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Epidemiology and risk profile of heart failure
Open accessAbstract
Heart failure (HF) is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing HF is one in five. Although promising evidence shows that the age-adjusted incidence of HF may have plateaued, HF still carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. HF represents a considerable burden to the health-care system, responsible for costs of more than $39 billion annually in the USA alone, and high rates of hospitalizations, readmissions, and outpatient visits. HF is not a single entity, but a clinical syndrome that may have different characteristics depending on age, sex, race or ethnicity, left ventricular ejection fraction (LVEF) status, and HF etiology. Furthermore, pathophysiological differences are observed among patients diagnosed with HF and reduced LVEF compared with HF and preserved LVEF, which are beginning to be better appreciated in epidemiological studies. A number of risk factors, such as ischemic heart disease, hypertension, smoking, obesity, and diabetes, among others, have been identified that both predict the incidence of HF as well as its severity. In this Review, we discuss key features of the epidemiology and risk profile of HF.
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“Despite advancements in clinical management, MI and ischemic cardiomyopathy are among the leading causes of heart failure, associated morbidity, and death worldwide 3,4 and continue to impose staggering financial burden on healthcare systems 3,5-8 .”
From Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure (2022) · cites this paper as [8]
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“Conditions known to be or suspected of being associated with DCM or HF [1, 7, 24, 28, 29] were considered at baseline, namely cardiovascular comorbidities, psychiatric comorbidities, endocrinal and metabolic comorbidities, other comorbidities, drugs, and lifestyle factors.”
BackgroundSjölander, M., Lindholm, L. H., Pfister, B., Jonsson, J., Schneede, J., Lövheim, H., & Gustafsson, M. V. (2018) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2018.05.006 · Cited by 22
Palliative Care in Heart Failure
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Haybar, H., Rezaeeyan, H., Shahjahani, M., Shirzad, R., & Saki, N. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27935 · Cited by 22
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“INTRODUCTION Heart failure (HF) is a major public health concern around the world and is associated with frequent hospitalizations and high mortality.(1,2) Sodium glucose cotransporter 2 (SGLT2) inhibitors have become recommended drugs for HF in patients with type 2 diabetes (T2D) for their positive results on various…”
Fitzsimons, S., Poppe, K., Choi, Y. C., Devlin, G., Lund, M., Lam, C. S. P., Troughton, R. W., Richards, M., & Doughty, R. N. (2022) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2021.12.018 · Cited by 22
Neutrophil crosstalk during cardiac wound healing after myocardial infarction
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Interfacial tissue engineering of heart regenerative medicine based on soft cell-porous scaffolds
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“Eight assessment items relevant to the quality appraisal were used in this meta-analysis with scores ranging from 0 to 16: (1) adequacy of the case definition; (2) representativeness of the cases; (3) selection of controls; (4) definition of controls; (5) comparability of cases and controls on the basis of the design…”
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“Women are at higher risk of left ventricular hypertrophy and symptomatic heart failure with preserved ejection fraction [29, 31].”
BackgroundJDP2 overexpression provokes cardiac dysfunction in mice
Heger, J., Bornbaum, J., Würfel, A., Hill, C., Brockmann, N., Gáspár, R., Pálóczi, J., Varga, Z. V., Sárközy, M., Bencsik, P., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26052-w · Cited by 21
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“As effective treatment of CHF could not only improve the survival and living quality of patients, but also reduce the economic burden of family and society,([7]) it is necessary to develop an efficient and economical therapeutic tool for the prevention and treatment of CHF.”
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“It is estimated that 23 million people worldwide have the condition.(11,12) Although its incidence appears to have stabilized in recent years, its prevalence continues to rise, due to aging populations, improvements in treatment and hence increased survival in HF and other cardiovascular diseases, and increased preval…”
BackgroundManagement of Heart Failure in a Resource-Limited Setting: Expert Opinion from India
Jain, P., Guha, S., Kumar, S., Sawhney, J. P. S., Sharma, K. H., Sureshkumar, K. P., Mehta, A., Dhediya, R., Gaurav, K., Mittal, R., et al. (2024) · Cardiology and Therapy · doi:10.1007/s40119-024-00367-4 · Cited by 24
“Heart failure (HF) is a significant global health issue affecting 23 million individuals world-wide [1], with a reported prevalence of 1.2 per 1000 people in India, according to the INDia Ukieri Study (INDUS) study [2].”
BackgroundInfluentialSaeed, H., Abdullah, M. B. B. S., Naeem, I., Zafar, A., Ahmad, B., Islam, T. U., Rizvi, S. S., Kumari, N., Kirmani, S. G. A., Mansoor, F., et al. (2024) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2024.200326 · Cited by 20
“African Americans have also been found to have multiple etiologies linked to HF, including hypertension, DM, and coronary artery disease [43].”
BackgroundJakubowiak, A. J., DeCara, J. M., & Mezzi, K. (2017) · Hematology · doi:10.1080/10245332.2017.1328165 · Cited by 20
“Patients with New York Heart Association Class III and IV heart failure, recent myocardial infarction, conduction abnormalities, angina, or uncontrolled arrhythmias may be at increased cardiovascular risk, and patients aged ≥75 years are at an increased risk of cardiac failure [26,27].”
BackgroundMunch, G. W., Rosenmeier, J. B., Petersen, M. A., Rinnov, A. R., Iepsen, U. W., Pedersen, B. K., & Mortensen, S. P. (2018) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000304 · Cited by 22
“After the first experimental day, patients were assigned (1:1 allocation ratio by sealed envelope lottery) to either (1) aerobic moderate-intensity cycling (AMC; n = 14) or (2) low-volume time-based resistance training (TRE; n = 14).”
MethodResultAmbulatory Intra Aortic Balloon Pump in Advanced Heart Failure
Naqvi, S. Y., Salama, I. G., Yoruk, A., & Chen, L. (2018) · Cardiac failure review · doi:10.15420/cfr.2018:22:1 · Cited by 21
“Heart failure is a progressive and fatal disease that affects more than 23 million people worldwide, and will affect more than 8 million people in the USA by 2030.(1,2) Despite major advancements in medical and device treatments for heart failure in recent decades,”
BackgroundBioinformatics Analysis and Identification of Genes and Pathways in Ischemic Cardiomyopathy
Cao, J., Liu, Z., Liu, J., Li, C., Zhang, G., & Shi, R. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s329980 · Cited by 20
Lawson, C. A., Lam, C. S. P., Jaarsma, T., Kadam, U. T., Strömberg, A., Ali, M., Tay, W. T., Clayton, L., Khunti, K., & Squire, I. B. (2022) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvac019 · Cited by 18
Otaki, Y., Watanabe, T., Shimizu, M., Tachibana, S., Sato, J., Kobayashi, Y., Saito, Y., Aono, T., Tamura, H., Kato, S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-20985-z · Cited by 20
“The purposes of the present study were to (1) OPEN”
MethodResultPrevalence, Incidence, Lifetime Risks, and Outcomes of Heart Failure in Asia
Hung, C., Chao, T., Tsai, C.-T., Liao, J., Lim, S., Tuan, T., Chen, T., Chan, Y., Chen, S., & Chiang, C. (2022) · JACC Heart Failure · doi:10.1016/j.jchf.2022.07.012 · Cited by 20
Sensitivity and Specificity of a Five-Minute Cognitive Screening Test in Patients With Heart Failure
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Continuous flow left ventricular assist devices: a valid option for heart failure patients
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Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong.
Cheng, H. Y., Chair, S. Y., Wang, Q., Sit, J. W. H., Wong, E. M. L., & Tang, S. W. (2016) · PubMed Central · doi:10.11909/j.issn.1671-5411.2016.05.013 · Cited by 22
Critical Questions about PARADIGM-HF and the Future.
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Lopatin, Y. M., Cowie, M., Гребенникова, А., Sisakian, H. S., Pagava, Z., Hayrapetyan, H., Абдуллаев, Т. А., Voronkov, L. G., Chesnikova, A. I., Tseluyko, V., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.12.093 · Cited by 22
Can Computerized Cognitive Training Improve Cognition in Patients With Heart Failure?
Kua, Z. J., Valenzuela, M., & Dong, Y. (2018) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000558 · Cited by 20
Ramchandra, R., Xing, D. T., Matear, M., Lambert, G. W., Allen, A. M., & May, C. N. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00026.2019 · Cited by 20
Psychological Disorders in Heart Failure
Palo, K. E. D. (2019) · Heart Failure Clinics · doi:10.1016/j.hfc.2019.08.011 · Cited by 20
Johnson, R., Nxele, X., Cour, M., Sangweni, N. F., Jooste, T., Hadebe, N., Samodien, E., Benjeddou, M., Mazino, M., Louw, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-69254-x · Cited by 20
Sex-related differences in chronic heart failure: a community-based study
Russo, G. L., Rea, F., Barbati, G., Cherubini, A., Stellato, K., Scagnetto, A., Iorio, A., Corrao, G., & Lenarda, A. D. (2020) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001049 · Cited by 20
Designing Biomaterial Platforms for Cardiac Tissue and Disease Modeling
House, A. A., Atalla, I., Lee, E. J., & Güvendiren, M. (2020) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000022 · Cited by 20
Wu, Z., Tian, T., Ma, W., Gao, W., & Song, N. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01790-w · Cited by 20
Wu, A., Zhang, L., Chen, J., Li, H., Yang, P., Chen, M., & Liu, Q. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04111-7 · Cited by 20
Diagnostic Accuracy of Cognitive Screening Instruments in Heart Failure
Cameron, J., Kure, C., Pressler, S. J., Ski, C. F., Clark, A. M., & Thompson, D. R. (2015) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000285 · Cited by 21
“KEY WORDS: heart failure, mild cognitive impairment, neuropsychological test, review, screening In an aging population, there is no more relevant chronic cardiovascular health problem than heart failure (HF), which is estimated to currently affect 23 million individuals worldwide and will continue to be a major public…”
BackgroundOptimizing Machine Learning Classifiers for Enhanced Cardiovascular Disease Prediction
Alanazi, S. M., & Khamis, G. S. M. (2024) · Engineering Technology & Applied Science Research · doi:10.48084/etasr.6684 · Cited by 19
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Addressing the Heterogeneity of Heart Failure in Future Randomized Trials
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Ferraro, R., Ogunmoroti, O., Zhao, D., Ndumele, C. E., Rao, V. N., Pandey, A., Larson, N. B., Bielinski, S. J., & Michos, E. D. (2021) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2021.04.022 · Cited by 19
Hsieh, M., Chen, D., Lee, C., Wu, C.-L., Chen, Y.-J., Huang, Y., & Chang, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.831730 · Cited by 19
“The incidences of HF and AD increase with age (1), but the incidence of new-onset HF in patients with AD has never been examined.”
BackgroundZormpas, C., Kahl, K. G., Hohmann, S., Oswald, H., Stiel, C., Veltmann, C., Bauersachs, J. K., & Duncker, D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.827967 · Cited by 19
Heart Disease Classification–Based on the Best Machine Learning Model
Rahma, M. M., & Salman, A. D. (2022) · Iraqi Journal of Science · doi:10.24996/ijs.2022.63.9.28 · Cited by 19
“As a result, cardiac failure arises [1].”
Shuvy, M., von Bardeleben, R. S., Grasso, C., Raake, P. W. J., Lurz, P. C., Zamorano, J. L., Asch, F. M., Kar, S., Maisano, F., & EXPAND Investigators (2023) · ESC Heart Failure · doi:10.1002/ehf2.14273 · Cited by 19
“Heart failure (HF) is a major health problem that is characterized by the worsening of symptoms and clinical deterioration.(1) Due to the increase in life expectancy and the evolution of therapy, a higher proportion of patients reach a more advanced stage of disease.”
BackgroundAdducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis
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CardioMEMS HF for the Management of Heart Failure—Effectiveness and Value
Ollendorf, D. A., Sandhu, A. T., & Pearson, S. D. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.5467 · Cited by 19
“atic processes for patient-clinician interaction; and (2) prioritiza-”
BackgroundThe Benefit of Donor-Recipient Matching for Patients Undergoing Heart Transplantation
Nguyen, V. P., Mahr, C., Mokadam, N. A., Pal, J. D., Smith, J. W., & Dardas, T. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.038 · Cited by 19
Foster, A., Platt, M. J., Huber, J. S., Eadie, A. L., Arkell, A. M., Romanova, N. A., Wright, D. C., Gillis, T. E., Murrant, C. L., Brunt, K. R., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1303 · Cited by 19
Sleep-Disordered Breathing in Heart Failure ― A Therapeutic Dilemma ―
Haruki, N., & Floras, J. S. (2017) · Circulation Journal · doi:10.1253/circj.cj-17-0440 · Cited by 21
Fujita, H., Sudarshan, V. K., Adam, M., Oh, S. L., Tan, J. H., Hagiwara, Y., Chua, K. C., Chua, K. P., & Acharya, U. R. (2017) · Lecture notes in computer science · doi:10.1007/978-3-319-60042-0_30 · Cited by 19
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“As systolic heart failure is more common than diastolic heart failure [22,23], we did not differentiate systolic and diastolic heart failure, which is one of the limitation of this study.”
BackgroundPredictive Value of Endoplasmic Reticulum Stress Markers in Low Ejection Fractional Heart Failure
Sabırlı, R., Köseler, A., MANSUR, N., Zeytünlüoğlu, A., Sabirli, G. T., Türkçüer, İ., & Kılıç, İ. D. (2019) · In Vivo · doi:10.21873/invivo.11640 · Cited by 19
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Nummi, A., Nieminen, T. V. M., Pätilä, T., Lampinen, M., Lehtinen, M. L., Kivistö, S., Holmström, M., Wilkman, E., Teittinen, K., Laine, M., et al. (2017) · Pilot and Feasibility Studies · doi:10.1186/s40814-017-0217-9 · Cited by 19
“In conclusion, given the severe problems associated with heart failure and its increasing high prevalence [50] in the elderly population, it is of utmost importance to devise effective novel evidence-based cell therapies.”
BackgroundRoth, K., Yang, Z., Agarwal, M., Birbeck, J. A., Westrick, J. A., Lydic, T. A., Gurdziel, K., & Petriello, M. C. (2024) · Environmental Health Perspectives · doi:10.1289/ehp14339 · Cited by 20
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Peng, S., Peng, J., Yang, L., & Ke, W. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1082845 · Cited by 18
“In turn, hyponatremia encourages greater RAAS activation, starting a vicious cycle (10).”
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Usability Testing of an Internet-Based e-Counseling Platform for Adults With Chronic Heart Failure
Payne, A. Y. M., Surikova, J., Liu, S., Ross, H. J., Mechetiuc, T., & Nolan, R. P. (2015) · JMIR Human Factors · doi:10.2196/humanfactors.4125 · Cited by 18
“It is a major cause of hospitalization and mortality, and it is increasing in prevalence [2].”
BackgroundBiermann, J., Neumann, T., Angermann, C. E., Düngen, H., Erbel, R. M., Herzog, W., Maisch, B., Müller‐Tasch, T., Özcelik, C., Pankuweit, S., et al. (2011) · Journal of Public Health · doi:10.1007/s10389-011-0452-0 · Cited by 18
Mechanical Circulatory Support and the Role of LVADs in Heart Failure Therapy
McLarty, A. J. (2015) · Clinical Medicine Insights Cardiology · doi:10.4137/cmc.s19694 · Cited by 48
“8 Current indications for LVAD implantation as DT include patients (1) with New”
BackgroundThe TNF-α/Sphingosine-1-Phosphate Signaling Axis Drives Myogenic Responsiveness in Heart Failure
Kroetsch, J. T., & Bolz, S. (2013) · Journal of Vascular Research · doi:10.1159/000350528 · Cited by 18
Past and Present of Total Artificial Heart Therapy: A Success Story
Samak, M., Fatullayev, J., Sabashnikov, A., Zeriouh, M., Rahmanian, P. B., Choi, Y., Wippermann, J., Wahlers, T., Schmack, B., Ruhparwar, A., et al. (2015) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.895418 · Cited by 18
“It is estimated that 1 in every 5 people will develop HF in their lifetime, a risk notoriously known to increases with age [3].”
BackgroundBeber, A. R. C., Polina, E. R., Biolo, A., dos Santos, B. L., Gomes, D. D. C., Porta, V. L. L., Olsen, V. D. R., Clausell, N., Rohde, L. E. P., & dos Santos, K. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161666 · Cited by 18
“Heart failure (HF) is a clinical syndrome of insufficient cardiac output resulting from myocardial injury that remains a leading cause of morbidity and mortality worldwide [1,2].”
Background
Metadata
- Authors
- Bui, A. L., Horwich, T. B., & Fonarow, G. C.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Fonarow, Gregg C.
- Venue
- Nature Reviews Cardiology
- Published
- 2010-11-09
- Volume
- 8
- Issue
- 1
- Pages
- 30-41
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- PMC
- PMC3033496
- OpenAlex
- W1992644002
- Cited by
- 2,077
- References
- 144
- Citations by year
- 2026: 48 · 2025: 91 · 2024: 126 · 2023: 158 · 2022: 173 · 2021: 186 · 2020: 209 · 2019: 169 · 2018: 191 · 2017: 211 · 2016: 174 · 2015: 121 · 2014: 91 · 2013: 60 · 2012: 46
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Heart Failure Society of America
- Ahmanson Foundation
- National Institutes of Health (5k23hl085097-04)
- National Heart, Lung, and Blood Institute (1K23HL085097, K23 HL085097, T32HL007895)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- heart failure, heart failure epidemiology, heart failure risk factors, heart failure prevalence, heart failure mortality, health care costs, ischemic heart disease, hypertension, smoking, obesity, diabetes mellitus
- MeSH terms
- Adult, Aged, Female, Heart Failure, Humans, Male, Middle Aged, Prognosis, Risk Factors, Time Factors, Incidence, Prevalence, Risk Assessment
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