Cited by 659Nutrition and Health in AgingTryptophan and brain disordersInflammatory Biomarkers in Disease Prognosis

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Cytokines and their relationship to the symptoms and outcome of cancer

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Seruga, Bostjan, Zhang, Haibo, Bernstein, Lori J., Tannock, Ian F.·2008·Nature Reviews Cancer

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Abstract

Tumours contain immune cells and a network of pro- and anti-inflammatory cytokines, which collaborate in the development and progression of cancer. Cytokine profiles might prove to be prognostic. The systemic effects of pro-inflammatory cytokines are associated with fatigue, depression and cognitive impairment, and can affect quality of life before, during and after treatment. In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment. However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis.

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Authors: Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F.
Affiliations: St. Michael's Hospital (CA)
Corresponding author: Tannock, Ian F.
ORCID: Zhang, Haibo
Bernstein, Lori J.
Tannock, Ian F.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2008-10-10
Volume: 8
Issue: 11
Pages: 887-899
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2507
OpenAlex: W2061366514
Cited by: 652
References: 248
Citations by year: 2026: 11 · 2025: 23 · 2024: 35 · 2023: 26 · 2022: 37 · 2021: 47 · 2020: 33 · 2019: 33 · 2018: 45 · 2017: 33 · 2016: 48 · 2015: 41 · 2014: 45 · 2013: 45 · 2012: 60
FWCI: 3.26
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
TSpace (University of Toronto) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: inflammatory cytokines, advanced cancer, cancer-related fatigue, cancer cachexia, anorexia, cancer pain, depression, cognitive impairment, treatment toxicity, treatment resistance, tumor immune microenvironment, quality of life, physical activity, cytokine signaling pathways
MeSH terms: Anorexia, Cachexia, Depressive Disorder, Humans, Neoplasms, Cytokines

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