Relton, Caroline L.

The MR-Base platform supports systematic causal inference across the human phenome

Hemani, G., Zheng, J., Elsworth, B., Wade, K. H., Haberland, V., Baird, D., Laurin, C., Burgess, S., Bowden, J., Langdon, R., et al. (2018) · eLife

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

Cited by 7,959

Guidelines for performing Mendelian randomization investigations

Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Holmes, M. V., Minelli, C., Relton, C. L., et al. (2020) · Wellcome Open Research

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 1,273

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 1,025

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Wahl, S., Drong, A., Lehne, B., Loh, M., Scott, W. R., Kunze, S., Tsai, P.-C., Ried, J. S., Zhang, W., Yang, Y., et al. (2017) · Nature

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 945

DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis

Joubert, B. R., Felix, J. F., Yousefi, P., Bakulski, K. M., Just, A. C., Breton, C., Reese, S. E., Markunas, C. A., Richmond, R. C., Xu, C.-J., et al. (2016) · The American Journal of Human Genetics

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 886

Systematic identification of genetic influences on methylation across the human life course

Gaunt, T. R., Shihab, H. A., Hemani, G., Min, J. L., Woodward, G., Lyttleton, O., Zheng, J., Duggirala, A., McArdle, W. L., Ho, K., et al. (2016) · Genome Biology

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 598

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

Relton, C. L., & Davey Smith, G. (2012) · International Journal of Epidemiology

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 567

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Min, J. L., Hemani, G., Hannon, E., Dekkers, K. F., Castillo-Fernandez, J., Luijk, R., Carnero-Montoro, E., Lawson, D. J., Burrows, K., Suderman, M., et al. (2021) · Nature Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 506

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Richmond, R. C., Simpkin, A. J., Woodward, G., Gaunt, T. R., Lyttleton, O., McArdle, W. L., Ring, S. M., Smith, A. D. A. C., Timpson, N. J., Tilling, K., et al. (2015) · Human Molecular Genetics

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 372

Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study

Dunn, E. C., Soare, T. W., Zhu, Y., Simpkin, A. J., Suderman, M. J., Klengel, T., Smith, A. D. A. C., Ressler, K. J., & Relton, C. L. (2019) · Biological Psychiatry

Epigenetics and DNA MethylationChild Abuse and Trauma

Cited by 315

Differences in smoking associated DNA methylation patterns in south asians and europeans

Elliott, H. R., Tillin, T., McArdle, W. L., Ho, K., Duggirala, A., Frayling, T. M., Davey Smith, G., Hughes, A. D., Chaturvedi, N., & Relton, C. L. (2014) · Clinical Epigenetics

Epigenetics and DNA MethylationSmoking Behavior and Cessation

Cited by 282

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

Relton, C. L., & Davey Smith, G. (2010) · PLoS Medicine

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 254

Prenatal and early life influences on epigenetic age in children: A study of mother–offspring pairs from two cohort studies

Simpkin, A. J., Hemani, G., Suderman, M., Gaunt, T. R., Lyttleton, O., Mcardle, W. L., Ring, S. M., Sharp, G. C., Tilling, K., Horvath, S., et al. (2016) · Human Molecular Genetics

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 246

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Slieker, R. C., Relton, C. L., Gaunt, T. R., Slagboom, P. E., & Heijmans, B. T. (2018) · Epigenetics & Chromatin

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

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Maternal adiposity—a determinant of perinatal and offspring outcomes?

Lawlor, D. A., Relton, C., Sattar, N., & Nelson, S. M. (2012) · Nature Reviews Endocrinology

Gestational Diabetes Research and ManagementBirth, Development, and Health

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Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age

Lee, K. W. K., Richmond, R., Hu, P., French, L., Shin, J., Bourdon, C., Reischl, E., Waldenberger, M., Zeilinger, S., Gaunt, T., et al. (2015) · Environmental Health Perspectives

Epigenetics and DNA MethylationSmoking Behavior and Cessation

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Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Mulder, R. H., Neumann, A., Cecil, C. A. M., Walton, E., Houtepen, L. C., Simpkin, A. J., Rijlaarsdam, J., Heijmans, B. T., Gaunt, T. R., Felix, J. F., et al. (2021) · Human Molecular Genetics

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 165

Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer

Yarmolinsky, J., Bull, C. J., Vincent, E. E., Robinson, J., Walther, A., Smith, G. D., Lewis, S. J., Relton, C. L., & Martin, R. M. (2020) · JAMA

Cancer, Lipids, and MetabolismBRCA gene mutations in cancer

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DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

Wiklund, P., Karhunen, V., Richmond, R. C., Parmar, P., Rodriguez, A., De Silva, M., Wielscher, M., Rezwan, F. I., Richardson, T. G., Veijola, J., et al. (2019) · Clinical Epigenetics

Epigenetics and DNA MethylationSmoking Behavior and Cessation

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Whole-genome sequence-based analysis of thyroid function

Taylor, P. N., Porcu, E., Chew, S., Campbell, P. J., Traglia, M., Brown, S. J., Mullin, B. H., Shihab, H. A., Min, J., Walter, K., et al. (2015) · Nature Communications

Genetic Associations and EpidemiologyThyroid Disorders and Treatments

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DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence

Cecil, C. A. M., Walton, E., Smith, R. G., Viding, E., McCrory, E. J., Relton, C. L., Suderman, M., Pingault, J.-B., McArdle, W., Gaunt, T. R., et al. (2016) · Translational Psychiatry

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

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An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication

Rijlaarsdam, J., Pappa, I., Walton, E., Bakermans-Kranenburg, M. J., Mileva-Seitz, V. R., Rippe, R. C. A., Roza, S. J., Jaddoe, V. W. V., Verhulst, F. C., Felix, J. F., et al. (2016) · Epigenetics

Epigenetics and DNA MethylationBirth, Development, and Health

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Biological embedding of early‐life exposures and disease risk in humans: a role for DNA methylation

Demetriou, C. A., van Veldhoven, K., Relton, C., Stringhini, S., Kyriacou, K., & Vineis, P. (2015) · European Journal of Clinical Investigation

Birth, Development, and HealthEpigenetics and DNA Methylation

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When Will Mendelian Randomization Become Relevant for Clinical Practice and Public Health?

Davey Smith, G., Paternoster, L., & Relton, C. (2017) · JAMA

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

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