwei Peter Wang · 2014 · Oncotarget
10. Notch after cleavage
    Sarah J. Bray, Maria J. Gomez-Lamarca · 2017 · Current Opinion in Cell Biology
11. NOTCH1 Aberrations in Chronic Lymphocytic Leukemia
    Emanuela Rosati, Stefano Baldoni, Filomena De Falco, Beatrice Del Papa, Erica Dorillo, Chiara Rompietti, Elisabetta Albi, Franca Falzetti, Mauro Di Ianni, Paolo Sportoletti · 2018 · Frontiers in Oncology
12. Bone marrow fibroblasts overexpress miR‐27b and miR‐214 in step with multiple myeloma progression, dependent on tumour cell‐derived exosomes
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13. The transcriptional landscape of Shh medulloblastoma
    Patryk Skowron, Hamza Farooq, Florence M.G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Hugo Vrej Djambazian, Helen Zhu, Karen L. Mungall et al. · 2021 · Nature Communications
14. Validation of SAG/RBX2/ROC2 E3 Ubiquitin Ligase as an Anticancer and Radiosensitizing Target
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15. Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia
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16. Recent advances in SCF ubiquitin ligase complex: Clinical implications
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17. Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase
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18. Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily
    Jonathan D.J. Wrigley, Gérald Gavory, Iain D. Simpson, Marian Preston, Helen Plant, Jenna Bradley, Anne U. Goeppert, Ewelina Rozycka, Gareth M. Davies, Jarrod J. Walsh et al. · 2017 · ACS Chemical Biology
19. Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation
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20. MicroRNA-223 Regulates Cyclin E Activity by Modulating Expression of F-box and WD-40 Domain Protein 7
    Yanfei Xu, Tanushri Sengupta, Lokesh Kukreja, Alex C. Minella · 2010 · Journal of Biological Chemistry
21. FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcomes with mTOR Inhibitors
    Denis L. Fontes Jardim, Jennifer J. Wheler, Kenneth R. Hess, Apostolia Maria Tsimberidou, Ralph Zinner, Filip Jankú, Vivek Subbiah, Aung Naing, Sarina Anne Piha-Paul, Shannon Neville Westin et al. · 2014 · PLoS ONE
22. Emerging roles of F-box proteins in cancer drug resistance
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23. Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy
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24. Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
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25. Subtype-Specific FBXW7 Mutation and MYCN Copy Number Gain in Wilms' Tumor
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26. Dimerization quality control ensures neuronal development and survival
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27. Systematic characterization of mutations altering protein degradation in human cancers
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28. Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal
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29. A therapeutic role for targeting c-Myc/Hif-1- dependent signaling pathways
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30. Animal models of cholangiocarcinoma
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31. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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32. Pathogenic Bacteria Target NEDD8-Conjugated Cullins to Hijack Host-Cell Signaling Pathways
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33. FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells
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34. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis
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35. Cell cycle‐dependent ubiquitylation and destruction of NDE1 by CDK5‐FBW7 regulates ciliary length
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36. Pleiotropy of Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Self-Renewal of Embryonic Stem Cells from Refractory Mouse Strains
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37. Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer
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38. The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPα for degradation
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39. JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation
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40. Rapamycin inhibits FBXW7 loss-induced epithelial–mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells
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41. Cullins and Cancer
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42. Mcl-1 Ubiquitination and Destruction
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43. Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation
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44. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1
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45. FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition
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46. Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid
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47. FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma
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48. LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity
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49. New insights to the ubiquitin–proteasome pathway (UPP) mechanism during spermatogenesis
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50. Ubiquitinations in the Notch Signaling Pathway
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51. BRD4 and MYC : power couple in transcription and disease
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52. Chapter 6 Mechanisms Regulating the Susceptibility of Hematopoietic Malignancies to Glucocorticoid‐Induced Apoptosis
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53. Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic
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54. Plk2 promotes tumor growth and inhibits apoptosis by targeting Fbxw7/Cyclin E in colorectal cancer
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55. Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines
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56. Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer
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57. SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
    Li-Yu Huang, Junjie Zhao, Hao Chen, Lixin Wan, Hiroyuki Inuzuka, Jianping Guo, Xuhong Fu, Yangyang Zhai, Zhao‐Ning Lu, Xuefei Wang et al. · 2018 · Nature Communications
58. The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression
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59. MiR-25 Regulates Wwp2 and Fbxw7 and Promotes Reprogramming of Mouse Fibroblast Cells to iPSCs
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60. Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade
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61. Ubiquitin ligases in cancer: Functions and clinical potentials
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62. miRNA in cardiac development and regeneration
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63. High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma
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64. MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7
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65. Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin
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66. FBXW7 negatively regulates ENO1 expression and function in colorectal cancer
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67. Genomic Instability and Colon Carcinogenesis: From the Perspective of Genes
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68. Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)
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69. Role of Notch signaling pathway in pancreatic cancer.
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70. Understanding Cullin-RING E3 Biology through Proteomics-based Substrate Identification
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71. DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase
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72. Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells
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73. CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas
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74. Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer
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75. FBXW7 circular RNA regulates proliferation, migration and invasion of colorectal carcinoma through NEK2, mTOR, and PTEN signaling pathways in vitro and in vivo
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76. The Fbw7 Tumor Suppressor Regulates Nuclear Factor E2-related Factor 1 Transcription Factor Turnover through Proteasome-mediated Proteolysis
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77. Dysregulation of ubiquitin ligases in cancer
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78. E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses
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79. Exosomal Transfer of Macrophage-Derived miR-223 Confers Doxorubicin Resistance in Gastric Cancer
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80. FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation
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81. Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias
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82. FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer
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83. E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma
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84. Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma
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85. FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma
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86. MicroRNA-25 promotes gastric cancer proliferation, invasion, and migration by directly targeting F-box and WD-40 Domain Protein 7, FBXW7
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87. Sequential expression of miR ‐182 and miR ‐503 cooperatively targets FBXW7 , contributing to the malignant transformation of colon adenoma to adenocarcinoma
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88. UbiNet 2.0: a verified, classified, annotated and updated database of E3 ubiquitin ligase–substrate interactions
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89. Fbw7 Repression by Hes5 Creates a Feedback Loop That Modulates Notch-Mediated Intestinal and Neural Stem Cell Fate Decisions
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90. Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients
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91. IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity
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92. Mcl-1 dynamics influence mitotic slippage and death in mitosis
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93. Sequential primed kinases create a damage-responsive phosphodegron on Eco1
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94. Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
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95. Emerging roles of the FBW7 tumour suppressor in stem cell differentiation
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96. Fbxw7 Controls Angiogenesis by Regulating Endothelial Notch Activity
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97. Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase Activity
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98. Fbxw7 regulates tumor apoptosis, growth arrest and the epithelial-to-mesenchymal transition in part through the RhoA signaling pathway in gastric cancer
    Hui Li, Ziwei Wang, Wei Zhang, Kun Qian, Wei Xu, Shouru Zhang · 2015 · Cancer Letters
99. Parkin-Dependent Degradation of the F-Box Protein Fbw7β Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1
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100. Moving Breast Cancer Therapy up a Notch
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