FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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2. Haploinsufficiency of thec-myctranscriptional repressorFIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1
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3. sel-11 and cdc-42, Two Negative Modulators of LIN-12/Notch Activity in C. elegans
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4. Significance of FBX8 in progression of gastric cancer
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5. Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases
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6. Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation
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7. Overexpression of WDR 79 in non‐small cell lung cancer is linked to tumour progression
   Yang Sun, Chao Yang, Jieying Chen, Xin Song, Zhen Li, Minlan Duan, Jianglin Li, Xiaoxiao Hu, Kuangpei Wu, Guobei Yan et al. · 2016 · Journal of Cellular and Molecular Medicine
8. The expression characteristics of FBXW7 in human testis suggest its function is different from that in mice
   Dai Zhou, Xingming Wang, Zhizhong Liu, Zeng‐Hui Huang, Hongchuan Nie, Wenbing Zhu, Yue‐Qiu Tan, Liqing Fan · 2019 · Tissue and Cell
9. SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK‐3‐mediated phosphorylation
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10. Early growth response-1 is a new substrate of the GSK3β-FBXW7 axis
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11. Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer
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12. Glucosamine, a naturally occurring amino monosaccharide, inhibits A549 and H446 cell proliferation by blocking G1/S transition
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13. Loss of FBXW7 is related to the susceptibility and poor prognosis of cervical squamous carcinoma
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14. Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels
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15. Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts
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16. Molecular genetics complexity impeding research progress in breast and ovarian cancers
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17. In vitro effects of FBXW7 mutation in serous endometrial cancer: Increased levels of potentially druggable proteins and sensitivity to SI‐2 and dinaciclib
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18. Type 1 secretion system and effectors in Rickettsiales
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19. Role of microRNAs in regulation of doxorubicin and paclitaxel responses in lung tumor cells
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20. SCF-Mediated Degradation of p100 (NF-κB2): Mechanisms and Relevance in Multiple MyelomaA Presentation from the Sixth International Conference on SUMO, Ubiquitin and UBL proteins: Implications for Human Diseases, MD Anderson Cancer Center, Houston, Texas, 8 to 11 February 2012.
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21. FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study
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22. FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation
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23. FBW7 in hematological tumors (Review)
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24. c-MYC Protein Stability Is Sustained by MAPKs in Colorectal Cancer
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25. The SCF–FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage
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26. Function analysis of rs9589207 polymorphism in miR-92a in gastric cancer
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27. Regulation of the Histone Deacetylase Hst3 by Cyclin-dependent Kinases and the Ubiquitin Ligase SCFCdc4
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28. Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63
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29. Detection of Merkel Cell Polyomavirus in Respiratory Tract Specimens
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30. Robust Prediction of Prognosis and Immunotherapeutic Response for Clear Cell Renal Cell Carcinoma Through Deep Learning Algorithm
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31. The Archipelago Ubiquitin Ligase Subunit Acts in Target Tissue to Restrict Tracheal Terminal Cell Branching and Hypoxic-Induced Gene Expression
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32. Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing
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33. Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis: Figure 1.
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34. Glutamine signaling specifically activates c-Myc and Mcl-1 to facilitate cancer cell proliferation and survival
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35. SIK2 : A critical glucolipid metabolic reprogramming regulator and potential target in ovarian cancer
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36. Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells
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37. Deregulation of the COP9 signalosome–cullin-RING ubiquitin-ligase pathway: Mechanisms and roles in urological cancers
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38. The ubiquitin ligase SCFFBXW7α promotes GATA3 degradation
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39. microRNAs Promoting Growth of Gastric Cancer Xenografts and Correlation to Clinical Prognosis
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40. SCF Ligases and Their Functions in Oogenesis and Embryogenesis—Summary of the Most Important Findings throughout the Animal Kingdom
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41. Advances in the potential roles of Cullin-RING ligases in regulating autoimmune diseases
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42. Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer
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43. Regulating the Master Regulator: Controlling Ubiquitination by Thinking Outside the Active Site
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44. RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses
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45. FBW7 targets KLF10 for ubiquitin-dependent degradation
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46. Fbxw7 regulates renal cell carcinoma migration and invasion via suppression of the epithelial-mesenchymal transition
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47. Genetic Deletion of Fbw7 in the mouse intestinal epithelium aggravated dextran sodium sulfate–induced colitis by modulating the inflammatory response of NF-κB pathway
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48. The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein
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49. Low expression of the ubiquitin ligase FBXW7 correlates with poor prognosis of patients with colorectal cancer.
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50. Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival
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51. Fbxo45 joins the ‘Par-4’ty in controlling apoptosis of cancer cells
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52. Correction to: Circular RNA circRNA_0000094 sponges microRNA‑223‑3p and up‑regulate F‑box and WD repeat domain containing 7 to restrain T cell acute lymphoblastic leukemia progression
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53. The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset
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54. Ubiquitin E3 ligases in cancer: somatic mutation and amplification
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55. Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc
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56. Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules
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57. Determinants in the LIN-12/Notch Intracellular Domain That Govern Its Activity and Stability DuringCaenorhabditis elegansVulval Development
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58. The endothelial nitric oxide synthase/cyclic guanosine monophosphate/protein kinase G pathway activates primordial follicles
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59. Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
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60. The Canonical Wnt Signal Restricts the Glycogen Synthase Kinase 3/Fbw7-Dependent Ubiquitination and Degradation of Eya1 Phosphatase
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61. Constitutional de novo deletion of the FBXW7 gene in a patient with focal segmental glomerulosclerosis and multiple primitive tumors
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62. Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis
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63. Correlation between high FBXW7 expression in pretreatment biopsy specimens and good response to chemoradiation therapy in patients with locally advanced esophageal cancer: A retrospective study
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65. Multiple Novel Alternative Splicing Forms of FBXW7α Have a Translational Modulatory Function and Show Specific Alteration in Human Cancer
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66. Myc - What We have Learned from Flies
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67. Genomic insights in gynecologic cancer
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68. Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapy.
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69. Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma
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70. Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates
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71. MYCN in human development and diseases
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72. The Stomatin-Like Protein SLP-1 and Cdk2 Interact with the F-Box Protein Fbw7-γ
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73. PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression
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74. Inhibitors Targeting the F-BOX Proteins
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75. Expanding the ubiquitin code in pancreatic cancer
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76. Whole‐exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women
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77. CtBP represses Dpp-dependent Mad activation during Drosophila eye development
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78. Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma
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79. F-Box/WD Repeat Domain-Containing 7 Induces Chemotherapy Resistance in Colorectal Cancer Stem Cells
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80. Post-translational modification and stability of low molecular weight cyclin E
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81. 14‐3‐3ζ targeting induced senescence in Hep‐2 laryngeal cancer cell through deneddylation of Cullin1 in the Skp1‐Cullin‐F‐box protein complex
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82. Allele-Specific Deletions in Mouse Tumors Identify Fbxw7 as Germline Modifier of Tumor Susceptibility
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83. RETRACTED: The function of long non-coding RNA MT1JP in the development and progression of gastric cancer
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85. CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma
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86. Cytoreductive Nephrectomy After Combination of Nivolumab Plus Ipilimumab for Mucinous Tubular and Spindle Cell Carcinoma of the Kidney With Bone Metastases: A Case Report
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87. Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations
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89. Biomedical importance of the ubiquitin–proteasome system in diabetes and metabolic transdifferentiation of pancreatic duct epithelial cells into β-cells
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90. Increased c‐Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa‐1‐deficiency
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91. COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation
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92. Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer
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93. Critical roles of the E3 ubiquitin ligase FBW7 in B‐cell response and the pathogenesis of experimental autoimmune arthritis
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94. Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice
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95. Lack of association between cancer history and PARKIN genotype: A family based study in PARKIN/Parkinson's Families
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96. dp53 Restrains Ectopic Neural Stem Cell Formation in the Drosophila Brain in a Non-Apoptotic Mechanism Involving Archipelago and Cyclin E
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97. Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 .BETA.-form in human gliomas
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98. Genetic ablation of S6-kinase does not prevent processing of SREBP1
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99. FBW7-Aurora B-p53 feedback loop regulates mitosis and cell growth
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100. Mutational Status of SMAD4 and FBXW7 Affects Clinical Outcome in TP53–Mutated Metastatic Colorectal Cancer
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