Cited by 193Gestational Diabetes Research and ManagementBirth, Development, and HealthPregnancy and preeclampsia studies

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Maternal adiposity—a determinant of perinatal and offspring outcomes?

Lawlor, Debbie A., Relton, Caroline, Sattar, Naveed, Nelson, Scott M.·2012·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2012.176

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Abstract

Experimental and animal data suggest that maternal obesity during pregnancy adversely affects offspring health in the short-term and the long-term. Whether these effects occur in humans and influence population health is less clear. This Review explores evidence from intervention studies and observational studies that have used designs (such as family-based comparisons and Mendelian randomization) that might help improve understanding of the causal effects of maternal obesity in humans. Collectively, human studies provide evidence that maternal overweight and obesity is causally related to pregnancy complications, increased offspring weight and adiposity at birth, and the difficulties associated with delivery of large-for-gestational-age infants. The underlying mechanisms for these effects probably involve maternal and fetal dysregulation of glucose, insulin, lipid and amino acid metabolism. Some evidence exists that extreme maternal obesity (BMI ≥40 kg/m(2)) is causally related to a long-term increase in offspring adiposity, but further exploration of this relationship is needed. High gestational weight gain may result in a long-term increase in offspring adiposity if women are already overweight or have obesity at the start of pregnancy. To date, little high-quality human evidence exists that any of these effects are mediated by epigenetic mechanisms, but approaches to appropriately test this possibility are being developed.

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Authors: Lawlor, D. A., Relton, C., Sattar, N., & Nelson, S. M.
Affiliations: University of Bristol (GB)
Centre for Life (GB)
University of Glasgow (GB)
Western Infirmary (GB)
Corresponding author: Lawlor, Debbie A.
ORCID: Lawlor, Debbie A.
Relton, Caroline
Sattar, Naveed
Nelson, Scott M.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2012-09-25
Volume: 8
Issue: 11
Pages: 679-688
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2012.176
OpenAlex: W1976542144
Cited by: 192
References: 95
Citations by year: 2026: 6 · 2025: 2 · 2024: 11 · 2023: 26 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 18 · 2018: 13 · 2017: 19 · 2016: 23 · 2015: 16 · 2014: 21 · 2013: 9
FWCI: 2.40
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Explore Bristol Research (publishedVersion)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: maternal obesity, maternal adiposity, gestational weight gain, perinatal outcomes, offspring adiposity, offspring weight, large for gestational age, pregnancy complications, epigenetic mechanisms, fetal metabolism, Mendelian randomization, causal effects
MeSH terms: Female, Humans, Infant, Newborn, Maternal Welfare, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Body Mass Index, Perinatal Care, Adiposity

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Maternal adiposity—a determinant of perinatal and offspring outcomes?

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