Cited by 3,115RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.

Knocking down barriers: advances in siRNA delivery

Open access

Whitehead, Kathryn A., Langer, Robert, Anderson, Daniel G.·2009·Nature Reviews Drug Discovery

Open this paper in CoChat — free account Open PDF

Abstract

In the 10 years that have passed since the Nobel prize-winning discovery of RNA interference (RNAi), billions of dollars have been invested in the therapeutic application of gene silencing in humans. Today, there are promising data from ongoing clinical trials for the treatment of age-related macular degeneration and respiratory syncytial virus. Despite these early successes, however, the widespread use of RNAi therapeutics for disease prevention and treatment requires the development of clinically suitable, safe and effective drug delivery vehicles. Here, we provide an update on the progress of RNAi therapeutics and highlight novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrd2742

Cites

106 of 106 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 5,018
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954
Factors affecting the clearance and biodistribution of polymeric nanoparticles
Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699
Toxicity of cationic lipids and cationic polymers in gene delivery
Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.014 · Cited by 2,286
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Soutschek, J., Akinc, A., Bramlage, B., Charissé, K., Constien, R., Donoghue, M., Elbashir, S. M., Geick, A., Hadwiger, P., Harborth, J., et al. (2004) · Nature · doi:10.1038/nature03121 · Cited by 2,206
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Grimm, D., Streetz, K. L., Jopling, C. L., Storm, T. A., Pandey, K., Davis, C. R., Marion, P., Salazar, F., & Kay, M. A. (2006) · Nature · doi:10.1038/nature04791 · Cited by 1,677

Flagged first, then by citations

Show all 106 references

Sorted by citations

Items 501–600 of 1,004

Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?
Guo, J., Bourré, L., Soden, D. M., O’Sullivan, G. C., & O’Driscoll, C. M. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.03.003 · Cited by 108
RNAi-combined nano-chemotherapeutics to tackle resistant tumors
Tekade, R. K., Tekade, M., Kesharwani, P., & D’Emanuele, A. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.06.029 · Cited by 105
DNA Nanostructures and DNA‐Functionalized Nanoparticles for Cancer Theranostics
Nicolson, F., Ali, A., Kircher, M. F., & Pal, S. (2020) · Advanced Science · doi:10.1002/advs.202001669 · Cited by 105
Nanoparticle-Mediated Drug Delivery Systems for Precision Targeting in Oncology
Hristova‐Panusheva, K., Xenodochidis, C., Georgieva, M., & Krasteva, N. A. (2024) · Pharmaceuticals · doi:10.3390/ph17060677 · Cited by 105
Prolonged gene silencing by combining siRNA nanogels and photochemical internalization
Raemdonck, K., Naeye, B., Høgset, A., Demeester, J., & Smedt, S. C. D. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.04.012 · Cited by 106
Magnetite nanoparticles as smart carriers to manipulate the cytotoxicity of anticancer drugs: magnetic control and pH-responsive release
Zhao, Z., Huang, D., Yin, Z., Chi, X., Wang, X., & Gao, J. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm31692g · Cited by 105
Simultaneous Magnetic Manipulation and Fluorescent Tracking of Multiple Individual Hybrid Nanostructures
Ruan, G., Vieira, G., Henighan, T., Chen, A., Thakur, D., Sooryakumar, R., & Winter, J. O. (2010) · Nano Letters · doi:10.1021/nl1011855 · Cited by 105
MicroRNAs as therapeutic targets in human cancers
Shah, M., & Călin, G. A. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1229 · Cited by 108
Versatile RNA Interference Nanoplatform for Systemic Delivery of RNAs
Choi, K. Y., Silvestre, O. F., Huang, X., Min, K. H., Howard, G. P., Hida, N., Jin, A. J., Carvajal, N., Lee, S. W., Hong, J.-I., et al. (2014) · ACS Nano · doi:10.1021/nn500085k · Cited by 104
Role of miRNAs in the progression of malignant melanoma
Mueller, D. W., & Bosserhoff, A. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605204 · Cited by 104
Smart Multilayered Assembly for Biocompatible siRNA Delivery Featuring Dissolvable Silica, Endosome-Disrupting Polycation, and Detachable PEG
Suma, T., Miyata, K., Anraku, Y., Watanabe, S. T., Christie, R. J., Takemoto, H., Shioyama, M., Gouda, N. A., Ishii, T., Nishiyama, N., et al. (2012) · ACS Nano · doi:10.1021/nn301164a · Cited by 104
Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery
Hao, J., Kós, P., Zhou, K., Miller, J. B., Xue, L., Yan, Y., Xiong, H., Elkassih, S. A., & Siegwart, D. J. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b03429 · Cited by 104
Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High‐Performance Anticancer Therapy
Zhang, F., Zhao, L., Wang, S., Yang, J., Lu, G., Luo, N., Gao, X., Ma, G., Xie, H., & Wei, W. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703326 · Cited by 104
The Progress and Promise of RNA Medicine─An Arsenal of Targeted Treatments
Sasso, J. M., Ambrose, B. J. B., Tenchov, R., Datta, R. S., Basel, M. T., DeLong, R. K., & Zhou, Q. A. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00024 · Cited by 108
Comparison of Cationic and Amphipathic Cell Penetrating Peptides for siRNA Delivery and Efficacy
Mo, R. H., Zaro, J. L., & Shen, W. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200481g · Cited by 103
Current Progress on aptamer-targeted Oligonucleotide Therapeutics
Dassie, J. P., & Giangrande, P. H. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.118 · Cited by 102
siRNA-Aptamer Chimeras on Nanoparticles: Preserving Targeting Functionality for Effective Gene Silencing
Bagalkot, V., & Gao, X. (2011) · ACS Nano · doi:10.1021/nn202772p · Cited by 104
Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
Cui, J., Qin, L., Zhang, J., Abrahimi, P., Li, H., Li, G., Tietjen, G. T., Tellides, G., Pober, J. S., & Saltzman, W. M. (2017) · Nature Communications · doi:10.1038/s41467-017-00297-x · Cited by 102
Hybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencing
Shi, J., Xu, Y., Xu, X., Zhu, X. D., Pridgen, E. M., Wu, J., Votruba, A. R., Swami, A., Zetter, B. R., & Farokhzad, O. C. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.03.006 · Cited by 102
Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models
Santel, A., Aleku, M., Röder, N., Möpert, K., Durieux, B., Janke, O., Keil, O., Endruschat, J., Dames, S., Lange, C. M., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1994 · Cited by 107
Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)‐Functionalized, Self‐Assembled Nanoconjugate
Liu, G., Choi, K. Y., Bhirde, A. A., Swierczewska, M., Yin, J. J., Lee, S. W., Park, J. H., Hong, J. I., Xie, J., Niu, G., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201105565 · Cited by 102
miRNA cassettes in viral vectors: Problems and solutions
Liu, Y. P., & Berkhout, B. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.05.014 · Cited by 101
Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers
Zheng, M., Librizzi, D., Kılıç, A., Liu, Y., Renz, H. E., Merkel, O. M., & Kissel, T. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.055 · Cited by 101
Pendant Polymer:Amino-β-Cyclodextrin:siRNA Guest:Host Nanoparticles as Efficient Vectors for Gene Silencing
Kulkarni, A., DeFrees, K., Hyun, S., & Thompson, D. H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300690j · Cited by 101
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery
Nguyen, D. N., Mahon, K. P., Chikh, G., Kim, P., Chung, H., Vicari, A. P., Love, K. T., Goldberg, M. S., Chen, S., Krieg, A. Μ., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121423109 · Cited by 103
Self-citation
Enhanced Intracellular siRNA Delivery using Bioreducible Lipid‐Like Nanoparticles
Wang, M., Alberti, K. A., Varone, A., Pouli, D., Georgakoudi, I., & Xu, Q. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400039 · Cited by 101
Topical delivery of siRNA into skin using ionic liquids
Dharamdasani, V., Mandal, A., Qi, Q. M., Suzuki, I., Bentley, M. V. L. B., & Mitragotri, S. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.038 · Cited by 100
Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs
Jeon, S. Y., Park, J. S., Yang, H. N., Woo, D. G., & Park, K.-H. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.051 · Cited by 100
Virus-mimetic polymeric micelles for targeted siRNA delivery
Xiong, X.-B., Uludağ, H., & Lavasanifar, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.075 · Cited by 102
Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation
Tzeng, S. Y., Hung, B. P., Grayson, W. L., & Green, J. J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.07.036 · Cited by 99
Targeting Macrophage Subsets for Infarct Repair
Ben-Mordechai, T., Palevski, D., Glucksam, Y., Elron-Gross, I., Margalit, R., & Leor, J. (2014) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248414534916 · Cited by 100
Reshaping the Future of Nanopharmaceuticals: Ad Iudicium
Moghimi, S. M., Peer, D., & Langer, R. (2011) · ACS Nano · doi:10.1021/nn2038252 · Cited by 104
Self-citation
Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain
Joo, J., Kwon, E. J., Kang, J., Skalak, M., Anglin, E. J., Mann, A. P., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2016) · Nanoscale Horizons · doi:10.1039/c6nh00082g · Cited by 100
Dendrimer‐Stabilized Gold Nanostars as a Multifunctional Theranostic Nanoplatform for CT Imaging, Photothermal Therapy, and Gene Silencing of Tumors
Wei, P., Chen, J., Hu, Y. M., Li, X., Wang, H., Shen, M., & Shi, X. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600923 · Cited by 99
Potential clinical application of lncRNAs in non-small cell lung cancer
Lu, T., Wang, Y., Chen, D., Liu, J., & Jiao, W. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s178431 · Cited by 99
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis
Pan, T. S., Zhou, Q., Miao, K., Zhang, L., Wu, G., Yu, J., Xu, Y., Xiong, W., Li, Y., & Wang, Y. (2020) · Theranostics · doi:10.7150/thno.48152 · Cited by 101
Lipid Nanoparticle Spherical Nucleic Acids for Intracellular DNA and RNA Delivery
Sinegra, A. J., Evangelopoulos, M., Park, J., Huang, Z. N., & Mirkin, C. A. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01973 · Cited by 100
NOVEL NANOMATERIALS FOR HEPATOBILIARY DISEASES TREATMENT AND FUTURE PERSPECTIVES
Huseynov, E. (2024) · Advances in Biology & Earth Sciences · doi:10.62476/abes9s81 · Cited by 99
Chimeric Capsid Protein as a Nanocarrier for siRNA Delivery: Stability and Cellular Uptake of Encapsulated siRNA
Choi, K.-M., Choi, S.-H., Jeon, H., Kim, I.-S., & Ahn, H. J. (2011) · ACS Nano · doi:10.1021/nn202597c · Cited by 99
Type 2 Diabetes Mellitus: Limitations of Conventional Therapies and Intervention with Nucleic Acid-Based Therapeutics
Kokil, G. R., Veedu, R. N., Ramm, G. A., Prins, J. B., & Parekh, H. S. (2015) · Chemical Reviews · doi:10.1021/cr5002832 · Cited by 100
Dendrimers as non-viral vectors for siRNA delivery
Liu, X., Rocchi, P., & Peng, L. (2011) · New Journal of Chemistry · doi:10.1039/c1nj20408d · Cited by 106
Cationic lipid-mediated nucleic acid delivery: beyond being cationic
Rao, N. M. (2010) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2010.01.001 · Cited by 98
A Combination RNAi-Chemotherapy Layer-by-Layer Nanoparticle for Systemic Targeting of KRAS/P53 with Cisplatin to Treat Non–Small Cell Lung Cancer
Gu, L., Deng, Z. J., Roy, S., & Hammond, P. T. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2186 · Cited by 99
Structured micro/nano materials synthesized via electrospray: a review
He, T., & Jokerst, J. V. (2020) · Biomaterials Science · doi:10.1039/d0bm01313g · Cited by 98
Exploiting gold nanoparticles for diagnosis and cancer treatments
D’Acunto, M., Cioni, P., Gabellieri, E., & Presciuttini, G. (2021) · Nanotechnology · doi:10.1088/1361-6528/abe1ed · Cited by 98
Graphene-based nanomaterials for cancer therapy and anti-infections
Wang, Y., Li, J., Li, X.-B., Shi, J., Jiang, Z., & Zhang, C. Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.01.045 · Cited by 99
Threaded macromolecules as a versatile framework for biomaterials
Tamura, A., & Yui, N. (2014) · Chemical Communications · doi:10.1039/c4cc03709j · Cited by 99
Cell transcytosing poly-arginine coated magnetic nanovector for safe and effective siRNA delivery
Omid Veiseh, A., Kievit, F. M., Mok, H., Ayesh, J., Clark, C. B., Fang, C., Leung, M. C., Arami, H., Park, J. O., & Zhang, M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.039 · Cited by 98
The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy
Liu, M., Li, M., Sun, S., Li, B., Du, D., Sun, J., Cao, F., Li, H., Jia, F., Wang, T., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.099 · Cited by 98
Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy
Buyens, K., Meyer, M., Wagner, E., Demeester, J., Smedt, S. C. D., & Sanders, N. N. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.08.026 · Cited by 98
Co-Delivery of Doxorubicin and Anti-BCL-2 siRNA by pH-Responsive Polymeric Vector to Overcome Drug Resistance in In Vitro and In Vivo HepG2 Hepatoma Model
Sun, W., Chen, X., Xie, C. L., Wang, Y., Lin, L., Zhu, K., & Shuai, X. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00272 · Cited by 98
Plug-and-Play Nanorization of Coarse Black Phosphorus for Targeted Chemo-photoimmunotherapy of Colorectal Cancer
Ou, W., Byeon, J. H., Thapa, R. K., Ku, S., Yong, C. S., & Kim, J. O. (2018) · ACS Nano · doi:10.1021/acsnano.8b04658 · Cited by 97
Current Aspects of siRNA Bioconjugate for In Vitro and In Vivo Delivery
Tai, W. (2019) · Molecules · doi:10.3390/molecules24122211 · Cited by 97
Cell Targeting with Hybrid Qβ Virus‐Like Particles Displaying Epidermal Growth Factor
Pokorski, J. K., Hovlid, M. L., & Finn, M. G. (2011) · ChemBioChem · doi:10.1002/cbic.201100469 · Cited by 97
Delivery of Therapeutic siRNA to the Lung Endothelium via Novel Lipoplex Formulation DACC
Fehring, V., Schaeper, U., Ahrens, K., Santel, A., Keil, O., Eisermann, M., Giese, K., & Kaufmann, J. (2014) · Molecular Therapy · doi:10.1038/mt.2013.291 · Cited by 97
Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery
Malamas, A. S., Gujrati, M. D., Kummitha, C. M., Xu, R., & Lu, Z. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.06.019 · Cited by 97
EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex
Subramanian, N., Kanwar, J. R., Athalya, P. K., Janakiraman, N., Khetan, V., Kanwar, R. K., Eluchuri, S., & Krishnakumar, S. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-014-0108-9 · Cited by 97
Advances in the use of nanocarriers for cancer diagnosis and treatment
Vieira, D. B., & Gamarra, L. F. (2016) · Einstein (São Paulo) · doi:10.1590/s1679-45082016rb3475 · Cited by 96
Ferritin-mediated siRNA delivery and gene silencing in human tumor and primary cells
Li, L., Muñoz‐Culla, M., Carmona, U., Lopez, M. P. R., Yang, F., Trigueros, C., Otaegui, D., Zhang, L., & Knez, M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.05.006 · Cited by 97
Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
Gibori, H., Eliyahu, S., Krivitsky, A., Ben‐Shushan, D., Epshtein, Y., Tiram, G., Blau, R., Ofek, P., Lee, J. S., Ruppin, E., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02283-9 · Cited by 96
The role of polymers in enabling RNAi-based technology for sustainable pest management
Quilez‐Molina, A. I., Sánchez, J. N., & Merino, D. (2024) · Nature Communications · doi:10.1038/s41467-024-53468-y · Cited by 96
Self-assembled siRNA–PLGA conjugate micelles for gene silencing
Hyeon, L. S., Mok, H., Lee, Y., & Park, T. G. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.12.007 · Cited by 96
Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles
Crawford, R., Dogdas, B., Keough, E., Haas, R. M., Wepukhulu, W., Krotzer, S., Burke, P. A., Sepp‐Lorenzino, L., Bagchi, A., & Howell, B. J. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.10.025 · Cited by 96
Protamine-Based Strategies for RNA Transfection
Jarzebska, N. T., Mellett, M., Frei, J., Kündig, T. M., & Pascolo, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060877 · Cited by 95
Beauty is Skin Deep: A Surface Monolayer Perspective on Nanoparticle Interactions with Cells and Bio‐macromolecules
Saha, K., Bajaj, A., Duncan, B., & Rotello, V. M. (2011) · Small · doi:10.1002/smll.201100478 · Cited by 97
Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid pKa on Cationic Lipid−Biomembrane Interactions
Zhang, J., Fan, H., Levorse, D. A., & Crocker, L. S. (2011) · Langmuir · doi:10.1021/la104590k · Cited by 96
Synthesis and Assembly of Click‐Nucleic‐Acid‐Containing PEG–PLGA Nanoparticles for DNA Delivery
Harguindey, A., Domaille, D. W., Fairbanks, B. D., Wagner, J., Bowman, C. N., & Cha, J. N. (2017) · Advanced Materials · doi:10.1002/adma.201700743 · Cited by 95
Degradable poly(ethylene glycol) (PEG)-based hydrogels for spatiotemporal control of siRNA/nanoparticle delivery
Wang, Y., Zhang, S., & Benoit, D. S. W. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.002 · Cited by 95
Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis
Zhou, H.-F., Yan, H., Pan, H., Hou, K. K., Akk, A. M., Springer, L. E., Hu, Y., Allen, J. S., Wickline, S. A., & Pham, C. T. N. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75673 · Cited by 95
Cell-Specific Aptamers as Emerging Therapeutics
Meyer, C., Hahn, U., & Rentmeister, A. (2011) · Journal of Nucleic Acids · doi:10.4061/2011/904750 · Cited by 94
Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice
Yang, C., Nilsson, L. L., Cheema, M. U., Wang, Y., Frøkiær, J., Gao, S., Kjems, J., & Nørregaard, R. (2014) · Theranostics · doi:10.7150/thno.9717 · Cited by 94
Effect of Polymer Structure on Micelles Formed between siRNA and Cationic Block Copolymer Comprising Thiols and Amidines
Christie, R. J., Miyata, K., Matsumoto, Y., Nomoto, T., Menasco, D., Lai, T. C., Pennisi, M., Osada, K., Fukushima, S., Nishiyama, N., et al. (2011) · Biomacromolecules · doi:10.1021/bm2006714 · Cited by 94
Hypoxia-responsive ionizable liposome delivery siRNA for glioma therapy
Liu, H., Zhang, Y., Xie, Y., Cai, Y., Baiyang, L., Li, W. J., Zeng, L.-Y., Li, Y., & Yu, R. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s125286 · Cited by 94
Self-assembly of amphiphilic phospholipid peptide dendrimer-based nanovectors for effective delivery of siRNA therapeutics in prostate cancer therapy
Dong, Y., Chen, Y., Zhu, D., Shi, K., Ma, C., Zhang, W., Rocchi, P., Jiang, L., & Liu, X. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.003 · Cited by 94
Novel RGD-lipid conjugate-modified liposomes for enhancing siRNA delivery in human retinal pigment epithelial cells
Chen, C., Lu, D., Yeh, Y., Shiau, & Chiang (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s24447 · Cited by 94
High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
Yang, B., Ming, X., Cao, C., Laing, B. M., Yuan, A., Porter, M. A., Hull-Ryde, E. A., Maddry, J. A., Suto, M. J., Janzen, W. P., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv060 · Cited by 98
New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids
Arukuusk, P., Pärnaste, L., Oskolkov, N., Copolovici, D. M., Margus, H., Padari, K., Möll, K., Maslovskaja, J., Tegova, R., Kivi, G., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.01.011 · Cited by 93
Gold-nanobeacons for simultaneous gene specific silencing and intracellular tracking of the silencing events
Conde, J., Rosa, J., de la Fuente, J. M., & Baptista, P. V. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.12.015 · Cited by 93
Five Years of siRNA Delivery: Spotlight on Gold Nanoparticles
Lytton‐Jean, A. K. R., Langer, R., & Anderson, D. G. (2011) · Small · doi:10.1002/smll.201100761 · Cited by 93
Self-citation
Multi-compartmental oral delivery systems for nucleic acid therapy in the gastrointestinal tract
Kriegel, C., Attarwala, H. Z., & Amiji, M. M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.11.003 · Cited by 94
Nanocarriers for Vascular Delivery of Anti-Inflammatory Agents
Howard, M. D., Hood, E. D., Zern, B. J., Shuvaev, V. V., Großer, T., & Muzykantov, V. R. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-140002 · Cited by 93
Blockage of immune checkpoint molecules increases T‐cell priming potential of dendritic cell vaccine
Hassannia, H., Chaleshtari, M. G., Atyabi, F., Nosouhian, M., Masjedi, A., Hojjat‐Farsangi, M., Namdar, A., Azizi, G., Mohammadi, H., Ghalamfarsa, G., et al. (2019) · Immunology · doi:10.1111/imm.13126 · Cited by 93
Modification of Lipid-Based Nanoparticles: An Efficient Delivery System for Nucleic Acid-Based Immunotherapy
Zhang, C., Ma, Y., Zhang, J., Kuo, J. C., Zhang, Z., Xie, H., Zhu, J., & Liu, T. (2022) · Molecules · doi:10.3390/molecules27061943 · Cited by 95
PEGylation of biodegradable dextran nanogels for siRNA delivery
Naeye, B., Raemdonck, K., Remaut, K., Sproat, B. S., Demeester, J., & Smedt, S. C. D. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.04.010 · Cited by 93
Targeted co-delivery of docetaxel and siPlk1 by herceptin-conjugated vitamin E TPGS based immunomicelles
Zhao, J., Mi, Y., & Feng, S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.009 · Cited by 92
Folic acid conjugated chitosan for targeted delivery of siRNA to activated macrophages in vitro and in vivo
Yang, C., Gao, S., & Kjems, J. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01374c · Cited by 92
FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer
Orellana, E. A., Tenneti, S., Rangasamy, L., Lyle, L. T., Low, P. S., & Kasinski, A. L. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aam9327 · Cited by 92
Synthesis and characterization of nanometer-sized liposomes for encapsulation and microRNA transfer to breast cancer cells
Lujan, H., Griffin, W. C., Taube, J. H., & Sayes, C. M. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s203330 · Cited by 92
Progress in treatment and risk stratification of neuroblastoma: Impact on future clinical and basic research
Øra, I., & Eggert, A. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.07.002 · Cited by 93
Chemistry and formulations for siRNA therapeutics
Gallas, A., Alexander, C., Davies, M. C., Puri, S., & Allen, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35520a · Cited by 93
Biomaterials Science: An Evolving, Multidisciplinary Endeavor
Ratner, B. D., Hoffman, A. S., Schöen, F. J., & Lemons, J. E. (2012) · Elsevier eBooks · doi:10.1016/b978-0-08-087780-8.00153-4 · Cited by 92
Happy birthday cell penetrating peptides: Already 20 years
Brasseur, R., & Divita, G. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.09.001 · Cited by 98
siRNA Delivery: From Lipids to Cell‐penetrating Peptides and Their Mimics
Gooding, M., Browne, L., Quinteiro, F. M., & Selwood, D. L. (2012) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12052 · Cited by 91
Conjugation Chemistry through Acetals toward a Dextran-Based Delivery System for Controlled Release of siRNA
Cui, L., Cohen, J. L., Chu, C. K., Wich, P. R., Kierstead, P. H., & Fréchet, J. M. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305552u · Cited by 91
Intelligent nucleic acid delivery systems based on stimuli-responsive polymers
Du, F., Wang, Y., Zhang, R., & Li, Z. (2009) · Soft Matter · doi:10.1039/b915020j · Cited by 91
Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: A promising strategy to overcome drug resistance in cancer
Salzano, G., Riehle, R. D., Navarro, G., Perche, F., Rosa, G. D., & Torchilin, V. P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.09.037 · Cited by 91
Non-viral nanocarriers for intracellular delivery of microRNA therapeutics
Bai, Z., Wei, J., Yu, C., Han, X., Qin, X., Zhang, C., Liao, W., Li, L., & Huang, W. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb02946f · Cited by 93
STAT3 signaling in ovarian cancer: a potential therapeutic target
Liang, R., Chen, X., Chen, L., Wan, F., Chen, K.-H., Sun, Y., & Zhu, X. (2019) · Journal of Cancer · doi:10.7150/jca.35011 · Cited by 91
Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy
Dogbey, D. M., Torres, V. E. S., Fajemisin, E. A., Mpondo, L., Ngwenya, T., Akinrinmade, O. A., Perriman, A. W., & Barth, S. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01362-3 · Cited by 97
Development of RNAi technology for targeted therapy — A track of siRNA based agents to RNAi therapeutics
Zhou, Y., Zhang, C., & Liang, W. P. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.044 · Cited by 94

Authors: Whitehead, K. A., Langer, R., & Anderson, D. G.
Affiliations: Massachusetts Institute of Technology (US)
Koch Institute for Integrative Cancer Research At MIT (US)
Corresponding author: Anderson, Daniel G.
ORCID: Whitehead, Kathryn A.
Anderson, Daniel G.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2009-02
Volume: 8
Issue: 2
Pages: 129-138
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd2742
PMC: PMC7097568
OpenAlex: W1964146045
Cited by: 3,115
References: 106
Citations by year: 2026: 96 · 2025: 114 · 2024: 150 · 2023: 120 · 2022: 159 · 2021: 207 · 2020: 148 · 2019: 191 · 2018: 183 · 2017: 199 · 2016: 220 · 2015: 218 · 2014: 240 · 2013: 233 · 2012: 222
FWCI: 16.16
Type: journal article
Language: en
Update notices: erratum (2010-05-01)
erratum (2009-06-01)
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: siRNA delivery, RNA interference therapy, gene silencing, nucleic acid encapsulation, intracellular delivery, age-related macular degeneration, respiratory syncytial virus, clinical trials
MeSH terms: Animals, Clinical Trials as Topic, Humans, Liposomes, Drug Delivery Systems, RNA Interference, RNA, Small Interfering, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Knocking down barriers: advances in siRNA delivery

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks