The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.
Cytokines and their relationship to the symptoms and outcome of cancer
Open accessAbstract
Tumours contain immune cells and a network of pro- and anti-inflammatory cytokines, which collaborate in the development and progression of cancer. Cytokine profiles might prove to be prognostic. The systemic effects of pro-inflammatory cytokines are associated with fatigue, depression and cognitive impairment, and can affect quality of life before, during and after treatment. In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment. However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The treatment of physical disorders, e.g., interferon-based or virostatic treatments for hepatitis C (167, 197), chemotherapy for the treatment of cancer (168), surgery (169) or transplantation (170), can lead to additional cytokine release.”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [168]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
Paik, S., Shak, S., Tang, G., Kim, C., Baker, J. B., Cronin, M. T., Baehner, F. L., Walker, M. G., Watson, D., Park, T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041588 · Cited by 6,321
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
The expanding universe of T-cell subsets: Th1, Th2 and more
Mosmann, T. R., & Sad, S. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80606-2 · Cited by 3,603
Cited by
Sorted by citations
Items 601–659 of 659
Evans, E. S. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/4h8k-2m22
Lopes, L. C. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.22.2019.tde-31072019-125447
Prognostic and Predictive Biomarkers for Men With Castration-Resistant Prostate Cancer
Li, J., & Armstrong, A. J. (2014) · Springer eBooks · doi:10.1007/978-94-007-7744-6_13-1
Efeitos termorregulatórios e neuroimunomodulatórios da serotonina
Mota, C. M. D. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2020.tde-13042020-153828
Development of an immunogenomics-based prognostic index model of laryngeal squamous cell carcinomaPreprint
Shen, Y., Zhou, H. P., Dong, S., Lu, M., Dong, W., & Zhang, L. (2020) · Research Square · doi:10.21203/rs.3.rs-56339/v1
Klinička prehrana i kolorektalni karcinom
Krznarić, Ž., & Kunović, A. (2015) · Hrčak Portal of scientific journals of Croatia (University Computing Centre)
Disease-modifying therapies in advanced cancer
Dajani, O. F., & Jordan, K. (2021) · doi:10.1093/med/9780198821328.003.0077
Medical Disorders and Behavioral Risk Factors
Cohen, R. A. (2013) · Springer eBooks · doi:10.1007/978-0-387-72639-7_16
Macdonald, N. (2012) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199694143.003.0037
Farquhar-Smith, P. W., & Gordon-Williams, R. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733126348.793571732
Koinis, F., & Gioulbasanis, I. (2015) · Springer eBooks · doi:10.1007/978-3-319-21683-6_38
Farahani, M. A., Soleimanpour, S., Mayo, S. J., Myers, J. S., Panesar, P., & Ameri, F. (2022) · Canadian Oncology Nursing Journal · doi:10.5737/236880763214960
Koinis, F., & Gioulbasanis, I. (2019) · Springer eBooks · doi:10.1007/978-3-030-16245-0_47
Yennurajalingam, S., & Bruera, E. D. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198821328.003.0066
Miceli, R., Cao, C., Maolanon, N. N., Jacobs, R., Wu, J., & Orlandi, R. (2022) · Clinical Breast Cancer · doi:10.1016/j.clbc.2022.05.007 · Cited by 1
Can nocturnal sleep after radiation therapy enhance treatment efficiency?
Enferadi, M. (2023) · Medical Hypotheses · doi:10.1016/j.mehy.2023.111083
dos Santos, K. N., & de Almeida, M. K. C. (2023) · Editora Conhecimento Livre eBooks · doi:10.37423/2023.edcl787
Zheng, B., Chen, J., & Gong, X. (2024) · BMC Surgery · doi:10.1186/s12893-024-02473-5
eLife Assessment: OpenNucleome for high resolution nuclear structural and dynamical modeling
Collepardo, R. (2024) · eLife · doi:10.7554/elife.93223.2.sa3
Wu, W. (2024) · Research Publications (Maastricht University) · doi:10.26481/dis.20240628ww
Association of Interleukin-17A with Biomarker Levels in Chronic Kidney Disease Patients
Alkharsan, N. H. (2025) · Technium BioChemMed · doi:10.47577/biochemmed.v12i.12394
Comorbid symptoms in cancer patients and caring for the caregiver
Strander, S. M., Chiu, D., Temel, J. S., Jacobs, J. M., & Forst, D. A. (2025) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2025.2542245 · Cited by 1
Rationally Engineered Adenosine A2A Decoy Receptor for Reversing Immunosuppression of Breast Cancer
Sun, C., Wang, L., Deng, J., Zhang, S., Qing, R., Wang, B., & Hao, S. (2025) · Small · doi:10.1002/smll.202504487 · Cited by 1
Couto, N. D., Hidde, M. C., Grigoriadis, G., Sparapani, R., Durand, M. J., Widlansky, M. E., Jankowski, C., Berendt, M., Canales, B., Golus, S., et al. (2025) · Cardio-Oncology · doi:10.1186/s40959-025-00378-7
Pope, Z., Yabluchanskiy, A., Mukli, P., Robertson, M. C., Oliver, J. A., Borengasser, S. J., Ratke, M. M., Matney, J., Mixon, C., Henson, C. E., et al. (2025) · JMIR Research Protocols · doi:10.2196/79739
Zhang, Q., Qu, H., Zhang, S., Zhou, M., Lv, X., Wang, X., Cui, J., Liu, X., & Zhao, T. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-10188-3
Silva, S. D. O., Silva, M. E., da Fonseca, J. F., Camara, R. P. D. P. O. A., da Silva, M. C. B., Pereira, V. D. S. L., Dantas, R. A. N., & Dantas, D. V. (2025) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130251380590
Mao, Q., Liu, Y., Chen, X., & Liu, C. J. (2024) · Figshare · doi:10.6084/m9.figshare.25237257
Kelly, D. (2014) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/5sek-y296
Mao, Q., Liu, Y., Chen, X., & Liu, C. J. (2024) · Figshare · doi:10.6084/m9.figshare.25237428
Zheng, B., Chen, J., & Gong, X. (2024) · Figshare · doi:10.6084/m9.figshare.26027602
Ansiedad en pacientes oncológicos hospitalizados: una revisión
Suárez Zambrana, J. (2024) · Scientia Insularum Revista de Ciencias Naturales en islas
The Perceptions of Australian Oncologists Regarding Cognitive Changes in Cancer Survivors
Smidt, K. (2015) · The Sydney eScholarship Repository (The University of Sydney)
Detection and investigation of a malassimilation syndrome in dogs
Wojcieszak, C. (2023) · HAL
de Sousa, L. M. O. D. S. (2021) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Lin, K. (2022) · Digital Commons - University of South Florida (University of South Florida)
Determining the Selenium Level in Patients With Cancer‐Related Fatigue (2023)
Yosefianjazi, A., Ansari, H., Hajigholami, A., & Alirezamansouri (2025) · International Journal of Clinical Practice · doi:10.1155/ijcp/9394802
Zhong, D., Liang, Y., Su, Y., Yang, Q., Yan, H., Shi, Y., Huang, X., & Shang, J. (2026) · Technology in Cancer Research & Treatment · doi:10.1177/15330338261421357
Lopes‐Júnior, L. C., Minarini, E. J. C. D. S., Pessanha, R. M., Neto, L. C. B. S., D’Agostini, N. S., Grassi, J., Vasconcellos, K. A., Silva, R. J. G., de Azevedo, L. B., Giacomin, L. M., et al. (2026) · The Breast Journal · doi:10.1155/tbj/5427340
Johnson, I., Bacchus, A., Budziszewski, R., Siegel, S. D., & Sims‐Mourtada, J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1694711
Genetic alterations of the metastatic lesions in ovarian carcinoma
Malek, J. A. (2011) · theses.fr (ABES) · doi:10.70675/daeacc64z14f1z4c89z9146ze071c9dc2314
Lenoir, L. (2011) · theses.fr (ABES) · doi:10.70675/c2231782z852fz4a77zacdbzd3b7c2a9e121
Innate immune response to tissue-specific infection : notochord infection in the zebrafish embryo
Phan, Q. T. (2016) · theses.fr (ABES) · doi:10.70675/130b8d35z27c0z48f9zb4f3z8ee044103085
Elias, J., Vidal, L., Gelatt, T., Dakhel, S., Jermyn, R. T., & Sanfilippo, J. (2026) · Journal of the American Osteopathic Academy of Orthopedics · doi:10.70709/v3pg0260a73h1o
Montoyo-Pujol, Y. G., Martínez-Peinado, P., Pascual-García, S., Ortuño‐Miquel, S., Ponce, J. J., Lozano, I., Castellón-Molla, E., Delgado-García, S., Martín-Bayón, T.-A., Ballester, H., et al. (2026) · Breast Cancer Research · doi:10.1186/s13058-026-02319-3
Chen, Y.-S., Yan, J.-H., Yan, H.-L., Wang, Y., Feng, G.-H., Li, L., Huang, M., Yi, W.-T., Liu, M., Zhao, K.-H., et al. (2026) · Journal of Clinical Nursing · doi:10.1111/jocn.70465
Li, R.-L., Zhang, X.-Y., Zhou, Y.-W., Wang, Y.-Q., Liu, J., & Thomas, T. H. (2026) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2026.152308
Jammoul, D., Ajibuwa, F., Jammoul, M., Schlosser‐Hupf, S., Müller, M., & El‐Najjar, N. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1784272
Wang, J., Tang, X., Li, Z., Qi, Q., Sun, C., Sun, W., Zhang, W., Yin, Y., Deng, Y., Ling, P., et al. (2026) · Advanced Science · doi:10.1002/advs.77976
Shaik, F., Uldrick, T. S., Mazinu, M., Gwebushe, N., & Mosam, A. (2026) · AIDS Research and Therapy · doi:10.1186/s12981-026-00960-8
Metadata
- Authors
- Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F.
- Affiliations
- St. Michael's Hospital (CA)
- Corresponding author
- Tannock, Ian F.
- Venue
- Nature Reviews Cancer
- Published
- 2008-10-10
- Volume
- 8
- Issue
- 11
- Pages
- 887-899
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2061366514
- Cited by
- 652
- References
- 248
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 35 · 2023: 26 · 2022: 37 · 2021: 47 · 2020: 33 · 2019: 33 · 2018: 45 · 2017: 33 · 2016: 48 · 2015: 41 · 2014: 45 · 2013: 45 · 2012: 60
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- inflammatory cytokines, advanced cancer, cancer-related fatigue, cancer cachexia, anorexia, cancer pain, depression, cognitive impairment, treatment toxicity, treatment resistance, tumor immune microenvironment, quality of life, physical activity, cytokine signaling pathways
- MeSH terms
- Anorexia, Cachexia, Depressive Disorder, Humans, Neoplasms, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
