The current state of pancreas transplantation

Gruessner, Rainer W. G.; Gruessner, Angelika C.

doi:10.1038/nrendo.2013.138

Cited by 256Pancreatic function and diabetesTransplantation: Methods and OutcomesOrgan Transplantation Techniques and Outcomes

The current state of pancreas transplantation

Gruessner, Rainer W. G., Gruessner, Angelika C.·2013·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2013.138

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Abstract

For many patients with type 1 diabetes mellitus and selected patients with type 2 diabetes mellitus, a successful pancreas transplant is the only definitive long-term treatment that both restores euglycaemia without the risk of severe hypoglycaemia and prevents, halts or reverses secondary complications. These benefits come at the cost of major surgery and lifelong immunosuppression. Nevertheless, pancreas transplants are safe and effective, with patient survival rates currently >95% at 1 year and >88% at 5 years; graft survival rates are almost 85% at 1 year and >60% at 5 years. The estimated half-life of a pancreas graft is now 7-14 years. The improvements in graft survival are attributable to considerable reductions in technical failures and in immunologic graft losses. Pancreas recipients have reduced mortality compared with waiting candidates or patients with diabetes mellitus who undergo a kidney transplant alone. Pancreas transplants should be more frequently offered to nonuraemic patients with brittle diabetes mellitus to prevent the development of secondary diabetic complications and to avoid the need for a kidney transplant. Although the results of islet transplantation have also improved, islet recipients rarely maintain long-term insulin independence despite the use of multiple organ donor pancreases. Pancreas transplants and islet transplants should be considered complementary, not mutually exclusive, procedures that are chosen on the basis of the individual patient's surgical risk.

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In experienced centres, combined kidney-pancreas transplant can give up to an 80% chance of insulin independence beyond 5 years, though it carries major surgical risk and needs immunosuppression.
“Simultaneous kidney and pancreas transplantation in experienced centres can offer an up to 80% chance of insulin independence for over 5 years, but there is substantial surgical risk, and the requirement of immunosuppression.159”
From Type 1 diabetes (2018) · cites this paper as [159]
Both whole organ pancreas and pancreatic islet transplantation can effectively prevent hypoglycemia, restore normoglycemia, and possibly stabilize the progression of complications of type 1 diabetes.
“Both therapeutic options can effectively prevent hypoglycemia, restore normoglycemia, and possibly stabilize the progression of complications of type 1 diabetes (223-227).”
From The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2021) · cites this paper as [223]

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Lauria, M. W., Figueiro, J., Machado, L. J. C., Sanches, M. D., Lana, Â. M. Q., & Ribeiro‐Oliveira, A. (2009) · Clinical Transplantation · doi:10.1111/j.1399-0012.2009.00969.x · Cited by 11 · see citing works

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Type 1 diabetes
DiMeglio, L. A., Evans-Molina, C., & Oram, R. A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31320-5 · Cited by 1,561 · see citing works
The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Holt, R. I. G., DeVries, J. H., Hess-Fischl, A., Hirsch, I. B., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, E., et al. (2021) · Diabetes Care · doi:10.2337/dci21-0043 · Cited by 699 · see citing works
Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia
Hering, B. J., Clarke, W. R., Bridges, N. D., Eggerman, T. L., Alejandro, R., Bellin, M. D., Chaloner, K., Czarniecki, C. W., Goldstein, J. S., Hunsicker, L. G., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1988 · Cited by 645 · see citing works
Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction
Sun, Y., Shi, H., Yin, S., Ji, C., Zhang, X., Zhang, B., Wu, P., Shi, Y., Mao, F., Yan, Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b07643 · Cited by 464 · see citing works
The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Holt, R., DeVries, J., Hess-Fischl, A., Hirsch, I., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, E., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05568-3 · Cited by 1,374 · see citing works
Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection
Boardman, D. A., Philippeos, C., Fruhwirth, G. O., Ibrahim, M. A. A., Hannen, R. F., Cooper, D., Marelli‐Berg, F. M., Watt, F. M., Lechler, R. I., Maher, J. F., et al. (2016) · American Journal of Transplantation · doi:10.1111/ajt.14185 · Cited by 321 · see citing works
Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia
Choudhary, P., Rickels, M. R., Senior, P. A., Vantyghem, M.-C., Maffi, P., Kay, T. W., Keymeulen, B., Inagaki, N., Saudek, F., Lehmann, R., et al. (2015) · Diabetes Care · doi:10.2337/dc15-0090 · Cited by 233 · see citing works
Coming of age: the artificial pancreas for type 1 diabetes
Thabit, H., & Hovorka, R. (2016) · Diabetologia · doi:10.1007/s00125-016-4022-4 · Cited by 205 · see citing works
Pancreas Transplantation of US and Non-US Cases from 2005 to 2014 as Reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR)
Gruessner, A. C., & Gruessner, R. W. G. (2016) · The Review of Diabetic Studies · doi:10.1900/rds.2016.13.35 · Cited by 208 · see citing works
Self-citation
One hundred years of insulin therapy
Mathieu, C., Martens, P.-J., & Vangoitsenhoven, R. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00542-w · Cited by 139 · see citing works
Current progress in stem cell therapy for type 1 diabetes mellitus
Chen, S., Du, K., & Zou, C. (2020) · Stem cell research & therapeutics · doi:10.1186/s13287-020-01793-6 · Cited by 109 · see citing works
Five-Year Metabolic, Functional, and Safety Results of Patients With Type 1 Diabetes Transplanted With Allogenic Islets Within the Swiss-French GRAGIL Network
Lablanche, S., Borot, S., Wojtusciszyn, A., Bayle, F., Tétaz, R., Badet, L., Thivolet, C. H., Morélon, E., Frimat, L., Penfornis, A., et al. (2015) · Diabetes Care · doi:10.2337/dc15-0094 · Cited by 121 · see citing works
Simultaneous pancreas and kidney transplantation
Redfield, R. R., Scalea, J. R., & Odorico, J. S. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000146 · Cited by 118 · see citing works
Pancreas Transplantation: An Alarming Crisis in Confidence
Stratta, R. J., Gruessner, A. C., Odorico, J. S., Fridell, J. A., & Gruessner, R. W. G. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13890 · Cited by 118 · see citing works
Self-citation
Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site
Pepper, A. R., Pawlick, R., Bruni, A., Wink, J., Rafiei, Y., O’Gorman, D., Yan-Do, R., Gala-Lopez, B., Kin, T., MacDonald, P. E., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.004 · Cited by 96 · see citing works
Glycemic Control in Simultaneous Islet-Kidney Versus Pancreas-Kidney Transplantation in Type 1 Diabetes: A Prospective 13-Year Follow-up
Lehmann, R., Graziano, J., Brockmann, J., Pfammatter, T., Kron, P., de Rougemont, O., Mueller, T., Zuellig, R. A., Spinas, G. A., & Gerber, P. A. (2015) · Diabetes Care · doi:10.2337/dc14-1686 · Cited by 94 · see citing works
Diagnosis and Treatment of Pancreas Rejection
Redfield, R. R., Kaufman, D. B., & Odorico, J. S. (2015) · Current Transplantation Reports · doi:10.1007/s40472-015-0061-x · Cited by 83 · see citing works
Combination immunotherapies for type 1 diabetes mellitus
Pozzilli, P., Maddaloni, E., & Buzzetti, R. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.8 · Cited by 81 · see citing works
Clinical islet transplantation: is the future finally now?
Pepper, A. R., Bruni, A. D. C., & Shapiro, A. M. J. (2018) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000546 · Cited by 79 · see citing works
Pancreas transplantation
Stratta, R. J., Fridell, J. A., Gruessner, A. C., Odorico, J. S., & Gruessner, R. W. G. (2016) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000319 · Cited by 76 · see citing works
Self-citation
Current treatment options and challenges in patients with Type 1 diabetes: Pharmacological, technical advances and future perspectives
Boscari, F., & Avogaro, A. (2021) · Reviews in Endocrine & Metabolic Disorders · doi:10.1007/s11154-021-09635-3 · Cited by 52 · see citing works
Pancreas Transplantation With Enteroanastomosis to Native Duodenum Poses Technical Challenges—But Offers Improved Endoscopic Access for Scheduled Biopsies and Therapeutic Interventions
Horneland, R., Paulsen, V., Lindahl, J. P., Grzyb, K., Eide, T. J., Lundin, K. U., Aabakken, L., Jenssen, T. G., Aandahl, E. M., Foss, A., et al. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12953 · Cited by 59 · see citing works
Pancreas Transplantation in the Modern Era
Redfield, R. R., Rickels, M. R., Naji, A., & Odorico, J. S. (2016) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2015.10.008 · Cited by 57 · see citing works
Hope vs hype: where are we in type 1 diabetes?
Skyler, J. S. (2018) · Diabetologia · doi:10.1007/s00125-017-4530-x · Cited by 51 · see citing works
Exocrine drainage in vascularized pancreas transplantation in the new millennium
Hennawy, H. M. E., Stratta, R. J., & Smith, F. R. (2016) · World Journal of Transplantation · doi:10.5500/wjt.v6.i2.255 · Cited by 51 · see citing works
Differentiation of human pluripotent stem cells into β-cells: Potential and challenges.
Quiskamp, N., Bruin, J. E., & Kieffer, T. (2015) · Best practice & research. Clinical endocrinology & metabolism · doi:10.1016/j.beem.2015.10.011 · Cited by 49 · see citing works
Endocrine pancreas engineered using porcine islets and partial pancreatic scaffolds
Katsuki, Y., Yagi, H., Okitsu, T., Kitago, M., Tajima, K., Kadota, Y., Hibi, T., Abe, Y., Shinoda, M., Itano, O., et al. (2016) · Pancreatology · doi:10.1016/j.pan.2016.06.007 · Cited by 46 · see citing works
Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses
Dedda, C. D., Vignali, D., Piemonti, L., & Monti, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194962 · Cited by 46 · see citing works
The emerging role of bile acids as critical components in nanotechnology and bioengineering: Pharmacology, formulation optimizers and hydrogel-biomaterial applications
Kovačević, B., Jones, M., Ionescu, C. M., Walker, D., Wagle, S. R., Chester, J., Foster, T., Brown, D. J., Mikov, M., Mooranian, A., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121459 · Cited by 45 · see citing works
Pancreas transplantation: a treatment option for people with diabetes
Mittal, S., & Gough, S. C. L. (2013) · Diabetic Medicine · doi:10.1111/dme.12373 · Cited by 41 · see citing works
Islet transplantation for Type 1 diabetes: where are we now?
Ahearn, A., Parekh, J., & Posselt, A. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.978291 · Cited by 38 · see citing works
Three-month pancreas graft function significantly influences survival following simultaneous pancreas-kidney transplantation in type 2 diabetes patients
Alhamad, T., Kunjal, R., Wellen, J. R., Brennan, D. C., Wiseman, A. C., Ruano, K., Hicks, V., Wang, M., Schnitzler, M. A., Chang, S., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15615 · Cited by 40 · see citing works
Concurrent biopsies of both grafts in recipients of simultaneous pancreas and kidney demonstrate high rates of discordance for rejection as well as discordance in type of rejection - a retrospective study
Parajuli, S., Arpalı, E., Astor, B. C., Djamali, A., Aziz, F., Redfield, R. R., Sollinger, H. W., Kaufman, D. B., Odorico, J. S., & Mandelbrot, D. A. (2017) · Transplant International · doi:10.1111/tri.13007 · Cited by 39 · see citing works
Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice
Sigmundsson, K., Ojala, J. R. M., Öhman, M. K., Österholm, A., Moreno‐Moral, A., Domogatskaya, A., Chong, L. Y., Sun, Y., Chai, X., Steele, J. A. M., et al. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.018 · Cited by 38 · see citing works
Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach
Gomes, A., Coelho, P., Soares, R. A., & Costa, R. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03461-4 · Cited by 37 · see citing works
Pancreas transplant alone
Niederhaus, S. V. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000157 · Cited by 37 · see citing works
Recent advances in cell replacement therapies for the treatment of type 1 diabetes.
Cogger, K. F., & Nostro, M. (2015) · Endocrinology · doi:10.1210/en.2014-1691 · Cited by 34 · see citing works
Duodenal leaks after pancreas transplantation with enteric drainage - characteristics and risk factors
Spetzler, V. N., Goldaracena, N., Marquez, M. A., Singh, S. K. S., Norgate, A., McGilvray, I. D., Schiff, J. R., Greig, P. D., Cattral, M. S., & Selzner, M. (2015) · Transplant International · doi:10.1111/tri.12535 · Cited by 36 · see citing works
Long-term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients
Shin, S. H., Jung, C. H., Choi, J. Y., Kwon, H. W., Jung, J. H., Kim, Y., & Han, D. J. (2016) · Transplantation · doi:10.1097/tp.0000000000001269 · Cited by 36 · see citing works
Pancreas transplantation: review
Meirelles, R. F., Salvalaggio, P. R. D. O., & Pacheco‐Silva, Á. (2015) · Einstein (São Paulo) · doi:10.1590/s1679-45082015rw3163 · Cited by 36 · see citing works
Islet number rather than islet size is a major determinant of β- and α-cell mass in humans.
Kou, K., Saisho, Y., Sato, S., Yamada, T., & Itoh, H. (2014) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-3731 · Cited by 11 · see citing works
Human umbilical cord matrix-derived stem cells exert trophic effects on β-cell survival in diabetic rats and isolated islets
Zhou, Y., Hu, Q., Chen, F., Zhang, J., Guo, J., Wang, H., Gu, J., Ma, L., & Ho, G. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.021857 · Cited by 35 · see citing works
Long-term Effects of Pancreas Transplantation on Diabetic Retinopathy and Incidence and Predictive Risk Factors for Early Worsening
Kim, Y. J., Shin, S. H., Han, D. J., Kim, Y. H., Lee, J. Y., Yoon, Y. H., & Kim, J.-G. (2017) · Transplantation · doi:10.1097/tp.0000000000001958 · Cited by 35 · see citing works
Interventions for increasing immunosuppressant medication adherence in solid organ transplant recipients
Mellon, L., Doyle, F., Hickey, A., Ward, K. D., de Freitas, D. G., McCormick, P. A., O’Connell, O. J., & Conlon, P. J. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012854.pub2 · Cited by 37 · see citing works
Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts
Pepper, A., Bruni, A., Pawlick, R., O'Gorman, D., Kin, T., Thiesen, A., & Shapiro, A. M. J. (2018) · Diabetes · doi:10.2337/db18-0788 · Cited by 31 · see citing works
Allograft Pancreatectomy: Indications and Outcomes
Nagai, S., Powelson, J. A., Taber, T. E., Goble, M. L., Mangus, R. S., & Fridell, J. A. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13287 · Cited by 32 · see citing works
Virtual HLA Crossmatching as a Means to Safely Expedite Transplantation of Imported Pancreata
Eby, B. C., Redfield, R. R., Ellis, T. M., LEVERSON, G. E., Schenian, A. R., & Odorico, J. S. (2016) · Transplantation · doi:10.1097/tp.0000000000001125 · Cited by 29 · see citing works
Ischemia-Reperfusion Injuries Assessment during Pancreas Preservation
Prudhomme, T., Mulvey, J. F., Young, L. A. J., Mesnard, B., Faro, M. L. L., Ogbemudia, A. E., Dengu, F., Friend, P. J., Ploeg, R. J., Hunter, J. P., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105172 · Cited by 29 · see citing works
A steady decline in pancreas transplantation rates
Benjamens, S., Leemkuil, M., Margreiter, C., Huurman, V. A. L., Leuvenink, H. G. D., & Pol, R. A. (2018) · Pancreatology · doi:10.1016/j.pan.2018.11.003 · Cited by 28 · see citing works
Preserving and perfusing the allograft pancreas: Past, present, and future
Dholakia, S., Royston, E., Sharples, E. J., Sankaran, V., Ploeg, R. J., & Friend, P. J. (2018) · Transplantation Reviews · doi:10.1016/j.trre.2018.02.001 · Cited by 27 · see citing works
Extracorporeal machine perfusion of the pancreas: technical aspects and its clinical implications – a systematic review of experimental models
Kuan, K. G., Wee, M. N., Chung, W. Y., Kumar, R., Mees, S. T., Dennison, A. R., Maddern, G. J., & Trochsler, M. (2015) · Transplantation Reviews · doi:10.1016/j.trre.2015.06.002 · Cited by 27 · see citing works
Favourable outcomes for the first 10 years of kidney and pancreas transplantation at Wits Donald Gordon Medical Centre, Johannesburg, South Africa
Fabian, J., Maher, H., Bentley, A., Gaylard, P., Crymble, K., Rossi, B., Aucamp, L., Gottlich, E., Loveland, J., Botha, J. R., et al. (2016) · South African Medical Journal · doi:10.7196/samj.2016.v106i2.10190 · Cited by 25 · see citing works
Benefits of healthy adipose tissue in the treatment of diabetes
Gunawardana, S. C. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i4.420 · Cited by 24 · see citing works
A Study of Normothermic Hemoperfusion of the Porcine Pancreas and Kidney
Kuan, K. G., Wee, M. N., Chung, W. Y., Kumar, R., Mees, S. T., Dennison, A. R., Maddern, G. J., & Trochsler, M. (2016) · Artificial Organs · doi:10.1111/aor.12770 · Cited by 24 · see citing works
In-Hospital Cardiovascular Complications After Pancreas Transplantation in the United States from 2003 to 2012
Kim, J., Schulman‐Marcus, J., Watkins, A. C., Feldman, D. N., Swaminathan, R. V., Lee, J. B., Muthukumar, T., Serur, D. S., Kim, L., & Hartono, C. (2017) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2017.05.038 · Cited by 23 · see citing works
Mold‐casted non‐degradable, islet macro‐encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice
Rios, P., Zhang, X., Luo, X., & Shea, L. D. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26005 · Cited by 23 · see citing works
Outcomes of Pancreatic Islet Allotransplantation Using the Edmonton Protocol at the University of Chicago
Tekin, Z., Garfinkel, M. R., Chon, W. J., Schenck, L., Gołąb, K., Savari, O., Thistlethwaite, J. R., Philipson, L. H., Majewski, C., Pannain, S., et al. (2016) · Transplantation Direct · doi:10.1097/txd.0000000000000609 · Cited by 23 · see citing works
Pancreas Transplantation from Donors after Circulatory Death: an Irrational Reluctance?
Leemkuil, M., Leuvenink, H. G. D., & Pol, R. A. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1238-y · Cited by 23 · see citing works
Current and Emerging Treatment Options in Diabetes Care
Clemmensen, C., Müller, T. D., Finan, B., Tschöp, M. H., & DiMarchi, R. D. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_7 · Cited by 22 · see citing works
Solitary pancreas transplantation: a review of the UK experience over a period of 10 yr
Vrakas, G., Arantes, R. M., Gerlach, U. A., Reddy, S., Friend, P. J., & Vaidya, A. C. (2015) · Clinical Transplantation · doi:10.1111/ctr.12650 · Cited by 21 · see citing works
Induction Therapy in Simultaneous Pancreas-Kidney Transplantation: Thymoglobulin Versus Basiliximab
Fernández-Burgos, I., Casado, M. C. M., Daga, J. A. P., Aranda-Narváez, J. M., Pérez, B. S., Díaz, F. J. L., Cabello-Díaz, M., Rodríguez-Burgos, D., Hernández, D., & Santoyo, J. S. (2015) · Transplantation Proceedings · doi:10.1016/j.transproceed.2014.12.003 · Cited by 20 · see citing works
Postoperative impaired glucose tolerance is an early predictor of pancreas graft failure
Mittal, S., Nagendran, M., Franklin, R. H., Sharples, E. J., Friend, P. J., & Gough, S. C. L. (2014) · Diabetologia · doi:10.1007/s00125-014-3320-y · Cited by 20 · see citing works
Engineering an endothelialized, endocrine Neo-Pancreas: evaluation of islet functionality in an ex vivo model.
Everwien, H., Keshi, E., Hillebrandt, K., Ludwig, B., Weinhart, M., Tang, P., Beierle, A., Napierala, H., Gassner, J., Seiffert, N., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.022 · Cited by 20 · see citing works
Pancreas After Islet Transplantation: A First Report of the International Pancreas Transplant Registry
Gruessner, R. W. G., & Gruessner, A. C. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13468 · Cited by 19 · see citing works
Self-citation
Medical, pharmaceutical, and nutritional applications of 3D-printing technology in diabetes
Amin, R., Marashi, S. M. H., Noori, S. M. R., Alavi, Z., Dehghani, E., Maleki, R., Safdarian, M., Rocky, A., Berizi, E., Alemohammad, S. M. A., et al. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.103002 · Cited by 19 · see citing works
Impact of Sarcopenia on Simultaneous Pancreas and Kidney Transplantation Outcomes: A Retrospective Observational Cohort Study
Meier, R. P. H., Noguchi, H., Kelly, Y. M., Sarwal, M., Conti, G., Ward, C., Halleluyan, R., Tavakol, M., Stock, P. G., & Freise, C. E. (2020) · Transplantation Direct · doi:10.1097/txd.0000000000001053 · Cited by 19 · see citing works
Challenges in pancreas transplantation
Sharples, E. J., Mittal, S., & Friend, P. J. (2016) · Acta Diabetologica · doi:10.1007/s00592-016-0865-x · Cited by 19 · see citing works
Heparin Thromboprophylaxis in Simultaneous Pancreas-Kidney Transplantation: A Systematic Review and Meta-Analysis of Observational Studies
Li, E. A., Farrokhi, K., Zhang, M. Y., Offerni, J. C. M., Luke, P. P. W., & Şener, A. (2023) · Transplant International · doi:10.3389/ti.2023.10442 · Cited by 17 · see citing works
Current outcomes in islet versus solid organ pancreas transplant for β-cell replacement in type 1 diabetes
Wisel, S. A., Braun, H. J., & Stock, P. G. (2016) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000332 · Cited by 17 · see citing works
Ex situ Perfusion of Pancreas for Whole-Organ Transplantation: Is it Safe and Feasible? A Systematic Review
Prudhomme, T., Kervella, D., Bas‐Bernardet, S. L., Cantarovich, D., Karam, G., Blancho, G., & Branchereau, J. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819869312 · Cited by 17 · see citing works
Liraglutide in whole-pancreas transplant patients with impaired glucose homoeostasis: A case series
Cariou, B., Bernard, C., & Cantarovich, D. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.10.004 · Cited by 17 · see citing works
Current status of pancreas transplantation
Stites, E., Kennealey, P. T., & Wiseman, A. C. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000264 · Cited by 17 · see citing works
Pancreas Retransplant After Pancreas Graft Failure in Simultaneous Pancreas-kidney Transplants Is Associated With Better Kidney Graft Survival
Parajuli, S., Arunachalam, A., Swanson, K. J., Aziz, F., Garg, N., Bath, N. M., Redfield, R. R., Kaufman, D. B., Djamali, A., Odorico, J. S., et al. (2019) · Transplantation Direct · doi:10.1097/txd.0000000000000919 · Cited by 16 · see citing works
Preoperative Muscle Volume Predicts Graft Survival After Pancreas Transplantation: A Retrospective Observational Cohort Study
Noguchi, H., Miyasaka, Y., Kaku, K., Kurihara, K., Nakamura, U., Okabe, Y., Ohtsuka, T., Ishigami, K., & Nakamura, M. (2018) · Transplantation Proceedings · doi:10.1016/j.transproceed.2018.03.018 · Cited by 15 · see citing works
Protocol Duodenal Graft Biopsies Aid Pancreas Graft Surveillance
Brockmann, J. G., Butt, A., AlHussaini, H. F., Almana, H., Alsaad, K. O., Al-Awwami, M. A., Broering, D. C., & Ali, T. Z. (2018) · Transplantation · doi:10.1097/tp.0000000000002412 · Cited by 15 · see citing works
Optimal surgical management in kidney and pancreas transplantation to minimise wound complications: A systematic review and meta-analysis
Shahrestani, S., Tran, H. M., Pleass, H. C. C., & Hawthorne, W. J. (2018) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2018.08.006 · Cited by 15 · see citing works
Islet Xeno/transplantation and the risk of contagion: local responses from Canada and Australia to an emerging global technoscience
Cheng, M. (2015) · Life Sciences Society and Policy · doi:10.1186/s40504-015-0030-2 · Cited by 15 · see citing works
Pancreas transplantation perceptions and practice: Results from a national US survey
Parsons, R. F., Matar, A. J., Lentine, K. L., Woodside, K. J., Singh, N., Alhamad, T., Basu, A., Rivera, F. H. C., Cheungpasitporn, W., Romeo, G. R., et al. (2021) · Clinical Transplantation · doi:10.1111/ctr.14432 · Cited by 14 · see citing works
Assessing Pancreas Transplant Candidate Cardiac Disease: Preoperative Protocol Development at a Rapidly Growing Transplant Program
Michel, D. S., Donnelly, T., Jackson, T., Taylor, B. S., Barth, R. N., Bromberg, J. S., & Scalea, J. R. (2019) · Methods and Protocols · doi:10.3390/mps2040082 · Cited by 14 · see citing works
Impact of Early Pancreatic Graft Loss on Outcome after Simultaneous Pancreas–Kidney Transplantation (SPKT)—A Landmark Analysis
Lehner, L. J., Öllinger, R., Globke, B., Naik, M. G., Budde, K., Pratschke, J., Eckardt, K., Kahl, A., Zhang, K., & Halleck, F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153237 · Cited by 14 · see citing works
The center volume–outcome effect in pancreas transplantation: a national analysis
Kim, Y., Dhar, V. K., Wima, K., Jung, A. D., Xia, B. T., Hoehn, R. S., Diwan, T. S., & Shah, S. A. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.02.025 · Cited by 14 · see citing works
Pancreas transplantation following total pancreatectomy for chronic pancreatitis
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Authors: Gruessner, R. W. G., & Gruessner, A. C.
Affiliations: University of Arizona (US)
Corresponding author: Gruessner, Rainer W. G.
ORCID: Gruessner, Rainer W. G.
Gruessner, Angelika C.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2013-07-30
Volume: 9
Issue: 9
Pages: 555-562
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2013.138
OpenAlex: W1997688914
Cited by: 256
References: 76
Citations by year: 2026: 5 · 2025: 8 · 2024: 13 · 2023: 26 · 2022: 15 · 2021: 19 · 2020: 20 · 2019: 25 · 2018: 21 · 2017: 13 · 2016: 37 · 2015: 39 · 2014: 14 · 2013: 1
Type: book review
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Minnesota
University of Arizona
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords: pancreas transplantation, type 1 diabetes, type 2 diabetes, islet transplantation, graft survival, immunosuppression, diabetes complications, brittle diabetes, kidney transplantation, insulin independence
MeSH terms: Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Male, Pancreas Transplantation, Islets of Langerhans Transplantation, Treatment Outcome

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