Online Questionnaire with Fibromyalgia Patients Reveals Correlations among Type of Pain, Psychological Alterations, and Effectiveness of Non-Pharmacological Therapies
Open accessAbstract
Fibromyalgia (FM) is a chronic pain syndrome with an unclear etiology. In addition to pain, FM patients suffer from a diverse array of symptoms and comorbidities, encompassing fatigue, cognitive dysfunction, mood disorders, sleep deprivation, and dizziness. Due to the complexity of FM, the diagnosis and treatment of it are highly challenging. The aim of the present work was to investigate some clinical and psychological characteristics of FM patients, and to uncover possible correlations with pharmacological and non-pharmacological therapies. We conducted a cross-sectional, questionnaire-based study aimed at evaluating pain, psychological traits, and the self-perceived effectiveness of pharmacological and non-pharmacological treatments in an Italian population of FM patients. Descriptive statistics, correlation, and inference analyses were performed. We found a prevalence of a neuropathic/nociplastic type of pain, which correlated with psychological traits such as anxiety, low mood, psychophysical discomfort, and the inability to relax. The pain type and psychological traits proved to play a role in determining the self-perceived effectiveness of therapeutic interventions. Patients revealed a better response to non-pharmacological therapies, particularly dietary interventions, relaxation techniques, and psychotherapy rather than pharmacological interventions. The sum of our data indicates that for better outcomes, the type of pain and psychological traits should be considered for tailor-made treatments considering non-pharmacological protocols as a complement to the use of drugs.
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Both pharmacological and nonpharmacological therapies for FM are generally disappointing, providing very limited benefit to FM patients.
“For what concerns FM, both pharmacological and nonpharmacological therapies are generally disappointing, providing very limited benefit to FM patients [4,140,155,156].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [4]
The Discussion (§4.3) reports lower perceived effectiveness for pharmacological therapies, but it describes clear benefits from non-pharmacological interventions. The Conclusions (§5) report high self-perceived effectiveness for dietary interventions, relaxation techniques, and psychotherapy, contrary to the claim that both types of therapy provide very limited benefit. (LLM, conf=0.86)
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- Authors
- Demori, I., Molinari, E., Rapallo, F., Mucci, V., Marinelli, L., Losacco, S., & Burlando, B.
- Affiliations
- University of Genoa (IT)
- Ente Ospedaliero Ospedali Galliera (IT)
- Western Sydney University (AU)
- Ospedale Policlinico San Martino (IT)
- Corresponding author
- Demori, Ilaria
- Venue
- Healthcare
- Publisher
- MDPI AG
- Published
- 2022-10-09
- Volume
- 10
- Issue
- 10
- Pages
- 1975
- ISSN
- 2227-9032 (ISSN-L)
- PMC
- PMC9602604
- OpenAlex
- W4303946411
- Cited by
- 16
- References
- 70
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 10
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Healthcare (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Funders
- University of Genova, Italy (100006-2020-SA-FRA_001, 100022-2012-DIP_01)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Keywords
- fibromyalgia, pain types, neuropathic pain, nociplastic pain, psychological characteristics, anxiety, depressive mood, non-pharmacological treatment, dietary intervention, relaxation techniques, psychotherapy, pharmacotherapy, personalized treatment
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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