Cited by 3,115RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

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Knocking down barriers: advances in siRNA delivery

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Whitehead, Kathryn A., Langer, Robert, Anderson, Daniel G.·2009·Nature Reviews Drug Discovery

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Abstract

In the 10 years that have passed since the Nobel prize-winning discovery of RNA interference (RNAi), billions of dollars have been invested in the therapeutic application of gene silencing in humans. Today, there are promising data from ongoing clinical trials for the treatment of age-related macular degeneration and respiratory syncytial virus. Despite these early successes, however, the widespread use of RNAi therapeutics for disease prevention and treatment requires the development of clinically suitable, safe and effective drug delivery vehicles. Here, we provide an update on the progress of RNAi therapeutics and highlight novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids.

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Authors: Whitehead, K. A., Langer, R., & Anderson, D. G.
Affiliations: Massachusetts Institute of Technology (US)
Koch Institute for Integrative Cancer Research At MIT (US)
Corresponding author: Anderson, Daniel G.
ORCID: Whitehead, Kathryn A.
Anderson, Daniel G.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2009-02
Volume: 8
Issue: 2
Pages: 129-138
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd2742
PMC: PMC7097568
OpenAlex: W1964146045
Cited by: 3,115
References: 106
Citations by year: 2026: 96 · 2025: 114 · 2024: 150 · 2023: 120 · 2022: 159 · 2021: 207 · 2020: 148 · 2019: 191 · 2018: 183 · 2017: 199 · 2016: 220 · 2015: 218 · 2014: 240 · 2013: 233 · 2012: 222
FWCI: 16.16
Type: journal article
Language: en
Update notices: erratum (2010-05-01)
erratum (2009-06-01)
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: siRNA delivery, RNA interference therapy, gene silencing, nucleic acid encapsulation, intracellular delivery, age-related macular degeneration, respiratory syncytial virus, clinical trials
MeSH terms: Animals, Clinical Trials as Topic, Humans, Liposomes, Drug Delivery Systems, RNA Interference, RNA, Small Interfering, Nanoparticles

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